Injection of iron compounds followed by induction of the stress response causes tissue injury and apoptosis

Shock

Volumn 14, Issue 4, 2000, Pages 460-464

  Jacob, Ammini K ^a   Hotchkiss, Richard S ^a   Swanson, Paul E ^a   Tinsley, Kevin W ^a   Karl, Irene E ^a   Buchman, Timothy G ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Box 8109 ^*  (United States)

Author keywords

Apoptosis; Experimental models; Heat shock; Iron; Organ failure; Tissue ulcer

Indexed keywords

HEMIN; HEMOGLOBIN; IRON;

ANIMAL; APOPTOSIS; ARTICLE; DRUG EFFECT; HEAT SHOCK RESPONSE; INJURY; MALE; MOUSE; PATHOLOGY; PHYSIOLOGY; SKELETAL MUSCLE; SUBCUTANEOUS DRUG ADMINISTRATION; ULCER;

ANIMALS; APOPTOSIS; HEAT-SHOCK RESPONSE; HEMIN; HEMOGLOBINS; INJECTIONS, SUBCUTANEOUS; IRON; MALE; MICE; MUSCLE, SKELETAL; ULCER;

EID: 0034305391     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200014040-00007     Document Type: Article

References (19)

1. Polla BS: Therapy by taking away: the case of iron. Biochem Pharmacol 57:1345-1349, 1999.
2. Jacob AK, Hotchkiss RS, DeMeester SL, Hiramatsu M, Karl IE, Cobb JP, Swanson PE, Buchman TG: Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism. Surgery 122:243-254, 1997.
3. Varani J, Dame MK, Gibbs DF, Taylor CG, Weinberg JM, Shayevitz J, Ward PA: Human umbilical vein endothelial cell killing by activated neutrophils. Lab Invest 66:708-714, 1992.
4. Balla G, Vercellotti GM, Eaton JW, Jacob HS: Iron loading of endothelial cells augments oxidant damage. J Lab Clin Med 116:546-554, 1990.
5. Lappas GD, Karl IE, Hotchkiss RS: Effect of ethanol and sodium arsenite on HSP-72 formation and on survival in a murine endotoxin model. Shock 2:34-39, 1994.
6. Connelly KG, Repine JE: Markers for predicting the development of acute respiratory distress syndrome. Annu Rev Med 48:429-445, 1997.
7. Bobbio-Pallavicini F, Verde G, Spriano P, et al.: Body iron status in critically ill patients: significance of serum ferritin. Intensive Care Med 15:171-178, 1989.
8. Ackerman Z, Seidenbaum M, Loewenthal E, Rubinov A: Overload of iron in the skin of patients with varicose ulcers. Arch Dermatol 124:1376-1378, 1988.
9. Bennett RM, Williams ED, Lewis SM, Holt PJL: Synovial iron deposition in rheumatoid arthritis. Arthritis Rheum 16:298-304, 1973.
10. Schett G, Redlich K, Xu Q, Bizan P, Groger M, Tohidast-Akrad M, Kiener H, Smolen J, Steiner G: Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue: differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J Clin Invest 102:302-311, 1998.
11. Qian YS, Buettner GR: Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations: an electron paramagnetic resonance spin trapping study. Free Radic Biol Med 26:1447-1456, 1999.
12. Hotchkiss RS, Tinsley KW, Swanson PE, Chang KC, Cobb JP, Buchman TG, Korsmeyer SJ, Karl IE: Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci USA 96:14541-14546, 1999.
13. Hotchkiss RS, Swanson PE, Freeman BD, Tinsely KW, Cobb JP, Matuschak GM, Buchman TG, Karl IE: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27:1230-1251, 1999.
14. Gutteridge JM, Quinlan GJ, Evans TW: Transient iron overload with bleomycin detectable iron in the plasma of patients with adult respiratory distress syndrome. Thorax 49:707-710, 1994.
15. Gutteridge JM: Is bleomycin-detectable iron present in the plasma of patients with septic shock? Intensive Care Med 23:635-639, 1997.
16. Connelly KG, Moss M, Parsons PE, Moore EE, Moore FA, Giclas PC, Seligman PA, Repine JE: Serum ferritin as a predictor of the acute respiratory distress syndrome. Am J Respir Crit Care Med 155:21-25, 1997.
17. Sharkey RA, Donnelly SC, Connelly KG, Robertson CE, Haslett C, Repine JE: Initial serum ferritin levels in patients with multiple trauma and the subsequent development of acute respiratory distress syndrome. Am J Respir Crit Care Med 159:1506-1509, 1999.
18. Yuan XM: Apoptotic macrophage-derived foam cells of human atheromas are rich in iron and ferritin, suggesting iron-catalysed reactions to be involved in apoptosis. Free Radic Res 30:221-231, 1999.
19. Kim Y-M, Chung H-T, Simmons RL, Billiar TR: Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition. J Biol Chem 275:10954-10961, 2000.