Iron chelation improves endothelial function in patients with coronary artery disease

Circulation

Volumn 103, Issue 23, 2001, Pages 2799-2804

  Duffy, Stephen J ^a   Biegelsen, Elizabeth S ^a   Holbrook, Monika ^a   Russell, Judson D ^a   Gokce, Noyan ^a   Keaney Jr , John F ^a   Vita, Joseph A ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Coronary disease; Endothelium; Iron; Nitric oxide

Indexed keywords

DEFEROXAMINE; DEFEROXAMINE MESYLATE; HYDROXYL RADICAL; IRON; IRON CHELATING AGENT; MANNITOL; METHACHOLINE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; SCAVENGER;

ADULT; ARM BLOOD FLOW; ARTERY ENDOTHELIUM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG EFFECT; FEMALE; HUMAN; IRON BLOOD LEVEL; IRON CHELATION; MALE; PRIORITY JOURNAL; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY;

EID: 0035849568     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.23.2799     Document Type: Article

References (33)

1. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men
2. Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women
3. Iron, atherosclerosis, and ischemic heart disease
4. Dietary iron intake and risk of coronary disease among men
5. Body iron stores and the risk of carotid atherosclerosis: Prospective results from the Bruneck study
6. Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice
7. Coronary heart disease and iron status: Meta-analyses of prospective studies
8. Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions
9. Antioxidants and atherosclerotic heart disease
10. Oxidative stress as a regulator of gene expression in the vasculature
11. Iron-dependent human platelet activation and hydroxyl radical formation: Involvement of protein kinase C
12. Nitric oxide and iron proteins
13. Atherosclerosis: An inflammatory disease
14. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
15. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease
16. Use of desferrioxamine as a "probe" for iron-dependent formation of hydroxyl radicals
17. Coronary artery responses to physiological stimuli are improved by deferoxamine but not by L-arginine in non-insulin-dependent diabetic patients with angiographically normal coronary arteries and no other risk factors
18. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension
19. Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium
20. Contribution of vasodilator prostanoids and nitric oxide to resting flow, metabolic vasodilation, and flow-mediated dilation in human coronary circulation
21. Heme coordination of NO in NO synthase
22. Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2
23. Mutation of the five conserved histidines in the endothelial nitric-oxide synthase hemoprotein domain
24. Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase
25. Neuroprotection by nitric oxide against hydroxyl radical-induced nigral neurotoxicity
26. The chemistry of free radicals and related "reactive species"
27. Mannitol: Molecule magnifique or a case of radical misinterpretation?
28. Mannitol: Kinetics of distribution, excretion and utilization in human beings
29. Evidence that desferrioxamine cannot enter cells by passive diffusion
30. Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients
31. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo
32. Studies in desferrioxamine and ferrioxamine metabolism in normal and iron-loaded subjects
33. Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease