Long intracellular retention of 4′-thio-arabinofuranosylcytosine 5′-triphosphate as a critical factor for the anti-solid tumor activity of 4′-thio-arabinofuranosylcytosine

Cancer Chemotherapy and Pharmacology

Volumn 57, Issue 6, 2006, Pages 772-780

  Someya, Hitoshi ^a   Waud, William R ^b   Parker, William B ^b  

^a University of Alabama at Birmingham   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

4 Thio arabinofuranosylcytosine; Arabinofuranosylcytosine; Half life of nucleoside triphosphate; Human UMP CMP kinase; Solid tumors

Indexed keywords

4' THIOARABINOFURANOSYLCYTOSINE; 4' THIOARABINOFURANOSYLCYTOSINE 5' TRIPHOSPHATE; CELL EXTRACT; CYTARABINE; CYTARABINE TRIPHOSPHATE; CYTIDINE DEAMINASE; CYTIDINE PHOSPHATE; CYTOSINE DERIVATIVE; DEOXYCYTIDINE KINASE; DEOXYCYTIDINE PHOSPHATE DEAMINASE; DNA; PHOSPHATE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; DNA REPLICATION; DRUG ACTIVITY; DRUG EXPOSURE; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; DRUG RETENTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; SOLID TUMOR; TUMOR CELL;

ANTINEOPLASTIC AGENTS; ARABINONUCLEOSIDES; ARABINONUCLEOTIDES; CELL LINE, TUMOR; CELL PROLIFERATION; CYTARABINE; CYTIDINE TRIPHOSPHATE; DNA; HALF-LIFE; HUMANS;

EID: 33645746390     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-005-0126-0     Document Type: Article

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