Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis

Journal of the American Chemical Society

Volumn 131, Issue 21, 2009, Pages 7470-7476

  Bunagan, Michelle R ^a   Gao, Jianmin ^b   Kelly, Jeffery W ^b   Gai, Feng ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMMON FEATURES; CONFORMATIONAL SEARCH; DENATURED STATE; EN-ROUTE; FOLDED STATE; FOLDING NUCLEI; FOLDING RATES; FOLDING TRANSITION STATE; HELICAL STRUCTURES; HYDROGEN-BOND FORMATION; MUTATION STRATEGY; NATIVE PROTEINS; RATE LIMITING; SIDE CHAINS; STRUCTURE FORMATIONS; SUBDOMAIN; TRANSITION STATE; VILLIN HEADPIECE;

AMIDES; BINDING SITES; ESTERS; HYDROGEN; PROTEIN FOLDING; REACTION KINETICS;

HYDROGEN BONDS;

HELIX LOOP HELIX PROTEIN; VILLIN; ACTIN BINDING PROTEIN;

ARTICLE; CHEMICAL MUTAGENESIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; DENATURATION; HYDROGEN BOND; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; THERMODYNAMICS; CHEMISTRY; GENETIC PROCEDURES; GENETICS; KINETICS; MUTAGENESIS; PHASE TRANSITION; PROTEIN CONFORMATION; TECHNIQUE;

HYDROGEN BONDING; KINETICS; METHODS; MICROFILAMENT PROTEINS; MOLECULAR PROBE TECHNIQUES; MUTAGENESIS; PHASE TRANSITION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY;

EID: 67650550291     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja901860f     Document Type: Article

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