Mitochondrial factors in the regulation of innate immunity

Microbes and Infection

Volumn 11, Issue 8-9, 2009, Pages 729-736

  Scott, Iain ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

CARD domain; Cardif; Innate Immunity; IPS 1; MAVS; Mitochondria; VISA

Indexed keywords

BETA INTERFERON; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CELL PROTEIN; GC1QR; HELICASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; LEUCINE RICH REPEAT KINASE 2; MELANOMA DIFFERENTIATION ASSOCIATED 5; MITOCHONDRIAL ANTIVIRAL SIGNALLING PROTEIN; MITOCHONDRIAL PROTEIN; NOD LIKE RECEPTOR FAMILY MEMBER X1; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PUROMYCIN; RETINOIC INDUCIBLE GENE I; SMALL INTERFERING RNA; TOBACCO SMOKE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; APOPTOSIS; AUTOPHAGY; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; EXPOSURE; HELA CELL; HEPATITIS A VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOPRECIPITATION; INNATE IMMUNITY; POLIOMYELITIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; DEAD-BOX RNA HELICASES; GENES, MITOCHONDRIAL; HUMANS; IMMUNITY, INNATE; MAMMALS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 67650529547     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2009.04.022     Document Type: Short Survey

References (43)

1. Janeway Jr. C.A., and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 20 (2002) 197-216
2. Kawai T., and Akira S. TLR signaling. Cell Death Differ. 13 (2006) 816-825
3. Malathi K., Dong B., Gale Jr. M., and Silverman R.H. Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 448 (2007) 816-819
4. Castelli J.C., Hassel B.A., Maran A., Paranjape J., Hewitt J.A., Li X.L., Hsu Y.T., Silverman R.H., and Youle R.J. The role of 20-50 oligoadenylate-activated ribonuclease L in apoptosis. Cell Death Differ. 5 (1998) 313-320
5. O'Neill L.A. Innate immunity: squelching anti-viral signalling with NLRX1. Curr. Biol. 18 (2008) 302-304
6. Meylan E., and Tschopp J. NLRX1: friend or foe?. EMBO Rep. 9 (2008) 243-245
7. Yoneyama M., Kikuchi M., Natsukawa T., Shinobu N., Imaizumi T., Miyagishi M., Taira K., Akira S., and Fujita T. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5 (2004) 730-737
8. Yoneyama M., and Fujita T. RNA recognition and signal transduction by RIG-I-like receptors. Immunol. Rev. 227 (2009) 54-65
9. Seth R.B., Sun L., Ea C.K., and Chen Z.J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122 (2005) 669-682
10. Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., and Sugano S. Large-scale identification and characterization of human genes that activate NF-kB and MAPK signaling pathways. Oncogene 22 (2003) 3307-3318
11. Kawai T., Takahashi K., Sato S., Coban C., Kumar H., Kato H., Ishii K.J., Takeuchi O., and Akira S. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6 (2005) 981-988
12. Meylan E., Curran J., Hofmann K., Moradpour D., Binder M., Bartenschlager R., and Tschopp J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437 (2005) 1167-1172
13. Xu L.G., Wang Y.Y., Han K.J., Li L.Y., Zhai Z., and Shu H.B. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell 19 (2005) 727-740
14. Potter J.A., Randall R.E., and Taylor G.L. Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain. BMC Struct. Biol. 8 (2008) 11
15. Saha S.K., Pietras E.M., He J.Q., Kang J.R., Liu S.-Y., Oganesyan G., Shahangian A., Zarnegar B., Shiba T.L., Wang Y., and Cheng G. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 25 (2006) 3257-3263
16. LI S.S.C. Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction. Biochem. J. 390 (2005) 641-653
17. Baril M., Racine M.-E., Penin F., and Lamarre D. MAVS Dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease. J. Virol. 83 (2009) 1299-1311
18. Tang E.D., and Wang C.Y. MAVS self-association mediates antiviral innate immune signaling. J. Virol. 83 (2009) 3420-3428
19. Yang Y., Liang Y., Qu L., Chen Z., Yi M., Li K., and Lemon S.M. Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor. Proc. Natl. Acad. Sci. U S A 104 (2007) 7253-7258
20. Rebsamen M., Meylan E., Curran J., and Tschopp J. The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. Cell Death Differ. 15 (2008) 1804-1811
21. Lad S.P., Yang G., Scott D.A., Chao T.-H., da Silva-Correia J., de la Torre J.C., and Li E. Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. Mol. Immunol 45 (2008) 2277-2287
22. Lin R., Lacoste J., Nakhaei P., Sun Q., Yang L., Paz S., Wilkinson P., Julkunen I., Vitour D., Meurs E., and Hiscott J. Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKε molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage. J. Virol. 80 (2006) 6072-6083
23. Li K., Foy E., Ferreon J.C., Nakamura M., Ferreon A.C.M., Ikeda M., Ray S.C., Gale M., and Lemon S.M. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc. Natl. Acad. Sci. U S A 102 (2005) 2992-2997
24. Foy E., Li K., Sumpter R., Loo Y.M., Johnson C.L., Wang C., Fish P.M., Yoneyama M., Fujita T., Lemon S.M., and Gale M. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signalling. Proc. Natl. Acad. Sci. U S A 102 (2005) 2986-2991
25. Chen Z., Benureau Y., Rijnbrand R., Yi J., Wang T., Warter L., Lanford R.E., Weinman S.A., Lemon S.M., Martin A., and Li K. GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. J. Virol. 81 (2007) 964-976
26. Jounai N., Takeshita F., Kobiyama K., Sawano A., Miyawaki A., Xin K.-Q., Ishii K.J., Kawai T., Akira S., Suzuki K., and Okuda K. The Atg5-Atg12 conjugate associates with innate antiviral immune responses. Proc. Natl. Acad. Sci. U S A 104 (2007) 14050-14055
27. Caspi Tal M., Sasai M., Lee H.K., Yordy B., Shadel G.S., and Iwasaki A. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc. Natl. Acad. Sci. U S A 106 (2009) 2770-2775
28. Youle R.J., and Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9 (2008) 47-59
29. McWhirter S.M., Tenoever B.R., and Maniatis T. Connecting mitochondria and innate immunity. Cell 122 (2005) 645-647
30. Sun Q., Sun L., Liu H.H., Chen X., Seth R.B., Forman J., and Chen Z.J. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24 (2006) 633-642
31. Holm G.H., Zurney J., Tumilasci V., Leveille S., Danthi P., Hiscott J., Sherry B., and Dermody T.S. Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. J. Biol. Chem. 282 (2007) 21953-21961
32. Kang M.-J., Lee C.G., Lee J.-Y., Dela Cruz C.S., Chen Z.J., Enelow R., and Elias J.A. Cigarette smoke selectively enhances viral PAMP - and virus-induced pulmonary innate immune and remodeling responses in mice. J. Clin. Invest. 118 (2008) 2771-2784
33. Boya P., Roumier T., Andreau K., Gonzalez-Polo R.A., Zamzami N., Castedo M., and Kroemer G. Mitochondrion-targeted apoptosis regulators of viral origin. Biochem. Biophys. Res. Commun. 304 (2003) 575-581
34. Barral P.M., Morrison J.M., Drahos J., Gupta P., Sarkar D., Fisher P.B., and Racaniello V.R. MDA-5 is cleaved in poliovirus-infected cells. J. Virol. 81 (2007) 3677-3684
35. Scott I., and Norris K.L. The mitochondrial antiviral signaling protein, MAVS, is cleaved during apoptosis. Biochem. Biophys. Res. Commun. 375 (2008) 101-106
36. Moore C.B., Bergstralh D.T., Duncan J.A., Lei Y., Morrison T.E., Zimmermann A.G., Accavitti-Loper M.A., Madden V.J., Sun L., Ye Z., Lich J.D., Heise M.T., Chen Z., and Ting J.P.-Y. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451 (2008) 573-577
37. Tattoli I., Carneiro L.A., Jéhanno M., Magalhaes J.G., Shu Y., Philpott D.J., Arnoul D., and Girardin S.E. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kB and JNK pathways by inducing reactive oxygen species production. EMBO Rep. 9 (2008) 293-300
38. Xu L., Xiao N., Liu F., Ren H., and Gu J. Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. Proc. Natl. Acad. Sci. U S A 106 (2009) 1530-1535
39. Dedio J., Jahnen-Dechent W., Bachmann M., and Muller-Esterl W. The multiligand-binding protein gC1qR, putative C1q receptor, is a mitochondrial protein. J. Immunol. 160 (1998) 3534-3542
40. Muta T., Kang D., Kitajama S., Fujiwara T., and Hamasaki N. p32 protein, a splicing factor 2-associated protein, is localized in the mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation. J. Biol. Chem. 272 (1997) 24363-24370
41. Jin L., Waterman P.M., Jonscher K.R., Short C.M., Reisdorph N.A., and Cambier J.C. MPYS, a Novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol. Biol. Cell 28 (2008) 5014-5026
42. Zhong B., Yang Y., Li S., Wang Y.-Y., Li Y., Diao F., Lei C., He X., Zhang L., Tien P., and Shu H.-B. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29 (2008) 538-550
43. Ishikawa H., and Barber G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455 (2008) 674-678