Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase

Journal of Molecular Biology

Volumn 317, Issue 2, 2002, Pages 171-177

  Bjørås, Magnar ^a   Seeberg, Erling ^a   Luna, Luisa ^a   Pearl, Laurence H ^b   Barrett, Tracey E ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

8oxo guanine DNA glycosylase; Crystal structure; Nucleophilic attack; Reciprocal flipping; Specificity pocket

Indexed keywords

8 HYDROXYGUANINE; DNA; DNA GLYCOSYLTRANSFERASE; GLYCOSIDE; LYSINE;

ARTICLE; CATALYSIS; CHEMICAL BINDING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA BINDING;

EID: 0036290411     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2002.5400     Document Type: Article

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