Anti-inflammatory activity and QSAR studies of compounds isolated from Hyacinthaceae species and Tachiadenus longiflorus Griseb. (Gentianaceae)

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 7, 2005, Pages 2561-2568

  Du Toit, Karen ^a   Elgorashi, Esameldin E ^a   Malan, Sarel F ^b   Drewes, Siegfried E ^a   Van Staden, Johannes ^a   Crouch, Neil R ^a,c   Mulholland, Dulcie A ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b NORTH WEST UNIVERSITY   (South Africa)

^c SOUTH AFRICAN NATIONAL BIODIVERSITY INSTITUTE   (South Africa)

Author keywords

Anti inflammatory activity; Cell microsomal fractions; COX 1 and COX 2 enzymes; Gentianaceae; Homoisoflavanones; Hyacinthaceae; QSAR

Indexed keywords

ALBUCA FASTIGIATA EXTRACT; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DRIMIA DELAGOENSIS EXTRACT; DRIMIOPSIS BURKEI EXTRACT; DRIMIOPSIS MACULATA EXTRACT; EUCOMIS COMOSA EXTRACT; EUCOMIS HUMILIS EXTRACT; EUCOMIS POLE EVANSII EXTRACT; INDOMETACIN; ISOFLAVONE DERIVATIVE; LEDEBOURIA OVATIFOLIA EXTRACT; MERWILLA PLUMBEA EXTRACT; PLANT EXTRACT; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; SCILLA ZEBRINA EXTRACT; TACHIADENUS LONGIFLORUS EXTRACT; UNCLASSIFIED DRUG;

ALBUCA FASTIGIATA; ANTIINFLAMMATORY ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BIOLOGY; CELL ASSAY; CELL FRACTIONATION; CHEMICAL INTERACTION; COMPUTER ANALYSIS; DENSITY; DIPOLE; DRIMIA DELAGOENSIS; DRIMIOPSIS BURKEI; DRIMIOPSIS MACULATA; DRUG ACTIVITY; DRUG ISOLATION; DRUG SCREENING; DRUG SPECIFICITY; DRUG STRUCTURE; ENERGY; ENTHALPY; ENTROPY; ENZYME ASSAY; ENZYME INHIBITION; EUCOMIS COMOSA; EUCOMIS HUMILIS; EUCOMIS POLE EVANSII; EVALUATION; GENTIANACEAE; HEAT; INHIBITION KINETICS; ISOLATION PROCEDURE; LEDEBOURIA OVATIFOLIA; MERWILLA PLUMBEA; MICROSOME; MODEL; PARAMETER; PHYSICAL CHEMISTRY; PLANT; POLARIZATION; PREDICTION; PROSTAGLANDIN SYNTHESIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SCILLA ZEBRINA; SPECIES; STRUCTURE ANALYSIS; SURFACE PROPERTY; SURFACE TENSION; TACHIADENUS LONGIFLORUS;

EID: 14844329083     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.036     Document Type: Article

References (41)

1. B.S. Kirkiacharian, M. Gomis, H.G. Tongo, J. Mahuteau, and J.D. Brion Org. Magn. Reson. 22 1984 106
2. M. Adinolfi, R. Lanzetta, G. Laonigro, M. Parrilli, and E. Breitmaier Magn. Reson. Chem. 24 1986 663
3. M. Adinolfi, G. Barone, M. Belardini, R. Lanzetta, G. Laonigro, and M. Parrilli Phytochemistry 24 1985 2423
4. T.S. Pohl, N.R. Crouch, and D.A. Mulholland Curr. Org. Chem. 4 2000 1287
5. F. Speta K. Kubitzki The Families and Genera of Vascular Plants III. Flowering Plants. Monocotyledons. Liliaceae (except Orchidaceae) 1998 Springer Berlin 261 285
6. W. Heller, and C. Tamm Fort. Chem. Org. Nat. 40 1981 106
7. R. Della Loggia, P. Del Negro, A. Tubaro, G. Barone, and M. Parrilli Planta Med. 55 1989 587
8. G. Amschler, A.W. Frahm, A. Hatzelmann, U. Kilian, D. Muller-Doblies, and U. Muller-Doblies Planta Med. 62 1996 534
9. L.J. Roberts II, and J.D. Morrow J.G. Hardman L.E. Limbird The Pharmacological Basis of Therapeutics 2001 McGraw-Hill New York 687 733
10. D.A. Lewis Anti-inflammatory drugs from Plant and Marine Sources 1989 Birkhauser Germany
11. M. Hamburger, and K. Hostettmann Phytochemistry 30 1991 3864
12. J.A. Mitchell, P. Akaradereenont, C. Thiemermann, R.J. Flower, and J.R. Vane Proc. Natl. Acad. Sci. U.S.A. 90 1994 11693
13. J.D. Morrow, and L.J. Roberts II J.G. Hardman L.E. Limbird The Pharmacological Basis of Therapeutics 2001 McGraw-Hill New York 669 732
14. S.G. Sparg, J. Van Staden, and A.K. Jäger J. Ethnopharm. 80 2002 95
15. J.M. Watt, and M.G. Breyer-Brandwijk The Medicinal and Poisonous Plants of Southern and Eastern Africa 1962 Livingstone London pp 669-725
16. A. Hutchings, A.H. Scott, G. Lewis, and A.B. Cunningham Zulu Medicinal plants. An Inventory 1996 University of Natal Press Pietermaritzburg pp 38-44
17. H.P. Rang, and M.M. Dale Pharmacology 1987 Churchill Livingstone New York pp 194-196
18. A. Robert B. Samuelsson R. Paoletti Advances in Prostaglandin and Thromboxane Research 1976 Raven New York 507 520
19. S. Bolton Pharmaceutical Statistics. Practical and Clinical Applications 1997 Marcel Dekker New York pp 638-644
20. T. Gund N.C. Cohen Guidebook on Molecular Modeling in Drug Design 1996 Academic San Diego 55 87
21. A. Itai, M.Y. Mizutani, Y. Nishibata, and N. Tomioka N.C. Cohen Guidebook on Molecular Modeling in Drug Design 1996 Academic San Diego 93 137
22. W.J. Hehre, J. Yu, P.E. Klunzinger, and L. Lou A Brief Guide to Molecular Mechanics and Quantum Chemical Calculations 1998 Wavefunction California pp 9, 90-144
23. H.L. White, and A.T. Glassman Prostaglandins 7 1974 123
24. A.K. Jäger, A. Hutchings, and J. Van Staden Ethnopharmacol 52 1996 95
25. Y. Noreen, T. Ringbom, P. Perera, H. Danielson, and L. Bohlin J. Nat. Prod. 61 1998 2
26. S. Zschocke, and J. Van Staden J. Ethnopharm. 71 2000 473
27. ® 1.0; Wavefunction: Irvine, 1999
28. ® 4.54; Advanced Chemistry Development Inc.: Toronto, Canada, 2000
29. ® Release MSI; San Diego, California, 2000
30. ® Excell; Microsoft Corporation: California, 2002
31. ® 6.0; Statsoft Inc.: California, 2003
32. Langlois, A. Ph.D. Dissertation; University of Natal, South Africa, 2003
33. Pohl, T. S. M.Sc. Dissertation; University of Natal, South Africa, 1999
34. Koorbanally, C. Ph.D. Dissertation; University of Natal, South Africa, 2003
35. R.E. Finckh, and C. Tamm Experientia 26 1970 472
36. Moodley, N. M.Sc. Dissertation; University of Natal, South Africa, 2001
37. N.R. Crouch, V. Bangani, and D.A. Mulholland Phytochemistry 51 1999 943
38. W.-Y. Tsui, and G.D. Brown Phytochemistry 43 1996 1413
39. T.K. Razdan, B. Oadri, S. Harbar, and E.S. Waight Phytochemistry 26 1987 2063
40. Koorbanally, C. M.Sc. Dissertation; University of Natal, South Africa, 2000
41. G. Barone, M.M. Corsaro, R. Lanzetta, and M. Parrilli Phytochemistry 27 1988 921