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Volumn 32, Issue 2, 2007, Pages 118-122

MK-0518. HIV integrase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ATAZANAVIR; BMS 707035; EFAVIRENZ; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; GS 9137; GS 9224; INTEGRASE INHIBITOR; JTK 303; L 900612; MIDAZOLAM; MK 0518; PLACEBO; RALTEGRAVIR POTASSIUM; RIFAMPICIN; RITONAVIR; S 364735; TENOFOVIR DISOPROXIL; TIPRANAVIR; UNCLASSIFIED DRUG;

EID: 34247524127     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2007.032.02.1076305     Document Type: Review
Times cited : (27)

References (29)
  • 1
    • 34247466224 scopus 로고    scopus 로고
    • Belyk, K.M, Morrison, H.G, Jones, P, Summa, V, Merck & Co, Inc, Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A, Potassium salt of an HIV integrase inhibitor. US 2006122205, WO 2006060712, WO 2006060730
    • Belyk, K.M., Morrison, H.G., Jones, P., Summa, V. (Merck & Co., Inc.; Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A.). Potassium salt of an HIV integrase inhibitor. US 2006122205, WO 2006060712, WO 2006060730.
  • 2
    • 34247480682 scopus 로고    scopus 로고
    • Discovery of MK-0518 a novel, potent and selective HIV integrase inhibitor in phase III clinical trials
    • Aug 13-18, Toronto, Abst THPE0020
    • Summa, V., Pace, P., Petrocchi, A. et al. Discovery of MK-0518 a novel, potent and selective HIV integrase inhibitor in phase III clinical trials. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst THPE0020.
    • (2006) 16th Int AIDS Conf
    • Summa, V.1    Pace, P.2    Petrocchi, A.3
  • 3
    • 34247533946 scopus 로고    scopus 로고
    • Discovery, synthesis and optimization of a new series of selective HIV integrase inhibitors leading to MK-0518 currently in phase III clinical trial for treatment of HIV/AIDS
    • Sept 10-14, San Francisco, Abst MEDI-298
    • Summa, V. Discovery, synthesis and optimization of a new series of selective HIV integrase inhibitors leading to MK-0518 currently in phase III clinical trial for treatment of HIV/AIDS. 232nd ACS Natl Meet (Sept 10-14, San Francisco) 2006, Abst MEDI-298.
    • (2006) 232nd ACS Natl Meet
    • Summa, V.1
  • 4
    • 33746046396 scopus 로고    scopus 로고
    • The hunt for HIV-1 integrase inhibitors
    • Lataillade, M., Kozal, M.J. The hunt for HIV-1 integrase inhibitors. AIDS Patient Care STDs 2006, 20(7): 489-501.
    • (2006) AIDS Patient Care STDs , vol.20 , Issue.7 , pp. 489-501
    • Lataillade, M.1    Kozal, M.J.2
  • 5
    • 0026459411 scopus 로고
    • Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells
    • LaFemina, R.L., Schneider, C.L., Robbins, H.L. et al. Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells. J Virol 1992, 66(12): 7414-9.
    • (1992) J Virol , vol.66 , Issue.12 , pp. 7414-7419
    • LaFemina, R.L.1    Schneider, C.L.2    Robbins, H.L.3
  • 6
  • 8
    • 18744371922 scopus 로고    scopus 로고
    • HIV-1 integration: An interplay between HIV-1 integrase, cellular and viral proteins
    • Van Male, B., Debyser, Z. HIV-1 integration: An interplay between HIV-1 integrase, cellular and viral proteins. AIDS Rev 2005, 7(1): 26-43.
    • (2005) AIDS Rev , vol.7 , Issue.1 , pp. 26-43
    • Van Male, B.1    Debyser, Z.2
  • 9
    • 0034723439 scopus 로고    scopus 로고
    • Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    • Hazuda, D.J., Felock, P., Witmer, M. et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000, 287: 646-50.
    • (2000) Science , vol.287 , pp. 646-650
    • Hazuda, D.J.1    Felock, P.2    Witmer, M.3
  • 10
    • 33845192798 scopus 로고    scopus 로고
    • Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor
    • Aug 13-18, Toronto, Abst THPE0302
    • Miller, M., Witmer, M., Stillmock, K. et al. Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst THPE0302.
    • (2006) 16th Int AIDS Conf
    • Miller, M.1    Witmer, M.2    Stillmock, K.3
  • 11
    • 34247541879 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and metabolism of MK-0518, a potent HIV integrase inhibitor in phase III clinical trials
    • Aug 13-18, Toronto, Abst THPE0027
    • Gonzalez-Paz, O., Taliani, M., Di Marco, A. et al. Preclinical pharmacokinetics and metabolism of MK-0518, a potent HIV integrase inhibitor in phase III clinical trials. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst THPE0027.
    • (2006) 16th Int AIDS Conf
    • Gonzalez-Paz, O.1    Taliani, M.2    Di Marco, A.3
  • 12
    • 34247508988 scopus 로고    scopus 로고
    • Laufer, R., Taliani, M., DiMarco, A. et al. Prediction of human pharmacokinetics for a series of potent and selective HIV integrase inhibitors leading to development of MK-0518 for the treatment of AIDS. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst CDA0141.
    • Laufer, R., Taliani, M., DiMarco, A. et al. Prediction of human pharmacokinetics for a series of potent and selective HIV integrase inhibitors leading to development of MK-0518 for the treatment of AIDS. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst CDA0141.
  • 13
    • 34247493944 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics after single and multiple doses of MK-0518 in healthy subjects
    • Sept 27-30, San Francisco, Abst A-376
    • Petry, A.S., Wenning, L.A., Laethem, M. et al. Safety, tolerability, and pharmacokinetics after single and multiple doses of MK-0518 in healthy subjects. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-376.
    • (2006) 46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
    • Petry, A.S.1    Wenning, L.A.2    Laethem, M.3
  • 14
    • 34247488997 scopus 로고    scopus 로고
    • Absorption, metabolism and excretion of MK-0518, a potent HIV-1 integrase inhibitor, in healthy male volunteers
    • Sept 27-30, San Francisco, Abst A-372
    • Kassahun, K., McIntosh, I., Hreniuk, D. et al. Absorption, metabolism and excretion of MK-0518, a potent HIV-1 integrase inhibitor, in healthy male volunteers. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-372.
    • (2006) 46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
    • Kassahun, K.1    McIntosh, I.2    Hreniuk, D.3
  • 15
    • 33845366857 scopus 로고    scopus 로고
    • Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
    • Markowitz, M., Morales-Ramirez, J.O., Nguyen, B.-Y et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr 2006, 43(5): 509-15.
    • (2006) J Acquir Immune Defic Syndr , vol.43 , Issue.5 , pp. 509-515
    • Markowitz, M.1    Morales-Ramirez, J.O.2    Nguyen, B.-Y.3
  • 16
    • 33845983393 scopus 로고    scopus 로고
    • Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, as part of combination ART in treatment-naive HIV-1 infected patients
    • Aug 13-18, Toronto, Abst THLB0214
    • Markowitz, M., Nguyen, B.-Y., Gotuzzo, E. et al. Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, as part of combination ART in treatment-naive HIV-1 infected patients. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst THLB0214.
    • (2006) 16th Int AIDS Conf
    • Markowitz, M.1    Nguyen, B.-Y.2    Gotuzzo, E.3
  • 17
    • 34247487618 scopus 로고    scopus 로고
    • Differential effect of MK-0518 and efavirenz on serum lipids and lipoproteins in antiretroviral therapy (ART)-naive patients
    • Sept 27-30, San Francisco, Abst H-256a
    • Teppler, H., Azrolan, N., Chen, J., Nguyen, B. Differential effect of MK-0518 and efavirenz on serum lipids and lipoproteins in antiretroviral therapy (ART)-naive patients. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst H-256a.
    • (2006) 46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
    • Teppler, H.1    Azrolan, N.2    Chen, J.3    Nguyen, B.4
  • 18
    • 34247544094 scopus 로고    scopus 로고
    • Potent efficacy of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus: 24-Week data
    • Sept 27-30, San Francisco, Abst H-1670b
    • Grinsztejn, B., Nguyen, B., Katlama, C. et al. Potent efficacy of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus: 24-Week data. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst H-1670b.
    • (2006) 46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
    • Grinsztejn, B.1    Nguyen, B.2    Katlama, C.3
  • 19
    • 33747593219 scopus 로고    scopus 로고
    • Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
    • Feb 5-9, Denver, Abst 159LB
    • Grinsztejn, B., Nguyen, B.Y., Katlama, C. et al. Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 13th Conf Retroviruses Opportunistic Infect (CROI) (Feb 5-9, Denver) 2006, Abst 159LB.
    • (2006) 13th Conf Retroviruses Opportunistic Infect (CROI)
    • Grinsztejn, B.1    Nguyen, B.Y.2    Katlama, C.3
  • 23
    • 34247545409 scopus 로고    scopus 로고
    • A study to evaluate the safety and antiretroviral activity of MK0518 versus efavirenz in treatment naive HIV-infected patients, each in combination with TRUVADA™ (NCT00369941). ClinicalTrials.gov Web site, February 15, 2007.
    • A study to evaluate the safety and antiretroviral activity of MK0518 versus efavirenz in treatment naive HIV-infected patients, each in combination with TRUVADA™ (NCT00369941). ClinicalTrials.gov Web site, February 15, 2007.
  • 24
    • 34247514134 scopus 로고    scopus 로고
    • Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PD) of MK-0518
    • Sept 27-30, San Francisco, Abst A-373
    • Iwamoto, M., Wenning, L.A., Petry, A.S. et al. Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PD) of MK-0518. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-373.
    • (2006) 46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
    • Iwamoto, M.1    Wenning, L.A.2    Petry, A.S.3
  • 25
    • 34247396153 scopus 로고    scopus 로고
    • Effect of tipranavir + ritonavir (TPV + RTV) on pharmacokinetics of MK-0518
    • Sept 27-30, San Francisco, Abst A-374
    • Wenning, L.A., Hanley, H., Stone, J. et al. Effect of tipranavir + ritonavir (TPV + RTV) on pharmacokinetics of MK-0518. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-374.
    • (2006) 46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
    • Wenning, L.A.1    Hanley, H.2    Stone, J.3
  • 26
    • 34247546849 scopus 로고    scopus 로고
    • Lack of a significant drug interaction between MK-0518 and tenofovir disoproxil fumarate (TDF)
    • Sept 27-30, San Francisco, Abst A-375
    • Wenning, L.A., Friedman, E., Kost, J.T. et al. Lack of a significant drug interaction between MK-0518 and tenofovir disoproxil fumarate (TDF). 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-375.
    • (2006) 46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
    • Wenning, L.A.1    Friedman, E.2    Kost, J.T.3
  • 27
    • 37549006934 scopus 로고    scopus 로고
    • Atazanavir and ritonavir increase plasma levels of MK-0518
    • Nov 12-16, Glasgow, Abst P291
    • Mistry, G.C., Wenning, L.A., Merschman, S. et al. Atazanavir and ritonavir increase plasma levels of MK-0518. 8th Int Congr Drug Ther HIV Infect (Nov 12-16, Glasgow) 2006, Abst P291.
    • (2006) 8th Int Congr Drug Ther HIV Infect
    • Mistry, G.C.1    Wenning, L.A.2    Merschman, S.3
  • 28
    • 34548073641 scopus 로고    scopus 로고
    • Rifampin (RIF) modestly reduces plasma levels of MK-0518
    • Nov 12-16, Glasgow, Abst P299
    • Iwamoto, M., Wenning, L.A., Liou, S.Y. et al. Rifampin (RIF) modestly reduces plasma levels of MK-0518. 8th Int Congr Drug Ther HIV Infect (Nov 12-16, Glasgow) 2006, Abst P299.
    • (2006) 8th Int Congr Drug Ther HIV Infect
    • Iwamoto, M.1    Wenning, L.A.2    Liou, S.Y.3
  • 29
    • 52349089632 scopus 로고    scopus 로고
    • Lack of a pharmacokinetic interaction of MK-0518 on midazolam (MDZ)
    • Nov 12-16, Glasgow, Abst P300
    • Iwamoto, M., Wenning, L.A., Troyer, M.D. et al. Lack of a pharmacokinetic interaction of MK-0518 on midazolam (MDZ). 8th Int Congr Drug Ther HIV Infect (Nov 12-16, Glasgow) 2006, Abst P300.
    • (2006) 8th Int Congr Drug Ther HIV Infect
    • Iwamoto, M.1    Wenning, L.A.2    Troyer, M.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.