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Belyk, K.M., Morrison, H.G., Jones, P., Summa, V. (Merck & Co., Inc.; Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A.). Potassium salt of an HIV integrase inhibitor. US 2006122205, WO 2006060712, WO 2006060730.
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Discovery of MK-0518 a novel, potent and selective HIV integrase inhibitor in phase III clinical trials
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Aug 13-18, Toronto, Abst THPE0020
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Summa, V., Pace, P., Petrocchi, A. et al. Discovery of MK-0518 a novel, potent and selective HIV integrase inhibitor in phase III clinical trials. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst THPE0020.
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16th Int AIDS Conf
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Summa, V.1
Pace, P.2
Petrocchi, A.3
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3
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34247533946
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Discovery, synthesis and optimization of a new series of selective HIV integrase inhibitors leading to MK-0518 currently in phase III clinical trial for treatment of HIV/AIDS
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Sept 10-14, San Francisco, Abst MEDI-298
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Summa, V. Discovery, synthesis and optimization of a new series of selective HIV integrase inhibitors leading to MK-0518 currently in phase III clinical trial for treatment of HIV/AIDS. 232nd ACS Natl Meet (Sept 10-14, San Francisco) 2006, Abst MEDI-298.
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232nd ACS Natl Meet
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Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells
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Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
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Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor
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Aug 13-18, Toronto, Abst THPE0302
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Miller, M., Witmer, M., Stillmock, K. et al. Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst THPE0302.
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16th Int AIDS Conf
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Miller, M.1
Witmer, M.2
Stillmock, K.3
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11
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Preclinical pharmacokinetics and metabolism of MK-0518, a potent HIV integrase inhibitor in phase III clinical trials
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Aug 13-18, Toronto, Abst THPE0027
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Gonzalez-Paz, O., Taliani, M., Di Marco, A. et al. Preclinical pharmacokinetics and metabolism of MK-0518, a potent HIV integrase inhibitor in phase III clinical trials. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst THPE0027.
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16th Int AIDS Conf
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Gonzalez-Paz, O.1
Taliani, M.2
Di Marco, A.3
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12
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Laufer, R., Taliani, M., DiMarco, A. et al. Prediction of human pharmacokinetics for a series of potent and selective HIV integrase inhibitors leading to development of MK-0518 for the treatment of AIDS. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst CDA0141.
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Laufer, R., Taliani, M., DiMarco, A. et al. Prediction of human pharmacokinetics for a series of potent and selective HIV integrase inhibitors leading to development of MK-0518 for the treatment of AIDS. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst CDA0141.
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13
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Safety, tolerability, and pharmacokinetics after single and multiple doses of MK-0518 in healthy subjects
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Sept 27-30, San Francisco, Abst A-376
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Petry, A.S., Wenning, L.A., Laethem, M. et al. Safety, tolerability, and pharmacokinetics after single and multiple doses of MK-0518 in healthy subjects. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-376.
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(2006)
46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
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Petry, A.S.1
Wenning, L.A.2
Laethem, M.3
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14
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Absorption, metabolism and excretion of MK-0518, a potent HIV-1 integrase inhibitor, in healthy male volunteers
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Sept 27-30, San Francisco, Abst A-372
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Kassahun, K., McIntosh, I., Hreniuk, D. et al. Absorption, metabolism and excretion of MK-0518, a potent HIV-1 integrase inhibitor, in healthy male volunteers. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-372.
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(2006)
46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
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Kassahun, K.1
McIntosh, I.2
Hreniuk, D.3
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15
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Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
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Markowitz, M., Morales-Ramirez, J.O., Nguyen, B.-Y et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr 2006, 43(5): 509-15.
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Markowitz, M.1
Morales-Ramirez, J.O.2
Nguyen, B.-Y.3
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16
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Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, as part of combination ART in treatment-naive HIV-1 infected patients
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Aug 13-18, Toronto, Abst THLB0214
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Markowitz, M., Nguyen, B.-Y., Gotuzzo, E. et al. Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, as part of combination ART in treatment-naive HIV-1 infected patients. 16th Int AIDS Conf (Aug 13-18, Toronto) 2006, Abst THLB0214.
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(2006)
16th Int AIDS Conf
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Markowitz, M.1
Nguyen, B.-Y.2
Gotuzzo, E.3
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17
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Differential effect of MK-0518 and efavirenz on serum lipids and lipoproteins in antiretroviral therapy (ART)-naive patients
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Sept 27-30, San Francisco, Abst H-256a
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Teppler, H., Azrolan, N., Chen, J., Nguyen, B. Differential effect of MK-0518 and efavirenz on serum lipids and lipoproteins in antiretroviral therapy (ART)-naive patients. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst H-256a.
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(2006)
46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
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Teppler, H.1
Azrolan, N.2
Chen, J.3
Nguyen, B.4
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18
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34247544094
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Potent efficacy of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus: 24-Week data
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Sept 27-30, San Francisco, Abst H-1670b
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Grinsztejn, B., Nguyen, B., Katlama, C. et al. Potent efficacy of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus: 24-Week data. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst H-1670b.
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(2006)
46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
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Grinsztejn, B.1
Nguyen, B.2
Katlama, C.3
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19
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Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
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Feb 5-9, Denver, Abst 159LB
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Grinsztejn, B., Nguyen, B.Y., Katlama, C. et al. Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 13th Conf Retroviruses Opportunistic Infect (CROI) (Feb 5-9, Denver) 2006, Abst 159LB.
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(2006)
13th Conf Retroviruses Opportunistic Infect (CROI)
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Grinsztejn, B.1
Nguyen, B.Y.2
Katlama, C.3
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23
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34247545409
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A study to evaluate the safety and antiretroviral activity of MK0518 versus efavirenz in treatment naive HIV-infected patients, each in combination with TRUVADA™ (NCT00369941). ClinicalTrials.gov Web site, February 15, 2007.
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A study to evaluate the safety and antiretroviral activity of MK0518 versus efavirenz in treatment naive HIV-infected patients, each in combination with TRUVADA™ (NCT00369941). ClinicalTrials.gov Web site, February 15, 2007.
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24
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34247514134
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Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PD) of MK-0518
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Sept 27-30, San Francisco, Abst A-373
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Iwamoto, M., Wenning, L.A., Petry, A.S. et al. Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PD) of MK-0518. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-373.
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(2006)
46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
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Iwamoto, M.1
Wenning, L.A.2
Petry, A.S.3
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25
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34247396153
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Effect of tipranavir + ritonavir (TPV + RTV) on pharmacokinetics of MK-0518
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Sept 27-30, San Francisco, Abst A-374
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Wenning, L.A., Hanley, H., Stone, J. et al. Effect of tipranavir + ritonavir (TPV + RTV) on pharmacokinetics of MK-0518. 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-374.
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(2006)
46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
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Wenning, L.A.1
Hanley, H.2
Stone, J.3
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26
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34247546849
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Lack of a significant drug interaction between MK-0518 and tenofovir disoproxil fumarate (TDF)
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Sept 27-30, San Francisco, Abst A-375
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Wenning, L.A., Friedman, E., Kost, J.T. et al. Lack of a significant drug interaction between MK-0518 and tenofovir disoproxil fumarate (TDF). 46th Intersci Conf Antimicrob Agents Chemother (ICAAC) (Sept 27-30, San Francisco) 2006, Abst A-375.
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(2006)
46th Intersci Conf Antimicrob Agents Chemother (ICAAC)
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Wenning, L.A.1
Friedman, E.2
Kost, J.T.3
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27
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37549006934
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Atazanavir and ritonavir increase plasma levels of MK-0518
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Nov 12-16, Glasgow, Abst P291
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Mistry, G.C., Wenning, L.A., Merschman, S. et al. Atazanavir and ritonavir increase plasma levels of MK-0518. 8th Int Congr Drug Ther HIV Infect (Nov 12-16, Glasgow) 2006, Abst P291.
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(2006)
8th Int Congr Drug Ther HIV Infect
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Mistry, G.C.1
Wenning, L.A.2
Merschman, S.3
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28
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34548073641
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Rifampin (RIF) modestly reduces plasma levels of MK-0518
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Nov 12-16, Glasgow, Abst P299
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Iwamoto, M., Wenning, L.A., Liou, S.Y. et al. Rifampin (RIF) modestly reduces plasma levels of MK-0518. 8th Int Congr Drug Ther HIV Infect (Nov 12-16, Glasgow) 2006, Abst P299.
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(2006)
8th Int Congr Drug Ther HIV Infect
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Iwamoto, M.1
Wenning, L.A.2
Liou, S.Y.3
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29
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52349089632
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Lack of a pharmacokinetic interaction of MK-0518 on midazolam (MDZ)
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Nov 12-16, Glasgow, Abst P300
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Iwamoto, M., Wenning, L.A., Troyer, M.D. et al. Lack of a pharmacokinetic interaction of MK-0518 on midazolam (MDZ). 8th Int Congr Drug Ther HIV Infect (Nov 12-16, Glasgow) 2006, Abst P300.
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(2006)
8th Int Congr Drug Ther HIV Infect
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Iwamoto, M.1
Wenning, L.A.2
Troyer, M.D.3
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