Synthesis and structure-activity correlation of brunsvicamide-inspired cyclopeptide collection

ChemBioChem

Volumn 10, Issue 7, 2009, Pages 1153-1162

  Walther, Thilo ^a,b   Renner, Steffen ^b   Waldmann, Herbert ^a,b   Arndt, Hans Dieter ^a,b  

^a TU DORTMUND UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Combinatorial chemistry; Inhibitors; Natural products; Peptidases; Solid phase synthesis

Indexed keywords

1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOALANYL)VALINYLLEUCYL N METHYLTRYPTOPHYLPHENYLALANINE]; 1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOISOLEUCYL)ALANYLLEUCYL N METHYLTRYPTOPHYLPHENYLALANINE]; 1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOISOLEUCYL)SERINYLLEUCYL N METHYLTRYPTOPHYLPHENYLALANINE]; 1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOISOLEUCYL)VALINYLALANYL N METHYLTRYPTOPHYLPHENYLALANINE]; 1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOISOLEUCYL)VALINYLLEUCYL N METHYLALANYLPHENYLALANINE]; 1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOISOLEUCYL)VALINYLLEUCYL N METHYLSERINYLPHENYLALANINE]; 1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOISOLEUCYL)VALINYLLEUCYL N METHYLTRYPTOPHYLALANINE]; 1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOISOLEUCYL)VALINYLLEUCYL N METHYLTRYPTOPHYLSERINE]; 1,5 ANHYDRO[DEXTRO LYSYL (NALPHA OXAMIDOISOLEUCYL)VALINYLSERINYL N METHYLTRYPTOPHYLPHENYLALANINE]; BRUNSVICAMIDE A; BRUNSVICAMIDE B; BRUNSVICAMIDE C; CARBOXYPEPTIDASE A; CYCLOPEPTIDE; ENZYME INHIBITOR; ISOLEUCINE; LYSINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; COW; CYANOBACTERIUM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; IC 50; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; SOLID PHASE SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SWINE; AMINO ACID SEQUENCE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; ENZYME ACTIVE SITE; KINETICS; STEREOISOMERISM; SYNTHESIS;

CYANOBACTERIA;

AMINO ACID SEQUENCE; CARBOXYPEPTIDASES A; CATALYTIC DOMAIN; COMPUTER SIMULATION; KINETICS; PEPTIDES, CYCLIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 67650457881     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900035     Document Type: Article

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