Structures of potent selective peptide mimetics bound to carboxypeptidase B

Acta Crystallographica Section D: Biological Crystallography

Volumn 64, Issue 2, 2008, Pages 149-157

  Adler, Marc ^a   Buckman, Brad ^a   Bryant, Judi ^a   Chang, Zheng ^a   Chu, Kieu ^a   Emayan, Kumar ^a   Hrvatin, Paul ^a   Islam, Imadul ^a   Morser, John ^a   Sukovich, Drew ^a   West, Christopher ^a   Yuan, Shendong ^a   Whitlow, Marc ^a  

^a BAYER CORPORATION   (United States)

Author keywords

Carboxypeptidase B; Inhibitors

Indexed keywords

CARBOXYPEPTIDASE B; PEPTIDE; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; HYDROGEN BOND; METABOLISM; METHODOLOGY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CARBOXYPEPTIDASE B; CARBOXYPEPTIDASE U; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES;

SUS;

EID: 38549163713     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444907057228     Document Type: Article

References (27)

1. Adler, M., Bryant, J., Buckman, B., Islam, I., Larsen, B., Finster, S., Kent, L., May, K., Mohan, R., Yuan, S. & Whitlow, M. (2005). Biochemistry, 44, 9339-9347.
2. Aloy, P., Companys, V., Vendrell, J., Avilés, F.-X., Fricker, L. D., Coll, M. & Gomis-Ruth, F. X. (2001). J. Biol. Chem. 276, 16177-16184.
3. Anderson, H. V. & Willerson, J. T. (1993). N. Eng. J. Med. 329, 703-709.
4. Boffa, M. B., Wang, W., Bajzar, L. & Nesheim, M. E. (1998). J. Biol. Chem. 273, 2127-2135.
5. Brünger, A. T. (1993). X-PLOR: A System for X-ray Crystallography and NMR, version 3.1. New Haven: Yale University Press.
6. Brünger, A. T., Kuriyan, J. & Karplus, M. (1987). Science, 235, 458-460.
7. Hendricks, D., van Sande, M. & Scharpe, S. (1986). Clin. Chim. Acta, 157, 103-108.
8. Howard, A. J., Gilliland, G. L., Finzel, B. C., Poulos, T. L., Ohlendorf, D. H. & Salemme, F. R. (1987). J. Appl. Cryst. 20, 383-387.
9. Kaplan, A. P. & Bartlett, P. A. (1991). Biochemistry, 30, 8165-8170.
10. Kim, H. & Lipscomb, W. N. (1991). Biochemistry, 30, 8171-8180.
11. Klement, P., Liao, P. & Bajzar, L. (1999). Blood, 94, 2735-2743.
12. Lenderink, T., Simoons, M. L., Van Es, G.-A., Van de Werf, F., Verstraete, M. & Arnold, A. E. R. (1995). Circulation, 92, 1110-1116.
13. McGee, D. E. (1992). J. Mol. Graph. 10, 44-46.
14. Minnema, M. C., Friederich, P. W., Levi, M., von dem Borne, P. A., Mosnier, L. O., Meijers, J. C., Biemond, B. J., Hack, C. E., Bouma, B. N. & ten Cate, H. (1998). J. Clin. Invest. 101, 10-14.
15. Myles, T., Nishimura, T., Yun, T. H., Nagashima, M., Morser, J., Patterson, A. J., Pearl, R. G., Lawrence, L. K. & Leung, L. L. (2003). J. Biol. Chem. 278, 51059-51067.
16. Nau, H. & Riordan, J. F. (1975). Biochemistry, 14, 5285-5294.
17. Park, J. D., Kim, D. H. & Kim, S. J. (2002). J. Med. Chem. 45, 5295-5302.
18. Rajamani, R. & Good, A. C. (2007). Curr. Opin. Drug Discov. Devel. 10, 308-315.
19. Redlitz, A., Tan, A. K., Eaton, D. L. & Plow, E. F. (1995). J. Clin. Invest. 96, 2534-2538.
20. Rees, D. C. & Lipscomb, W. N. (1982). J. Mol. Biol. 160, 475-498.
21. Refino, C. J., DeGuzman, L., Schmitt, D., Smyth, R., Jeet, S., Lipari, M. T., Eaton, D. & Bunting, S. (2000). Fibrinolysis Proteolysis, 14, 305-314.
22. Schüttelkopf, A. W. & van Aalten, D. M. F. (2004). Acta Cryst. D60, 1355-1363.
23. Suzuki, S., Hachimori, Y. & Yaoeda, U. (1970). Anal. Chem. 42, 101-103.
24. Tan, A. K. & Eaton, D. L. (1995). Biochemistry, 34, 5811-5816.
25. Wang, Y. X., da Cunha, V., Vincelette, J., Zhao, L., Nagashima, M., Kawai, K., Yuan, S., Emayan, K., Islam, I., Hosoya, J., Sullivan, M. E., Dole, W. P., Morser, J., Buckman, B. O. & Vergona, R. (2007). Thromb. Haemost. 97, 54-61.
26. Wang, Y. X., Zhao, L. et al. (2007). Thromb. Haemost. 97, 45-53.
27. Willemse, J. L. & Hendriks, D. F. (2006). Clin. Chim. Acta, 371, 124-129.