Synthesis and conformational analysis of stevastelin C3 analogues and their activity against the dual-specific vaccina H1-related phosphatase

Chemistry - A European Journal

Volumn 14, Issue 29, 2008, Pages 8847-8860

  Bisek, Nicola ^a,b   Wetzel, Stefan ^a,b   Arndt, Hans Dieter ^a,b   Waldmann, Herbert ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

Author keywords

Biological activity conformation analysis; Cyclodepsipeptides; Macrocyclization; Phosphorylation

Indexed keywords

ACIDS; BINDING ENERGY; BIOACTIVITY; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; NUCLEAR MAGNETIC RESONANCE; OPTICAL DEVICES; PHOSPHORYLATION;

ACTIVITY PROFILES; BIOLOGICAL ACTIVITIES; BIOLOGICAL ACTIVITY CONFORMATION ANALYSIS; CONFORMATIONAL ANALYSES; CONFORMATIONAL PREFERENCES; CONFORMATIONAL PROPERTIES; CONFORMATIONAL SPACES; CYCLIC DEPSIPEPTIDES; CYCLODEPSIPEPTIDES; DEPSIPEPTIDES; DERIVATIZATION OF; DIASTEREOMERIC; ENZYME BINDINGS; GOOD YIELDS; HIGH POTENTIALS; HYDROXY ACIDS; INHIBITORY ACTIVITIES; LINEAR PRECURSORS; MACROCYCLIC; MACROCYCLIC NATURAL PRODUCTS; MACROCYCLIZATION; PHOSPHORYLATED DERIVATIVES; SOLID SUPPORTS; SPECTROSCOPIC DATUM; STEVASTELINS; STRUCTURAL DATUM; SYNTHESIS OF;

CONFORMATIONS;

DEPSIPEPTIDE; ENZYME INHIBITOR; PHOSPHATASE; STEVASTELIN C3;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; SYNTHESIS; VACCINIA VIRUS;

DEPSIPEPTIDES; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; VACCINIA VIRUS;

EID: 55049130107     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200800692     Document Type: Article

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