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A referee pointed out that amino acid stereochemistry determination by chiral GC (as reported in ref 2) is typically reliable. We agree, but note that depending on the amount and quality of the isolated materials misassignments can occur, especially with noncanonical linkages (e.g., urea) or less common stereoisomers (e.g., allo). For a related case see: (a) Zampella, A.; Randazzo, A.; Borbone, N.; Luciani, S.; Trevisis, L.; Debitus, C.; D'Auria, M. V. Tetrahedron Lett. 2002, 43, 6163-6166.
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A referee pointed out that amino acid stereochemistry determination by chiral GC (as reported in ref 2) is typically reliable. We agree, but note that depending on the amount and quality of the isolated materials misassignments can occur, especially with noncanonical linkages (e.g., urea) or less common stereoisomers (e.g., allo). For a related case see: (a) Zampella, A.; Randazzo, A.; Borbone, N.; Luciani, S.; Trevisis, L.; Debitus, C.; D'Auria, M. V. Tetrahedron Lett. 2002, 43, 6163-6166.
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