Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model

Molecular Reproduction and Development

Volumn 76, Issue 8, 2009, Pages 733-750

  Deroo, Bonnie J ^a,b,c   Hewitt, Sylvia C ^a   Collins, Jennifer B ^a   Grissom, Sherry F ^a,d   Hamilton, Katherine J ^a   Korach, Kenneth S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b WESTERN UNIVERSITY   (Canada)

^c CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

^d ILLUMINA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; PLACEBO; RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST DEVELOPMENT; BREAST DUCT; CARBOHYDRATE METABOLISM; CATABOLISM; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; GENE EXPRESSION; GENOMICS; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; MAMMARY GLAND; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARIECTOMY; PREPUBERTY; PRIORITY JOURNAL; PUBERTY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BREAST NEOPLASMS; CARBOHYDRATE METABOLISM; CELL GROWTH PROCESSES; CLUSTER ANALYSIS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; OVARIECTOMY; SEXUAL MATURATION;

MUS;

EID: 67650424297     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.21041     Document Type: Article

References (93)

1. Aldaz CM, Hu Y, Daniel R, Gaddis S, Kittrell F, Medina D. 2002. Serial analysis of gene expression in normal p53 null mammary epithelium. Oncogene 21:6366-6376.
2. Baik MG, Lee MJ, Choi YJ. 1998. Gene expression during involution of mammary gland (review). Int J Mol Med 2:39-44.
3. Bale TL, Dorsa DM. 1997. Cloning, novel promoter sequence, and estrogen regulation of a rat oxytocin receptor gene. Endocrinology 138:1151-1158. (Pubitemid 27089773)
4. Basak S, Speicher D, Eck S, Wunner W, Maul G, Simmons MS, Herlyn D. 1998. Colorectal carcinoma invasion inhibition by CO17-1A/GA733 antigen and its murine homologue. J Natl Cancer Inst 90:691-697. (Pubitemid 28222143)
5. Bocchinfuso WP, Korach KS. 1997. Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J Mammary Gland Biol Neoplasia 2:323-334.
6. Bocchinfuso WP, Lindzey JK, Hewitt SC, Clark JA, Myers PH, Cooper R, Korach KS. 2000. Induction of mammary gland development in estrogen receptor-{alpha} knockout mice. Endocrinology 141:2982-2994. (Pubitemid 32250463)
7. Bucco R, Zheng W, Wardlaw S, Davis J, Sierra-Rivera E, Osteen K, Melner M, Kakkad B, Ong D. 1996. Regulation and localization of cellular retinol-binding protein, retinol-binding protein, cellular retinoic acid-binding protein (CRABP), and CRABP II in the uterus of the pseudopregnant rat. Endocrinology 137: 3111-3122. (Pubitemid 126425502)
8. Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. 2005. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 122:33-43. (Pubitemid 40977938)
9. Choi I, Gudas LJ, Katzenellenbogen BS. 2000. Regulation of keratin 19 gene expression by estrogen in human breast cancer cells and identification of the estrogen responsive gene region. Mol Cell Endocrinol 164:225-237. (Pubitemid 30665516)
10. Dai XM, Ryan GR, Hapel AJ, Dominguez MG, Russell RG, Kapp S, Sylvestre V, Stanley ER. 2002. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99: 111-120. (Pubitemid 34532972)
11. Daikoku T, Shinohara Y, Shima A, Yamazaki N, Terada H. 2000. Specific elevation of transcript levels of particular protein subtypes induced in brown adipose tissue by cold exposure. Biochim Biophys Acta 1457:263-272. (Pubitemid 30201489)
12. Daniel CW, Silberstein GB, Strickland P. 1987. Direct action of 17 beta-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiography. Cancer Res 47:6052-6057. (Pubitemid 18018753)
13. Dennis G, Jr., Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. 2003. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4:P3.
14. Dimitrakakis C, Zhou J, Wang J, Matyakhina L, Mezey E, Wood JX, Wang D, Bondy C. 2006. Co-expression of estrogen receptoralpha and targets of estrogen receptor action in proliferating monkey mammary epithelial cells. Breast Cancer Res 8:R10. (Pubitemid 44644829)
15. Edgar R, Domrachev M, Lash AE. 2002. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30:207-210. (Pubitemid 34679544)
16. Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L, Barcellos-Hoff MH. 2002. Latent transforming growth factor-beta activation in mammary gland: Regulation by ovarian hormones affects ductal and alveolar proliferation. Am J Pathol 160: 2081-2093. (Pubitemid 34663401)
17. Fisher CR, Graves KH, Parlow AF, Simpson ER. 1998. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 95:6965-6970. (Pubitemid 28278090)
18. Flux DS. 1954. Growth of the mammary duct system in intact and ovariectomized mice of the CHI strain. J Endocrinol 11:223-237.
19. Foster JS, Henley DC, Bukovsky A, Seth P, Wimalasena J. 2001. Multifaceted regulation of cell cycle progression by estrogen: Regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function. Mol Cell Biol 21:794-810. (Pubitemid 32104728)
20. Frasor J, Stossi F, Danes JM, Komm B, Lyttle CR, Katzenellenbogen BS. 2004. Selective estrogen receptor modulators: Discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res 64: 1522-1533. (Pubitemid 38235626)
21. Ghosh MG, Thompson DA, Weigel RJ. 2000. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Cancer Res 60:6367-6375. (Pubitemid 30952138)
22. Goruppi S, Chiaruttini C, Ruaro ME, Varnum B, Schneider C. 2001. Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells. Mol Cell Biol 21:902-915. (Pubitemid 32104738)
23. Gouon-Evans V, Rothenberg ME, Pollard JW. 2000. Postnatal mammary gland development requires macrophages and eosinophils. Development 127:2269-2282. (Pubitemid 30386567)
24. Gouon-Evans V, Lin EY, Pollard JW. 2002. Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development. Breast Cancer Res 4:155-164. (Pubitemid 35012324)
25. Gruvberger S, Ringner M, Chen Y, Panavally S, Saal LH, Borg A, Ferno M, Peterson C, Meltzer PS. 2001. Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res 61:5979-5984. (Pubitemid 32762524)
26. Haslam SZ. 1988. Local versus systemically mediated effects of estrogen on normal mammary epithelial cell deoxyribonucleic acid synthesis. Endocrinology 122:860-867. (Pubitemid 18082040)
27. Hedrich HJ, editor. 2004. The laboratory mouse. New York: Elsevier Academic Press.
28. Hennighausen L, Robinson GW. 1998. Think globally, act locally: The making of a mouse mammary gland. Genes Dev 12: 449-455. (Pubitemid 28101007)
29. Hennighausen L, Robinson GW. 2005. Information networks in the mammary gland. Nat Rev Mol Cell Biol 6:715-725.
30. Hewitt SC, Deroo BJ, Hansen K, Collins J, Grissom S, Afshari CA, Korach KS. 2003. Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen. Mol Endocrinol 17:2070-2083. (Pubitemid 37281798)
31. Hewitt SC, Collins J, Grissom S, Deroo B, Korach KS. 2005. Global uterine genomics in vivo: Microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism. Mol Endocrinol 19:657-668. (Pubitemid 40349438)
32. Ivanga M, Labrie Y, Calvo E, Belleau P, Martel C, Luu-The V, Morissette J, Labrie F, Durocher F. 2007. Temporal analysis of E2 transcriptional induction of PTP and MKP and downregulation of IGF-I pathway key components in the mouse uterus. Physiol Genomics 29:13-23. (Pubitemid 46708758)
33. Kanehisa M, Goto S, Kawashima S, Okuno Y, Hattori M. 2004. The KEGG resource for deciphering the genome. Nucleic Acids Res 32:D277-D280.
34. Kayisli UA, Guzeloglu-Kayisli O, Arici A. 2004. Endocrine-immune interactions in human endometrium. Ann NY Acad Sci 1034: 50-63.
35. Kian Tee M, Rogatsky I, Tzagarakis-Foster C, Cvoro A, An J, Christy RJ, Yamamoto KR, Leitman DC. 2004. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell 15:1262-1272.
36. Klein A, Guhl E, Zollinger R, Tzeng YJ, Wessel R, Hummel M, Graessmann M, Graessmann A. 2005. Gene expression profiling: Cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals. J Mol Med 83:362-376. (Pubitemid 41201801)
37. Kouros-Mehr H, Werb Z. 2006. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn 235:3404-3412. (Pubitemid 44888206)
38. Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. 2006. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127:1041-1055. (Pubitemid 44792255)
39. Lacroix M, Leclercq G. 2004. About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-alpha gene (ESR1) in breast cancer. Mol Cell Endocrinol 219: 1-7. (Pubitemid 38659520)
40. Lanigan F, O'Connor D, Martin F, Gallagher WM. 2007. Molecular links between mammary gland development and breast cancer. Cell Mol Life Sci 64:3159-3184.
41. Lazennec G, Bresson D, Lucas A, Chauveau C, Vignon F. 2001. ER beta inhibits proliferation and invasion of breast cancer cells. Endocrinology 142:4120-4130. (Pubitemid 32802685)
42. Levenson AS, Svoboda KM, Pease KM, Kaiser SA, Chen B, Simons LA, Jovanovic BD, Dyck PA, Jordan VC. 2002. Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res 62:4419-4426. (Pubitemid 34827302)
43. Li RW, Capuco AV. 2008. Canonical pathways and networks regulated by estrogen in the bovine mammary gland. Funct Integr Genomics 8:55-68.
44. Martinez-Lacaci I, Saceda M, Plowman GD, Johnson GR, Normanno N, Salomon DS, Dickson RB. 1995. Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines. Endocrinology 136:3983-3992.
45. Master SR, Hartman JL, D'Cruz CM, Moody SE, Keiper EA, Ha SI, Cox JD, Belka GK, Chodosh LA. 2002. Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis. Mol Endocrinol 16:1185-1203.
46. Master SR, Stoddard AJ, Bailey LC, Pan TC, Dugan KD, Chodosh LA. 2005. Genomic analysis of early murine mammary gland development using novel probe-level algorithms. Genome Biol 6:R20.
47. McBryan J, Howlin J, Kenny PA, Shioda T, Martin F. 2007. ERalpha -CITED1 co-regulated genes expressed during pubertal mammary gland development: Implications for breast cancer prognosis. Oncogene 26:6406-6419. (Pubitemid 47494221)
48. Mikaelian I, Hovick M, Silva KA, Burzenski LM, Shultz LD, Ackert- Bicknell CL, Cox GA, Sundberg JP. 2006. Expression of terminal differentiation proteins defines stages of mouse mammary gland development. Vet Pathol 43:36-49. (Pubitemid 43127845)
49. Mo R, Tony Zhu Y, Zhang Z, Rao SM, Zhu YJ. 2007. GAS6 is an estrogen-inducible gene in mammary epithelial cells. Biochem Biophys Res Commun 353:189-194. (Pubitemid 44958358)
50. Muraoka-Cook RS, Feng SM, Strunk KE, Earp HS III. 2008. ErbB4/ HE R4: Role in mammary gland development, differentiation and growth inhibition. J Mammary Gland Biol Neoplasia 13:235-246.
51. Murphy LJ, Murphy LC, Friesen HG. 1987. Estrogen induction of N-myc and c-myc proto-oncogene expression in the rat uterus. Endocrinology 120:1882-1888. (Pubitemid 17069218)
52. Musgrove EA, Sergio CM, Anderson LR, Inman CK, McNeil CM, Alles MC, Gardiner-Garden M, Ormandy CJ, Butt AJ, Sutherland RL. 2008. Identification of downstream targets of estrogen and c-myc in breast cancer cells. Adv Exp Med Biol 617:445-451.
53. Nelson CM, Vanduijn MM, Inman JL, Fletcher DA, Bissell MJ. 2006. Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science 314:298-300. (Pubitemid 44571974)
54. Pedram A, Razandi M, Aitkenhead M, Hughes CC, Levin ER. 2002. Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem 277:50768-50775. (Pubitemid 36042240)
55. Pentecost BT, Bradley LM, Gierthy JF, Ding Y, Fasco MJ. 2005. Gene regulation in an MCF-7 cell line that naturally expresses an estrogen receptor unable to directly bind DNA. Mol Cell Endocrinol 238:9-25. (Pubitemid 40799578)
56. Perou CM, Jeffrey SS, van de Rijn M, Rees CA, Eisen MB, Ross DT, Pergamenschikov A, Williams CF, Zhu SX, Lee JC, Lashkari D, Shalon D, Brown PO, Botstein D. 1999. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci USA 96:9212-9217. (Pubitemid 29374734)
57. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen -Dale AL, Brown PO, Botstein D. 2000. Molecular portraits of human breast tumours. Nature 406:747-752. (Pubitemid 30671230)
58. Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:2002-2007.
59. Porter S, Scott SD, Sassoon EM, Williams MR, Jones JL, Girling AC, Ball RY, Edwards DR. 2004. Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma. Clin Cancer Res 10:2429-2440. (Pubitemid 38445703)
60. Prall OW, Carroll JS, Sutherland RL. 2001. Alow abundance pool of nascent p21WAF1/Cip1 is targeted by estrogen to activate cyclin E*Cdk2. J Biol Chem 276:45433-45442.
61. Rae JM, Johnson MD, Scheys JO, Cordero KE, Larios JM, Lippman ME. 2005. GREB 1 is a critical regulator of hormone dependent breast cancer growth. Breast Cancer Res Treat 92:141-149. (Pubitemid 40933578)
62. Rhodes D, Chinnaiyan A. 2004. Bioinformatics strategies for translating genome-wide expression analyses into clinically useful cancer markers. Ann NY Acad Sci 1020:32-40. (Pubitemid 38736922)
63. Ruan W, Catanese V, Wieczorek R, Feldman M, Kleinberg DL. 1995. Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid. Endocrinology 136:1296-1302.
64. Rudland PS, Hughes CM. 1989. Immunocytochemical identification of cell types in human mammary gland: Variations in cellular markers are dependent on glandular topography and differentiation. J Histochem Cytochem 37:1087-1100. (Pubitemid 19167291)
65. Rudland PS, Leinster SJ, Winstanley J, Green B, Atkinson M, Zakhour HD. 1993. Immunocytochemical identification of cell types in benign and malignant breast diseases: Variations in cell markers accompany the malignant state. J Histochem Cytochem 41:543-553. (Pubitemid 23094007)
66. Rybarczyk BJ, Simpson-Haidaris PJ. 2000. Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells. Cancer Res 60:2033-2039. (Pubitemid 30207667)
67. Scarpace PJ, Matheny M, Tumer N. 1999. Differential downregulation of beta3-adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats. Pflugers Arch 437:479-483. (Pubitemid 29071948)
68. Sebastian J, Richards RG, Walker MP, Wiesen JF, Werb Z, Derynck R, Hom YK, Cunha GR, DiAugustine RP. 1998. Activation and function of the epidermal growth factor receptor and erbB -2 during mammary gland morphogenesis. Cell Growth Differ 9:777-785. (Pubitemid 28425874)
69. Shelesnyak MC. 1959. Histamine releasing activity of natural estrogens. Proc Soc Exp Biol Med 100:739-741.
70. Shyamala G, Ferenczy A. 1982. The nonresponsiveness of lactating mammary gland to estradiol. Endocrinology 110:1249-1256.
71. Shyamala G, Ferenczy A. 1984. Mammary fat pad may be a potential site for initiation of estrogen action in normal mouse mammary glands. Endocrinology 115:1078-1081. (Pubitemid 14074478)
72. Silberstein GB, Van Horn K, Shyamala G, Daniel CW. 1994. Essential role of endogenous estrogen in directly stimulating mammary growth demonstrated by implants containing pure antiestrogens. Endocrinology 134:84-90. (Pubitemid 24021973)
73. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein Lonning P, Borresen-Dale AL. 2001. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874. (Pubitemid 32878711)
74. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL, Botstein D. 2003. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 100: 8418-8423. (Pubitemid 36842560)
75. Stern DF. 2003. ErbBs in mammary development. Exp Cell Res 284:89-98.
76. Stern DF. 2008. ERBB3/HER3 and ERBB2/HER2 duet in mammary development and breast cancer. J Mammary Gland Biol Neoplasia 13:215-223.
77. Stoughton RS, Dai H. 2002. Statistical combining of cell expression profiles. USA patent 6351712.
78. Thomas TJ, Faaland CA, Adhikarakunnathu S, Watkins LF, Thomas T. 1998. Induction of p21 (CIP1/WAF1/SID1) by estradiol in a breast epithelial cell line transfected with the recombinant estrogen receptor gene: A possible mechanism for a negative regulatory role of estradiol. Breast Cancer Res Treat 47: 181-193. (Pubitemid 28046089)
79. Toft D, O'Malley BW. 1972. Target tissue receptors for progesterone: The influence of estrogen treatment. Endocrinology 90: 1041-1045.
80. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, Parrish M, Atsma D, Witteveen A, Glas A, Delahaye L, van der Velde T, Bartelink H, Rodenhuis S, Rutgers ET, Friend SH, Bernards R. 2002. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347:1999-2009.
81. van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH. 2002. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530-536.
82. Varnum BC, Young C, Elliott G, Garcia A, Bartley TD, Fridell YW, Hunt RW, Trail G, Clogston C, Toso RJ, Yanagihara D, Bennett L, Sylber M, Mereweather LA, Tseng A, Escobar E, Liu ET, Yamane HK. 1995. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature 373: 623-626.
83. Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F, Talantov D, Timmermans M, Meijer-van Gelder ME, Yu J, Jatkoe T, Berns EM, Atkins D, Foekens JA. 2005. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365:671-679. (Pubitemid 40260888)
84. Weng L, Dai H, Zhan Y, He Y, Stepaniants SB, Bassett DE. 2006. Rosetta error model for gene expression analysis. Bioinformatics 22:1111-1121.
85. West M, Blanchette C, Dressman H, Huang E, Ishida S, Spang R, Zuzan H, Olson JA, Jr., Marks JR, Nevins JR. 2001. Predicting the clinical status of human breast cancer by using gene expression profiles. Proc Natl Acad Sci USA 98:11462-11467. (Pubitemid 32928751)
86. Wiesen JF, Young P, Werb Z, Cunha GR. 1999. Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development 126: 335-344. (Pubitemid 29083971)
87. Wilson CL, Sims AH, Howell A, Miller CJ, Clarke RB. 2006. Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue. Endocr Relat Cancer 13:617-628. (Pubitemid 43886681)
88. Wurfel J, Rosel M, Seiter S, Claas C, Herlevsen M, Weth R, Zoller M. 1999. Metastasis-association of the rat ortholog of the human epithelial glycoprotein antigen EGP314. Oncogene 18:2323-2334. (Pubitemid 29192709)
89. Xie W, Paterson AJ, Chin E, Nabell LM, Kudlow JE. 1997. Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development. Mol Endocrinol 11: 1766-1781. (Pubitemid 27467755)
90. Xu J, Fan S, Rosen EM. 2005. Regulation of the estrogen-inducible gene expression profile by the breast cancer susceptibility gene BRCA1. Endocrinology 146:2031-2047. (Pubitemid 40396914)
91. Zeppa R, Womack NA. 1962. The role of histamine release in chronic cystic mastitis. Surgery 52:195-202.
92. Zhao H, Langerod A, Ji Y, Nowels KW, Nesland JM, Tibshirani R, Bukholm IK, Karesen R, Botstein D, Borresen-Dale AL, Jeffrey SS. 2004. Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell 15:2523-2536. (Pubitemid 38691844)
93. Zucchi I, Mento E, Kuznetsov VA, Scotti M, Valsecchi V, Simionati B, Vicinanza E, Valle G, Pilotti S, Reinbold R, Vezzoni P, Albertini A, Dulbecco R. 2004. Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis. Proc Natl Acad Sci 101: 18147-18152. (Pubitemid 40054088)