Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures

Science

Volumn 314, Issue 5797, 2006, Pages 298-300

  Nelson, Celeste M ^a   VanDuijn, Martijn M ^b   Inman, Jamie L ^a   Fletcher, Daniel A ^a,b   Bissell, Mina J ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b University of California at Berkeley   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR MICROENVIRONMENT; EPITHELIAL TUBULES; MAMMARY GLAND; TISSUE GEOMETRY;

ALGORITHMS; GEOMETRY; THREE DIMENSIONAL; TISSUE;

BIOLOGICAL ORGANS;

MORPHOGEN; TRANSFORMING GROWTH FACTOR BETA;

ALGORITHM; GEOMETRY; MORPHOGENESIS; RODENT; THREE-DIMENSIONAL MODELING;

ALGORITHM; ANIMAL TISSUE; ARTICLE; BRANCHING MORPHOGENESIS; BREAST EPITHELIUM; CALCULATION; CELL INVASION; EXTRACELLULAR MATRIX; GEOMETRY; IMMUNOFLUORESCENCE; MAMMARY GLAND; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; NONHUMAN; ORGAN CULTURE; PREDICTION; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; TISSUE CULTURE;

ALGORITHMS; ANIMALS; CELL LINE; DIFFUSION; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; EPITHELIUM; FEMALE; HEPATOCYTE GROWTH FACTOR; MAMMARY GLANDS, ANIMAL; MICE; MORPHOGENESIS; ORGAN CULTURE TECHNIQUES; ORGANOIDS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TISSUE ENGINEERING; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33749992857     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1131000     Document Type: Article

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31. We thank J. Tien, D. Radisky, and M. LaBarge and other members of the Bissell laboratory for insightful discussions and C. Gilles, Y. Hirai, K. Luo, A. Roberts, and L. Sorokin for generously providing reagents. Supported by grants from the U.S. Department of Energy (DE-AC03-76SF00098 and a Distinguished Fellow Award to M.J.B.), the NIH (CA64786 and CA57621 to M.J.B., GM72736 to D.A.F.), the U.S. Department of Defense (an Innovator Award to M.J.B. and W81XWH-04-1-0582 to C.M.N.), a Lawrence Berkeley National Laboratory Laboratory Directed Research and Development grant (D.A.F.), an NSF Career. Award (D.A.F.), and a QB3 fellowship (M.V.D.). We dedicate this paper to the memory of Anita Roberts, codiscoverer of TGFbeta