Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development

Molecular Endocrinology

Volumn 11, Issue 12, 1997, Pages 1765-1781

  Xie, Wen ^a   Paterson, Andrew J ^a   Chin, Edward ^a   Nabell, Lisle M ^a   Kudlow, Jeffrey E ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST DEVELOPMENT; BREAST DUCT; CONTROLLED STUDY; FEMALE; LONG TERMINAL REPEAT; MALE; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PUBERTY; RECEPTOR UPREGULATION; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DOMINANT GENE; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENE; UDDER;

ANIMALIA; MAMMARY TUMOR ONCOVIRUS; MAMMARY TUMOR VIRUS; MOUSE MAMMARY TUMOR VIRUS; MUS MUSCULUS; ONCOVIRINAE; TUMOR VIRUS;

ANIMALS; DNA; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; GENES, DOMINANT; MAMMARY GLANDS, ANIMAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PUBERTY; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSGENES;

EID: 0031280262     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.12.0019     Document Type: Article

References (66)

1. Dickson RB, Lippman ME 1995 Growth factors in breast cancer. Endocr Rev 16:559-5589
2. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pederson RA, Werb Z, Derynck R 1995 Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376:337-341
3. Sibilia M, Wagner EF 1995 Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234-238
4. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey RJ, Magnuson T 1995 Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230-234
5. Carpenter G, Cohen S 1990 Epidermal growth factor. J Biol Chem 265:7709-7712
6. Todaro GJ, Fryling C, DeLarco JE 1980 Transforming growth factors produced by certain tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc Natl Acad Sci USA 77:5258-5262
7. Shoyab M, Plowman GD, McDonald VL, Brandley JG, Todaro GL 1989 Structure and function of human amphiregulin: a member of epidermal growth factor family. Science 243:1074-1076
8. Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M 1991 A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251:936-939
9. Sasada R, Ono Y, Taniyama Y, Shing Y, Folkman J, Igarashik K 1993 Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. Biochem Biophys Res Commun 190:1173-1179
10. Luetteke NC, Qiu TH, Peiffer RL, Oliver P, Smithies O, Lee DC 1993 TGF-alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73:263-278
11. Mann GB, Fowler KJ, Gabriel KM, Nice EC, Williams RL, Dunn AR 1993 Mice with a null mutation of the TGF-alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73:249-261
12. Ullrich A, Schlessinger J 1990 Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212
13. Carraway III KL, Cerione RA 1993 Inhibition of epidermal growth factor receptor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain. J Biol Chem 268:23860-23867
14. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawaon T, Pelicci PG 1992 A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93-104
15. Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J 1992 The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinase to ras signaling. Cell 70:431-442
16. Hurwitz DR, Emanuel SL, Nathan MH, Sarver N, Ullrich A, Felder S, Lax I, Schlessinger J 1991 EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain. J Biol Chem 266:22035-22043
17. Yarden Y, Schlessinger J 1987 Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric action. Biochemistry 26:1434-1442
18. Kashles O, Yarden Y, Fisher R, Ullrich A, Shlessinger J 1991 A dominant negative mutation suppresses the function of normal epidermal growth factor receptor by heterodimerization. Mol Cell Biol 11:1454-1463
19. Redemann N, Holzmann B, Von Ruden T, Wagner EF, Schlessinger J, Ullrich A 1992 Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants. Mol Cell Biol 12:491-498
20. Murillas R, Larcher F, Conti CJ, Santos M, Ullrich A, Jorcano JL 1995 Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. EMBO J 14:5216-5223
21. Edery M, Pang K, Larson L, Colosi T, Nandi S 1985 Epidermal growth factor receptor levels in mouse mammary glands in various physiological states. Endocrinology 117:405-411
22. Taketani Y, Oka T 1983 Possible physiological role of epidermal growth factor in the development of the mouse mammary gland during pregnancy. FEBS Lett 152:256-260
23. Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT 1990 TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61:1137-1146
24. Matsui Y, Halter SA, Holt JT, Hogan BLM, Coffey RJ 1990 Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice. Cell 61:1147-1155
25. Sandgren EP, Luetteke NC, Palmiter RD, Brinster RL, Lee DC 1990 Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 61: 1121-1135
26. Lin CQ, Dempsey PJ, Coffey RJ, Bissell MJ 1995 Extra- cellular matrix regulates whey acidic protein gene expression by suppression of TGF-a in mouse mammary epithelial cells: studies in culture and in transgenic mice. J Cell Biol 129:1115-1126
27. Valverius EM, Bates SE, Stampfer MR, Clark R, McCormick F, Salomon DS, Lippman ME, Dickson RB 1989 Transforming growth factor alpha and its receptor in human mammary epithelial cells: modulation of epidermal growth factor receptor function with oncogenic transformation. Mol Endocrinol 3:203-214
28. Filmus J, Pollak MN, Cailleau R, Buik RN 1985 MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF. Biochem Biophys Res Commun 128:898-905
29. Ro J, North SM, Gallick GE, Hortobagyi GN, Gutterman JU, Blick M 1988 Amplified and overexpressed epidermal growth factor receptor gene in uncultured primary human breast carcinoma. Cancer Res 48:161-164
30. Pierce Jr DF, Johnson MD, Matsui Y, Robinson SD, Gold LI, Purchio AF, Daniel CW, Hogan BLM, Moses HL 1993 Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-β1. Genes Dev 7:2308-2317
31. Aviv A, Lax I, Ullrich A, Schlessinger J, Givol D, Morse B 1991 Comparison of EGF receptor sequences as a guide to study the ligand binding site. Oncogene 6:673-676
32. Wells A, Welsh JB, Lazar CS, Wiley HS, Gill GN, Rosendeld MG 1990 Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. Science 247:962-964
33. Livneh E, Prywes R, Kashle O, Reiss N, Sasson I, Mory Y, Ullrich A, Schlessinger J 1986 Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells. J Biol Chem 261:12490-12497
34. Bjorge JD, Kudlow JE 1987 Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor. J Biol Chem 262:6615-6622
35. Palmiter RD, Wilkie TM, Chen HY, Brinster RL 1984 Transmission distortion and mosaicism in an unusual transgenic mouse pedigree. Cell 36:869-877
36. Groner B 1992 Oncogene expression in mammary epithelial cells. J Cell Biochem 49:129-139
37. Peters K, Werner S, Liao X, Wert S, Whitsett J, Williams L 1994 Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. EMBO J 13:3296-3301
38. Werner S, Weinberg W, Liao X, Peters KG, Blessing M, Yuspa S, Weiner RL, Williams LT 1993 Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J 12:2635-2643
39. Millauer B, Shawyer LK, Plate KH, Risau W, Ullrich A 1994 Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367:576-579
40. Chang P-Y, Goodyear LJ, Benecke H, Markuns JS, Moller DE 1995 Impaired insulin signaling in skeletal muscles from transgenic mice expressing kinase-deficient insulin receptors. J Biol Chem 270:12593-12600
41. Korach KS 1994 In sights from the study of animal lacking functional estrogen receptor. Science 266:1524-1527
42. Moses HL 1990 The biological activities of transforming growth factor β. In: Sara V, Hall K, Low H (eds) Growth Factors, from Genes to Clinical Application. Raven Press, New York, pp 141-151
43. Daniel CW, Silberstein GB, Van Hom K, Strickland P, Robinson S 1989 TGFβ1-induced inhibition of mouse mammary ductal growth: developmental specificity and characterization. Dev Biol 135:20-30
44. Mueller SG, Kudlow JE 1991 Transforming growth factor β inhibits TGFα expression in bovine anterior pituitary-derived cells. Mol Endocrinol 5:1439-1446
45. Haslam SZ 1988 Local vs. systemically mediated effects of estrogen on normal mammary epithelial cell deoxyribonucleic acid synthesis. Endocrinology 122:860-867
46. Silberstein GB, Van Horn K, Shyamala G, Daniel CW 1994 Essential role of endogenous estrogen in directly stimulating mammary growth demonstrated by implants containing pure antiestrogens. Endocrinology 134:84-90
47. Kobrin MS, Asa SL, Samsoondar J, Kudlow JE 1987 Alpha-transforming growth factor in the bovine anterior pituitary gland: secretion by dispersed cells and immunohistochemical localization. Endocrinology 121:1412-1416
48. Tamada H, Das SK, Andrews GK, Dey SK 1991 Cell-type- specific expression of transforming growth factor-α in the mouse uterus during the peri-implantation period. Biol Reprod 45:365-372
49. Saeki T, Cristiano A, Lynch MJ, Brattain M, Kim N, Normanno N, Kenney N, Ciardiello F, Salomon DS 1991 Regulation by estrogen through the 5′-flanking region of the transforming growth factor alpha gene. Mol Endocrinol 5:1955-1963
50. El-Ashry D, Chrysogelos SA, Lippman ME, Kern FG 1996 Estrogen induction of TGF-alpha is mediated by an estrogen response element composed of two imperfect palindromes. J Steroid Bichem Mol Biol 59:261-269
51. Ignar-Trowbridge DM, Pimentel M, Teng CT, Korach KS, McLachlan JA 1995 Crosstalk between peptide growth factor and estrogen receptor signaling system. Environ Health Perspect 103 [Suppl 7]:35-38
52. Scheffield LG, Welsh CW 1987 Influence of submandibular salivary glands on hormone responsiveness of mouse mammary glands. Proc Soc Exp Med 186: 368-377
53. Vonderhaar BK 1987 Local effects of EGF, α-TGF and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo. J Cell Physiol (Lond) 132:581-584
54. Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery Jr CA, Shyamala G, Conneely OM, O'Malley BW 1995 Mice lacking progesterone receptor exhibit pleitropic reproductive abnormalities. Genes Dev 9:2266-2278
55. Nandi S 1958 Endocrine control of mammary gland development and function in the C3H/He Crgl mouse. J Natl Cancer Inst 21:1039-1063
56. Neville MC, Daniel CW eds 1987 The Mammary Gland Development, Regulation, and Function. Plenum Press, New York
57. Ormandy CJ, Camus A, Barra J, Damotte D, Lucas B, Buteau H, Edery M, Brousse N, Babinet C, Binart N, Kelly PA 1997 Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 11:167-178
58. Fowler KJ, Walker F, Alexander W, Hibbs ML, Nice EC, Bohmer RM, Mann GB, Thumwood C, Maglitto R, Danks JA, Chetty R, Burgress AW, Dunn AR 1995 A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci USA 92:1465-146
59. Bouchard L, Lamarre L, Tremblay PJ, Jolicoeur P 1989 Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell 57:931-936
60. Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P 1988 Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 54:105-115
61. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, Press MF 1989 Studies of the HER2/neu proto-oncogene in human breast and ovarian cancer. Science 244:707-712
62. Dougall WC, Qian X, Paterson NC, Miller MJ, Samanta A, Green MI 1994 The neu-oncogene: signal transduction pathways, transformation mechanism and evolving therapies. Oncogene 9:2109-2123
63. Spivak-Kroizman T, Rotin D, Pinchasi D, Ullrich A, Schlessinger J, Lax I 1992 Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. J Biol Chem 267:8056-8063
64. Nabell LM, Raja RH, Sayeski PP, Paterson AJ, Kudlow JE 1994 Human immunodeficiency virus 1 Tat stimulates transcription of the transforming growth factor alpha gene in an epidermal growth factor-dependent manner. Cell Growth Differ 5:87-93
65. McAndrew J, Paterson AJ, Asa SL, McCarthy KJ, Kudlow JE 1995 Targeting of transforming growth factor-a expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas. Endocrinology 136:4479-4488
66. Van den Berg J, Van Ooyen A, Mantei N, Schambock A, Grosveld G, Flavell RA, Weissmann C 1978 Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pair of introns. Nature 276:37-44