DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer

British Journal of Cancer

Volumn 94, Issue 4, 2006, Pages 593-598

  Kawakami, K ^a   Ruszkiewicz, A ^b   Bennett, G ^b   Moore, J ^c   Grieu, F ^d   Watanabe, G ^a   Iacopetta, B ^d  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^b INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Ageing; DNMT3b; ER ; MYOD; Polymorphism; Promoter methylation

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); APC PROTEIN; DEATH ASSOCIATED PROTEIN KINASE; DNA METHYLTRANSFERASE 3B; ESTROGEN RECEPTOR ALPHA; METHIONINE SYNTHASE; METHYL GROUP; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MYOD PROTEIN; PROTEIN MLH1; PROTEIN P14; PROTEIN P16INK4A; THYMIDYLATE SYNTHASE; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER PATIENT; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA DETERMINATION; DNA HYPERMETHYLATION; DNA METHYLATION; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN TISSUE; MALE; METABOLISM; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS;

AGE FACTORS; CARRIER PROTEINS; COLORECTAL NEOPLASMS; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ESTROGEN RECEPTOR ALPHA; GENOTYPE; HUMANS; INTESTINAL MUCOSA; MYOD PROTEIN; NUCLEAR PROTEINS; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROMOTER REGIONS (GENETICS); SEX FACTORS;

EID: 33344467235     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602940     Document Type: Article

References (40)

1. Ahuja N, Li Q, Mohan AL, Baylin SB, Issa JP (1998) Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res 58: 5489-5494
2. Bariol C, Suter C, Cheong K, Ku SL, Meagher A, Hawkins N, Ward R (2003) The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol 162: 1361-1371
3. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72: 141-196
4. Chen J, Kyte C, Valcin M, Chan W, Wetmur JG, Selhub J, Hunter DJ, Ma J (2004) Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer 110: 617-620
5. Choi SW, Mason JB (2002) Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 132: 2413S-2418S
6. Eads CA, Lord RV, Wickramasinghe K, Kurumboor SK, Bernstein L, Peters JH, DeMeester SR, DeMeester TR, Skinner KA, Laird PW (2001) Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res 61: 3410-3418
7. Feinberg AP, Vogelstein B (1983) Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301: 89-92
8. Frazier ML, Xi L, Zong J, Viscofsky N, Rashid A, Wu EF, Lynch PM, Amos CI, Issa JP (2003) Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer. Cancer Res 63: 4805-4808
9. Frigola J, Sole X, Paz MF, Moreno V, Esteller M, Capella G, Peinado MA (2005) Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum Mol Genet 14: 319-326
10. Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, Corrocher R, Selhub J (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 99: 5606-5611
11. Grieu F, Joseph D, Norman P, Iacopetta B (2004) Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studies. Oncol Rep 11: 501-504
12. Hawkins N, Norrie M, Cheong K, Mokany E, Ku SL, Meagher A, O'Connor T, Ward R (2002) CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 122: 1376-1387
13. Ishiguro K, Kawakami K, Maeda K, Ishida Y, Omura K, Watanabe G (2003) Microsatellite instability in gastric cancer is closely associated with hMLH1 hypermethylation at the proximal region of the promoter. Int J Mol Med 12: 603-608
14. Issa JP (1999) Aging, DNA methylation and cancer. Crit Rev Oncol Hematol 32: 31-43
15. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7: 536-540
16. Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Barker MA, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass JR, Leggett BA (2004) BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53: 1137-1144
17. Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM, Kolodner R (1997) Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumours and mismatch repair-defective human tumour cell lines. Cancer Res 57: 808-811
18. Kawakami K, Ruszkiewicz A, Bennett G, Moore J, Watanabe G, Iacopetta B (2003) The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase. Clin Cancer Res 9: 5860-5865
19. Kawakami K, Watanabe G (2003) Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 63: 6004-6007
20. Kim YI (2004) Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev 13: 511-519
21. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1: 686-692
22. Nakagawa H, Nuovo GJ, Zervos EE, Martin EW, Salovaara R, Aaltonen LA, de la Chapelle A (2001) Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res 61: 6991-6995
23. Paz MF, Avila S, Fraga MF, Pollan M, Capella G, Peinado MA, Sanchez-Cespedes M, Herman JG, Esteller M (2002) Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumours. Cancer Res 62: 4519-4524
24. Rashid A, Issa JP (2004) CpG island methylation in gastroenterologic neoplasia: a maturing field. Gastroenterology 127: 1578-1588
25. Ruszkiewicz A, Bennett G, Moore J, Manavis J, Rudzki B, Shen L, Suthers G (2002) Correlation of mismatch repair gene immunohistochemistry and microsatellite instability status in HNPCC-associated tumours. Pathology 34: 541-547
26. Samowitz WS, Albertsen H, Herrick J, Levin TR, Sweeney C, Murtaugh MA, Wolff RK, Slattery ML (2005a) Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 129: 837-845
27. Samowitz WS, Sweeney C, Herrick J, Albertsen H, Levin TR, Murtaugh MA, Wolff RK, Slattery ML (2005b) Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res 65: 6063-6069
28. Sharp L, Little J (2004) Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159: 423-443
29. Shen H, Wang L, Spitz MR, Hong WK, Mao L, Wei Q (2002) A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res 62:4992-4995
30. Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, Houlihan PS, Krouse RS, Prasad AR, Einspahr JG, Buckmeier J, Alberts DS, Hamilton SR, Issa JP (2005) MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst 97: 1330-1338
31. Stern LL, Mason JB, Selhub J, Choi SW (2000) Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev 9: 849-853
32. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP (1999) CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 96: 8681-8686
33. Van Rijnsoever M, Elsaleh H, Joseph D, McCaul K, Iacopetta B (2003) CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer. Clin Cancer Res 9: 2898-2903
34. Van Rijnsoever M, Grieu F, Elsaleh H, Joseph D, Iacopetta B (2002) Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut 51: 797-802
35. Waki T, Tamura G, Tsuchiya T, Sato K, Nishizuka S, Motoyama T (2002) Promoter methylation status of E-cadherin, hMLH1, and p16 genes in non-neoplastic gastric epithelia. Am J Pathol 161: 399-403
36. Ward RL, Cheong K, Ku SL, Meagher A, O'Connor T, Hawkins NJ (2003) Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J Clin Oncol 21: 3729-3736
37. Ward RL, Williams R, Law M, Hawkins NJ (2004) The CpG island methylator phenotype is not associated with a personal or family history of cancer. Cancer Res 64: 7618-7621
38. Whitehall VL, Wynter CV, Walsh MD, Simms LA, Purdie D, Pandeya N, Young J, Meltzer SJ, Leggett BA, Jass JR (2002) Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer. Cancer Res 62: 6011-6014
39. Yamashita K, Dai T, Dai Y, Yamamoto F, Perucho M (2003) Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell 4:121-131
40. Young J, Barker MA, Simms LA, Walsh MD, Biden KG, Buchanan D, Buttenshaw R, Whitehall VL, Arnold S, Jackson L, Kambara T, Spring KJ, Jenkins MA, Walker GJ, Hopper JL, Leggett BA, Jass JR (2005) Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer. Clin Gastroenterol Hepatol 3: 254-263