Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 20547-20554

  Kremer, Laurent ^a   Dover, Lynn G ^b   Morbidoni, Hector R ^c   Vilchèze, Catherine ^c   Maughan, William N ^b   Baulard, Alain ^a   Tu, Shiao Chun ^d   Honoré, Nadine ^e   Deretic, Vojo ^f   Sacchettini, James C ^g   Locht, Camille ^a   Jacobs Jr , William R ^c   Besra, Gurdyal S ^b  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d University of Houston   (United States)

^e INSTITUT PASTEUR   (France)

^f UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^g TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOSYNTHESIS; DRUG PRODUCTS; ENZYME INHIBITION;

MYCOLIC ACID;

ENZYMES;

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ACYL CARRIER PROTEIN; BACTERIAL ENZYME; BETA KETOACYL ACP SYNTHASE A; CERULENIN; DIAZABORINE; ENZYME INHIBITOR; ETHIONAMIDE; HYGROMYCIN; ISONIAZID; KATG PROTEIN; MYCOLIC ACID; OXIDOREDUCTASE; PROTEIN INHA; STREPTOMYCIN; TIOCARLIDE; TRICLOSAN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; DRUG TARGETING; ENZYME INHIBITION; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTIBODIES; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, MICROBIAL; ETHIONAMIDE; ISONIAZID; MULTIENZYME COMPLEXES; MUTATION; MYCOBACTERIUM SMEGMATIS; OXIDOREDUCTASES;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0038419726     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302435200     Document Type: Article

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