Endogenous ligands for C-type lectin receptors: The true regulators of immune homeostasis

Immunological Reviews

Volumn 230, Issue 1, 2009, Pages 22-37

  García Vallejo, Juan J ^a   Van Kooyk, Yvette ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

C type lectin receptors; Dendritic cells; Glycosylation; Immune homeostasis

Indexed keywords

BUTYROPHILIN; CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CD11B ANTIGEN; CD209 ANTIGEN; CD45 ANTIGEN; DECTIN 1; EPITOPE; GLYCOPROTEIN; GLYCOSYLTRANSFERASE; INTERCELLULAR ADHESION MOLECULE 2; INTERCELLULAR ADHESION MOLECULE 3; LANGERIN; LECTIN RECEPTOR; LECTIN RECEPTOR C; LIGAND; MANNOSE; MANNOSE RECEPTOR; MUCIN 1; NATURAL KILLER CELL RECEPTOR; PROTEIN BDCA 2; PROTEIN CLEC9A; PROTEIN DCAR; PROTEIN DCIR; PROTEIN DNGR 1; PROTEIN MICL; PROTEIN MINCLE; PROTEIN SAP130; TN ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; APOPTOSIS; BINDING SITE; CANCER GROWTH; CELL ADHESION; DENDRITIC CELL; GENETIC TRANSCRIPTION; GLYCOSYLATION; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; INNATE IMMUNITY; INTERNALIZATION; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL ADHESION MOLECULES; DENDRITIC CELLS; GLYCOSYLATION; HOMEOSTASIS; HUMANS; LECTINS, C-TYPE; LIGANDS; RECEPTORS, MITOGEN;

EID: 67649781789     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2009.00786.x     Document Type: Review

References (151)

1. Janeway CA Jr., Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002 20 : 197 216. (Pubitemid 34293424)
2. Kawai T, Akira S. Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci 2008 1143 : 1 20.
3. O'Neill LA. When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. Immunity 2008 29 : 12 20. (Pubitemid 351952460)
4. van Vliet SJ, den Dunnen J, Gringhuis SI, Geijtenbeek TB, van Kooyk Y. Innate signaling and regulation of dendritic cell immunity. Curr Opin Immunol 2007 19 : 435 440. (Pubitemid 47284852)
5. Drickamer K. C-type lectin-like domains. Curr Opin Struct Biol 1999 9 : 585 590. (Pubitemid 29460584)
6. Zelensky AN, Gready JE. The C-type lectin-like domain superfamily. Febs J 2005 272 : 6179 6217. (Pubitemid 41815610)
7. Weis WI, Taylor ME, Drickamer K. The C-type lectin superfamily in the immune system. Immunol Rev 1998 163 : 19 34. (Pubitemid 28327859)
8. Drickamer K. Engineering galactose-binding activity into a C-type mannose-binding protein. Nature 1992 360 : 183 186.
9. Fiete DJ, Beranek MC, Baenziger JU. A cysteine-rich domain of the "mannose" receptor mediates GalNAc-4-SO4 binding. Proc Natl Acad Sci USA 1998 95 : 2089 2093.
10. Brown J, et al. Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function. Protein Sci 2007 16 : 1042 1052. (Pubitemid 46849214)
11. Frison N, et al. Oligolysine-based oligosaccharide clusters: selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin. J Biol Chem 2003 278 : 23922 23929.
12. Appelmelk BJ, van Die I, van Vliet SJ, Vandenbroucke-Grauls CM, Geijtenbeek TB, van Kooyk Y. Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol 2003 170 : 1635 1639. (Pubitemid 36197376)
13. Robinson MJ, Sancho D, Slack EC, LeibundGut-Landmann S, Reis e Sousa C. Myeloid C-type lectins in innate immunity. Nat Immunol 2006 7 : 1258 1265. (Pubitemid 46111243)
14. McGreal EP, Miller JL, Gordon S. Ligand recognition by antigen-presenting cell C-type lectin receptors. Curr Opin Immunol 2005 17 : 18 24. (Pubitemid 40094008)
15. Areschoug T, Gordon S. Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands. Contrib Microbiol 2008 15 : 45 60.
16. Curtis BM, Scharnowske S, Watson AJ. Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120. Proc Natl Acad Sci USA 1992 89 : 8356 8360.
17. Geijtenbeek TB, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000 100 : 587 597.
18. Geijtenbeek TB, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000 100 : 575 585.
19. Guo Y, et al. Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol 2004 11 : 591 598. (Pubitemid 38823524)
20. Garcia-Vallejo JJ, et al. DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2. Mol Immunol 2008 45 : 2359 2369.
21. Geijtenbeek TB, et al. DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. Nat Immunol 2000 1 : 353 357.
22. Bogoevska V, et al. DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues. Glycobiology 2007 17 : 324 333. (Pubitemid 46344684)
23. Malcherek G, Mayr L, Roda-Navarro P, Rhodes D, Miller N, Trowsdale J. The B7 homolog butyrophilin BTN2A1 is a novel ligand for DC-SIGN. J Immunol 2007 179 : 3804 3811.
24. Naarding MA, et al. Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells. Antimicrob Agents Chemother 2006 50 : 3367 3374. (Pubitemid 44527512)
25. van Gisbergen KP, Sanchez-Hernandez M, Geijtenbeek TB, van Kooyk Y. Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN. J Exp Med 2005 201 : 1281 1292. (Pubitemid 40629071)
26. van Gisbergen KP, Ludwig IS, Geijtenbeek TB, van Kooyk Y. Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils. FEBS Lett 2005 579 : 6159 6168. (Pubitemid 41546264)
27. van Gisbergen KP, Aarnoudse CA, Meijer GA, Geijtenbeek TB, van Kooyk Y. Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin. Cancer Res 2005 65 : 5935 5944. (Pubitemid 40911200)
28. Bogoevska V, Horst A, Klampe B, Lucka L, Wagener C, Nollau P. CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues. Glycobiology 2006 16 : 197 209. (Pubitemid 43264686)
29. Jimenez D, Roda-Navarro P, Springer TA, Casasnovas JM. Contribution of N-linked glycans to the conformation and function of intercellular adhesion molecules (ICAMs). J Biol Chem 2005 280 : 5854 5861. (Pubitemid 40280067)
30. Green RS, Stone EL, Tenno M, Lehtonen E, Farquhar MG, Marth JD. Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis. Immunity 2007 27 : 308 320. (Pubitemid 47284915)
31. van Kooyk Y, Geijtenbeek TB. A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. Immunol Rev 2002 186 : 47 56.
32. Garcia-Vallejo JJ, et al. Activation of human endothelial cells by tumor necrosis factor-alpha results in profound changes in the expression of glycosylation-related genes. J Cell Physiol 2006 206 : 203 210. (Pubitemid 41740733)
33. van Gisbergen KP, Geijtenbeek TB, van Kooyk Y. Close encounters of neutrophils and DCs. Trends Immunol 2005 26 : 626 631. (Pubitemid 41628194)
34. Naarding MA, et al. Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes. J Clin Invest 2005 115 : 3256 3264. (Pubitemid 41567590)
35. Nonaka M, et al. Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells. J Immunol 2008 180 : 3347 3356.
36. Geijtenbeek TB, et al. Mycobacteria target DC-SIGN to suppress dendritic cell function. J Exp Med 2003 197 : 7 17. (Pubitemid 36110253)
37. Gringhuis SI, den Dunnen J, Litjens M, van het Hof B, van Kooyk Y, Geijtenbeek TB. C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. Immunity 2007 26 : 605 616. (Pubitemid 46756345)
38. Engering A, et al. The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J Immunol 2002 168 : 2118 2126. (Pubitemid 34171810)
39. Caparros E, et al. DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production. Blood 2006 107 : 3950 3958. (Pubitemid 43726801)
40. Hovius JW, et al. Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathog 2008 4 : e31.
41. Powlesland AS, Ward EM, Sadhu SK, Guo Y, Taylor ME, Drickamer K. Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins. J Biol Chem 2006 281 : 20440-20449.
42. Koppel EA, et al. Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection. Eur J Immunol 2005 35 : 2962 2969. (Pubitemid 41555092)
43. Lanoue A, et al. SIGN-R1 contributes to protection against lethal pneumococcal infection in mice. J Exp Med 2004 200 : 1383 1393. (Pubitemid 39657286)
44. Koppel EA, Litjens M, van den Berg VC, van Kooyk Y, Geijtenbeek TB. Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae. Mol Immunol 2008 45 : 2881 2887.
45. Suzuki N, Yamamoto K, Toyoshima S, Osawa T, Irimura T. Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. J Immunol 1996 156 : 128 135. (Pubitemid 26006955)
46. Valladeau J, et al. Immature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosis. J Immunol 2001 167 : 5767 5774. (Pubitemid 33062768)
47. van Vliet SJ, Gringhuis SI, Geijtenbeek TB, van Kooyk Y. Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45. Nat Immunol 2006 7 : 1200 1208. (Pubitemid 44594316)
48. van Vliet SJ, et al. Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells. Int Immunol 2005 17 : 661 669. (Pubitemid 41417863)
49. Takada A, et al. Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry. J Virol 2004 78 : 2943 2947. (Pubitemid 38314351)
50. Saeland E, et al. The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma. Cancer Immunol Immunother 2007 56 : 1225 1236. (Pubitemid 46763937)
51. van Vliet SJ, Paessens LC, Broks-van den Berg VC, Geijtenbeek TB, van Kooyk Y. The C-type lectin macrophage galactose-type lectin impedes migration of immature APCs. J Immunol 2008 181 : 3148 3155.
52. van Vliet SJ, van Liempt E, Geijtenbeek TB, van Kooyk Y. Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets. Immunobiology 2006 211 : 577 585. (Pubitemid 44241650)
53. Napoletano C, et al. Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells. Cancer Res 2007 67 : 8358 8367. (Pubitemid 47395175)
54. Dwek MV, et al. Helix pomatia agglutinin lectin-binding oligosaccharides of aggressive breast cancer. Int J Cancer 2001 95 : 79 85. (Pubitemid 32187077)
55. Konno A, Hoshino Y, Terashima S, Motoki R, Kawaguchi T. Carbohydrate expression profile of colorectal cancer cells is relevant to metastatic pattern and prognosis. Clin Exp Metastasis 2002 19 : 61 70. (Pubitemid 34208355)
56. Laack E, et al. Lectin histochemistry of resected adenocarcinoma of the lung: helix pomatia agglutinin binding is an independent prognostic factor. Am J Pathol 2002 160 : 1001 1008. (Pubitemid 34224588)
57. Hakomori S. Traveling for the glycosphingolipid path. Glycoconj J 2000 17 : 627 647. (Pubitemid 32480349)
58. Birkle S, Zeng G, Gao L, Yu RK, Aubry J. Role of tumor-associated gangliosides in cancer progression. Biochimie 2003 85 : 455 463. (Pubitemid 36626016)
59. Narita I, Gejyo F. Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy. Clin Exp Nephrol 2008 12 : 332 338.
60. Ju T, Cummings RD. Protein glycosylation: chaperone mutation in Tn syndrome. Nature 2005 437 : 1252.
61. Berger EG. Tn-syndrome. Biochim Biophys Acta 1999 1455 : 255 268. (Pubitemid 29435993)
62. Ju T, Cummings RD. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. Proc Natl Acad Sci USA 2002 99 : 16613 16618. (Pubitemid 36034021)
63. van Vliet SJ, Aarnoudse CA, Broks-van den Berg VC, Boks M, Geijtenbeek TB, van Kooyk Y. MGL-mediated internalization and antigen presentation by dendritic cells: a role for tyrosine-5. Eur J Immunol 2007 37 : 2075 2081. (Pubitemid 47250199)
64. Tsuiji M, et al. Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J Biol Chem 2002 277 : 28;892 28;901.
65. Onami TM, et al. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Mol Cell Biol 2002 22 : 5173 5181. (Pubitemid 34700706)
66. Yuita H, et al. Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos. Glycobiology 2005 15 : 1368 1375. (Pubitemid 41724341)
67. Franz S, et al. Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis. Cytometry A 2006 69 : 230 239.
68. Matsumoto M, et al. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol 1999 163 : 5039 5048. (Pubitemid 29501272)
69. Wells CA, et al. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol 2008 180 : 7404 7413.
70. Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol 2008 9 : 1179 1188.
71. Lee SJ, et al. Mannose receptor-mediated regulation of serum glycoprotein homeostasis. Science 2002 295 : 1898 1901. (Pubitemid 34218139)
72. Nauta AJ, et al. Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol 2003 33 : 2853 2863. (Pubitemid 37337151)
73. Bates EE, et al. APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J Immunol 1999 163 : 1973 1983. (Pubitemid 29382200)
74. Huang X, et al. Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. Biochem Biophys Res Commun 2001 281 : 131 140. (Pubitemid 32924410)
75. Richard M, Thibault N, Veilleux P, Gareau-Page G, Beaulieu AD. Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2. Mol Immunol 2006 43 : 1716 1721. (Pubitemid 43308325)
76. Kanazawa N, Okazaki T, Nishimura H, Tashiro K, Inaba K, Miyachi Y. DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motif. J Invest Dermatol 2002 118 : 261 266. (Pubitemid 34158479)
77. Meyer-Wentrup F, et al. DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production. J Leukoc Biol 2009 85 : 518 525.
78. Meyer-Wentrup F, et al. Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production. Blood 2008 111 : 4245 4253.
79. Fujikado N, et al. Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. Nat Med 2008 14 : 176 180. (Pubitemid 351214549)
80. Kanazawa N, Tashiro K, Inaba K, Miyachi Y. Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain. J Biol Chem 2003 278 : 32;645 32;652.
81. Kanazawa N. Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells. J Dermatol Sci 2007 45 : 77 86. (Pubitemid 46108481)
82. Dzionek A, et al. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol 2000 165 : 6037 6046.
83. Pascual V, Banchereau J, Palucka AK. The central role of dendritic cells and interferon-alpha in SLE. Curr Opin Rheumatol 2003 15 : 548 556. (Pubitemid 37041391)
84. Dzionek A, et al. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med 2001 194 : 1823 1834. (Pubitemid 34028661)
85. Ronnblom L, Alm GV. A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J Exp Med 2001 194 : F59 F63.
86. Rock J, et al. CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCgamma2. Eur J Immunol 2007 37 : 3564 3575.
87. Cao W, et al. BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. PLoS Biol 2007 5 : e248.
88. Ryan EJ, et al. Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4. J Immunol 2002 169 : 5638 5648. (Pubitemid 35291665)
89. Ryan EJ, Magaletti D, Draves KE, Clark EA. Ligation of dendritic cell-associated lectin-1 induces partial maturation of human monocyte derived dendritic cells. Hum Immunol 2009 70 : 1 5.
90. Marshall AS, Willment JA, Lin HH, Williams DL, Gordon S, Brown GD. Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J Biol Chem 2004 279 : 14;792 14;802.
91. Bakker AB, et al. C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia. Cancer Res 2004 64 : 8443 8450. (Pubitemid 39491785)
92. Chen CH, et al. Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production. Blood 2006 107 : 1459 1467.
93. Han Y, et al. KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. Blood 2004 104 : 2858 2866. (Pubitemid 39434972)
94. Pyz E, Huysamen C, Marshall AS, Gordon S, Taylor PR, Brown GD. Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. Eur J Immunol 2008 38 : 1157 1163.
95. Ariizumi K, et al. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem 2000 275 : 20157 20167. (Pubitemid 30441627)
96. Weck MM, et al. hDectin-1 is involved in uptake and cross-presentation of cellular antigens. Blood 2008 111 : 4264 4272.
97. Sancho D, et al. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest 2008 118 : 2098 2110. (Pubitemid 351872329)
98. Caminschi I, et al. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood 2008 112 : 3264 3273.
99. Huysamen C, Willment JA, Dennehy KM, Brown GD. CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. J Biol Chem 2008 283 : 16693 16701.
100. Sancho D, et al. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 2009 doi :.
101. Swiggard WJ, Mirza A, Nussenzweig MC, Steinman RM. DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization, and N-terminal amino acid sequence. Cell Immunol 1995 165 : 302 311.
102. Jiang W, et al. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 1995 375 : 151 155.
103. Kronin V, Wu L, Gong S, Nussenzweig MC, Shortman K. DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses. Int Immunol 2000 12 : 731 735. (Pubitemid 30248906)
104. Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002 196 : 1627 1638. (Pubitemid 36026474)
105. Hawiger D, et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001 194 : 769 779. (Pubitemid 32983013)
106. Mahnke K, Qian Y, Knop J, Enk AH. Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood 2003 101 : 4862 4869. (Pubitemid 36857748)
107. Bruder D, et al. On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes 2005 54 : 3395 3401. (Pubitemid 43334328)
108. Mahnke K, Qian Y, Fondel S, Brueck J, Becker C, Enk AH. Targeting of antigens to activated dendritic cells in vivo cures metastatic melanoma in mice. Cancer Res 2005 65 : 7007 7012. (Pubitemid 41060741)
109. Gazi U, Martinez-Pomares L. Influence of the mannose receptor in host immune responses. Immunobiology 2009 doi :.
110. Leteux C, et al. The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin. J Exp Med 2000 191 : 1117 1126. (Pubitemid 30207675)
111. Taylor PR, Gordon S, Martinez-Pomares L. The mannose receptor: linking homeostasis and immunity through sugar recognition. Trends Immunol 2005 26 : 104 110.
112. Mi Y, Shapiro SD, Baenziger JU. Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo. J Clin Invest 2002 109 : 269 276. (Pubitemid 34083747)
113. Lee SJ, Zheng NY, Clavijo M, Nussenzweig MC. Normal host defense during systemic candidiasis in mannose receptor-deficient mice. Infect Immun 2003 71 : 437 445. (Pubitemid 36026048)
114. Shibata Y, Metzger WJ, Myrvik QN. Chitin particle-induced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production. J Immunol 1997 159 : 2462 2467. (Pubitemid 127681041)
115. Zhang J, Zhu J, Imrich A, Cushion M, Kinane TB, Koziel H. Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors. Infect Immun 2004 72 : 3147 3160. (Pubitemid 38697735)
116. Tachado SD, Zhang J, Zhu J, Patel N, Cushion M, Koziel H. Pneumocystis-mediated IL-8 release by macrophages requires coexpression of mannose receptors and TLR2. J Leukoc Biol 2007 81 : 205 211. (Pubitemid 46021270)
117. Sato K, et al. Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J Biol Chem 2006 281 : 38854 38866.
118. Chieppa M, et al. Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J Immunol 2003 171 : 4552 4560. (Pubitemid 37310570)
119. Kornfeld R, Kornfeld S. Assembly of asparagine-linked oligosaccharides. Annu Rev Biochem 1985 54 : 631 664. (Pubitemid 15073660)
120. Garcia-Vallejo JJ, Gringhuis SI, van Dijk W, van Die I. Gene expression analysis of glycosylation-related genes by real-time polymerase chain reaction. Methods Mol Biol 2006 347 : 187 209.
121. Nairn AV, York WS, Harris K, Hall EM, Pierce JM, Moremen KW. Regulation of glycan structures in animal tissues: transcript profiling of glycan-related genes. J Biol Chem 2008 283 : 17298 17313.
122. Comelli EM, et al. A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology 2006 16 : 117 131. (Pubitemid 43125968)
123. Bax M, et al. Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins. J Immunol 2007 179 : 8216 8224.
124. Comelli EM, et al. Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans. J Immunol 2006 177 : 2431 2440. (Pubitemid 44201004)
125. Abbott KL, et al. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics 2008 8 : 3210 3220.
126. Koike T, et al. Hypoxia induces adhesion molecules on cancer cells: a missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci USA 2004 101 : 8132 8137. (Pubitemid 38698066)
127. Underhill GH, Zisoulis DG, Kolli KP, Ellies LG, Marth JD, Kansas GS. A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells. Blood 2005 106 : 3867 3873. (Pubitemid 41739025)
128. Hiraiwa N, et al. Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element. Blood 2003 101 : 3615 3621. (Pubitemid 36857950)
129. Garcia-Vallejo JJ, van Dijk W, van Die I, Gringhuis SI. Tumor necrosis factor-alpha up-regulates the expression of beta1,4-galactosyltransferase I in primary human endothelial cells by mRNA stabilization. J Biol Chem 2005 280 : 12676 12682.
130. Gringhuis SI, Garcia-Vallejo JJ, van Het Hof B, van Dijk W. Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin. Mol Cell Biol 2005 25 : 6454 6463. (Pubitemid 41023221)
131. Charron M, Shaper JH, Shaper NL. The increased level of beta1,4-galactosyltransferase required for lactose biosynthesis is achieved in part by translational control. Proc Natl Acad Sci USA 1998 95 : 14805 14810.
132. Breton C, Mucha J, Jeanneau C. Structural and functional features of glycosyltransferases. Biochimie 2001 83 : 713 718. (Pubitemid 32821235)
133. Ma J, Simonovic M, Qian R, Colley KJ. Sialyltransferase isoforms are phosphorylated in the cis-medial Golgi on serine and threonine residues in their luminal sequences. J Biol Chem 1999 274 : 8046 8052.
134. Wu X, et al. Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder. Nat Med 2004 10 : 518 523. (Pubitemid 38667911)
135. Priatel JJ, et al. The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity 2000 12 : 273 283. (Pubitemid 30953245)
136. Niittymaki J, Mattila P, Renkonen R. Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII. APMIS 2006 114 : 539 548. (Pubitemid 44252508)
137. Luhn K, Wild MK, Eckhardt M, Gerardy-Schahn R, Vestweber D. The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter. Nat Genet 2001 28 : 69 72. (Pubitemid 32405820)
138. Grigorian A, et al. Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem 2007 282 : 20027 20035.
139. Wang P, et al. Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor. Biochem J 2004 380 : 425 433. (Pubitemid 38788114)
140. Comstock LE, Kasper DL. Bacterial glycans: key mediators of diverse host immune responses. Cell 2006 126 : 847 850. (Pubitemid 44310786)
141. Arnold JN, Saldova R, Hamid UM, Rudd PM. Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation. Proteomics 2008 8 : 3284 3293.
142. van Dijk W, Havenaar EC, Brinkman-van der Linden EC. Alpha 1-acid glycoprotein (orosomucoid): pathophysiological changes in glycosylation in relation to its function. Glycoconj J 1995 12 : 227 233.
143. De Graaf TW, Van der Stelt ME, Anbergen MG, van Dijk W. Inflammation-induced expression of sialyl Lewis X-containing glycan structures on alpha 1-acid glycoprotein (orosomucoid) in human sera. J Exp Med 1993 177 : 657 666. (Pubitemid 23104277)
144. Renkonen J, Tynninen O, Hayry P, Paavonen T, Renkonen R. Glycosylation might provide endothelial zip codes for organ-specific leukocyte traffic into inflammatory sites. Am J Pathol 2002 161 : 543 550. (Pubitemid 36142163)
145. Yang J, Rosen SD, Bendele P, Hemmerich S. Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. BMC Immunol 2006 7 : 12.
146. Pablos JL, et al. A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells. BMC Immunol 2005 6 : 6.
147. da Costa Martins P, et al. P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium. Arterioscler Thromb Vasc Biol 2007 27 : 1023 1029.
148. Dennis JW, Laferte S, Waghorne C, Breitman ML, Kerbel RS. Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 1987 236 : 582 585. (Pubitemid 17069927)
149. Varki NM, Varki A. Diversity in cell surface sialic acid presentations: implications for biology and disease. Lab Invest 2007 87 : 851 857. (Pubitemid 47267816)
150. Dube DH, Bertozzi CR. Glycans in cancer and inflammation - potential for therapeutics and diagnostics. Nat Rev Drug Discov 2005 4 : 477 488. (Pubitemid 40861990)
151. van Vliet SJ, Saeland E, van Kooyk Y. Sweet preferences of MGL: carbohydrate specificity and function. Trends Immunol 2008 29 : 83 90.