The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

Blood

Volumn 112, Issue 8, 2008, Pages 3264-3273

  Caminschi, Irina ^a   Proietto, Anna I ^a   Ahmet, Fatma ^a   Kitsoulis, Susie ^a   Teh, Joo Shin ^a   Lo, Jennifer C Y ^a   Rizzitelli, Alexandra ^b   Wu, Li ^a   Vremec, David ^a   Van Dommelen, Serani L H ^a   Campbell, Ian K ^a   Maraskovsky, Eugene ^c   Braley, Hal ^c   Davey, Gayle M ^a   Mottram, Patricia ^d   Van De Velde, Nicholas ^d   Jensen, Kent ^e   Lew, Andrew M ^a   Wright, Mark D ^b   Heath, William R ^a   Shortman, Ken ^a   Lahoud, Mireille H ^a   more..

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c CSL LIMITED   (Australia)

^d AUSTIN HOSPITAL   (Australia)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; LECTIN; LECTIN CLEC 9A; MONOCLONAL ANTIBODY; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMISTRY; CYTOLOGY; HEMATOPOIETIC STEM CELL; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; LECTINS, C-TYPE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; VACCINES;

EID: 54049145131     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-05-155176     Document Type: Article

References (52)

1. Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol. 2006;6:476-483.
2. Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol. 2007;7:19-30.
3. Grouard G, Rissoan MC, Filgueira L, Durand I, Banchereau J, Liu YJ. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med. 1997; 185:1101-1111.
4. Asselin-Paturel C, BoonstraA, Dalod M, et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol. 2001;2:1144-1150.
5. O'Keeffe M, Hochrein H, Vremec D, et al. Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J Exp Med. 2002;196:1307-1319.
6. Naik SH, Metcalf D, van Nieuwenhuijze A, et al. Intrasplenic steady-state dendritic cell precursors which are distinct from monocytes. Nat Immunol. 2006;7:663-671.
7. Allan RS. Smith CM, Belz GT, et al. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science. 2003; 301:1925-1928.
8. Allan RS, Waithman J, Bedoui S, et al. Migratory dendritic cells transfer antigen to a lymph noderesident dendritic cell population for efficient CTL priming. Immunity. 2006;25:153-162.
9. Naik S, Vremec D, Wu L, O'Keeffe M, Shortman K. CD8alpha+ mouse spleen dendritic cells do not originate from the CD8alpha-dendritic cell subset. Blood. 2003;102:601-604.
10. den Haan JM, Lehar SM, Bevan MJ. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med. 2000;192:1685-1696.
11. Pooley J, Heath WR, Shortman K. Intravenous soluble antigen is presented to CD4T cells by CDS-Dendritic cells but cross-presented to CD8+ T cells by CD8+ Dendritic cells. J Immunol. 2001;166:5327-5330.
12. Schnorrer P, Behrens GM, Wilson NS, et al. The dominant role of CD8+ dendritic cells in crosspresentation is not dictated by antigen capture. Proc Natl Acad Sci U S A. 2006;103:10729-10734.
13. Hochrein H, Shortman K, Vremec D, Scott B, Hertzog P, O'Keeffe M. Differential production of IL-12, IFN-alpha. and IFN-gamma by mouse dendritic cell subsets. J Immunol. 2001:166:5448-5455.
14. Reis e Sousa C, Hieny S, Scharton-Kersten T, et al. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med. 1997;186:1819-1829.
15. Vandenabeele S, Hochrein H, Mavaddat N, Winkel K, Shortman K. Human thymus contains 2 distinct dendritic cell populations. Blood. 2001:97: 1733-1741.
16. Bendriss-Vermare N, Barthelemy C, Durand I, et al. Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+), and mature interdigitating dendritic cells. J Clin Invest. 2001;107: 835-844.
17. Galibert L Diemer GS, Liu Z, et al. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-l-restricted T-cellassociated molecule. J Biol Chem. 2005;280: 21955-21964.
18. Carter RW, Thompson C, Reid DM, Wong SY Tough DF Preferential induction of CD4+ T cell responses through in vivo targeting of antigen to dendritic cell-associated G-type lectin-1. J Immunol. 2006;177:2276-2284.
19. Corbett AJ, Caminschi I. McKenzie BS. et al. Antigen delivery via two molecules on the CDS-dendritic cell subset induces humoral immunity in the absence of conventional "danger." Eur J Immunol. 2005;35:2815-2825.
20. Dudziak D, Kamphorst AO, Heidkamp GR et al. Differential antigen processing by dendritic cell subsets in vivo. Science. 2007;315:107-111.
21. Finkelman FD, Lees A. Birnbaum R, Gause WC, Morris SC. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol. 1996;157:1406-1414.
22. Wang H. Griffiths MN, Burton DR. Ghazal P. Rapid antibody responses by low-dose, singlestep, dendritic cell-targeted immunization. Proc Natl Acad Sci U S A. 2000;97:847-852.
23. Pereira CF Torensma R, Hebeda K, et al. In vivo targeting of DC-SIGN-positive antigen-presenting cells in a nonhuman primate model. J Immunother. 2007;30:705-714.
24. Tacken PJ, de Vries IJ, Torensma R, Figdor CG. Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting. Nat Rev Immunol. 2007:7: 790-802.
25. Bourges D, Zhan Y, Brady JL, et al. Targeting the gut vascular endothelium induces gut effector CDS Tcell responses via cross-presentation by dendritic cells. J Immunol. 2007;179:5678-5685.
26. Mukhopadhaya A, Hanafusa T, Jarchum I, et al. Selective delivery of {beta} cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. Proc Natl Acad Sci U S A 2008.
27. Idoyaga J, Cheong C, Suda K. et al. Cutting edge: Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo. J Immunol. 2008;180: 3647-3650.
28. Hawiger D, Inaba K, Dorsett Y, et al. Dendritic cells induce peripheral Tcell unresponsiveness under steady state conditions in vivo. J Exp Med. 2001:194:769-779.
29. Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med. 2002;196:1627-1638.
30. Bonifaz LC, Bonnyay DP, Charalambous A, et al. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves Tcell vaccination. J Exp Med. 2004;199:815-824.
31. Lahoud MH, Proietto AL Gartlan K, et al. Sirp Molecules are Differentially Expressed by CD8-Dendritic Cells. J Immunol. 2006;177:372-382.
32. Basic local alignment search tool. Bethesda, MD: National Center for Biotechnology Information. http://www.ncbi.nlm.nih.gov. Accessed April 26, 2007.
33. Genome Browser. Santa Cruz, CA: University of California Santa Cruz. http://www.genome. ucsc.edu. Accessed April 26. 2007
34. Yamamoto M, Sato S, Hemmi H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003;301: 640-643.
35. Adachi O, Kawai T, Takeda K, et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 1998;9: 143-150.
36. Van deVelde N, Mottram PL, Hogarth PM. FcgRII and multi-system autoimmune disease. Springer Semin Immunol. 2006;28:329-338.
37. Vremec D, Pooley J, Hochrein H, Wu L Shortman K. CD4 and CDS expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol. 2000;164:2978-2986.
38. Caminschi I, Ahmet F, Heger K, et al. Putative IKDCs are functionally and developmentaly similar to natural killer cells, but not to dendritic cells. J Exp Med. 2007;204:2579-2590.
39. Villadangos JA, Schnorrer P. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat Rev Immunol. 2007:7:543-555.
40. Edwards AD. Chaussabel D, Tomlinson S. Schulz O, Sher A, Reis ESC. Relationships among murine GD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns. J Immunol. 2003;171:47-60.
41. Proietto Al, O'Keeffe M, Gartlan K, et al. Differential production of inflammatory chemokines by murine dendritic cell subsets. Immunobiology. 2004;209:163-172.
42. Fuller GL Williams JA, Tomlinson MG, et al. The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. J Biol Ghem. 2007;282: 12397-12409.
43. Weis Wl, Taylor ME, Drickamer K. The C-type lectin superfamily in the immune system. Immunol Rev. 1998;163:19-34.
44. Naik SH, Proietto Al, Wilson NS, et al. Cutting edge: generation of splenic GD8+ and GD8-dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol. 2005: 174:6592-6597.
45. Vremec D, O'Keeffe M, Hochrein H, et al. Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells. Blood. 2007;109:1165-1173.
46. O'Keeffe M, Hochrein H, Vremec D, et al. Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors. Blood. 2003;101: 1453-1459.
47. Pulendran B, Smith JL Caspary G, et al. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci U S A. 1999;96:1036-1041.
48. Maldonada-Lopez R, De Smedt T Pajak B, et al. Role of CD8alpha+ and CD8alpha-dendritic cells in the induction of primary immune responses in vivo. J Leukoc Biol. 1999;66:242-246
49. Sancho D, Mourao-Sa D, Joffre OP. et al. Tumor therapy in mice via antigen targeting to a novel DC-restricted C-type lectin. J Clin Invest. 2008; 118:2098-2110.
50. Caminschi I, Gorbett AJ, Zahra C, et al. Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN. Int Immunol. 2006; 18:741-753.
51. Caminschi I, Vandenabeele S, Sofi M, et al. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. DNASeq. 2006;17:8-14.
52. Huysamen C, Willment JA, Dennehy KM, Brown GD. CLEC9 A is a novel activation C-type lectinlike receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. J Biol Chem. 2008:283:16693-16701.