메뉴 건너뛰기




Volumn 67, Issue 17, 2007, Pages 8358-8367

Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells

Author keywords

[No Author keywords available]

Indexed keywords

GLYCAN DERIVATIVE; GLYCOPEPTIDE; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; LECTIN; MACROPHAGE GALACTOSE TYPE C TYPE LECTIN; MACROPHAGE GALACTOSE TYPE C TYPE LECTIN RECEPTOR; MUCIN 1; N ACETYLGALACTOSAMINE; RECEPTOR; RECOMBINANT PROTEIN; TN ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 34548593215     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1035     Document Type: Article
Times cited : (115)

References (49)
  • 1
    • 20844437106 scopus 로고    scopus 로고
    • Glycans in cancer and inflammation - potential for therapeutics and diagnostics
    • Dube DH, Bertozzi CR. Glycans in cancer and inflammation - potential for therapeutics and diagnostics. Nat Rev Drug Discov 2005;4:477-88.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 477-488
    • Dube, D.H.1    Bertozzi, C.R.2
  • 3
    • 0034963231 scopus 로고    scopus 로고
    • Tumor-associated carbohydrate antigens defining tumor malignancy: Basis for development of anti-cancer vaccines
    • Hakomori S. Tumor-associated carbohydrate antigens defining tumor malignancy: basis for development of anti-cancer vaccines. Adv Exp Med Biol 2001;491:369-402.
    • (2001) Adv Exp Med Biol , vol.491 , pp. 369-402
    • Hakomori, S.1
  • 4
    • 10044265684 scopus 로고    scopus 로고
    • Glycoprotein tumor antigens for immunotherapy of breast cancer
    • Vlad AM, Finn OJ. Glycoprotein tumor antigens for immunotherapy of breast cancer. Breast Dis 2004;20:73-9.
    • (2004) Breast Dis , vol.20 , pp. 73-79
    • Vlad, A.M.1    Finn, O.J.2
  • 5
    • 0025777046 scopus 로고
    • Structure and biology of a carcinoma-associated mucin, MUC1
    • Gendler SJ, Spicer AP, Lalani EN, et al. Structure and biology of a carcinoma-associated mucin, MUC1. Am Rev Respir Dis 1991;144:S42-7.
    • (1991) Am Rev Respir Dis , vol.144
    • Gendler, S.J.1    Spicer, A.P.2    Lalani, E.N.3
  • 6
    • 0035077832 scopus 로고    scopus 로고
    • O-Glycosylation of the mucin type
    • Hanisch FG. O-Glycosylation of the mucin type. Biol Chem 2001;382:143-9.
    • (2001) Biol Chem , vol.382 , pp. 143-149
    • Hanisch, F.G.1
  • 9
    • 0033989671 scopus 로고    scopus 로고
    • MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines
    • Acres B, Apostolopoulos V, Balloul JM, et al. MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines. Cancer Immunol Immunother 2000;48:588-94.
    • (2000) Cancer Immunol Immunother , vol.48 , pp. 588-594
    • Acres, B.1    Apostolopoulos, V.2    Balloul, J.M.3
  • 10
    • 0034331218 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
    • Brossart P, Wirths S, Stuhler G, Reichardt VL, Kanz L, Brugger W. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 2000;96:3102-8.
    • (2000) Blood , vol.96 , pp. 3102-3108
    • Brossart, P.1    Wirths, S.2    Stuhler, G.3    Reichardt, V.L.4    Kanz, L.5    Brugger, W.6
  • 11
    • 33745126667 scopus 로고    scopus 로고
    • Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]
    • Apostolopoulos V, Pietersz GA, Tsibanis A, et al. Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]. Breast Cancer Res 2006;8:R27.
    • (2006) Breast Cancer Res , vol.8
    • Apostolopoulos, V.1    Pietersz, G.A.2    Tsibanis, A.3
  • 12
    • 19944433959 scopus 로고    scopus 로고
    • Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer
    • Ramanathan RK, Lee KM, McKolanis J, et al. Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer. Cancer Immunol Immunother 2005;54:254-64.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 254-264
    • Ramanathan, R.K.1    Lee, K.M.2    McKolanis, J.3
  • 13
    • 31144451097 scopus 로고    scopus 로고
    • Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance
    • Sorensen AL, Reis CA, Tarp MA, et al. Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance. Glycobiology 2006;16:96-107.
    • (2006) Glycobiology , vol.16 , pp. 96-107
    • Sorensen, A.L.1    Reis, C.A.2    Tarp, M.A.3
  • 14
    • 17444428086 scopus 로고    scopus 로고
    • Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn
    • Kagan E, Ragupathi G, Yi SS, et al. Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunol Immunother 2005;54:424-30.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 424-430
    • Kagan, E.1    Ragupathi, G.2    Yi, S.S.3
  • 15
    • 0032862879 scopus 로고    scopus 로고
    • Macrophage-tumor cell interactions: Indentification of MUC1 on breast cancer cells as a potential counter receptor for the macrophage-restricted receptor, sialoadhesin
    • Nath D, Hartnell A, Happerfield L, et al. Macrophage-tumor cell interactions: indentification of MUC1 on breast cancer cells as a potential counter receptor for the macrophage-restricted receptor, sialoadhesin. Immunology 1999;98:231-19.
    • (1999) Immunology , vol.98 , pp. 231-219
    • Nath, D.1    Hartnell, A.2    Happerfield, L.3
  • 16
    • 0037278398 scopus 로고    scopus 로고
    • Regulated expression of MUC1 epithelial antigen in erythropoiesis
    • Rughetti A, Biffoni M, Pierelli L, et al. Regulated expression of MUC1 epithelial antigen in erythropoiesis. Br J Haematol 2003;120:344-52.
    • (2003) Br J Haematol , vol.120 , pp. 344-352
    • Rughetti, A.1    Biffoni, M.2    Pierelli, L.3
  • 17
    • 20444403424 scopus 로고    scopus 로고
    • Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells
    • Rughetti A, Pellicciotta I, Biffoni M, et al. Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells. J Immunol 2005;174:7764-72.
    • (2005) J Immunol , vol.174 , pp. 7764-7772
    • Rughetti, A.1    Pellicciotta, I.2    Biffoni, M.3
  • 18
    • 0141533076 scopus 로고    scopus 로고
    • Dual function of C-type lectin-like receptors in the immune system
    • Cambi A, Figdor CG. Dual function of C-type lectin-like receptors in the immune system. Curr Opin Cell Biol 2003;15:539-46.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 539-546
    • Cambi, A.1    Figdor, C.G.2
  • 21
    • 21344449731 scopus 로고    scopus 로고
    • Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin
    • van Gisbergen KP, Aarnoudse CA, Meijer GA, Geijtenbeek TB, van Kooyk Y. Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin. Cancer Res 2005;65:5935-44.
    • (2005) Cancer Res , vol.65 , pp. 5935-5944
    • van Gisbergen, K.P.1    Aarnoudse, C.A.2    Meijer, G.A.3    Geijtenbeek, T.B.4    van Kooyk, Y.5
  • 22
    • 0030059770 scopus 로고    scopus 로고
    • Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen
    • Suzuki N, Yamamoto K, Toyoshima S, Osawa T, Irimura T. Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. J Immunol 1996;156:128-35.
    • (1996) J Immunol , vol.156 , pp. 128-135
    • Suzuki, N.1    Yamamoto, K.2    Toyoshima, S.3    Osawa, T.4    Irimura, T.5
  • 23
    • 0027692043 scopus 로고
    • Synthesis of large multideterminant peptide immunogens using a poly-proline β-turn helix motif
    • Fontenot JD, Finn OJ, Dales N, Andrews PC, Montelaro RC. Synthesis of large multideterminant peptide immunogens using a poly-proline β-turn helix motif. Pept Res 1993;6:330-6.
    • (1993) Pept Res , vol.6 , pp. 330-336
    • Fontenot, J.D.1    Finn, O.J.2    Dales, N.3    Andrews, P.C.4    Montelaro, R.C.5
  • 24
    • 15444344929 scopus 로고    scopus 로고
    • Cloning of a human UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyl transferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat
    • Bennett EP, Hassan H, Mandel U, et al. Cloning of a human UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyl transferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. J Biol Chem 1998;273:30472-81.
    • (1998) J Biol Chem , vol.273 , pp. 30472-30481
    • Bennett, E.P.1    Hassan, H.2    Mandel, U.3
  • 25
    • 0037151059 scopus 로고    scopus 로고
    • Schwientek T, Bennett EP, F lores C, et al. Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. J Biol Chem 2002;277:22623-38.
    • Schwientek T, Bennett EP, F lores C, et al. Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. J Biol Chem 2002;277:22623-38.
  • 26
    • 0037081467 scopus 로고    scopus 로고
    • Comparison of antibody titers after immunization with monovalent or tetravalent KLH conjugate vaccines
    • Ragupathi G, Cappello S, Yi SS, et al. Comparison of antibody titers after immunization with monovalent or tetravalent KLH conjugate vaccines. Vaccine 2002;20:1030-8.
    • (2002) Vaccine , vol.20 , pp. 1030-1038
    • Ragupathi, G.1    Cappello, S.2    Yi, S.S.3
  • 27
    • 33947198189 scopus 로고    scopus 로고
    • The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: Lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation
    • Wandall HH, Irazoqui F, Tarp MA, et al. The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation. Glycobiology 2007;17:374-87.
    • (2007) Glycobiology , vol.17 , pp. 374-387
    • Wandall, H.H.1    Irazoqui, F.2    Tarp, M.A.3
  • 28
    • 0031885382 scopus 로고    scopus 로고
    • Development and characterization of an antibody directed to an α-N-acetyl-D-galactosamine glycosylated MUC2 peptide
    • Reis CA, Sorensen T, Mandel U, et al. Development and characterization of an antibody directed to an α-N-acetyl-D-galactosamine glycosylated MUC2 peptide. Glycoconj J 1998;15:51-62.
    • (1998) Glycoconj J , vol.15 , pp. 51-62
    • Reis, C.A.1    Sorensen, T.2    Mandel, U.3
  • 29
    • 0022527678 scopus 로고
    • Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-Gal/UDP-GalNAc 4-epimerase deficient mutant
    • Kingsley DM, Kozarsky KF, Hobbie L, Krieger M. Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-Gal/UDP-GalNAc 4-epimerase deficient mutant. Cell 1986;44:749-59.
    • (1986) Cell , vol.44 , pp. 749-759
    • Kingsley, D.M.1    Kozarsky, K.F.2    Hobbie, L.3    Krieger, M.4
  • 30
    • 18544381567 scopus 로고    scopus 로고
    • The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells
    • Higashi N, Fujioka K, Denda-Nagai K, et al. The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells. J Biol Chem 2002;277:20686-93.
    • (2002) J Biol Chem , vol.277 , pp. 20686-20693
    • Higashi, N.1    Fujioka, K.2    Denda-Nagai, K.3
  • 32
    • 28044464696 scopus 로고    scopus 로고
    • Genes to vaccines for immunotherapy: How the molecular biology revolution has influenced cancer immunology
    • Laheru DA, Pardoll DM, Jaffee EM. Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology. Mol Cancer Ther 2005;4:1645-52.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1645-1652
    • Laheru, D.A.1    Pardoll, D.M.2    Jaffee, E.M.3
  • 33
  • 34
    • 30044438884 scopus 로고    scopus 로고
    • Processing and presentation of tumor antigens and vaccination strategies
    • van der Bruggen P, Van den Eynde BJ. Processing and presentation of tumor antigens and vaccination strategies. Curr Opin Immunol 2006;18:98-104.
    • (2006) Curr Opin Immunol , vol.18 , pp. 98-104
    • van der Bruggen, P.1    Van den Eynde, B.J.2
  • 35
    • 22544457164 scopus 로고    scopus 로고
    • Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity
    • Carlos CA, Dong HF, Howard OMZ, Oppenheim JJ, Hanish FG, Finn OJ. Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity. J Immunol 2005;175:1628-35.
    • (2005) J Immunol , vol.175 , pp. 1628-1635
    • Carlos, C.A.1    Dong, H.F.2    Howard, O.M.Z.3    Oppenheim, J.J.4    Hanish, F.G.5    Finn, O.J.6
  • 36
    • 0035988217 scopus 로고    scopus 로고
    • Human macrophage lectin specific for galactose/N-acetylgalactosamine is a marker for cells at an intermediate stage in their differentiation from monocytes into macrophages
    • Higashi N, Morikawa A, Fujioka K, et al. Human macrophage lectin specific for galactose/N-acetylgalactosamine is a marker for cells at an intermediate stage in their differentiation from monocytes into macrophages. Int Immunol 2002;14:545-54.
    • (2002) Int Immunol , vol.14 , pp. 545-554
    • Higashi, N.1    Morikawa, A.2    Fujioka, K.3
  • 37
    • 0036628808 scopus 로고    scopus 로고
    • Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of glycosylated antigens
    • Denda-Nagai K, Kubota N, Tsuiji M, Kamata M, Irimura T. Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of glycosylated antigens. Glycobiology 2002;12:443-50.
    • (2002) Glycobiology , vol.12 , pp. 443-450
    • Denda-Nagai, K.1    Kubota, N.2    Tsuiji, M.3    Kamata, M.4    Irimura, T.5
  • 38
    • 25144506380 scopus 로고    scopus 로고
    • Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells
    • van Vliet SJ, van Liempt E, Saeland E, et al. Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells. Int Immunol 2005;17:661-9.
    • (2005) Int Immunol , vol.17 , pp. 661-669
    • van Vliet, S.J.1    van Liempt, E.2    Saeland, E.3
  • 39
    • 33846918192 scopus 로고    scopus 로고
    • Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation
    • van Liempt E, van Vliet SJ, Engering A, et al. Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation. Mol Immunol 2007;44:2605-15.
    • (2007) Mol Immunol , vol.44 , pp. 2605-2615
    • van Liempt, E.1    van Vliet, S.J.2    Engering, A.3
  • 40
    • 0035865261 scopus 로고    scopus 로고
    • Anti-tumor immunity provided by a synthetic multiple antigenic glycopeptide displaying a tri-Tn glycotope
    • Lo-Man R, Vichier-Guerre S, Bay S, Deriaud E, Cantacuzene D, Leclerc C. Anti-tumor immunity provided by a synthetic multiple antigenic glycopeptide displaying a tri-Tn glycotope. J Immunol 2001;166:2849-54.
    • (2001) J Immunol , vol.166 , pp. 2849-2854
    • Lo-Man, R.1    Vichier-Guerre, S.2    Bay, S.3    Deriaud, E.4    Cantacuzene, D.5    Leclerc, C.6
  • 41
    • 34248578810 scopus 로고    scopus 로고
    • The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma
    • Saeland E, van Vliet SJ, Backstrom M, et al. The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma. Cancer Immunol Immunother 2007;56:1225-36.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1225-1236
    • Saeland, E.1    van Vliet, S.J.2    Backstrom, M.3
  • 42
    • 0034292388 scopus 로고    scopus 로고
    • The mechanism of unresponsiveness to circulating tumor antigen MUC1 is a block in intracellular sorting and processing by dendritic cells
    • Hiltbold EM, Vlad AM, Ciborowski P, Watkins SC, Finn OJ. The mechanism of unresponsiveness to circulating tumor antigen MUC1 is a block in intracellular sorting and processing by dendritic cells. J Immunol 2000;165:3730-41.
    • (2000) J Immunol , vol.165 , pp. 3730-3741
    • Hiltbold, E.M.1    Vlad, A.M.2    Ciborowski, P.3    Watkins, S.C.4    Finn, O.J.5
  • 43
    • 0348013088 scopus 로고    scopus 로고
    • O-Linked glycans control glycoprotein processing by antigen-presenting cells: A biochemical approach to the molecular aspects of MUC1 processing by dendritic cells
    • Hanisch FG, Schwientek T, Von Bergwelt-Baildon MS, Schultze JL, Finn O. O-Linked glycans control glycoprotein processing by antigen-presenting cells: a biochemical approach to the molecular aspects of MUC1 processing by dendritic cells. Eur J Immunol 2003;33:3242-54.
    • (2003) Eur J Immunol , vol.33 , pp. 3242-3254
    • Hanisch, F.G.1    Schwientek, T.2    Von Bergwelt-Baildon, M.S.3    Schultze, J.L.4    Finn, O.5
  • 44
    • 0033563771 scopus 로고    scopus 로고
    • Presentation of MUC1 tumor antigen by class I HLA and CTL function correlate with the glycosylation state of the protein taken up by dendritic cells
    • Hiltbold EM, Alter MD, Ciborowski P, Finn OJ. Presentation of MUC1 tumor antigen by class I HLA and CTL function correlate with the glycosylation state of the protein taken up by dendritic cells. Cell Immunol 1999;194:143-9.
    • (1999) Cell Immunol , vol.194 , pp. 143-149
    • Hiltbold, E.M.1    Alter, M.D.2    Ciborowski, P.3    Finn, O.J.4
  • 45
    • 14744303722 scopus 로고    scopus 로고
    • The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans
    • Dzhambazov B, Holmdahl M, Yamada H, et al. The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans. Eur J Immunol 2005;35:357-66.
    • (2005) Eur J Immunol , vol.35 , pp. 357-366
    • Dzhambazov, B.1    Holmdahl, M.2    Yamada, H.3
  • 46
    • 0029024049 scopus 로고
    • A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2
    • Dudler T, Machado DC, Kolbe L, et al. A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2. J Immunol 1995;155:2605-13.
    • (1995) J Immunol , vol.155 , pp. 2605-2613
    • Dudler, T.1    Machado, D.C.2    Kolbe, L.3
  • 47
    • 1542283702 scopus 로고    scopus 로고
    • Designer glycopeptides for cytotoxic T cell-based elimination of carcinomas
    • Xu Y, Gendler SJ, Franco A. Designer glycopeptides for cytotoxic T cell-based elimination of carcinomas. J Exp Med 2004;199:707-16.
    • (2004) J Exp Med , vol.199 , pp. 707-716
    • Xu, Y.1    Gendler, S.J.2    Franco, A.3
  • 48
    • 0028318850 scopus 로고
    • Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes
    • Haurum JS, Arsequell G, Lellouch AC, et al. Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes. J Exp Med 1994;180:739-44.
    • (1994) J Exp Med , vol.180 , pp. 739-744
    • Haurum, J.S.1    Arsequell, G.2    Lellouch, A.C.3
  • 49
    • 33644821094 scopus 로고    scopus 로고
    • O-Glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma
    • Stepensky D, Tzehoval E, Vadai E, Eisenbach L. O-Glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma. Clin Exp Immunol 2006;143:139-49.
    • (2006) Clin Exp Immunol , vol.143 , pp. 139-149
    • Stepensky, D.1    Tzehoval, E.2    Vadai, E.3    Eisenbach, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.