-
1
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
DOI 10.1038/ng0497-356
-
Steck, P.A., Pershouse, M.A., Jasser, S.A., Yung, W.K., Lin, H., Ligon, A.H., Langford, L.A., Baumgard, M.L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D.H. and Tavtigian, S.V. (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15: 356-362. (Pubitemid 27147102)
-
(1997)
Nature Genetics
, vol.15
, Issue.4
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.A.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
Frye, C.11
Hu, R.12
Swedlund, B.13
Teng, D.H.F.14
Tavtigian, S.V.15
-
2
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S.I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S.H., Giovanella, B.C., Ittmann, M., Tycko, B. and Hibshoosh, H., Wigler, M.H. and Parsons, R. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
3
-
-
67649604754
-
Mutational analysis in the MMAC1 gene associated in patients with juvenile polyposis syndrome and cowden disease
-
Nassiri, I., Tavasoli, M. and Faghihi, M. (2008) Mutational analysis in the MMAC1 gene associated in patients with juvenile polyposis syndrome and cowden disease. AAJC 7: 25-30.
-
(2008)
AAJC
, vol.7
, pp. 25-30
-
-
Nassiri, I.1
Tavasoli, M.2
Faghihi, M.3
-
4
-
-
0031203265
-
Germline mutations in PTEN are present in Bannayan-Zonana Syndrome
-
Marsh, D.J., Dahia, P.L., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R.J. and Eng, C. (1997) Germline mutations in PTEN are present in Bannayan-Zonana Syndrome. Nat. Genet. 16: 333-334.
-
(1997)
Nat. Genet.
, vol.16
, pp. 333-334
-
-
Marsh, D.J.1
Dahia, P.L.2
Zheng, Z.3
Liaw, D.4
Parsons, R.5
Gorlin, R.J.6
Eng, C.7
-
5
-
-
4344698040
-
PTENless means more
-
DOI 10.1016/j.ydbio.2004.06.008, PII S0012160604004233
-
Stiles, B., Groszer, M., Wang, S. and Jiao, J. and Wu, H. (2004) PTENless means more. Dev. Biol. 273: 175-184. (Pubitemid 39144393)
-
(2004)
Developmental Biology
, vol.273
, Issue.2
, pp. 175-184
-
-
Stiles, B.1
Groszer, M.2
Wang, S.3
Jiao, J.4
Wu, H.5
-
6
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
-
DOI 10.1016/S0092-8674(00)81663-3
-
Lee, J.O., Yang, .H, Georgescu, M.M., Di Cristodfano, A., Maehama, T., Shi, Y., Dixon, JE., Pandolfi, P. and Pavletich, NP. (1999) Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99: 323-334. (Pubitemid 29519911)
-
(1999)
Cell
, vol.99
, Issue.3
, pp. 323-334
-
-
Lee, J.-O.1
Yang, H.2
Georgescu, M.-M.3
Cristofano, A.D.4
Maehama, T.5
Shi, Y.6
Dixon, J.E.7
Pandolfi, P.8
Pavletich, N.P.9
-
7
-
-
1242284600
-
Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
-
DOI 10.1126/science.1092089
-
Raftopoulou, M., Etienne-Manneville, S., Self, A., Nicholls, S. and Hall, A. (2004) Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303: 1179-1181. (Pubitemid 38233580)
-
(2004)
Science
, vol.303
, Issue.5661
, pp. 1179-1181
-
-
Raftopoulou, M.1
Etienne-Manneville, S.2
Self, A.3
Nicholls, S.4
Hall, A.5
-
8
-
-
0037179847
-
Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
-
DOI 10.1038/sj.onc.1205923
-
Pene, F., Claessens, Y.E., Muller, O., Viguie, F., Mayeux, P., Dreyfus, F., Lacombe, C. and Bouscary, D. (2002) Role of the phosphatidylinositol 3- kinase/Akt and mTOR/P70S6 kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene 21: 6587-6597. (Pubitemid 35177037)
-
(2002)
Oncogene
, vol.21
, Issue.43
, pp. 6587-6597
-
-
Pene, F.1
Claessens, Y.-E.2
Muller, O.3
Viguie, F.4
Mayeux, P.5
Dreyfus, F.6
Lacombe, C.7
Bouscary, D.8
-
9
-
-
3242781701
-
Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer
-
DOI 10.1111/j.1440-1827.2004.01576.x
-
Chung, M., Jung, S.H., Lee, B.J., Kang, M.J. and Lee, D.G. (2004) Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis , of breast cancer. Pathol. Int. 54:10-15. (Pubitemid 38979576)
-
(2004)
Pathology International
, vol.54
, Issue.1
, pp. 10-15
-
-
Chung, M.J.1
Jung, S.H.2
Lee, B.J.3
Kang, M.J.4
Lee, D.G.5
-
10
-
-
0033621797
-
Transcriptional activation of p21(WAF1) by PTEN/MMAC1 tumor suppressor
-
Wu, R.C., Li, X. and Schonthal, A.H. (2000) Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumour suppressor. Mol. Cell Biochem. 203: 59-71. (Pubitemid 30111777)
-
(2000)
Molecular and Cellular Biochemistry
, vol.203
, Issue.1-2
, pp. 59-71
-
-
Wu, R.-C.1
Li, X.2
Schonthal, A.H.3
-
11
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
DOI 10.1016/S1097-2765(01)00323-9
-
Stambolic, V., MacPherson, D., Sas, D., Lin, Y., Snow, B., Jang Y., Benchimol, S. and Mak, T.W. (2001) Regulation of PTEN transcription by p53. Mol. Cell 8: 317-325. (Pubitemid 32831549)
-
(2001)
Molecular Cell
, vol.8
, Issue.2
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
Benchimol, S.7
Mak, T.W.8
-
12
-
-
0028825698
-
TOR mutations confer rapamycin resistance by preventing interaction with FKBP12 rapamycin
-
Lorenz, M.C. and Heitman, J. (1995) TOR mutations confer rapamycin resistance by preventing interaction with FKBP12 rapamycin. J. Biol. Chem. 270: 27531-27537.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27531-27537
-
-
Lorenz, M.C.1
Heitman, J.2
-
13
-
-
0032849890
-
Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase
-
DOI 10.1016/S0014-5793(99)01094-7, PII S0014579399010947
-
Heesom, K.J. and Denton, R.M. (1999) Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase. FEBS Lett. 457: 489-493. (Pubitemid 29414749)
-
(1999)
FEBS Letters
, vol.457
, Issue.3
, pp. 489-493
-
-
Heesom, K.J.1
Denton, R.M.2
-
14
-
-
34347220473
-
Defining the Role of mTOR in Cancer
-
DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
-
Guertin, D. and Sabatini, D.M. (2007) Defining the role of mTOR in cancer. Cancer Cell 12: 9-22. (Pubitemid 47001784)
-
(2007)
Cancer Cell
, vol.12
, Issue.1
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
15
-
-
0016713286
-
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Sehgal, S.N., Baker, H. and Vezina, C. (1975) Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J. Antibiot. (Tokyo) 28: 727-732.
-
(1975)
J. Antibiot. (Tokyo)
, vol.28
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vezina, C.3
-
16
-
-
0004136246
-
-
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
-
Sambrook, J., Fritsh, E.F. and Maniatis, T. (2001) Molecular Cloning: A Laboratory Manual. 2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
-
(2001)
Molecular Cloning: a Laboratory Manual. 2nd Ed.
-
-
Sambrook, J.1
Fritsh, E.F.2
Maniatis, T.3
-
17
-
-
0024284028
-
A simple salting-out procedure for extracting DNA from human nucleated cells
-
Miller, S.A., Dykes, D.D. and Polesky, H.F. (1988) A simple salting-out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16: 12-15.
-
(1988)
Nucleic Acids Res.
, vol.16
, pp. 12-15
-
-
Miller, S.A.1
Dykes, D.D.2
Polesky, H.F.3
-
18
-
-
0033579163
-
Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphate activity
-
Ali, I.U., Schriml, L.M. and Dean, M. (1999) Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphate activity. J. Natl. Cancer Inst. 91: 1922-1932.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 1922-1932
-
-
Ali, I.U.1
Schriml, L.M.2
Dean, M.3
-
19
-
-
0025968683
-
Analysis of the VNTR locus DIS80 by the PCR followed by high-resolution PAGE
-
Budowle, B., Chakraborty, R., Giusti, A.M., Eisenberg, A.J. and Allen, R.C. (1991) Analysis of the VNTR locus D1S80 by PCR followed by high resolution PAGE. Am. J. Hum. Genet. 48: 137-144. (Pubitemid 21903036)
-
(1991)
American Journal of Human Genetics
, vol.48
, Issue.1
, pp. 137-144
-
-
Budowle, B.1
Chakraborty, R.2
Giusti, A.M.3
Eisenberg, A.J.4
Allen, R.C.5
-
20
-
-
34250771165
-
Single-strand conformation polymorphism analysis using capillary array electrophoresis for large-scale mutation detection
-
DOI 10.1038/nprot.2007.200, PII NPROT.2007.200
-
Larsen, L.A., Jespersqaard, C. and Andersen, P.S. (2007) Single-strand conformation polymorphism analysis using capillary array electrophoresis for large scale mutation detection. Nat. Protoc. 2: 1458-1466. (Pubitemid 46957312)
-
(2007)
Nature Protocols
, vol.2
, Issue.6
, pp. 1458-1466
-
-
Larsen, L.A.1
Jespersgaard, C.2
Andersen, P.S.3
-
21
-
-
34250782433
-
Heteroduplex analysis by capillary array electrophoresis for rapid mutation detection in large multiexon genes
-
DOI 10.1038/nprot.2006.482, PII NPROT.2006.482
-
Velasco, E., Infante, M., Duran, M., Perez- Cabornero, L., Sanz, D.J., Esteban-Cardenosa, E. and Miner, C. (2007) Heteroduplex analysis by capillary array electrophoresis for rapid mutation detection in large multiexon genes. Nat. Protoc. 2: 237-246. (Pubitemid 47040089)
-
(2007)
Nature Protocols
, vol.2
, Issue.1
, pp. 237-246
-
-
Velasco, E.1
Infante, M.2
Duran, M.3
Perez-Cabornero, L.4
Sanz, D.J.5
Esteban-Cardenosa, E.6
Miner, C.7
-
22
-
-
0034131260
-
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay
-
Han, S.Y., Kato, H., Kato, S., Suzuki, T., Shibata, H., Ishii, S., Shiiba, K., Matsuno, S., Kanamaru, R. and Ishioka, C. (2000) Functional Evaluation of PTEN Missense Mutations Using in vitro Phosphoinositide Phosphatase Assay. Cancer Res. 60: 3147-3151. (Pubitemid 30407908)
-
(2000)
Cancer Research
, vol.60
, Issue.12
, pp. 3147-3151
-
-
Han, S.-Y.1
Kato, H.2
Kato, S.3
Suzuki, T.4
Shibata, H.5
Ishii, S.6
Shiiba, K.-I.7
Matsuno, S.8
Kanamaru, R.9
Ishioka, C.10
-
23
-
-
33745888913
-
PTEN function in normal and neoplastic growth
-
DOI 10.1016/j.canlet.2005.11.042, PII S0304383505010219
-
Chow, L.M. and Baker, S.J. (2006) PTEN function in normal and neoplastic growth. Cancer Lett. 241:184-196. (Pubitemid 44163047)
-
(2006)
Cancer Letters
, vol.241
, Issue.2
, pp. 184-196
-
-
Chow, L.M.L.1
Baker, S.J.2
-
24
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. and Weinberg, R.A. (2000). The hallmarks of cancer. Cell 100: 57-70. (Pubitemid 30046295)
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
25
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata, Y., Lan, K.H., Zhou, X., Tan, M., Esteva, F.j., Sahin, A.A., Klos, K.S., Li, P., Monia, B.P., Nguyen, N.T., Hortobagyi, G.N., Hung, M.C. and Yu, D. (2004) PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6: 117-126.
-
(2004)
Cancer Cell
, vol.6
, pp. 117-126
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
Tan, M.4
Esteva, F.J.5
Sahin, A.A.6
Klos, K.S.7
Li, P.8
Monia, B.P.9
Nguyen, N.T.10
Hortobagyi, G.N.11
Hung, M.C.12
Yu, D.13
-
26
-
-
0033621042
-
The tumor-suppressor activity of PTEN is regulated by its carboxyl- Terminal region
-
DOI 10.1073/pnas.96.18.10182
-
Georgescu, M.M., Kirsch, K.H., Akagi, T., Shishido, T. and Hanafusa, H. (1999) The tumor-suppressor activity of PTEN is regulated by its carboxyl terminal region. Proc. Natl. Acad. Sci. USA. 96: 10182-10187. (Pubitemid 29422533)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.18
, pp. 10182-10187
-
-
Georgescu, M.-M.1
Kirsch, K.H.2
Akagi, T.3
Shishido, T.4
Hanafusa, H.5
-
27
-
-
0033950079
-
The importance of being proline: The interaction of proline-rich motifs in signaling proteins with their cognate domains
-
Kay, B.K., Williamson, M.P. and Sudol, M. (2000) The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J. 14: 231-241. (Pubitemid 30086060)
-
(2000)
FASEB Journal
, vol.14
, Issue.2
, pp. 231-241
-
-
Kay, B.K.1
Williamson, M.P.2
Sudol, M.3
-
28
-
-
27944490866
-
Tumor suppressor genetics Carcinogenesis
-
Shannon, R. and Christopher, J. (2005) Tumor suppressor genetics Carcinogenesis. Carcinogenesis 26: 2031-2045.
-
(2005)
Carcinogenesis
, vol.26
, pp. 2031-2045
-
-
Shannon, R.1
Christopher, J.2
-
29
-
-
37549020704
-
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
-
Saal, L.H., Gruvberger-Saal, S.K., Persson, C., Lövgren, K., Jumppanen, M., Staaf, J., Jönsson, G., Pires, M.M., Maurer, M., Holm, K., Koujak, S., Subramaniyam, S., Vallon-Christersson, J., Olsson, H., Su, T., Memeo, L., Ludwig, T., Ethier, S.P., Krogh, M., Szabolcs, M., Murtv, V.V., Isola, J., Hibshoosh, H., Parsons, R. and Borg, A. (2007) Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat. Genet 40: 102-107.
-
(2007)
Nat. Genet
, vol.40
, pp. 102-107
-
-
Saal, L.H.1
Gruvberger-Saal, S.K.2
Persson, C.3
Lövgren, K.4
Jumppanen, M.5
Staaf, J.6
Jönsson, G.7
Pires, M.M.8
Maurer, M.9
Holm, K.10
Koujak, S.11
Subramaniyam, S.12
Vallon-Christersson, J.13
Olsson, H.14
Su, T.15
Memeo, L.16
Ludwig, T.17
Ethier, S.P.18
Krogh, M.19
Szabolcs, M.20
Murtv, V.V.21
Isola, J.22
Hibshoosh, H.23
Parsons, R.24
Borg, A.25
more..
-
30
-
-
33846004477
-
PTEN enters the nuclear age
-
Baker, S.J. (2007) PTEN enters the nuclear age. Cell 128: 25-28.
-
(2007)
Cell
, vol.128
, pp. 25-28
-
-
Baker, S.J.1
-
31
-
-
0032428151
-
Modeling stochastic gene expression: Implications for haploinsufficiency
-
DOI 10.1073/pnas.95.26.15641
-
Cook, D.L., Gerber, A.N. and Tapscott, S.J. (1998) Modeling stochastic gene expression: Implications for haploinsufficiency. Proc. Natl. Acad. Sci. USA 95: 15641-15646. (Pubitemid 29018753)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.26
, pp. 15641-15646
-
-
Cook, D.L.1
Gerber, A.N.2
Tapscott, S.J.3
-
32
-
-
33748063941
-
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance
-
DOI 10.1016/j.advenzreg.2006.01.004, PII S0065257106000033, Proceedings of teh 46th International Sumposium on Regulation of the Enzym Activity ans Synthesis in Normal and Neoplastic Tissues
-
McCubrey, J.A., Steelman, L.S., Abrams, S.L., Lee, J.T., Chang, F., Bertrand, F.E., Navolanic, P.M., Terrian, D.M., Franklin, R.A., D'Assoro, A.B., Salisbury, J.L., Mazzarino, M.C., Stivala, F. and Libra, M. (2006) Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv. Enzyme Regul. 46: 249-279. (Pubitemid 44301348)
-
(2006)
Advances in Enzyme Regulation
, vol.46
, Issue.1
, pp. 249-279
-
-
McCubrey, J.A.1
Steelman, L.S.2
Abrams, S.L.3
Lee, J.T.4
Chang, F.5
Bertrand, F.E.6
Navolanic, P.M.7
Terrian, D.M.8
Franklin, R.A.9
D'Assoro, A.B.10
Salisbury, J.L.11
Mazzarino, M.C.12
Stivala, F.13
Libra, M.14
-
33
-
-
0036279974
-
Reduced expression of PTEN correlates with breast cancer progression
-
DOI 10.1053/hupa.2002.124721
-
Bose, S., Crane, A., Hibshoosh, H., Mansukhani, M., Sandweis, L. and Parsons, R. (2002) Reduced expression of PTEN correlates with breast cancer progression. Hum. Pathol. 33: 405-409. (Pubitemid 34627590)
-
(2002)
Human Pathology
, vol.33
, Issue.4
, pp. 405-409
-
-
Bose, S.1
Crane, A.2
Hibshoosh, H.3
Mansukhani, M.4
Sandweis, L.5
Parsons, R.6
-
34
-
-
4143138570
-
Promoter methylation of the PTEN gene is a common molecular change in breast cancer
-
DOI 10.1002/gcc.20062
-
García, J.M., Silva, J., Peña, C., Garcia, V., Rodríguez, R., Cruz, M.A., Cantos, B., Provencio, M., España, P. and Bonilla, F. (2004) Promoter methylation of the PTEN gene is a common molecular change in breast cancer. Genes Chromosomes Cancer. 41:117-124. (Pubitemid 39096737)
-
(2004)
Genes Chromosomes and Cancer
, vol.41
, Issue.2
, pp. 117-124
-
-
Garcia, J.M.1
Silva, J.2
Pena, C.3
Garcia, V.4
Rodriguez, R.5
Cruz, M.A.6
Cantos, B.7
Provencio, M.8
Espana, P.9
Bonilla, F.10
-
35
-
-
0032843540
-
Impaired Fas response and autoimmunity in Pten(+/-) mice
-
DOI 10.1126/science.285.5436.2122
-
Di Cristofano, A., Kotsi, P., Peng, Y.F., Cordon- Cardo, C., Elkon, K.B. and Pandolfi, PP. (1999) Impaired Fas response and autoimmunity in Pten+/- mice. Science 285: 2122-2125. (Pubitemid 29451429)
-
(1999)
Science
, vol.285
, Issue.5436
, pp. 2122-2125
-
-
Di Cristofano, A.1
Kotsi, P.2
Peng, Y.F.3
Cordon-Cardo, C.4
Elkon, K.B.5
Pandolfi, P.P.6
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