Molecular mechanism of adaphostin-mediated G1 arrest in prostate cancer (PC-3) cells: Signaling events mediated by hepatocyte growth factor receptor, c-Met, and p38 MAPK pathways

Journal of Biological Chemistry

Volumn 281, Issue 49, 2006, Pages 37330-37344

  Mukhopadhyay, Indranil ^a   Sausville, Edward A ^b   Doroshow, James H ^a   Roy, Krishnendu K ^a,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; ENZYMES; ESTERS; GROWTH KINETICS; MOLECULAR DYNAMICS; TUMORS;

ADAPHOSTIN; HEPATOCYTE GROWTH FACTOR; LEUKEMIA MODELS; TYRPHOSTIN;

CELLS;

ADAPHOSTIN; CYCLIN A; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEOPHOSMIN; RETINOBLASTOMA PROTEIN; SCATTER FACTOR RECEPTOR;

ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAMANTANE; BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; G1 PHASE; HUMANS; HYDROQUINONES; MALE; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MET; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 33846012546     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605569200     Document Type: Article

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