Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 11, 2007, Pages 4594-4599

  Miething, Cornelius ^a,c   Grundler, Rebekka ^a   Mugler, Claudia ^a   Brero, Simone ^a   Hoepfl, Josef ^a   Geigl, Jochen ^a,d   Speicher, Michael R ^a,d   Ottmann, Oliver ^b   Peschel, Christian ^a   Duyster, Justus ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; FLUOROURACIL; IMATINIB; PHOSPHOTRANSFERASE INHIBITOR; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX3; ANTINEOPLASTIC AGENT; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW TRANSPLANTATION; CANCER PATIENT; CANCER RISK; CANCER STEM CELL; CELL CLONE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG DOSE INCREASE; FEMALE; GENE; GENE INDUCTION; GENE INSERTION; GENE LOCATION; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LEUKEMIA RELAPSE; MALE; MOUSE; MUTAGENESIS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; PROVIRUS; RETROVIRUS; RUNX GENE; RUNX1 GENE; RUNX3 GENE; SOUTHERN BLOTTING; TREATMENT OUTCOME; TREATMENT RESPONSE; ANIMAL; CELL LINE; DRUG RESISTANCE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC PROCEDURES; GENETICS; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA; MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CORE BINDING FACTOR ALPHA 3 SUBUNIT; DRUG RESISTANCE, NEOPLASM; GENETIC TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, CHRONIC; MALE; MICE; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; PIPERAZINES; PYRIMIDINES; RETROVIRIDAE;

EID: 34248328788     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0604716104     Document Type: Article

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