Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice

Nature Genetics

Volumn 32, Issue 1, 2002, Pages 160-165

  Lund, Anders H ^a   Turner, Geoffrey ^b   Trubetskoy, Alla ^b   Verhoeven, Els ^a   Wientjens, Ellen ^a   Hulsman, Danielle ^a   Russell, Robert ^b   DePinho, Ronald A ^c   Lenz, Jack ^b   van Lohuizen, Maarten ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE INSERTION; GENOME; HUMAN; LYMPHOMA; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROVIRUS; TUMOR SUPPRESSOR GENE; UNINDEXED SEQUENCE; VIRUS CARCINOGENESIS;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHROMOSOME MAPPING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENOME; HUMANS; LYMPHOMA; MICE; MOLECULAR SEQUENCE DATA; MOLONEY MURINE LEUKEMIA VIRUS; MUTAGENESIS, INSERTIONAL; NEOPLASMS; PROVIRUSES;

ANIMALIA; INSERTION SEQUENCES; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; MURINE LEUKEMIA VIRUS; ONCOVIRINAE; RODENTIA; UNIDENTIFIED RETROVIRUS;

EID: 0036725322     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng956     Document Type: Article

References (29)

1. The Cdkn2a network in tumour suppression
2. The p16INK4a/CDKN 2A tumor suppressor and its relatives
3. Role of the INK4a locus in tumor suppression and cell mortality
4. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
5. Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1
6. p14ARF links the tumour suppressors RB and p53
7. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
8. JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression
9. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
10. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers
11. Shtutma-dependent growth arrest and cooperates with Ras in transformation
12. Senescence of human fibroblasts induced by oncogenic Raf
13. p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation
14. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
15. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
16. Retroviral insertional mutagenesis as a strategy to identify cancer genes
17. Transforming G proteins
18. Selected glimpses into the activation and function of Src kinase
19. A novel dual specificity phosphatase induced by serum stimulation and heat shock
20. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
21. NF-KB and cell-cycle regulation: The cyclin connection
22. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
23. Causal relationship between the loss of RUNX 3 expression and gastric cancer
24. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
25. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via Cdkn2a
26. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase
27. New genes involved in cancer identified by retroviral tagging
28. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
29. The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse