메뉴 건너뛰기




Volumn 54, Issue 3, 2009, Pages 283-294

Morphological and ultrastructural effects of microcystin-LR from Microcystis aeruginosa extract on a kidney cell line

Author keywords

Cytotoxicity; Fluorescence microscopy; Microcystin LR; TEM; Vero cells

Indexed keywords

MICROCYSTIN LR;

EID: 67649414226     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.04.014     Document Type: Article
Times cited : (66)

References (75)
  • 1
    • 0042929500 scopus 로고    scopus 로고
    • Microcystin-LR causes the collapse of actin filaments in primary human hepatocytes
    • Batista T., De Sousa G., Suput J.S., Rahmani R., and Šuput D. Microcystin-LR causes the collapse of actin filaments in primary human hepatocytes. Aquat. Toxicol. 65 (2003) 85-91
    • (2003) Aquat. Toxicol. , vol.65 , pp. 85-91
    • Batista, T.1    De Sousa, G.2    Suput, J.S.3    Rahmani, R.4    Šuput, D.5
  • 2
    • 0035881870 scopus 로고    scopus 로고
    • Autophagy delays sulindac sílfide-induced apoptosis in the human intestinal colon cancer cell line HT-29
    • Bauvy C., Gane P., Arico S., Codogno P., and Ogier-Denis E. Autophagy delays sulindac sílfide-induced apoptosis in the human intestinal colon cancer cell line HT-29. Exp. Cell Res. 268 (2001) 139-149
    • (2001) Exp. Cell Res. , vol.268 , pp. 139-149
    • Bauvy, C.1    Gane, P.2    Arico, S.3    Codogno, P.4    Ogier-Denis, E.5
  • 3
    • 0023755530 scopus 로고
    • Isolated rat liver perfusion studies with cyclic heptapeptide toxins of Microcystins and Oscillatoria (freshwater cyanobacteria)
    • Berg K., Wyman J., Carmichael W., and Dabholkar A. Isolated rat liver perfusion studies with cyclic heptapeptide toxins of Microcystins and Oscillatoria (freshwater cyanobacteria). Toxicon 26 (1988) 827-837
    • (1988) Toxicon , vol.26 , pp. 827-837
    • Berg, K.1    Wyman, J.2    Carmichael, W.3    Dabholkar, A.4
  • 4
    • 42649101990 scopus 로고    scopus 로고
    • Toxic response indicators of microcystin-LR in F344 rats following a single dose treatment
    • Billam M., Mukhi S., Tang L., Weimin G., and Wang J.-S. Toxic response indicators of microcystin-LR in F344 rats following a single dose treatment. Toxicon 51 (2008) 1068-1080
    • (2008) Toxicon , vol.51 , pp. 1068-1080
    • Billam, M.1    Mukhi, S.2    Tang, L.3    Weimin, G.4    Wang, J.-S.5
  • 5
    • 0034764730 scopus 로고    scopus 로고
    • The toxicology of microcystin-LR: occurrence, toxicokinetics, toxicodynamics, diagnosis and treatment
    • Bischoff K. The toxicology of microcystin-LR: occurrence, toxicokinetics, toxicodynamics, diagnosis and treatment. Vet. Hum. Toxicol. 43 (2001) 294-297
    • (2001) Vet. Hum. Toxicol. , vol.43 , pp. 294-297
    • Bischoff, K.1
  • 6
    • 29244445465 scopus 로고    scopus 로고
    • Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures cell lines: a comparative study
    • Boaru D.A., Dragoş N., and Schrimer K. Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures cell lines: a comparative study. Toxicology 218 (2006) 134-148
    • (2006) Toxicology , vol.218 , pp. 134-148
    • Boaru, D.A.1    Dragoş, N.2    Schrimer, K.3
  • 7
    • 0021990499 scopus 로고
    • Toxicity determined in vitro by morphological alterations and neutral red absorption
    • Borenfreund E., and Puerner J. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 24 (1985) 119-124
    • (1985) Toxicol. Lett. , vol.24 , pp. 119-124
    • Borenfreund, E.1    Puerner, J.2
  • 8
    • 1242314785 scopus 로고    scopus 로고
    • The role of microcystin-LR induction of apoptosis and oxidative stress in CaCo2 cells
    • Botha N., Gehringer M.M., Downing T.G., Venter M., and Shepard E.G. The role of microcystin-LR induction of apoptosis and oxidative stress in CaCo2 cells. Toxicon 43 (2004) 185-192
    • (2004) Toxicon , vol.43 , pp. 185-192
    • Botha, N.1    Gehringer, M.M.2    Downing, T.G.3    Venter, M.4    Shepard, E.G.5
  • 9
    • 1342328049 scopus 로고    scopus 로고
    • Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured hepatocytes
    • Bouaïcha N., and Maatouk I. Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured hepatocytes. Toxicol. Lett. 148 (2004) 53-63
    • (2004) Toxicol. Lett. , vol.148 , pp. 53-63
    • Bouaïcha, N.1    Maatouk, I.2
  • 11
    • 0034012322 scopus 로고    scopus 로고
    • Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
    • Bursch W., Hochegger K., Török L., Marian B., Ellinger A., and Hermann R.S. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J. Cell. Sci. 113 (2000) 1189-1198
    • (2000) J. Cell. Sci. , vol.113 , pp. 1189-1198
    • Bursch, W.1    Hochegger, K.2    Török, L.3    Marian, B.4    Ellinger, A.5    Hermann, R.S.6
  • 12
    • 0002766875 scopus 로고
    • The toxins of cyanobacteria
    • Carmichael W.W. The toxins of cyanobacteria. Nat. Toxins 270 (1994) 64-72
    • (1994) Nat. Toxins , vol.270 , pp. 64-72
    • Carmichael, W.W.1
  • 16
    • 0023105617 scopus 로고
    • Ultrastructural changes in the mouse liver induced by hepatotoxin from the freshwater cyanobacterium Microcystis aeruginosa strain 7820
    • Dabholkar A.S., and Carmichael W.W. Ultrastructural changes in the mouse liver induced by hepatotoxin from the freshwater cyanobacterium Microcystis aeruginosa strain 7820. Toxicon 25 (1987) 285-292
    • (1987) Toxicon , vol.25 , pp. 285-292
    • Dabholkar, A.S.1    Carmichael, W.W.2
  • 17
    • 67649396850 scopus 로고
    • Evidence for the regulation of exocytic transport by protein phosphorylation
    • Davidson H.W., McGowan C.H., and Balch W.E. Evidence for the regulation of exocytic transport by protein phosphorylation. Trends Cell Biol. 2 (1992) 156-168
    • (1992) Trends Cell Biol. , vol.2 , pp. 156-168
    • Davidson, H.W.1    McGowan, C.H.2    Balch, W.E.3
  • 18
    • 61449170919 scopus 로고    scopus 로고
    • Comparative study of the cytotoxic effect of microcystin-LR and purified extracts from M. aeruginosa on a kidney cell line
    • 10.1016/j.toxicon.2009.01.029
    • Dias E., Andrade M., Alverca E., Pereira P., Batoréu M.C.C., Jordan P., and Silva M.J. Comparative study of the cytotoxic effect of microcystin-LR and purified extracts from M. aeruginosa on a kidney cell line. Toxicon (2009) 10.1016/j.toxicon.2009.01.029
    • (2009) Toxicon
    • Dias, E.1    Andrade, M.2    Alverca, E.3    Pereira, P.4    Batoréu, M.C.C.5    Jordan, P.6    Silva, M.J.7
  • 20
    • 0037436437 scopus 로고    scopus 로고
    • Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity
    • Ding W.-X., and Ong C.-N. Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity. FEMS Microbiol. Lett. 220 (2003) 1-7
    • (2003) FEMS Microbiol. Lett. , vol.220 , pp. 1-7
    • Ding, W.-X.1    Ong, C.-N.2
  • 21
    • 0034801483 scopus 로고    scopus 로고
    • 2+ in microcystin-induced mitochondrial permeability transition in rat hepatocytes
    • 2+ in microcystin-induced mitochondrial permeability transition in rat hepatocytes. Biochem. Biophys. Res. Commun. 285 (2001) 1155-1161
    • (2001) Biochem. Biophys. Res. Commun. , vol.285 , pp. 1155-1161
    • Ding, W.-X.1    Shen, H.-M.2    Ong, C.-N.3
  • 22
    • 0033844686 scopus 로고    scopus 로고
    • Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induces rapid apoptosis in rat hepatocytes
    • Ding W.-X., Shen H.-M., and Ong C.-N. Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induces rapid apoptosis in rat hepatocytes. Hepatology 32 (2000) 547-555
    • (2000) Hepatology , vol.32 , pp. 547-555
    • Ding, W.-X.1    Shen, H.-M.2    Ong, C.-N.3
  • 23
    • 0033846898 scopus 로고    scopus 로고
    • Microcystic cyanobacteria extract induces cytoskeleton disruption and intracellular glutathione alteration in hepatocytes
    • Ding W.-X., Shen H.-M., and Ong C.-N. Microcystic cyanobacteria extract induces cytoskeleton disruption and intracellular glutathione alteration in hepatocytes. Environ. Health Perspect. 108 (2000) 605-609
    • (2000) Environ. Health Perspect. , vol.108 , pp. 605-609
    • Ding, W.-X.1    Shen, H.-M.2    Ong, C.-N.3
  • 25
    • 0033658402 scopus 로고    scopus 로고
    • Toxicology and risk assessment of freshwater cyanobacterial (blue-green algal) toxins in water
    • Duy T.N., Lam P.K.S., Shaw G.R., and Connell D.W. Toxicology and risk assessment of freshwater cyanobacterial (blue-green algal) toxins in water. Rev. Environ. Contam. Toxicol. 163 (2000) 113-186
    • (2000) Rev. Environ. Contam. Toxicol. , vol.163 , pp. 113-186
    • Duy, T.N.1    Lam, P.K.S.2    Shaw, G.R.3    Connell, D.W.4
  • 30
    • 0348010476 scopus 로고    scopus 로고
    • Microcystin-LR affects cytoskeleton and morphology of rabbit primary whole embryo cultured cells in vitro
    • Frangež R., Žužek M.C., Mrkun J., Šuput D., Sedmak B., and Kosec M. Microcystin-LR affects cytoskeleton and morphology of rabbit primary whole embryo cultured cells in vitro. Toxicon 41 (2003) 999-1005
    • (2003) Toxicon , vol.41 , pp. 999-1005
    • Frangež, R.1    Žužek, M.C.2    Mrkun, J.3    Šuput, D.4    Sedmak, B.5    Kosec, M.6
  • 31
    • 22044451505 scopus 로고    scopus 로고
    • Altered expression of p 53, Bcl-2 and Bax induced by microcystin-LR in vivo and in vitro
    • Fu W.Y., Chen J.P., Wang X.M., and Xu L.H. Altered expression of p 53, Bcl-2 and Bax induced by microcystin-LR in vivo and in vitro. Toxicon 46 (2005) 171-177
    • (2005) Toxicon , vol.46 , pp. 171-177
    • Fu, W.Y.1    Chen, J.P.2    Wang, X.M.3    Xu, L.H.4
  • 32
    • 40749135901 scopus 로고    scopus 로고
    • In vivo DNA damage induced by the cyanotoxin microcystin-LR: comparison of intra-peritoneal and oral administration by use of the comet assay
    • Gaudin J., Huet S., Jarry G., and Fessard V. In vivo DNA damage induced by the cyanotoxin microcystin-LR: comparison of intra-peritoneal and oral administration by use of the comet assay. Mutat. Res. 652 (2008) 65-71
    • (2008) Mutat. Res. , vol.652 , pp. 65-71
    • Gaudin, J.1    Huet, S.2    Jarry, G.3    Fessard, V.4
  • 33
    • 0032830150 scopus 로고    scopus 로고
    • Hepatic oxidative stress following prolonged sublethal microcystin-LR exposure
    • Guzman R.E., and Solter P.H. Hepatic oxidative stress following prolonged sublethal microcystin-LR exposure. Toxicol. Pathol. 27 (1999) 582-588
    • (1999) Toxicol. Pathol. , vol.27 , pp. 582-588
    • Guzman, R.E.1    Solter, P.H.2
  • 34
    • 0037427972 scopus 로고    scopus 로고
    • The superfamily of organic anion transporting polypeptides
    • Hagenbuch B., and Meier P.J. The superfamily of organic anion transporting polypeptides. Biochim. Biophys. Acta 1609 (2003) 1-18
    • (2003) Biochim. Biophys. Acta , vol.1609 , pp. 1-18
    • Hagenbuch, B.1    Meier, P.J.2
  • 35
    • 20544435937 scopus 로고    scopus 로고
    • Golgi structure in stress sensing and apoptosis
    • Hicks S.W., and Machamer C.E. Golgi structure in stress sensing and apoptosis. Biochim. Biophys. Acta 1744 (2005) 406-414
    • (2005) Biochim. Biophys. Acta , vol.1744 , pp. 406-414
    • Hicks, S.W.1    Machamer, C.E.2
  • 37
    • 0033794092 scopus 로고    scopus 로고
    • Fulminant hepatocyte apoptosis in vivo following microcystin-LR administration to rats
    • Hooser S.B. Fulminant hepatocyte apoptosis in vivo following microcystin-LR administration to rats. Toxicol. Pathol. 278 (2000) 726-733
    • (2000) Toxicol. Pathol. , vol.278 , pp. 726-733
    • Hooser, S.B.1
  • 38
    • 0034644853 scopus 로고    scopus 로고
    • Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon
    • Humpage A.R., Hardy S.J., Moore E.J., Froscio S.M., and Falconer I.R. Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon. J. Toxicol. Environ. Health A 61 (2000) 155-165
    • (2000) J. Toxicol. Environ. Health A , vol.61 , pp. 155-165
    • Humpage, A.R.1    Hardy, S.J.2    Moore, E.J.3    Froscio, S.M.4    Falconer, I.R.5
  • 39
    • 38949155634 scopus 로고    scopus 로고
    • Available at:
    • IARC. Cyanobacterial Peptide Toxins (2006). http://monographs.iarc.fr/ENG/Meetings/94-cyanobacteria.pdf Available at:
    • (2006) Cyanobacterial Peptide Toxins
    • IARC1
  • 40
    • 0031081357 scopus 로고    scopus 로고
    • Hepatic necrosis in aged mice by oral administration of microcystin-LR
    • Ito E., Kondo F., and Harada K.-I. Hepatic necrosis in aged mice by oral administration of microcystin-LR. Toxicon 35 (1997) 231-239
    • (1997) Toxicon , vol.35 , pp. 231-239
    • Ito, E.1    Kondo, F.2    Harada, K.-I.3
  • 41
    • 0029799689 scopus 로고    scopus 로고
    • Microcystin-LR and kinetics of cytoskeletal reorganization in hepatocytes, kidney cells and fibroblasts
    • Khan S.A., Wickstrom M.L., Haschek W.M., Schaeffer D.J., Ghosh S., and Beasley V.R. Microcystin-LR and kinetics of cytoskeletal reorganization in hepatocytes, kidney cells and fibroblasts. Nat. Toxins 4 (1996) 206-214
    • (1996) Nat. Toxins , vol.4 , pp. 206-214
    • Khan, S.A.1    Wickstrom, M.L.2    Haschek, W.M.3    Schaeffer, D.J.4    Ghosh, S.5    Beasley, V.R.6
  • 42
    • 0029009363 scopus 로고
    • Comparative pathology of microcystin-LR in cultured hepatocytes, fibroblasts and renal epithelial cells
    • Khan S.A., Ghosh S., Wickstrom M., Miller L.A., Hess R., Haschek W.M., and Beasley V.R. Comparative pathology of microcystin-LR in cultured hepatocytes, fibroblasts and renal epithelial cells. Nat. Toxins 3 (1995) 119-128
    • (1995) Nat. Toxins , vol.3 , pp. 119-128
    • Khan, S.A.1    Ghosh, S.2    Wickstrom, M.3    Miller, L.A.4    Hess, R.5    Haschek, W.M.6    Beasley, V.R.7
  • 45
    • 0037532605 scopus 로고    scopus 로고
    • Effect on microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle, and apoptosis in CHO-K1 cells
    • Lankoff A., Banasik A., Obe G., Deperas M., Kuzminski K., Tarczynska M., Jurczak T., and Wojcik A. Effect on microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle, and apoptosis in CHO-K1 cells. Toxicol. Appl. Pharmacol. 189 (2003) 204-213
    • (2003) Toxicol. Appl. Pharmacol. , vol.189 , pp. 204-213
    • Lankoff, A.1    Banasik, A.2    Obe, G.3    Deperas, M.4    Kuzminski, K.5    Tarczynska, M.6    Jurczak, T.7    Wojcik, A.8
  • 46
    • 0032895860 scopus 로고    scopus 로고
    • Osmotically induced cell volume changes alter anterograde and retrograde transport, Golgi structure, and COPI dissociation
    • Lee T.H., and Linstedt A.D. Osmotically induced cell volume changes alter anterograde and retrograde transport, Golgi structure, and COPI dissociation. Mol. Biol. Cell 10 (1999) 1445-1462
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1445-1462
    • Lee, T.H.1    Linstedt, A.D.2
  • 47
    • 34247568857 scopus 로고    scopus 로고
    • Biochemical and ultrastructural changes of the liver and kidney of the phytoplanktivorous silver carp feeding naturally on toxic Microcystis blooms in Taihu Lake, China
    • Li L., Xie P., and Chen J. Biochemical and ultrastructural changes of the liver and kidney of the phytoplanktivorous silver carp feeding naturally on toxic Microcystis blooms in Taihu Lake, China. Toxicon 49 (2007) 1042-1053
    • (2007) Toxicon , vol.49 , pp. 1042-1053
    • Li, L.1    Xie, P.2    Chen, J.3
  • 48
    • 24344481760 scopus 로고    scopus 로고
    • In vivo studies on toxin accumulation in liver and ultrastructural changes in hepatocytes of the phytoplanktivorous bighead carp i.p. injected with extracted microcystins
    • Li L., Xie P., and Chen J. In vivo studies on toxin accumulation in liver and ultrastructural changes in hepatocytes of the phytoplanktivorous bighead carp i.p. injected with extracted microcystins. Toxicon 46 (2005) 533-545
    • (2005) Toxicon , vol.46 , pp. 533-545
    • Li, L.1    Xie, P.2    Chen, J.3
  • 49
    • 0035198955 scopus 로고    scopus 로고
    • Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR
    • Li X.Y., Liu Y.D., and Song L.R. Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR. Environ. Toxicol. 16 (2001) 517-522
    • (2001) Environ. Toxicol. , vol.16 , pp. 517-522
    • Li, X.Y.1    Liu, Y.D.2    Song, L.R.3
  • 51
    • 0042266400 scopus 로고    scopus 로고
    • Death from within: apoptosis and the secretory pathway
    • Maag R.S., Hicks S.W., and Machamer C.E. Death from within: apoptosis and the secretory pathway. Curr. Opin. Cell Biol. 15 (2003) 456-461
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 456-461
    • Maag, R.S.1    Hicks, S.W.2    Machamer, C.E.3
  • 54
    • 0032400774 scopus 로고    scopus 로고
    • The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types
    • McDermott C.M., Nho C.W., Howard W., and Holton B. The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types. Toxicon 36 (1998) 1981-1996
    • (1998) Toxicon , vol.36 , pp. 1981-1996
    • McDermott, C.M.1    Nho, C.W.2    Howard, W.3    Holton, B.4
  • 55
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for growth and survival - application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for growth and survival - application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 56
  • 57
    • 0026751750 scopus 로고
    • Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR
    • Nishiwaki-Matsushima R., Otha T., and Nishiwaki S. Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J. Cancer Res. Clin. Oncol. 118 (1992) 420-424
    • (1992) J. Cancer Res. Clin. Oncol. , vol.118 , pp. 420-424
    • Nishiwaki-Matsushima, R.1    Otha, T.2    Nishiwaki, S.3
  • 61
    • 67249104059 scopus 로고    scopus 로고
    • Pallet, N., Bouvier, N., Beaunen, P., Legendre, C., Thrervet, E., Anglicheau, D. Le stress du réticulum endoplasmique au cours des néphropathies: une question de vie et de mort? Nephrol. Ther., doi:10.1016/j.nephro.2008.10.007
    • Pallet, N., Bouvier, N., Beaunen, P., Legendre, C., Thrervet, E., Anglicheau, D. Le stress du réticulum endoplasmique au cours des néphropathies: une question de vie et de mort? Nephrol. Ther., doi:10.1016/j.nephro.2008.10.007
  • 62
    • 0002569886 scopus 로고
    • Dye exclusion tests for cell viability
    • Kruse P.F., and Patterson M.K. (Eds), Academic Press, NY
    • Philips H.J. Dye exclusion tests for cell viability. In: Kruse P.F., and Patterson M.K. (Eds). Tissue Culture: Methods and Applications (1973), Academic Press, NY 406-408
    • (1973) Tissue Culture: Methods and Applications , pp. 406-408
    • Philips, H.J.1
  • 63
    • 27644577702 scopus 로고    scopus 로고
    • The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR
    • Pichardo S., Jos A., Zurita J.L., Salguero M., Camean A.M., and Repetto. The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR. Toxicol. In Vitro 19 (2005) 865-873
    • (2005) Toxicol. In Vitro , vol.19 , pp. 865-873
    • Pichardo, S.1    Jos, A.2    Zurita, J.L.3    Salguero, M.4    Camean, A.M.5    Repetto6
  • 64
    • 0035355341 scopus 로고    scopus 로고
    • 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action
    • 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J. 20 (2001) 2690-2701
    • (2001) EMBO J. , vol.20 , pp. 2690-2701
    • Pinton, P.1    Ferrari, D.2    Rapizzi, E.3    Di Virgilio, F.D.4    Pozzan, T.5    Rizzuto, R.6
  • 65
    • 0034705666 scopus 로고    scopus 로고
    • Isolation and preparative purification of microcystin variants
    • Ramanan S., Tang J., and Velayudhan A. Isolation and preparative purification of microcystin variants. J. Chromatogr. A. 883 (2000) 103-112
    • (2000) J. Chromatogr. A. , vol.883 , pp. 103-112
    • Ramanan, S.1    Tang, J.2    Velayudhan, A.3
  • 67
    • 59349111783 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and autophagy as targets for cancer therapy
    • Schönthal A.H. Endoplasmic reticulum stress and autophagy as targets for cancer therapy. Cancer Lett. 275 (1999) 163-169
    • (1999) Cancer Lett. , vol.275 , pp. 163-169
    • Schönthal, A.H.1
  • 70
    • 0032838940 scopus 로고    scopus 로고
    • Toxins affecting cell signaling and alteration of cytoskeletal structure
    • Toivola D.M., and Eriksson J.E. Toxins affecting cell signaling and alteration of cytoskeletal structure. Toxicol. In Vitro 13 (1999) 521-530
    • (1999) Toxicol. In Vitro , vol.13 , pp. 521-530
    • Toivola, D.M.1    Eriksson, J.E.2
  • 71
    • 0030006616 scopus 로고    scopus 로고
    • Detection of microcystins, a blue-green algal hepatotoxins, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay
    • Ueno Y., Nagata S., Tsutsumi T., Hasegawa A., Watanabe M.F., Park H.D., Chen G.C., Chen G., and Yu S.Z. Detection of microcystins, a blue-green algal hepatotoxins, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis 17 (1996) 1317-1321
    • (1996) Carcinogenesis , vol.17 , pp. 1317-1321
    • Ueno, Y.1    Nagata, S.2    Tsutsumi, T.3    Hasegawa, A.4    Watanabe, M.F.5    Park, H.D.6    Chen, G.C.7    Chen, G.8    Yu, S.Z.9
  • 72
    • 67649408258 scopus 로고    scopus 로고
    • Multiplex PCR for detection of microcystins-producing cyanobacteria from freshwater samples
    • in press
    • Valério, E., Chambel, L., Paulino, S., Faria, N., Pereira, P., Tenreiro, R., 2009. Multiplex PCR for detection of microcystins-producing cyanobacteria from freshwater samples. Environ. Toxicol., in press.
    • (2009) Environ. Toxicol
    • Valério, E.1    Chambel, L.2    Paulino, S.3    Faria, N.4    Pereira, P.5    Tenreiro, R.6
  • 73
    • 33847147603 scopus 로고    scopus 로고
    • The role of ROS in microcystin-LR-induced hepatocytes apoptosis and liver injury in mice
    • Weng D., Lu Y., Wei Y., Liu Y., and Shen P. The role of ROS in microcystin-LR-induced hepatocytes apoptosis and liver injury in mice. Toxicology 232 (2007) 15-23
    • (2007) Toxicology , vol.232 , pp. 15-23
    • Weng, D.1    Lu, Y.2    Wei, Y.3    Liu, Y.4    Shen, P.5
  • 75
    • 49349091541 scopus 로고    scopus 로고
    • In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit
    • Zhao Y., Xie P., Tang R., Zhang X., Li L., and Li D. In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 148 (2008) 204-210
    • (2008) Comp. Biochem. Physiol. C Toxicol. Pharmacol. , vol.148 , pp. 204-210
    • Zhao, Y.1    Xie, P.2    Tang, R.3    Zhang, X.4    Li, L.5    Li, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.