Freshwater cyanobacterium Microcystis aeruginosa (UTEX 2385) induced DNA damage in vivo and in vitro

Environmental Toxicology and Pharmacology

Volumn 5, Issue 1, 1998, Pages 1-6

  Lakshmana Rao, P V ^a   Bhattacharya, R ^a   Parida, M M ^a   Jana, A M ^a   Bhaskar, A S B ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Cyanobacterium; DNA damage; DNA fragmentation; Genotoxicity; Microcystis aeruginosa

Indexed keywords

FRESH WATER;

ANABAENA; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; CYANOBACTERIUM; CYTOTOXICITY; DNA DAMAGE; GENOTOXICITY; HEALTH HAZARD; IN VITRO STUDY; LIVER TOXICITY; NONHUMAN; NOSTOC; PRIORITY JOURNAL;

EID: 0031934796     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(97)00022-7     Document Type: Article

References (23)

1. Bhattacharya R., Rao P.V.L., Bhaskar A.S.B., Pant S.C., Dube S.N. Liver slice culture for assessing hepatotoxicity of freshwater cyanobacteria. Hum. Exp. Toxicol. 15:1996;105.
2. Boe R., Gjertsen B.T., Vintemyr O.L., Houge G., Lanotle M., Doskeland S.O. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell Res. 195:1991;237.
3. Brunk C.F.K., Jones K.C., James T.W. Assay of nannogram quantities of DNA in cellular homogenates. Anal. Biochem. 92:1979;497.
4. Carmichael W.W. Cyanobacterial secondary metabolites- cyanotoxins. J. Appl. Bacteriol. 72:1992;445.
5. Carmichael W.W. The toxins of cyanobacteria. Sci. Am. 270:1994;78.
6. Carmichael, W.W., Falconer, I.R., 1993. Diseases related to freshwater algal blooms. In: Falconer, I.R. (Ed.), Algal Toxins in Seafood and Drinking Water. Academic Press, London, 187 pp.
7. Codd G.A., Bell S.G., Brooks P. Cyanobacterial toxins in water. Water Sci. Technol. 21:1989;1.
8. Eriksson J.E., Paatero G.L., Meriluto J.A.O., Codd G.A., Kass G.E.N., Nicotera P., Orrenius S. Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin. Exp. Cell Res. 185:1989;86.
9. Falconer I.R. Tumor promotion and injury caused by oral consumption of cyanobacteria. Environ. Toxicol. Water Qual. 6:1991;177.
10. Falconer I.R., Runnegar M.T.C. Effect of peptide toxin from M. aeruginosa on intracellular calcium, pH and membrane integrity in mammalian cells. Chem.-Biol. Interact. 63:1987;215.
11. Jackson A.R.B., McInnes A., Falconer I.R., Runnegar M.T.C. Clinical and pathological changes in sheep experimentally poisoned by the blue-green alga Microcystis aeruginosa. Vet. Pathol. 21:1984;102.
12. Khan S.A., Ghosh S., Wickstrom M., Miller L.U., Hess R., Haschek W.M., Beasley V.R. Comparative pathology of microcystin-LR in cultured hepatocytes, fibroblasts, and renal epithelial cells. Nat. Toxins. 3:1995;119.
13. Mackintosh C., Beattie K.A., Klumpp S., Cohen F., Codd G.A. Cyanobacterial toxin microcystin-LR is a potent and specific inhibitor of protein phosphatase 1 and 2A. FEBS Lett. 264:1990;187.
14. Melnick, J.L., Wenner, H.A., Phillips, C.A., 1979. In: Lennette, E.H., Schmidt, M.J. (Eds.), Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections, 5th ed. American Public Health Association, Washington.
15. Nishiwaki-Matsushima R., Ohta T., Nishiwaki S., Suganuma M., Kohyama K., Ishikawa T., Carmichael W.W., Fujiki H. Liver cancer promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J. Cancer Res. Clin. Oncol. 118:1992;420.
16. Prigent P., Blanpied C., Aten J., Hirsch F. A safe and rapid method for analyzing apoptosis-induced fragmentation of DNA extracted from tissues or cultured cells. J. Immunol. Methods. 160:1993;139.
17. Rao P.V.L., Bhattacharya R., Das Gupta S. Isolation, culture and toxicity of cyanobacterium (blue-green alga) Microcystis aeruginosa from freshwater source in India. Bull. Environ. Contam. Toxicol. 52:1994;878.
18. Rao P.V.L., Bhattacharya R., Pant S.C., Bhaskar A.S.B. Toxicity evaluation of freshwater cyanobacterium M. aeruginosa: 1. Hepatotoxic and histopathological effects in rats. Biomed. Environ. Sci. 8:1995;254.
19. Reitman S., Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 28:1957;56.
20. Repavich W.M., Standridge W.C., Wedephol W.E., Meisner L.F. Cyanobacteria (blue-green algae) in Wisconsin waters: Acute and chronic toxicity. Water Res. 24:1990;225.
21. Wickstrom M.L., Khan S.A., Haschek W.M., Wyman J.F., Eriksson J.E., Scheffer D.J., Beasley V.R. Alterations in microtubules, intermediate filaments and microfilaments induced by microcystin-LR in cultured cells. Toxicol. Pathol. 23:1995;326.
22. Wyllie A.H. Glucocorticoid-induced thymocyte apoptois is associated with endogeneous endonuclease activation. Nature. 284:1980;555.
23. Yu, S.Z., 1989. Drinking water and primary liver cancer. In: Tang, Z.Y., Wu, M.C., Xia, S.S. (Eds.), Primary Liver Cancer. Springer, Berlin, 30 pp.