메뉴 건너뛰기




Volumn 49, Issue 7, 2007, Pages 1042-1053

Biochemical and ultrastructural changes of the liver and kidney of the phytoplanktivorous silver carp feeding naturally on toxic Microcystis blooms in Taihu Lake, China

Author keywords

Biochemical and ultrastructural changes; Kidney; Large fish pen; LC MS; Liver; Microcystin; Microcystis; Phytoplanktivorous silver carp

Indexed keywords

CATALASE; CYANOGINOSIN; GLUTATHIONE TRANSFERASE;

EID: 34247568857     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2007.01.013     Document Type: Article
Times cited : (50)

References (51)
  • 1
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H. Catalase in vitro. Methods Enzymol. 105 (1984) 121-126
    • (1984) Methods Enzymol. , vol.105 , pp. 121-126
    • Aebi, H.1
  • 2
    • 0023130150 scopus 로고
    • Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions
    • Bayer W.F., and Fridovich J.L. Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. Anal. Biochem. 161 (1987) 559-566
    • (1987) Anal. Biochem. , vol.161 , pp. 559-566
    • Bayer, W.F.1    Fridovich, J.L.2
  • 4
    • 0037202005 scopus 로고    scopus 로고
    • Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio)
    • Best J.H., Pflugmacher S., Wiegand C., Eddy F.B., Metcalf J.S., and Codd G.A. Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio). Aquat. Toxicol. 60 (2002) 223-231
    • (2002) Aquat. Toxicol. , vol.60 , pp. 223-231
    • Best, J.H.1    Pflugmacher, S.2    Wiegand, C.3    Eddy, F.B.4    Metcalf, J.S.5    Codd, G.A.6
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein using the principle of protein dye-binding
    • Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein using the principle of protein dye-binding. Anal. Biochem. 72 (1976) 248-254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 6
    • 0002828891 scopus 로고    scopus 로고
    • Cytological alterations in fish hepatocytes following in vivo and in vitro sublethal exposure to xenobiotics-structural biomarkers of environmental contamination
    • Braunbeck T., Hinton D.E., and Streit B. (Eds), Birkhäuser, Basel
    • Braunbeck T. Cytological alterations in fish hepatocytes following in vivo and in vitro sublethal exposure to xenobiotics-structural biomarkers of environmental contamination. In: Braunbeck T., Hinton D.E., and Streit B. (Eds). Fish Ecotoxicology (1998), Birkhäuser, Basel 61-140
    • (1998) Fish Ecotoxicology , pp. 61-140
    • Braunbeck, T.1
  • 7
    • 0002304119 scopus 로고    scopus 로고
    • The histopathology of carp, Cyprinus carpio L., exposed to microcystins by gavage, immersion and intraperitoneal administration
    • Carbis C.R., Rawlin G.T., Mitchell G.F., Anderson J.W., and McCauley I. The histopathology of carp, Cyprinus carpio L., exposed to microcystins by gavage, immersion and intraperitoneal administration. J. Fish. Dis. 19 (1996) 199-207
    • (1996) J. Fish. Dis. , vol.19 , pp. 199-207
    • Carbis, C.R.1    Rawlin, G.T.2    Mitchell, G.F.3    Anderson, J.W.4    McCauley, I.5
  • 8
    • 0003080927 scopus 로고    scopus 로고
    • Toxic microcystis and the environment
    • Watanabe M.F., Harada K.-I., Carmichael W.W., and Fujiki H. (Eds), CRC Press, Boca Raton, FL
    • Carmichael W.W. Toxic microcystis and the environment. In: Watanabe M.F., Harada K.-I., Carmichael W.W., and Fujiki H. (Eds). Toxic Microcystis (1996), CRC Press, Boca Raton, FL 1-11
    • (1996) Toxic Microcystis , pp. 1-11
    • Carmichael, W.W.1
  • 9
    • 15044358224 scopus 로고    scopus 로고
    • Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in two freshwater shrimps, Palaemon modestus and Macrobrachium nipponensis, from a large shallow, eutrophic lake of the subtropical China
    • Chen J., and Xie P. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in two freshwater shrimps, Palaemon modestus and Macrobrachium nipponensis, from a large shallow, eutrophic lake of the subtropical China. Toxicon 45 (2005) 615-625
    • (2005) Toxicon , vol.45 , pp. 615-625
    • Chen, J.1    Xie, P.2
  • 10
    • 0029416317 scopus 로고
    • Cyanobacterial toxins: occurrence, properties and biological significance
    • Codd G.A. Cyanobacterial toxins: occurrence, properties and biological significance. Water Sci. Technol. 32 (1995) 149-156
    • (1995) Water Sci. Technol. , vol.32 , pp. 149-156
    • Codd, G.A.1
  • 11
    • 0032124844 scopus 로고    scopus 로고
    • The toxicology of microcystin
    • Dawson R.M. The toxicology of microcystin. Toxicon 36 (1998) 953-962
    • (1998) Toxicon , vol.36 , pp. 953-962
    • Dawson, R.M.1
  • 12
    • 0037436437 scopus 로고    scopus 로고
    • Role of oxidative stress and mitochondrial changes in cyanobactera-induced apoptosis and hepatotoxicity
    • Ding W.X., and Ong C.N. Role of oxidative stress and mitochondrial changes in cyanobactera-induced apoptosis and hepatotoxicity. FEMS Microbiol. Lett. 220 (2003) 1-7
    • (2003) FEMS Microbiol. Lett. , vol.220 , pp. 1-7
    • Ding, W.X.1    Ong, C.N.2
  • 13
    • 0031749543 scopus 로고    scopus 로고
    • Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes
    • Ding W.X., Shen H.M., Zhu H.G., and Ong C.N. Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes. Environ. Res. 78 (1998) 12-18
    • (1998) Environ. Res. , vol.78 , pp. 12-18
    • Ding, W.X.1    Shen, H.M.2    Zhu, H.G.3    Ong, C.N.4
  • 14
    • 0033846898 scopus 로고    scopus 로고
    • Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes
    • Ding W.X., Shen H.M., and Ong C.N. Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes. Environ. Health Perspect. 108 (2000) 605-609
    • (2000) Environ. Health Perspect. , vol.108 , pp. 605-609
    • Ding, W.X.1    Shen, H.M.2    Ong, C.N.3
  • 15
    • 0035941161 scopus 로고    scopus 로고
    • Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes
    • Ding W.X., Shen H.M., and Ong C.N. Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes. J. Toxicol. Environ. Health A 64 (2001) 507-519
    • (2001) J. Toxicol. Environ. Health A , vol.64 , pp. 507-519
    • Ding, W.X.1    Shen, H.M.2    Ong, C.N.3
  • 16
    • 0001896020 scopus 로고
    • Evidence for glutathione peroxidase activities in cultured plant cells
    • Drotar A., Phelps P., and Fall R. Evidence for glutathione peroxidase activities in cultured plant cells. Plant. Sci. 42 (1985) 35-40
    • (1985) Plant. Sci. , vol.42 , pp. 35-40
    • Drotar, A.1    Phelps, P.2    Fall, R.3
  • 17
    • 0030322756 scopus 로고    scopus 로고
    • Fish antioxidant defenses. A comparative approach
    • Filho W. Fish antioxidant defenses. A comparative approach. Braz. J. Med. Bio. Res. 29 (1996) 1735-1742
    • (1996) Braz. J. Med. Bio. Res. , vol.29 , pp. 1735-1742
    • Filho, W.1
  • 18
    • 0034176293 scopus 로고    scopus 로고
    • Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio)
    • Fischer W.J., and Dietrich D.R. Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio). Toxicol. Appl. Pharmacol. 164 (2000) 73-81
    • (2000) Toxicol. Appl. Pharmacol. , vol.164 , pp. 73-81
    • Fischer, W.J.1    Dietrich, D.R.2
  • 19
    • 1642559254 scopus 로고    scopus 로고
    • Microcystin-LR and okadaic acid induced cellular effects: a dualistic response
    • Gehringer M. Microcystin-LR and okadaic acid induced cellular effects: a dualistic response. FEBS Lett. 557 (2003) 1-8
    • (2003) FEBS Lett. , vol.557 , pp. 1-8
    • Gehringer, M.1
  • 20
    • 0019167355 scopus 로고
    • Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
    • Griffith O. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106 (1980) 207-212
    • (1980) Anal. Biochem. , vol.106 , pp. 207-212
    • Griffith, O.1
  • 21
    • 0037723070 scopus 로고    scopus 로고
    • Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice
    • Gupta N., Pant S.C., Vijayaraghavan R., and Lakshmana Rao P.V. Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 188 (2003) 285-296
    • (2003) Toxicology , vol.188 , pp. 285-296
    • Gupta, N.1    Pant, S.C.2    Vijayaraghavan, R.3    Lakshmana Rao, P.V.4
  • 22
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
    • (1974) J. Biol. Chem. , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 24
    • 16844374445 scopus 로고    scopus 로고
    • Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions
    • Jos A., Pichardo S., Prieto A.I., Repetto G., Vázquez C.M., Moreno I., and Cameán A.M. Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions. Aquat. Toxicol. 72 (2005) 261-271
    • (2005) Aquat. Toxicol. , vol.72 , pp. 261-271
    • Jos, A.1    Pichardo, S.2    Prieto, A.I.3    Repetto, G.4    Vázquez, C.M.5    Moreno, I.6    Cameán, A.M.7
  • 26
    • 0029945765 scopus 로고    scopus 로고
    • Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout (Oncorhynchus mykiss)
    • Kotak B.J., Semalulu S., Friytz D.L., Prepas E.E., Hrudey S.E., and Coppock R.W. Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout (Oncorhynchus mykiss). Toxicon 34 (1996) 517-525
    • (1996) Toxicon , vol.34 , pp. 517-525
    • Kotak, B.J.1    Semalulu, S.2    Friytz, D.L.3    Prepas, E.E.4    Hrudey, S.E.5    Coppock, R.W.6
  • 27
    • 0141543868 scopus 로고    scopus 로고
    • Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR
    • Li X.Y., Liu Y.D., Song L.R., and Liu J. Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR. Toxicon 42 (2003) 85-89
    • (2003) Toxicon , vol.42 , pp. 85-89
    • Li, X.Y.1    Liu, Y.D.2    Song, L.R.3    Liu, J.4
  • 28
    • 8644230019 scopus 로고    scopus 로고
    • Subchronic oral toxicity of microcystin in common carp (Cyprinus carpio L.) exposed to Microcystis under laboratory conditions
    • Li X.Y., Chung I.K., Kim J.I., and Lee J.A. Subchronic oral toxicity of microcystin in common carp (Cyprinus carpio L.) exposed to Microcystis under laboratory conditions. Toxicon 44 (2004) 821-827
    • (2004) Toxicon , vol.44 , pp. 821-827
    • Li, X.Y.1    Chung, I.K.2    Kim, J.I.3    Lee, J.A.4
  • 29
    • 23944517789 scopus 로고    scopus 로고
    • Oral exposure to Microcystis increases activity-augmented antioxidant enzymes in the liver of loach (Misgurnus mizolepis) and has no effect on lipid peroxidation
    • Li X.Y., Chun I., Kim J., and Lee J. Oral exposure to Microcystis increases activity-augmented antioxidant enzymes in the liver of loach (Misgurnus mizolepis) and has no effect on lipid peroxidation. Comp. Biochem. Physiol. C (2005) 292-296
    • (2005) Comp. Biochem. Physiol. C , pp. 292-296
    • Li, X.Y.1    Chun, I.2    Kim, J.3    Lee, J.4
  • 30
    • 34247619211 scopus 로고    scopus 로고
    • Effects of copper and its complex compound (Cu-EDTA) on the glutathione system of liver in goldfish (Carassius auratus)
    • (in Chinese)
    • Liu H., Wang X.R., Zhang J.F., and Shen H. Effects of copper and its complex compound (Cu-EDTA) on the glutathione system of liver in goldfish (Carassius auratus). J. Nanjing Univ. 40 (2004) 356-361 (in Chinese)
    • (2004) J. Nanjing Univ. , vol.40 , pp. 356-361
    • Liu, H.1    Wang, X.R.2    Zhang, J.F.3    Shen, H.4
  • 31
    • 0025333146 scopus 로고
    • Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants
    • MacKintosh C., Beattie K.A., Klumpp S., Cohen P., and Codd G.A. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 264 (1990) 187-192
    • (1990) FEBS Lett. , vol.264 , pp. 187-192
    • MacKintosh, C.1    Beattie, K.A.2    Klumpp, S.3    Cohen, P.4    Codd, G.A.5
  • 33
    • 1642265731 scopus 로고    scopus 로고
    • Effect of microcystin-LR on protein phosphatase activity in fed and fasted juvenile goldfish Carassius auratus L
    • Malbrouck C., Trausch G., Devos P., and Kestemont P. Effect of microcystin-LR on protein phosphatase activity in fed and fasted juvenile goldfish Carassius auratus L. Toxicon 43 (2004) 295-301
    • (2004) Toxicon , vol.43 , pp. 295-301
    • Malbrouck, C.1    Trausch, G.2    Devos, P.3    Kestemont, P.4
  • 34
    • 13944255112 scopus 로고    scopus 로고
    • Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally
    • Moreno I., Pichardo S., Jos A., Gomez-Amores L., Mate A., Vázquez C.M., and Cameán A. Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally. Toxicon 45 (2005) 395-402
    • (2005) Toxicon , vol.45 , pp. 395-402
    • Moreno, I.1    Pichardo, S.2    Jos, A.3    Gomez-Amores, L.4    Mate, A.5    Vázquez, C.M.6    Cameán, A.7
  • 36
    • 0027876735 scopus 로고
    • Food habits, feeding behavior and impact of triploid bighead carp, Hypophthalmichthys nobilis, in experimental ponds
    • Opuszynski K., and Shireman J.V. Food habits, feeding behavior and impact of triploid bighead carp, Hypophthalmichthys nobilis, in experimental ponds. J. Fish Biol. 42 (1995) 517-530
    • (1995) J. Fish Biol. , vol.42 , pp. 517-530
    • Opuszynski, K.1    Shireman, J.V.2
  • 37
    • 0002430075 scopus 로고    scopus 로고
    • Harmful freshwater algal blooms, with an emphasis on cyanobacteria
    • Paerl H.W., Fulton R.S., Moisander P.H., and Dyble J. Harmful freshwater algal blooms, with an emphasis on cyanobacteria. Sci. World J. 1 (2001) 76-113
    • (2001) Sci. World J. , vol.1 , pp. 76-113
    • Paerl, H.W.1    Fulton, R.S.2    Moisander, P.H.3    Dyble, J.4
  • 38
    • 0031973956 scopus 로고    scopus 로고
    • Temporal variabilities of the concentration of intra and extracellular microcystin and toxic Microcystis species in a hypertrophic lake, Lake Suwa, Japan (1991-1994)
    • Park H.D., Iwami C., Watanabe M.F., Harada K.I., Okino T., and Hayashi H. Temporal variabilities of the concentration of intra and extracellular microcystin and toxic Microcystis species in a hypertrophic lake, Lake Suwa, Japan (1991-1994). Environ. Toxicol. Water Qual. 13 (1998) 61-72
    • (1998) Environ. Toxicol. Water Qual. , vol.13 , pp. 61-72
    • Park, H.D.1    Iwami, C.2    Watanabe, M.F.3    Harada, K.I.4    Okino, T.5    Hayashi, H.6
  • 39
    • 34247577115 scopus 로고    scopus 로고
    • Peuthert, A., Wiegand, C., 2004. Glutathione involvement in the biotransformation of microcystins in Dreissena polymorpha. In: Poster Abstract, Sixth International Conference on Toxic Cyanobacteria (ICTC), 21-27 June, Bergen, Norway.
  • 40
    • 8644263817 scopus 로고    scopus 로고
    • Promotion of oxidative stress in the aquatic macrophyte Ceratophyllum demersum during biotransformation of the cyanobacterial toxin microcystin-LR
    • Pflugmacher S. Promotion of oxidative stress in the aquatic macrophyte Ceratophyllum demersum during biotransformation of the cyanobacterial toxin microcystin-LR. Aquat. Toxicol. 70 (2004) 169-178
    • (2004) Aquat. Toxicol. , vol.70 , pp. 169-178
    • Pflugmacher, S.1
  • 41
    • 0031788805 scopus 로고    scopus 로고
    • Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication
    • Pflugmacher S., Wiegand C., Oberemm A., Beattie K.A., Krause E., Codd G.A., and Steinberg C.E.W. Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication. Biochim. Biophys. Acta 1425 (1998) 527-533
    • (1998) Biochim. Biophys. Acta , vol.1425 , pp. 527-533
    • Pflugmacher, S.1    Wiegand, C.2    Oberemm, A.3    Beattie, K.A.4    Krause, E.5    Codd, G.A.6    Steinberg, C.E.W.7
  • 42
    • 27644577702 scopus 로고    scopus 로고
    • The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR
    • Pichardo S., Jos A., Zurita J.L., Salguero M., Camean A.M., and Repetto G. The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR. Toxicol. In Vitro 19 (2005) 865-873
    • (2005) Toxicol. In Vitro , vol.19 , pp. 865-873
    • Pichardo, S.1    Jos, A.2    Zurita, J.L.3    Salguero, M.4    Camean, A.M.5    Repetto, G.6
  • 45
    • 0025733722 scopus 로고
    • Histopathological effects of microcystin-LR, a cyclic peptide toxin from the cyanobacterium (blue-green alga) Microcystis aeruginosa, on common carp (Cyprinus carpio L.)
    • Råbergh C.M.I., Bylund G., and Erikssonl J.E. Histopathological effects of microcystin-LR, a cyclic peptide toxin from the cyanobacterium (blue-green alga) Microcystis aeruginosa, on common carp (Cyprinus carpio L.). Aquat. Toxicol. 20 (1991) 131-146
    • (1991) Aquat. Toxicol. , vol.20 , pp. 131-146
    • Råbergh, C.M.I.1    Bylund, G.2    Erikssonl, J.E.3
  • 46
    • 0027443273 scopus 로고
    • Hepatocellular transport of bile acids
    • Suchy F.J. Hepatocellular transport of bile acids. Semin. Liver Dis. 13 (1993) 235-247
    • (1993) Semin. Liver Dis. , vol.13 , pp. 235-247
    • Suchy, F.J.1
  • 47
    • 0030934727 scopus 로고    scopus 로고
    • Biochemical characterization of microcystin toxicity in rainbow trout (Oncorhynchus Mykiss)
    • Tencalla F., and Dietrich D. Biochemical characterization of microcystin toxicity in rainbow trout (Oncorhynchus Mykiss). Toxicon 35 (1997) 583-595
    • (1997) Toxicon , vol.35 , pp. 583-595
    • Tencalla, F.1    Dietrich, D.2
  • 48
    • 0032838940 scopus 로고    scopus 로고
    • Toxins affecting cell signaling and alteration of cytoskeletal structure
    • Toivola D.M., and Eriksson J.E. Toxins affecting cell signaling and alteration of cytoskeletal structure. Toxicol. In Vitro 13 (1999) 521-530
    • (1999) Toxicol. In Vitro , vol.13 , pp. 521-530
    • Toivola, D.M.1    Eriksson, J.E.2
  • 49
    • 0033057130 scopus 로고    scopus 로고
    • Uptake and effects of microcystin-LR on detoxification enzymes of early life stages of the Zebrafish (Danio rerio)
    • Wiegand C., Pflugmacher S., Oberemm A., Meems N., Beattie K.A., Steinberg C., and Codd G.A. Uptake and effects of microcystin-LR on detoxification enzymes of early life stages of the Zebrafish (Danio rerio). Environ. Toxicol. 14 (1999) 89-95
    • (1999) Environ. Toxicol. , vol.14 , pp. 89-95
    • Wiegand, C.1    Pflugmacher, S.2    Oberemm, A.3    Meems, N.4    Beattie, K.A.5    Steinberg, C.6    Codd, G.A.7
  • 50
    • 1542601156 scopus 로고    scopus 로고
    • Practical success of biomanipulation using filter-feeding fish to control cyanobacteria blooms: synthesis of decades of research and application in a subtropical hypereutrophic lake
    • Xie P., and Liu J.K. Practical success of biomanipulation using filter-feeding fish to control cyanobacteria blooms: synthesis of decades of research and application in a subtropical hypereutrophic lake. Sci. World J. 1 (2001) 337-356
    • (2001) Sci. World J. , vol.1 , pp. 337-356
    • Xie, P.1    Liu, J.K.2
  • 51
    • 0028818446 scopus 로고
    • Primary prevention of hepatocelluar carcinoma
    • Yu S.J. Primary prevention of hepatocelluar carcinoma. J. Gastroenterol. Hepatol. 10 (1995) 674-682
    • (1995) J. Gastroenterol. Hepatol. , vol.10 , pp. 674-682
    • Yu, S.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.