Adrenergic regulation of the rapid component of delayed rectifier K+ current: Implications for arrhythmogenesis in LQT2 patients

Heart Rhythm

Volumn 6, Issue 7, 2009, Pages 1038-1046

  Zankov, Dimitar P ^a   Yoshida, Hidetada ^b   Tsuji, Keiko ^a   Toyoda, Futoshi ^a   Ding, Wei Guang ^a   Matsuura, Hiroshi ^a   Horie, Minoru ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

1A adrenoceptor; 1 and 2 adrenoceptor; IKr; KCNH2 mutation; Long QT syndrome

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; FORSKOLIN; GREEN FLUORESCENT PROTEIN; ISOBUTYLMETHYLXANTHINE; PHENYLEPHRINE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C DELTA1; POTASSIUM CHANNEL; PROTEIN KV11.1; UNCLASSIFIED DRUG;

ADRENERGIC STIMULATION; ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; CHO CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; LONG QT SYNDROME; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADULT; ANIMALS; CELLS, CULTURED; CRICETINAE; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; HUMANS; LONG QT SYNDROME; MICROSCOPY, CONFOCAL; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, ADRENERGIC, BETA;

EID: 67549116757     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.02.045     Document Type: Article

References (29)

1. Moss A.J., and Kass R.S. Long QT syndrome: from channels to cardiac arrhythmias. J Clin Invest 115 (2005) 2018-2024
2. Schwartz P.J., Priori S.G., Spazzolini C., et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 103 (2001) 89-95
3. Wilde A.A.M., Jongbloed R.J.E., Doevendans P.A., et al. Auditory stimuli as trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1). J Am Coll Cardiol 33 (1999) 327-332
4. 1-adrenergic agonists. Cardiovasc Res 43 (1999) 901-908
5. Drouin E., Charpentier F., and Gauthier C. Alpha 1-adrenergic stimulation induces early afterdepolarizations in ferret Purkinje fibers. J Cardiovasc Pharmacol 27 (1996) 320-326
6. Moss A.J., Zareba W., Hall J., et al. Effectiveness and limitations of β-blocker therapy in congenital long-QT syndrome. Circulation 101 (2000) 616-623
7. Grubb B.P. The use of oral labetalol in the treatment of arrhythmias associated with the long QT syndrome. Chest 100 (1991) 1724-1725
8. 1A-adrenoceptors. J Mol Med 82 (2004) 826-837
9. Jiang M., Dun W., Fan J.-S., et al. Use-dependent 'agonist' effect of azimilide on the HERG channel. J Pharmacol Exp Ther 291 (1999) 1324-1336
10. Bian J., Cui J., and McDonald T.V. HERG K+ channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate. Circ Res 89 (2001) 1168-1176
11. Kr. Am J Physiol 287 (2004) H2154-H2163
12. + channel by dual pathways. Curr Biol 10 (2000) 671-664
13. Thomas D., Zhang W., Karle C.A., et al. Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A. J Biol Chem 274 (1999) 27457-27462
14. 1-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways. Cardiovasc Res 53 (2002) 355-362
15. Kr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes. J Physiol 522.3 (2000) 391-402
16. Claycomb W.C., Lanson N.A., Stallworth B.S., et al. Hl-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocytes. Proc Natl Acad Sci U S A 95 (1998) 2979-2984
17. Yang Z., Shen W., Rottman J.N., et al. Rapid stimulation causes electrical remodeling in cultured atrial myocytes. J Mol Cell Cardiol 38 (2005) 299-308
18. + channel activity in recombinant systems. Mol Biol Cell 17 (2006) 4666-4674
19. Hamill O.P., Marty A., Neher E., et al. Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflügers Arch 391 (1981) 85-100
20. Kr potassium channel. Cell 81 (1995) 299-307
21. Balla T., and Várnai P. Visualizing cellular phosphoinositide pools with GFP-fused protein-modules. Sci STKE 125 (2002) PL3
22. Ben-David J., and Zipes D.P. α-Adrenoceptor stimulation and blockade modulates cesium-induced early afterdepolarizations and ventricular tachyarrhythmias in dogs. Circulation 82 (1990) 225-233
23. Carlsson L., Abrahamsson C., Andersson B., et al. Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarizations. Cardiovasc Res 27 (1993) 2186-2193
24. Khositseth A., Nemec J., Hejlik J., et al. Effect of phenylephrine provocation on dispersion of repolarization in congenital long QT syndrome. Ann Noninvasive Electrocardiol 8 (2003) 208-214
25. Lee J.H., and Rosen M.R. Alpha 1-adrenergic receptor modulation of repolarization in canine Purkinje fibers. J Cardiovasc Electrophysiol 5 (1994) 232-240
26. Antzelevitch C., and Shimizu W. Cellular mechanisms underlying the long QT syndrome. Curr Opin Cardiol 17 (2002) 43-51
27. Noda T., Takaki H., Kurita T., et al. Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2, and LQT3 forms of congenital long QT syndrome. Eur Heart J 23 (2002) 975-983
28. Shimizu W., Noda T., Takaki H., et al. Diagnostic value of epinephrine test for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome. Heart Rhythm 3 (2004) 276-283
29. Shimizu W., and Antzelevitch C. Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 35 (2000) 778-786