Effect of phenylephrine provocation on dispersion of repolarization in congenital long QT syndrome

Annals of Noninvasive Electrocardiology

Volumn 8, Issue 3, 2003, Pages 208-214

  Khositseth, Anant ^a   Nemec, Jan ^a,b   Hejlik, Joseph ^a   Shen, Win K ^a   Ackerman, Michael J ^a  

^a MAYO CLINIC   (United States)

^b Minnesota Heart Clinic   (United States)

Author keywords

Dispersion of repolarization; Electrocardiography; Long QT syndrome; Phenylephrine

Indexed keywords

PHENYLEPHRINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT;

ADOLESCENT; ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENOTYPE; HEART REPOLARIZATION; HUMAN; LONG QT SYNDROME; MALE; PRIORITY JOURNAL; PROVOCATION TEST; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; BRADYCARDIA; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; CONGENITAL HEART MALFORMATION; ELECTROCARDIOGRAPHY; GENETIC PREDISPOSITION; GENETICS; HEART RATE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; PATHOPHYSIOLOGY; TREATMENT OUTCOME;

ADOLESCENT; ADRENERGIC ALPHA-AGONISTS; ADULT; BLOOD PRESSURE; BRADYCARDIA; ELECTROCARDIOGRAPHY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEART DEFECTS, CONGENITAL; HEART RATE; HUMANS; HYPERTENSION; INFUSIONS, INTRAVENOUS; LONG QT SYNDROME; MALE; PHENYLEPHRINE; TREATMENT OUTCOME;

EID: 1542545952     PISSN: 1082720X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1542-474X.2003.08307.x     Document Type: Article

References (27)

1. Moss AJ, Schwartz PJ, Crampton RS, et al. The long QT syndrome: A prospective international study. Circulation 1985;71:17-21.
2. Moss AJ, Schwartz PJ, Crampton RS, et al. The long QT syndrome: Prospective longitudinal study of 328 families. Circulation 1991;84:1136-1144.
3. Li H, Fuentes-Garcia J, Towbin JA. Current concepts in long QT syndrome. Pediatr Cardiol 2000;21:542-550.
4. Ackerman MJ. The long QT syndrome: Ion channel diseases of the heart. Mayo Clin Proc 1998;73:250-269.
5. Ackerman MJ, Clapham DE. Ion channels: Basic science and clinical disease. N Engl J Med 1997;336:1575-1586.
6. Vincent GM. The molecular genetics of the long QT syndrome: Genes causing fainting and sudden death. Annu Rev Med 1998;49:263-274.
7. Chiang C, Roden DM. The long QT syndromes: Genetic basis and clinical implications. J Am Coll Cardiol 2000;36:1-12.
8. Russel MW. The long QT syndromes. Prog Pediatr Cardiol 1996;6:43-51.
9. Ackerman MJ, Tester DJ, Porter CJ. Swimming, a gene-specific arrhythmogenic trigger for inherited long QT syndrome. Mayo Clin Proc 1999;74:1088-1094.
10. Zareba W, Moss AJ, Schwartz PJ, et al., for the International Long-QT Syndrome Registry Research Group. Influence of genotype on the clinical course of the long-QT syndrome. N Engl J Med 1998;339:960-965.
11. Yan GX, Shimizu W, Antzelevitch C. Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations. Circulation 1998;98:1921-1927.
12. Antzelevitch C. Tpeak-Tend interval as an index of transmural dispersion of repolarization. Eur J Clin Invest 2001;31:555-557.
13. Shimizu W, Antzelevitch C. Cellular basis for the ECG features of the LQT1 form of the long QT syndrome: Effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation 1998;21:2314-2322.
14. Shimuizu W, Antzelevitch C. Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 2000;35:778-786.
15. Napolitano C, Priori SG, Schwartz PJ. Significance of QT dispersion in the long QT syndrome. Prog Cardiovasc Dis 2000;42:345-350.
16. Vincent GM, Timothy KW, Leppert M, et al. The spectrum of symptoms and QT intervals in carriers of the gene for the long QT syndrome. N Engl J Med 1992;327:846-852.
17. Ackerman MJ, Tester DJ, Driscoll DJ. Molecular autopsy of sudden unexplained death in the young. Am J Forensic Med Pathol 2001;22:105-111.
18. Kaufman ES, Priori SG, Napolitano C, et al. Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: Experience in 101 related family members. J Cardiovasc Electrophysiol 2001;12:455-461.
19. Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long QT syndrome gene-specific triggers for life-threatening arrhythmias. Circulation 2001;103:89-95.
20. Malik M, Batchvarov VN. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol 2000;36:1749-1766.
21. Batchvarov V, Malik M. Measurement and interpretation of QT dispersion. Prog Cardiovasc Dis 2000;42:325-344.
22. Day CP, McComb JM, Campbell RW. QT dispersion: An indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990;63:342-344.
23. Viswanathan PC, Rudy Y. Cellular arrhythmogenic effects of congenital and acquired long QT syndrome in the heterogenous myocardium. Circulation 2000;101:1192-1198.
24. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long QT syndrome. Circulation 1998;98:1928-1936.
25. Tanabe Y, Inagaki M, Kurita T, et al. Sympathetic stimulation produces a greater increase in both transmural and spatial dispersion of repolarization in LQT1 than LQT2 forms of congential long QT syndrome. J Am Coll Cardiol 2001;37:911-919.
26. Sun ZH, Swan H, Vitasalo M, et al. Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome. J Am Coll Cardiol 1998;31:1400-1405.
27. Moss AJ, Zareba W, Hall WJ, et al. Effectiveness and limitations of β-blocker therapy in congenital long QT syndrome. Circulation 2000;101:616-623.