Differences in the electrophysiologic response of four canine ventricular cell types to α1-adrenergic agonists

Cardiovascular Research

Volumn 43, Issue 4, 1999, Pages 901-908

  Burashnikov, Alexander ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

Adrenergic agonists; Autonomic nervous system; Canine; Electrophysiology; Experimental; Heart; M cell; Purkinje fiber

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; CHLOROETHYLCLONIDINE; METHOXAMINE; PHENYLEPHRINE; PRAZOSIN;

ANIMAL CELL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CELL TYPE; CONTROLLED STUDY; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER;

ACTION POTENTIALS; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; CLONIDINE; DIOXANES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCARDIUM; HEART VENTRICLES; METHOXAMINE; MICROELECTRODES; PERICARDIUM; PHENYLEPHRINE; PRAZOSIN; PROPRANOLOL; PURKINJE FIBERS;

EID: 0032829180     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00124-8     Document Type: Article

References (46)

1. Burashnikov A., Antzelevitch C. Alpha-agonists produce opposite effect on action potential duration in Purkinje and M cells isolated from the canine left ventricle. PACE. 18:1995;II-935. Abstract.
2. Burashnikov A., Antzelevitch C. Differences in the response of four canine ventricular cell types to α1 adrenergic agonists. PACE. 20:1997;II-1115. Abstract.
3. Dukes I.D., VaughamWilliams E.M. Effects of selective α1-, α2-, β1- and β2-adrenoceptor stimulation on potentials and contractions in the rabbit heart. J. Physiol. (Lond.). 355:1984;523-546.
4. Kimura S., Cameron J.S., Kozlovskis P.L., Bassett A.L., Myerburg R.J. Delayed afterdepolarizations and triggered activity induced in feline Purkinje fibers by α-adrenergic stimulation in the presence of elevated calcium levels. Circulation. 70:1984;1074-1082.
5. Rosen M.R., Hordof A.J., Ilvento J.P., Danilo P. Jr. Effects of adrenergic amines on electrophysiological properties and automaticity of neonatal and adult canine Purkinje fibers. Circ. Res. 40:1977;390-400.
6. Drouin E., Charpentier F., Gauthier C. α1-adrenergic stimulation induces early afterdepolarizations in ferret Purkinje fibers. J. Cardiovasc. Pharmacol. 27:1996;320-326.
7. Ledda F., Marchetti P., Manni A. Influence of phenylephrine on transmembrane potentials and effective refractory period of single Purkinje fibers of sheep heart. Pharmacol. Res. Commun. 3:1971;195-206.
8. Hescheler J., Nawrath H., Tang M., Trautwein W. Adrenoceptor-mediated changes of excitation and contraction in ventricular heart muscle from guinea pigs and rabbits. J. Physiol. (Lond.). 397:1988;657-670.
9. Dirksen R.T., Sheu S.-S. Modulation of ventricular action potential by α1-adrenoceptors and protein kinase C. Am. J. Physiol. 258:1990;H907-H911.
10. Bruckner R., Scholz H. Effects of α-adrenoceptor stimulation with phenylephrine in the presence of propranolol on force of contraction, slow inward current and cyclic AMP content in the bovine heart. Br. J. Pharmacol. 82:1984;223-232.
11. Ertl R., Jahnel U., Nawrath H., Carmeliet E., Vereecke J. Differential electrophysiological and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats. Naunyn-Schmied Arch. Pharmacol. 344:1991;574-581.
12. Flores N.A., Sheridan D.J. Electrophysiological effects of alpha-adrenoceptor stimulation in perfused and superfused myocardium. J. Mol. Cell. Cardiol. 23:1991;973-985.
13. Jacob H., Nawrath H., Rupp J. Adrenoceptor-mediated changes of action potential and force of contraction in human isolated ventricular heart muscle. Br. J. Pharmacol. 94:1988;584-590.
14. Jahnel U., Jakob H., Nawrath H. Electrophysiologic and inotropic effects of α-adrenoceptor stimulation in human isolated atrial heart muscle. Naunyn-Schmied Arch. Pharmacol. 346:1992;82-87.
15. Lee J.H., Steinberg S.F., Rosen M.R. A WB 4101-sensitive alpha-1 adrenergic receptor subtype modulates repolarization in canine Purkinje fibers. J. Pharmacol. Exp. Ther. 258:1991;681-687.
16. Marchi S., Szabo B., Lazzara R. Adrenergic induction of delayed afterdepolarizations in ventricular myocardial cells: Beta-induction and Alpha-Modulation. J. Cardiovasc. Electrophysiol. 2:1991;476-491.
17. Antzelevitch C., Sicouri S., Litovsky S.H., et al. Heterogeneity within the ventricular wall: electrophysiology and pharmacology of epicardial, endocardial and M cells. Circ. Res. 69:1991;1427-1449.
18. Antzelevitch C., Sicouri S., Lukas A., et al. Regional differences in the electrophysiology of ventricular cells: physiological and clinical implications. Zipes D.P., Jalife J. Cardiac electrophysiology: From cell to bedside. 2nd ed :1995;228-245 W.B. Saunders Co, Philadelphia.
19. Liu D.W., Gintant G.A., Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ. Res. 72:1993;671-687.
20. Antzelevitch C., Sicouri S. Clinical relevance of cardiac arrhythmias generated by afterdepolarizations: The role of M cells in the generation of U waves, triggered activity and torsade de pointes. J. Am. Coll. Cardiol. 23:1994;259-277.
21. Ks contributes to the longer action potential of the M cell. Circ. Res. 76:1995;351-365.
22. Antzelevitch C. The M cell. J Cardiovasc Pharmacol Therapeut. 2:1997;73-76. Invited Editorial Comment.
23. Apkon M., Nerbonne J.M. a1-Adrenergic agonists selectively suppress voltage-dependent K+ currents in rat ventricular myocytes. Proc. Natl. Acad. Sci. USA. 85:1988;8756-8760.
24. Tohse N., Nakaya H., Kanno M. Alpha1-adrenoceptor stimulation enhances the delayed rectifier K current of guinea pig ventricular cells through the activation of protein kinase C. Circ. Res. 71:1992;1441-1446.
25. Fedida D., Braun A.P., Giles W.R. α1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiological Rev. 73:1993;469-487.
26. Shah A., Cohen I.S., Rosen M.R. Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway. Biophys. J. 54:1988;219-225.
27. Liu S.J., Kennedy R.H. Alpha1-Adrenergic activation of L-type Ca current in rat ventricular myocytes: perforated patch-clamp recordings. Am. J. Physiol. 274:1998;H2203-H2207.
28. 2+ currents in single canine Purkinje cells. Circ. Res. 65:1989;1735-1750.
29. Pappano A.J. Propranolol-insensitive effects of epinephrine in action potential repolarization in electrically driven atria of the guinea pig. J. Pharmacol. Exp. Ther. 177:1971;85-95.
30. Priori S.G., Corr P.B. Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. Am. J. Physiol. 258:1990;H1796-H1805.
31. Anyukhovsky E.P., Sosunov E.A., Rosen M.R. Regional differences in electrophysiologic properties of epicardium, midmyocardium and endocardium: In vitro and in vivo correlations. Circulation. 94:1996;1981-1988.
32. Samson R.A., Cai J.J., Shibata E.F., Martins J.B., Lee H.-C. Electrophysiological effect of α2-adrenergic stimulation in canine cardiac Purkinje fibers. Am. J. Physiol. 268:1995;H2024-H2035.
33. Sicouri S., Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle: The M cell. Circ. Res. 68:1991;1729-1741.
34. Sicouri S., Antzelevitch C. Electrophysiologic characteristics of M cells in the canine left ventricular free wall. J. Cardiovasc. Electrophysiol. 6:1995;591-603.
35. Sicouri S., Antzelevitch C. Afterdepolarizations and triggered activity develop in a select population of cells (M cells) in canine ventricular myocardium: The effects of acetylstrophanthidin and Bay K 8644. PACE. 14:1991;1714-1720.
36. Lee J.H., Rosen M.R. Alpha 1-adrenergic receptor modulation of repolarization in canine Purkinje fibers. J. Cardiovasc. Electrophysiol. 5:1994;232-240.
37. Fedida D., Shimoni Y., Giles W.R. Alpha-adrenergic modulation of the transient outward current in rabbit atrial myocytes. J. Physiol. (Lond.). 423:1990;257-277.
38. Walsh K.B., Kass R. Distinct voltage-dependent regulation of a heart-delayed IK by protein kinases A and C. Am. J. Physiol. 261:1991;C1081-C1090.
39. Snyders D.J., VanBogaert P.P. Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac Purkinje fibers. Pflugers Arch. 394:1982;230-238.
40. Litovsky S.H., Antzelevitch C. Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: The role of the transient outward current. J. Am. Coll. Cardiol. 14:1989;1053-1066.
41. Wang X.L., Wettwer E., Gross G.J., Ravens U. Reduction of cardiac outward currents by alpha-1 adrenoceptor stimulation: A subtype-specific effect? J. Pharmacol. Exp. Ther. 259:1991;783-788.
42. Ks current density. Circulation. 96:1997;I-293. Abstract.
43. Carlsson L., Abrahamsson C., Andersson B., Duker G., Schiller-Linhardt G. Proarrhythmic effects of the class III agent almokalant: importance of infusion rate. QT dispersion, and early afterdepolarisations. Cardiovasc. Res. 27:1993;2186-2193.
44. Antzelevitch C., Sun Z.Q., Zhang Z.Q., Yan G.X. Cellular and ionic mechanisms underlying erythromycin-induced long QT and torsade de pointes. J. Am. Coll. Cardiol. 28:1996;1836-1848.
45. Shimizu W., Antzelevitch C. Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation. 96:1997;2038-2047.
46. El-Sherif N., Caref E.B., Yin H., Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: Tridimensional mapping of activation and recovery patterns. Circ. Res. 79:1996;474-492.