A novel cyclic adenosine monophosphate-responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein-coupled receptor drug discovery efforts

Journal of Biomolecular Screening

Volumn 12, Issue 5, 2007, Pages 740-746

  Chepurny, Oleg G ^a   Holz, George G ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cAMP response element; Drug discovery; G protein coupled receptor; High throughput screen; Luciferase reporter

Indexed keywords

CYCLIC AMP; EXENDIN 4; FIREFLY LUCIFERASE; G PROTEIN COUPLED RECEPTOR; GLUCAGON; INSULIN; LUCIFERASE;

AGONIST; ARTICLE; DRUG SCREENING; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GENES, REPORTER; HUMANS; KIDNEY; LUCIFERASES, FIREFLY; RECEPTORS, G-PROTEIN-COUPLED; REPRODUCIBILITY OF RESULTS; TRANSFECTION;

RATTUS;

EID: 34547793553     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057107301856     Document Type: Article

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