The Shelterin Protein TRF2 Inhibits Chk2 Activity at Telomeres in the Absence of DNA Damage

Current Biology

Volumn 19, Issue 10, 2009, Pages 874-879

  Buscemi, Giacomo ^a   Zannini, Laura ^a   Fontanella, Enrico ^a   Lecis, Daniele ^a   Lisanti, Sofia ^a   Delia, Domenico ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

DNA

Indexed keywords

ATM PROTEIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 2; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; TELOMERASE; TELOMERIC REPEAT BINDING FACTOR 2; TUMOR SUPPRESSOR PROTEIN;

ANIMAL; ARTICLE; CELL AGING; CELL LINE; DNA DAMAGE; GENETICS; HUMAN; METABOLISM; NEOPLASM; PROTEIN TERTIARY STRUCTURE; TELOMERE;

ANIMALS; CELL AGING; CELL CYCLE PROTEINS; CELL LINE; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; TELOMERASE; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 2; TUMOR SUPPRESSOR PROTEINS;

EID: 67349246601     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2009.03.064     Document Type: Article

References (28)

1. de Lange T. Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
2. Shay J.W., and Wright W.E. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Mol. Cell 14 (2004) 420-421
3. d'Adda di Fagagna F., Teo S.H., and Jackson S.P. Functional links between telomeres and proteins of the DNA-damage response. Genes Dev. 18 (2004) 1781-1799
4. Antoni L., Sodha N., Collins I., and Garrett M.D. CHK2 kinase: Cancer susceptibility and cancer therapy-two sides of the same coin?. Nat. Rev. Cancer 7 (2007) 925-936
5. Chen C.R., Wang W., Rogoff H.A., Li X., Mang W., and Li C.J. Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: Checkpoint activation as a strategy against cancer. Cancer Res. 65 (2005) 6017-6021
6. Bradshaw P.S., Stavropoulos D.J., and Meyn M.S. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nat. Genet. 37 (2005) 193-197
7. Karlseder J., Hoke K., Mirzoeva O.K., Bakkenist C., Kastan M.B., Petrini J.H., and de Lange T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol. 2 (2004) 1150-1156
8. Blanco R., Muñoz P., Flores J.M., Klatt P., and Blasco M.A. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev. 21 (2007) 206-220
9. Abraham R.T. PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways. DNA Repair (Amst.) 3 (2004) 883-887
10. d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., von Zglinicki T., Saretzki G., Carter N.P., and Jackson S.P. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 (2003) 194-198
11. Di Micco R., Fumagalli M., Cicalese A., Piccinin S., Gasparini P., Luise C., Schurra C., Garre' M., Nuciforo P.G., Bensimon A., et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444 (2006) 638-642
12. Zhu X.D., Küster B., Mann M., Petrini J.H., and de Lange T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat. Genet. 25 (2000) 347-352
13. Lukas C., Falck J., Bartkova J., Bartek J., and Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5 (2003) 255-260
14. van Steensel B., Smogorzewska A., and de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 (1998) 401-413
15. Schwarz J.K., Lovly C.M., and Piwnica-Worms H. Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. Mol. Cancer Res. 8 (2003) 598-609
16. Buscemi G., Carlessi L., Zannini L., Lisanti S., Fontanella E., Canevari S., and Delia D. DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol. Cell. Biol. 26 (2006) 7832-7845
17. Hickson I., Zhao Y., Richardson C.J., Green S.J., Martin N.M., Orr A.I., Reaper P.M., Jackson S.P., Curtin N.J., and Smith G.C. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64 (2004) 9152-9159
18. Lansing T.J., McConnell R.T., Duckett D.R., Spehar G.M., Knick V.B., Hassler D.F., Noro N., Furuta M., Emmitte K.A., Gilmer T.M., et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol. Cancer Ther. 6 (2007) 450-459
19. Hosoi Y., Miyachi H., Matsumoto Y., Ikehata H., Komura J., Ishii K., Zhao H.J., Yoshida M., Takai Y., Yamada S., et al. A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation. Int. J. Cancer 78 (1998) 642-647
20. Ismail I.H., Mårtensson S., Moshinsky D., Rice A., Tang C., Howlett A., McMahon G., and Hammarsten O. SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization. Oncogene 23 (2004) 873-882
21. Li J., and Stern D.F. Regulation of CHK2 by DNA-dependent protein kinase. J. Biol. Chem. 280 (2005) 12041-12050
22. Solier S., Sordet O., Kohn K.W., and Pommier Y. Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. Mol. Cell. Biol. 29 (2009) 68-82
23. Shangary S., Brown K.D., Adamson A.W., Edmonson S., Ng B., Pandita T.K., Yalowich J., Taccioli G.E., and Baskaran R. Regulation of DNA-dependent protein kinase activity by ionizing radiation-activated abl kinase is an ATM-dependent process. J. Biol. Chem. 275 (2000) 30163-30168
24. De Boeck G., Forsyth R.G., Praet M., and Hogendoorn P.C. Telomere-associated proteins: Cross-talk between telomere maintenance and telomere-lengthening mechanisms. J. Pathol. 217 (2009) 327-344
25. Carlessi L., Buscemi G., Larson G., Hong Z., Wu J.Z., and Delia D. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol. Cancer Ther. 6 (2007) 935-944
26. Tanaka H., Mendonca M.S., Bradshaw P.S., Hoelz D.J., Malkas L.H., Meyn M.S., and Gilley D. DNA damage-induced phosphorylation of the human telomere-associated protein TRF2. Proc. Natl. Acad. Sci. USA 102 (2005) 15539-15544
27. Halazonetis T.D., Gorgoulis V.G., and Bartek J. An oncogene-induced DNA damage model for cancer development. Science 319 (2008) 1352-1355
28. Nijjar T., Bassett E., Garbe J., Takenaka Y., Stampfer M.R., Gilley D., and Yaswen P. Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells. Oncogene 24 (2005) 3369-3376