Potassium channel expression in human CD4+ regulatory and naïve T cells from healthy subjects and multiple sclerosis patients

Immunology Letters

Volumn 124, Issue 2, 2009, Pages 95-101

  Varga, Zoltan ^a   Csepany, Tunde ^a   Papp, Ferenc ^b   Fabian, Akos ^a   Gogolak, Peter ^a   Toth, Agnes ^a   Panyi, Gyorgy ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Cell capacitance; Channel density; Multiple sclerosis; Potassium channel; Regulatory T cell

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.3;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL MEMBRANE CONDUCTANCE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VOLUNTEER;

ADULT; ANTIGENS, CD4; FEMALE; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; KV1.3 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MULTIPLE SCLEROSIS; T-LYMPHOCYTES, REGULATORY;

EID: 67349228780     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2009.04.008     Document Type: Article

References (36)

1. + channels in human T lymphocytes: a role in mitogenesis?. Nature 307 (1984) 465-468
2. Matteson D.R., and Deutsch C. K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion. Nature 307 (1984) 468-471
3. Koo G.C., Blake J.T., Talento A., Nguyen M., Lin S., Sirotina A., et al. Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J Immunol 158 (1997) 5120-5128
4. Logsdon N.J., Kang J., Togo J.A., Christian E.P., and Aiyar J. A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. J Biol Chem 272 (1997) 32723-32726
5. Panyi G., Varga Z., and Gaspar R. Ion channels and lymphocyte activation. Immunol Lett 92 (2004) 55-66
6. Panyi G., Vamosi G., Bacso Z., Bagdany M., Bodnar A., Varga Z., et al. Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells. Proc Natl Acad Sci USA 101 (2004) 1285-1290
7. Nicolaou S.A., Szigligeti P., Neumeier L., Lee S.M., Duncan H.J., Kant S.K., et al. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. J Immunol 179 (2007) 346-356
8. + channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes. Am J Physiol Cell Physiol 292 (2007) C1431-C1439
9. + channel in effector memory T cells as new target for MS. J Clin Invest 111 (2003) 1703-1713
10. Rus H., Pardo C.A., Hu L., Darrah E., Cudrici C., Niculescu T., et al. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci USA 102 (2005) 11094-11099
11. + channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci USA 98 (2001) 13942-13947
12. Prieto G.A., and Rosenstein Y. Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation. Immunology 118 (2006) 58-65
13. Schumacher A., Wafula P.O., Bertoja A.Z., Sollwedel A., Thuere C., Wollenberg I., et al. Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy. Obstet Gynecol 110 (2007) 1137-1145
14. + regulatory T cells in patients with multiple sclerosis. J Exp Med 199 (2004) 971-979
15. high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol 35 (2005) 3343-3352
16. + T-cells from patients with type 1 diabetes. Diabetes 54 (2005) 92-99
17. Bluestone J.A., Tang Q., and Sedwick C.E. T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol 28 (2008) 677-684
18. + regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer 98 (2003) 1089-1099
19. Wolf A.M., Wolf D., Steurer M., Gastl G., Gunsilius E., and Grubeck-Loebenstein B. Increase of regulatory T cells in the peripheral blood of cancer patients. Clin Cancer Res 9 (2003) 606-612
20. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
21. high regulatory cells in human peripheral blood. J Immunol 167 (2001) 1245-1253
22. Wood K.J., Sakaguchi S., and Regulatory. T cells in transplantation tolerance. Nat Rev Immunol 3 (2003) 199-210
23. Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
24. + T reg cells. J Exp Med 203 (2006) 1701-1711
25. Li J., Huston G., and Swain S.L. IL-7 promotes the transition of CD4 effectors to persistent memory cells. J Exp Med 198 (2003) 1807-1815
26. high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help. J Immunol 174 (2005) 5926-5930
27. Lopez-Diego R.S., and Weiner H.L. Novel therapeutic strategies for multiple sclerosis-a multifaceted adversary. Nat Rev Drug Discov 7 (2008) 909-925
28. Bruserud O., Ersvaer E., Olsnes A., and Gjertsen B.T. Anticancer immunotherapy in combination with proapoptotic therapy. Curr Cancer Drug Targets 8 (2008) 666-675
29. + T cell subsets that are differentially depleted during HIV infection. J Immunol 180 (2008) 5582-5592
30. + channels: effects of alterations in the carboxy-terminal region. Neuron 7 (1991) 547-556
31. Deutsch C., Krause D., and Lee S.C. Voltage-gated potassium conductance in human T lymphocytes stimulated with phorbol ester. J Physiol 372 (1986) 405-423
32. + regulatory T cells in the steady state. J Exp Med 198 (2003) 737-746
33. + channels in human and murine T lymphocytes. J Gen Physiol 93 (1989) 1061-1074
34. Grissmer S., Nguyen A.N., and Cahalan M.D. Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology. J Gen Physiol 102 (1993) 601-630
35. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10 (1998) 1969-1980
36. von Herrath M.G., and Harrison L.C. Antigen-induced regulatory T cells in autoimmunity. Nat Rev Immunol 3 (2003) 223-232