The Ca2+-activated K+ channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes

American Journal of Physiology - Cell Physiology

Volumn 292, Issue 4, 2007, Pages

  Nicolaou, Stella A ^a   Neumeier, Lisa ^a   Peng, YouQing ^a   Devor, Daniel C ^b   Conforti, Laura ^a,c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Ion channels; Membrane distribution; T cell activation

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL KCA3.1; CD3 ANTIGEN; CD3 EPSILON ANTIGEN; F ACTIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIBODY LABELING; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CALCIUM TRANSPORT; CELL COMPARTMENTALIZATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE ACTIVATION;

ACTINS; ANTIGEN PRESENTATION; CALCIUM; CALCIUM SIGNALING; CELL COMPARTMENTATION; CELL MEMBRANE; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; LYMPHOCYTE ACTIVATION; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; PATCH-CLAMP TECHNIQUES; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES;

HUMAN HERPESVIRUS 4;

EID: 34247337971     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00376.2006     Document Type: Article

References (31)

1. Bi K, Tanaka Y, Coudronniere N, Sugie K, Hong S, van Stipdonk MJ, Altman A. Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation. Nat Immun 2: 556-563, 2001.
2. Bunnell SC, Kapoor V, Trible RP, Zhang W, Samelson LE. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity 14: 315-329, 2001.
3. Cannon JL, Burkhardt JK. The regulation of actin remodeling during T-cell-APC conjugate formation. Immunol Rev 186: 90-99, 2002.
4. Conforti L, Bodi I, Nisbet JW, Millhorn DE. O2-sensitive K+ channels: role of the Kv1.2-subunit in mediating the hypoxic response. J Physiol 524: 783-793, 2000.
5. Das V, Nal B, Roumier A, Meas-Yedid V, Zimmer C, Olivo-Marin JC, Roux P, Ferrier P, Dautry-Varsat A, Alcover A. Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation. Immunol Rev 189: 123-135, 2002.
6. + channels of human erythrocytes by endogenous protein kinase C. Biochim Biophys Acta 1612: 107-116, 2003.
7. Dolmetsch RE, Xu K, Lewis RS. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392: 933-936, 1998.
8. Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity 17: 809-822, 2002.
9. Friedl P, den Boer AT, Gunzer M. Tuning immune responses: diversity and adaptation of the immunological synapse. Nat Rev Immunol 5: 532-545, 2005.
10. Friedl P, Gunzer M. Interaction of T cells with APCs: the serial encounter model. Trends Immunol 22: 187-191, 2001.
11. + channels as targets for specific immunomodulation. Trends Pharmacol Sci 25: 280-289, 2004.
12. Gerlach AC, Gangopadhyay NN, Devor DC. Kinase-dependent regulation of the intermediate conductance, calcium-dependent potassium channel, hIK1. J Biol Chem 275: 585-598, 2000.
13. Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem 275: 37137-37149, 2000.
14. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
15. Hess SD, Oortgiesen M, Cahalan MD. Calcium oscillations in human T and natural killer cells depend upon membrane potential and calcium influx. J Immunol 150: 2620-2633, 1993.
16. Kupfer A, Kupfer H. Imaging immune cell interactions and functions: SMACs and the Immunological Synapse. Semin Immunol 15: 295-300, 2003.
17. Kupper J. Functional expression of GFP-tagged Kv1.3 and Kv14 channels in HEK 293 cells. Eur J Neurosci 10: 3908-3912, 1998.
18. Negulescu PA, Shastri N, Cahalan MD. Intracellular calcium dependence of gene expression in single T lymphocytes. Proc Natl Acad Sci USA 91: 2873-2877, 1994.
19. + channels expressed in Xenopus oocytes. Pflügers Arch 448: 613-620, 2004.
20. Panyi G, Bagdany M, Bodnar A, Vamosi G, Szentesi G, Jenei A, Matyus L, Varga S, Waldmann TA, Gaspar R, Damjanovich S. Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes. Proc Natl Acad Sci USA 100: 2592-2597, 2003.
21. Panyi G, Vamosi G, Bacso Z, Bagdany M, Bodnar A, Varga Z, Gaspar R, Matyus L, Damjanovich S. Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells. Proc Natl Acad Sci USA 101: 1285-1290, 2004.
22. Panyi G, Varga Z, Gaspar R. Ion channels and lymphocyte activation. Immunol Lett 92: 55-66, 2004.
23. Robbins JR, Lee SM, Filipovich AH, Szigligeti P, Neumeier L, Petrovic M, Conforti L. Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels. J Physiol 564: 131-143, 2005.
24. Skalhegg BS, Tasken K, Hansson V, Huitfeldt HS, Jahnsen T, Lea T. Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex. Science 263: 84-87, 1994.
25. 2+ signaling. Cell Calcium 17: 287-300, 1995.
26. Winslow MM, Crabtree Immunology GR. Decoding calcium signaling. Science 307: 56-57, 2005.
27. + channel in effector memory T cells as new target for MS. J Clin Invest 111: 1703-1713, 2003.
28. + channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci USA 97: 8151-8156, 2000.
29. Wulfing C, Sjaastad MD, Davis MM. Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. Proc Natl Acad Sci USA 95: 6302-6307, 1998.
30. Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B. Discs large (Dlg1) complexes in lymphocyte activation. J Cell Biol 166: 173-178, 2004.
31. Zhou W, Vergara L, Konig R. T cell receptor induced intracellular redistribution of type I protein kinase A. Immunology 113: 453-459, 2004.