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Volumn 10, Issue 6, 2009, Pages 647-654

Development of immunoglobulin λ-chain-positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; PROTEIN BCL 2;

EID: 67349211157     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1732     Document Type: Article
Times cited : (67)

References (50)
  • 1
    • 20644455960 scopus 로고    scopus 로고
    • Control of lymphocyte development by nuclear factor-κB
    • Siebenlist, U., Brown, K. & Claudio, E. Control of lymphocyte development by nuclear factor-κB. Nat. Rev. Immunol. 5, 435-445 (2005).
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 435-445
    • Siebenlist, U.1    Brown, K.2    Claudio, E.3
  • 2
    • 33750467991 scopus 로고    scopus 로고
    • Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models
    • Gerondakis, S. et al. Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models. Oncogene 25, 6781-6799 (2006).
    • (2006) Oncogene , vol.25 , pp. 6781-6799
    • Gerondakis, S.1
  • 3
    • 34247574625 scopus 로고    scopus 로고
    • B cells and the BAFF/APRIL axis: Fast-forward on autoimmunity and signaling
    • Mackay, F., Silveira, P.A. & Brink, R. B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling. Curr. Opin. Immunol. 19, 327-336 (2007).
    • (2007) Curr. Opin. Immunol , vol.19 , pp. 327-336
    • Mackay, F.1    Silveira, P.A.2    Brink, R.3
  • 4
    • 0037119628 scopus 로고    scopus 로고
    • IκB kinase signaling is essential for maintenance of mature B cells
    • Pasparakis, M., Schmidt-Supprian, M. & Rajewsky, K. IκB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196, 743-752 (2002).
    • (2002) J. Exp. Med , vol.196 , pp. 743-752
    • Pasparakis, M.1    Schmidt-Supprian, M.2    Rajewsky, K.3
  • 5
    • 33744989924 scopus 로고    scopus 로고
    • Canonical NF-κB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation
    • Sasaki, Y. et al. Canonical NF-κB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity 24, 729-739 (2006).
    • (2006) Immunity , vol.24 , pp. 729-739
    • Sasaki, Y.1
  • 6
    • 47749136267 scopus 로고    scopus 로고
    • IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver
    • Luedde, T. et al. IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver. Proc. Natl. Acad. Sci. USA 105, 9733-9738 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9733-9738
    • Luedde, T.1
  • 7
    • 2942598309 scopus 로고    scopus 로고
    • Feng, B., Cheng, S., Pear, W.S. & Liou, H.C. NF-κB inhibitor blocks B cell development at two checkpoints. Med. Immunol. 3, 1 (2004).
    • Feng, B., Cheng, S., Pear, W.S. & Liou, H.C. NF-κB inhibitor blocks B cell development at two checkpoints. Med. Immunol. 3, 1 (2004).
  • 8
    • 26444604518 scopus 로고    scopus 로고
    • + pre-B cells to small, CD43- pre-B cells
    • + pre-B cells to small, CD43- pre-B cells. Int. Immunol. 17, 815-825 (2005).
    • (2005) Int. Immunol , vol.17 , pp. 815-825
    • Jimi, E.1
  • 9
    • 17444424575 scopus 로고    scopus 로고
    • A role for nuclear factor κB/rel transcription factors in the regulation of the recombinase activator genes
    • Verkoczy, L. et al. A role for nuclear factor κB/rel transcription factors in the regulation of the recombinase activator genes. Immunity 22, 519-531 (2005).
    • (2005) Immunity , vol.22 , pp. 519-531
    • Verkoczy, L.1
  • 10
    • 33748992038 scopus 로고    scopus 로고
    • Receptor editing in lymphocyte development and central tolerance
    • Nemazee, D. Receptor editing in lymphocyte development and central tolerance. Nat. Rev. Immunol. 6, 728-740 (2006).
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 728-740
    • Nemazee, D.1
  • 11
    • 57649114834 scopus 로고    scopus 로고
    • DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes
    • Bredemeyer, A.L. et al. DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature 456, 819-823 (2008).
    • (2008) Nature , vol.456 , pp. 819-823
    • Bredemeyer, A.L.1
  • 12
    • 33748774926 scopus 로고    scopus 로고
    • Testing gene function early in the B cell lineage in mb1-cre mice
    • Hobeika, E. et al. Testing gene function early in the B cell lineage in mb1-cre mice. Proc. Natl. Acad. Sci. USA 103, 13789-13794 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 13789-13794
    • Hobeika, E.1
  • 13
    • 15444371841 scopus 로고    scopus 로고
    • An immunoglobulin C κ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system
    • Ait-Azzouzene, D. et al. An immunoglobulin C κ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. J. Exp. Med. 201, 817-828 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 817-828
    • Ait-Azzouzene, D.1
  • 14
    • 0027189754 scopus 로고
    • Deletion of the immunoglobulin κ chain intron enhancer abolishes κ chain gene rearrangement in cis but not λ chain gene rearrangement in trans
    • Takeda, S. et al. Deletion of the immunoglobulin κ chain intron enhancer abolishes κ chain gene rearrangement in cis but not λ chain gene rearrangement in trans. EMBO J. 12, 2329-2336 (1993).
    • (1993) EMBO J , vol.12 , pp. 2329-2336
    • Takeda, S.1
  • 15
    • 0025939204 scopus 로고
    • Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    • Strasser, A. et al. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA 88, 8661-8665 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8661-8665
    • Strasser, A.1
  • 16
    • 34250694086 scopus 로고    scopus 로고
    • Vagaries of conditional gene targeting
    • Schmidt-Supprian, M. & Rajewsky, K. Vagaries of conditional gene targeting. Nat. Immunol. 8, 665-668 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 665-668
    • Schmidt-Supprian, M.1    Rajewsky, K.2
  • 17
    • 0035892228 scopus 로고    scopus 로고
    • Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    • Allman, D. et al. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 167, 6834-6840 (2001).
    • (2001) J. Immunol , vol.167 , pp. 6834-6840
    • Allman, D.1
  • 18
    • 34249796982 scopus 로고    scopus 로고
    • Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes
    • Debnath, I., Roundy, K.M., Weis, J.J. & Weis, J.H. Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes. J. Immunol. 178, 7139-7150 (2007).
    • (2007) J. Immunol , vol.178 , pp. 7139-7150
    • Debnath, I.1    Roundy, K.M.2    Weis, J.J.3    Weis, J.H.4
  • 19
    • 33947239920 scopus 로고    scopus 로고
    • Generation of peripheral B cells occurs via two spatially and temporally distinct pathways
    • Lindsley, R.C., Thomas, M., Srivastava, B. & Allman, D. Generation of peripheral B cells occurs via two spatially and temporally distinct pathways. Blood 109, 2521-2528 (2007).
    • (2007) Blood , vol.109 , pp. 2521-2528
    • Lindsley, R.C.1    Thomas, M.2    Srivastava, B.3    Allman, D.4
  • 20
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radic, M.Z., Erikson, J., Litwin, S. & Weigert, M. B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 177, 1165-1173 (1993).
    • (1993) J. Exp. Med , vol.177 , pp. 1165-1173
    • Radic, M.Z.1    Erikson, J.2    Litwin, S.3    Weigert, M.4
  • 21
    • 0031019217 scopus 로고    scopus 로고
    • Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development
    • Constantinescu, A. & Schlissel, M.S. Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development. J. Exp. Med. 185, 609-620 (1997).
    • (1997) J. Exp. Med , vol.185 , pp. 609-620
    • Constantinescu, A.1    Schlissel, M.S.2
  • 22
    • 0030071522 scopus 로고    scopus 로고
    • Re-evaluation of the probabilities for productive arrangements on the κ and λ loci
    • Arakawa, H., Shimizu, T. & Takeda, S. Re-evaluation of the probabilities for productive arrangements on the κ and λ loci. Int. Immunol. 8, 91-99 (1996).
    • (1996) Int. Immunol , vol.8 , pp. 91-99
    • Arakawa, H.1    Shimizu, T.2    Takeda, S.3
  • 23
    • 0030694311 scopus 로고    scopus 로고
    • Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells
    • Lang, J. et al. Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells. J. Exp. Med. 186, 1513-1522 (1997).
    • (1997) J. Exp. Med , vol.186 , pp. 1513-1522
    • Lang, J.1
  • 24
    • 0028922885 scopus 로고
    • Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
    • Motoyama, N. et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267, 1506-1510 (1995).
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1
  • 25
    • 0043127142 scopus 로고    scopus 로고
    • The pims and outs of survival signaling: Role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines
    • White, E. The pims and outs of survival signaling: Role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines. Genes Dev. 17, 1813-1816 (2003).
    • (2003) Genes Dev , vol.17 , pp. 1813-1816
    • White, E.1
  • 26
    • 33748441252 scopus 로고    scopus 로고
    • Alternative and classical NF-κ B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease
    • Enzler, T. et al. Alternative and classical NF-κ B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25, 403-415 (2006).
    • (2006) Immunity , vol.25 , pp. 403-415
    • Enzler, T.1
  • 27
    • 0030038917 scopus 로고    scopus 로고
    • Acquisition of CD40 expression during murine B-cell differentiation
    • Grandien, A., Bras, A. & Martinez, C. Acquisition of CD40 expression during murine B-cell differentiation. Scand. J. Immunol. 43, 47-55 (1996).
    • (1996) Scand. J. Immunol , vol.43 , pp. 47-55
    • Grandien, A.1    Bras, A.2    Martinez, C.3
  • 28
    • 0036735155 scopus 로고    scopus 로고
    • Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines
    • Applequist, S.E., Wallin, R.P. & Ljunggren, H.G. Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines. Int. Immunol. 14, 1065-1074 (2002).
    • (2002) Int. Immunol , vol.14 , pp. 1065-1074
    • Applequist, S.E.1    Wallin, R.P.2    Ljunggren, H.G.3
  • 29
    • 36049033394 scopus 로고    scopus 로고
    • Signaling to NF-κB by Toll-like receptors
    • Kawai, T. & Akira, S. Signaling to NF-κB by Toll-like receptors. Trends Mol. Med. 13, 460-469 (2007).
    • (2007) Trends Mol. Med , vol.13 , pp. 460-469
    • Kawai, T.1    Akira, S.2
  • 30
    • 84934437953 scopus 로고    scopus 로고
    • Characteristics and biological functions of TRAF6
    • Inoue, J., Gohda, J. & Akiyama, T. Characteristics and biological functions of TRAF6. Adv. Exp. Med. Biol. 597, 72-79 (2007).
    • (2007) Adv. Exp. Med. Biol , vol.597 , pp. 72-79
    • Inoue, J.1    Gohda, J.2    Akiyama, T.3
  • 31
    • 49949151852 scopus 로고    scopus 로고
    • TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties
    • Mackay, F. & Schneider, P. TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev. 19, 263-276 (2008).
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 263-276
    • Mackay, F.1    Schneider, P.2
  • 32
    • 56349091862 scopus 로고    scopus 로고
    • Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling
    • Stadanlick, J.E. et al. Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling. Nat. Immunol. 9, 1379-1387 (2008).
    • (2008) Nat. Immunol , vol.9 , pp. 1379-1387
    • Stadanlick, J.E.1
  • 33
    • 0032030643 scopus 로고    scopus 로고
    • Induction of nuclear factor-κB during primary B cell differentiation
    • Kistler, B. et al. Induction of nuclear factor-κB during primary B cell differentiation. J. Immunol. 160, 2308-2317 (1998).
    • (1998) J. Immunol , vol.160 , pp. 2308-2317
    • Kistler, B.1
  • 34
    • 44049091757 scopus 로고    scopus 로고
    • Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
    • Amin, R.H. & Schlissel, M.S. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat. Immunol. 9, 613-622 (2008).
    • (2008) Nat. Immunol , vol.9 , pp. 613-622
    • Amin, R.H.1    Schlissel, M.S.2
  • 35
    • 8644262467 scopus 로고    scopus 로고
    • Important roles for E protein binding sites within the immunoglobulin κ chain intronic enhancer in activating Vκ Jκ rearrangement
    • Inlay, M.A., Tian, H., Lin, T. & Xu, Y. Important roles for E protein binding sites within the immunoglobulin κ chain intronic enhancer in activating Vκ Jκ rearrangement. J. Exp. Med. 200, 1205-1211 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 1205-1211
    • Inlay, M.A.1    Tian, H.2    Lin, T.3    Xu, Y.4
  • 36
    • 0030299799 scopus 로고    scopus 로고
    • Corepression of RelA and c-rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes
    • Scherer, D.C. et al. Corepression of RelA and c-rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes. Immunity 5, 563-574 (1996).
    • (1996) Immunity , vol.5 , pp. 563-574
    • Scherer, D.C.1
  • 37
    • 39149143650 scopus 로고    scopus 로고
    • Rearrangement of mouse immunoglobulin κ deleting element recombining sequence promotes immune tolerance and λ B cell production
    • Vela, J.L. et al. Rearrangement of mouse immunoglobulin κ deleting element recombining sequence promotes immune tolerance and λ B cell production. Immunity 28, 161-170 (2008).
    • (2008) Immunity , vol.28 , pp. 161-170
    • Vela, J.L.1
  • 38
    • 0033062994 scopus 로고    scopus 로고
    • B cells are programmed to activate κ and λ for rearrangement at consecutive developmental stages
    • Engel, H., Rolink, A. & Weiss, S. B cells are programmed to activate κ and λ for rearrangement at consecutive developmental stages. Eur. J. Immunol. 29, 2167-2176 (1999).
    • (1999) Eur. J. Immunol , vol.29 , pp. 2167-2176
    • Engel, H.1    Rolink, A.2    Weiss, S.3
  • 39
    • 0035399827 scopus 로고    scopus 로고
    • Transcription factor NF-κ B regulates Ig λ light chain gene rearrangement
    • Bendall, H.H., Sikes, M.L. & Oltz, E.M. Transcription factor NF-κ B regulates Ig λ light chain gene rearrangement. J. Immunol. 167 264-269 (2001).
    • (2001) J. Immunol , vol.167 , pp. 264-269
    • Bendall, H.H.1    Sikes, M.L.2    Oltz, E.M.3
  • 40
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T. et al. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1
  • 41
    • 0033638970 scopus 로고    scopus 로고
    • NEMO/IKK gamma-deficient mice model incontinentia pigmenti
    • Schmidt-Supprian, M. et al. NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol. Cell 5, 981-992 (2000).
    • (2000) Mol. Cell , vol.5 , pp. 981-992
    • Schmidt-Supprian, M.1
  • 42
    • 17744386318 scopus 로고    scopus 로고
    • Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kB and neural tube closure
    • Ruland, J. et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kB and neural tube closure. Cell 104, 33-42 (2001).
    • (2001) Cell , vol.104 , pp. 33-42
    • Ruland, J.1
  • 43
    • 0035004320 scopus 로고    scopus 로고
    • Regulation of the T-independent humoral response by TACI
    • von Bulow, G.U., van Deursen, J.M. & Bram, R.J. Regulation of the T-independent humoral response by TACI. Immunity 14, 573-582 (2001).
    • (2001) Immunity , vol.14 , pp. 573-582
    • von Bulow, G.U.1    van Deursen, J.M.2    Bram, R.J.3
  • 44
    • 0037142027 scopus 로고    scopus 로고
    • TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
    • Pasparakis, M. et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 417, 861-866 (2002).
    • (2002) Nature , vol.417 , pp. 861-866
    • Pasparakis, M.1
  • 45
    • 13244278180 scopus 로고    scopus 로고
    • The Pim kinases control rapamycin-resistant T cell survival and activation
    • Fox, C.J., Hammerman, P.S. & Thompson, C.B. The Pim kinases control rapamycin-resistant T cell survival and activation. J. Exp. Med. 201, 259-266 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 259-266
    • Fox, C.J.1    Hammerman, P.S.2    Thompson, C.B.3
  • 46
    • 34047189274 scopus 로고    scopus 로고
    • Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
    • Gareus, R. et al. Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat. Cell Biol. 9, 461-469 (2007).
    • (2007) Nat. Cell Biol , vol.9 , pp. 461-469
    • Gareus, R.1
  • 47
    • 41949087380 scopus 로고    scopus 로고
    • Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    • Imai, Y. et al. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133, 235-249 (2008).
    • (2008) Cell , vol.133 , pp. 235-249
    • Imai, Y.1
  • 48
    • 48249121979 scopus 로고    scopus 로고
    • Complementary functions of ATM and H2AX in development and suppression of genomic instability
    • Zha, S. et al. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc. Natl. Acad. Sci. USA 105, 9302-9306 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9302-9306
    • Zha, S.1
  • 49
    • 0028447437 scopus 로고
    • The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
    • Kawabe, T. et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1, 167-178 (1994).
    • (1994) Immunity , vol.1 , pp. 167-178
    • Kawabe, T.1
  • 50
    • 3242718815 scopus 로고    scopus 로고
    • Generation and selection of an IgG-driven autoimmune repertoire during B-lymphopoiesis in Igmicro-deficient/lpr mice
    • Seagal, J., Edry, E., Naftali, H. & Melamed, D. Generation and selection of an IgG-driven autoimmune repertoire during B-lymphopoiesis in Igmicro-deficient/lpr mice. Int. Immunol. 16, 905-913 (2004).
    • (2004) Int. Immunol , vol.16 , pp. 905-913
    • Seagal, J.1    Edry, E.2    Naftali, H.3    Melamed, D.4


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