T-bet expression is regulated by EGR1-mediated signaling in activated T cells

Clinical Immunology

Volumn 131, Issue 3, 2009, Pages 385-394

  Shin, Hyun Jin ^a   Lee, Jee Boong ^b   Park, Sung Hwan ^c   Chang, Jun ^b   Lee, Chang Woo ^a  

^a Samsung Medical Center   (South Korea)

^b Ewha Womans University   (South Korea)

^c The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

EGR1; Promoter; T helper cells; T bet; TCR signaling; Transcription

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR T BET;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EGR1 GENE; GENE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE, TUMOR; EARLY GROWTH RESPONSE PROTEIN 1; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 67349179539     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2009.02.009     Document Type: Article

References (36)

1. Avni O., Lee D., Macian F., Szabo S.J., Glimcher L.H., and Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3 (2002) 643-651
2. Ho I.C., and Glimcher L.H. Transcription: tantalizing times for T cells. Cell 109 (2002) S109-S120
3. Farrar J.D., Asnagli H., and Murphy K.M. T helper subset development: roles of instruction, selection, and transcription. J. Clin. Invest. 109 (2002) 431-435
4. Lighvani A.A., Frucht D.M., Jankovic D., Yamane H., Aliberti J., Hissong B.D., Nquven B.V., Gadina M., Sher A., Paul W.E., and O'Shea J.J. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 15137-15142
5. Afkarian M., Sedy J.R., Yang J., Jacobson N.G., Cereb N., Yang S.Y., Murphy T.L., and Murphy K.M. T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat. Immunol. 3 (2002) 549-557
6. Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat. Rev., Immunol. 2 (2002) 933-944
7. Shi M., Lin T.H., Appell K.C., and Berg L.J. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 28 (2008) 763-773
8. Mullen A.C., High F.A., Hutchins A.S., Lee H.-W., Villarino A.V., Livingston D.M., Kung A.L., Cereb N., Yao T.P., Yang S.Y., and Reiner S.L. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292 (2001) 1907-1910
9. Djuretic I.M., Levanon D., Negreanu V., Groner Y., Rao A., and Ansel K.M. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat. Immunol. 8 (2007) 145-153
10. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., and Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-669
11. Hwang E.-S., Szabo S.J., Schwartzberg P.L., and Glimcher L.H. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307 (2005) 430-433
12. Szabo S.J., Sullivan B.M., Stemmann C., Satoskar A.R., Sleckman B.P., and Glimcher L.H. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295 (2002) 338-342
13. Finotto S., Neurath M.F., Glickman J.N., Qin S., Lehr H.A., Green F.H., Ackerman K., Haley K., Galle P.R., Szabo S.J., Drazen J.M., De Sanctis G.T., and Glimcher L.H. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295 (2002) 336-338
14. Munthe-Kaas M.C., Carlsen K.H., Håland G., Devulapalli C.S., Gervin K., Egeland T., Carlsen K.L., and Undlien D. T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. J. Allergy Clin. Immunol. 121 (2008) 51-56
15. Tantisira K.G., Hwang E.-S., Raby B.A., Silverman E.S., Lake S.L., Richter B.G., Peng S.L., Drazen J.M., Glimcher L.H., and Weiss S.T. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc. Natl. Acad. Sci.U. S. A. 101 (2004) 18099-18104
16. Lugo-Villarino G., Ito S., Klinman D.M., and Glimcher L.H. The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 13248-13253
17. Sullivan B.M., Jobe O., Lazarevic V., Vasquez K., Bronson R., Glimcher L.H., and Kramnik I. Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production. J. Immunol. 175 (2005) 4593-4602
18. Garrett W.S., Lord G.M., Punit S., Lugo-Villarino G., Mazmanian S.K., Ito S., Glickman J.N., and Glimcher L.H. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 131 (2007) 33-45
19. Townsend M.J., Weinmann A.S., Matsuda J.L., Salomon R., Farnham P.J., Biron C.A., Gapin L., and Glimcher L.H. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20 (2004) 477-494
20. Wang J., Fathman J.W., Lugo-Villarino G., Scimone L., von Andrian U., Dorfman D.M., and Glimcher L.H. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J. Clin. Invest. 116 (2006) 414-421
21. Joshi N.S., Cui W., Chandele A., Lee H.-K., Urso D.R., Hagman J., Gapin L., and Kaech S.M. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27 (2007) 281-295
22. Gashler A., and Sukhatme V.P. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog. Nucleic Acid Res. Mol. Biol. 50 (1995) 191-224
23. Shao H., Kono D.H., Chen L.Y., Rubin E.M., and Kaye J. Induction of the early growth response (Egr) family of transcription factors during thymic selection. J. Exp. Med. 185 (1997) 731-744
24. Bettini M., Xi H., Milbrandt J., and Kersh G.J. Thymocyte development in early growth response gene 1-deficient mice. J. Immunol. 169 (2002) 1713-1720
25. Seyfert V.L., McMahon S., Glenn W., Cao X.M., Sukhatme V.P., and Monroe J.G. Egr-1 expression in surface Ig-mediated B cell activation. Kinetics and association with protein kinase C activation. J. Immunol. 145 (1990) 3647-3653
26. Makover D., Cuddy M., Yum S., Bradley K., Alpers J., Sukhatme V., and Reed J.C. Phorbol ester-mediated inhibition of growth and regulation of proto-oncogene expression in the human T cell leukemia line JURKAT. Oncogene 6 (1991) 455-460
27. Skerka C., Decker E.L., and Zipfel P.F. A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1. J. Biol. Chem. 270 (1995) 22500-22506
28. Lin J.X., and Leonard W.J. The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites. Mol. Cell. Biol. 17 (1997) 3714-3722
29. Decker E.L., Nehmann N., Kampen E., Eibel H., Zipfel P.F., and Skerka C. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res. 31 (2003) 911-921
30. Dzialo-Hatton R., Milbrandt J., Hockett Jr. R.D., and Weaver C.T. Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members. J. Immunol. 166 (2001) 4534-4542
31. Cron R.Q., Bandyopadhyay R., Genin A., Brunner M., Kersh G.J., Yin J., Finkel T.H., and Crow M.K. Early growth response-1 is required for CD154 transcription. J. Immunol. 176 (2006) 811-818
32. Morinobu A., Kanno Y., and O'Shea J.J. Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression. J. Biol. Chem. 279 (2004) 40640-40646
33. Rengarajan J., Szabo S.J., and Glimcher L.H. Transcriptional regulation of Th1/Th2 polarization. Immunol. Today 21 (2000) 479-483
34. Yang Y., Ochando J.C., Bromberg J.S., and Ding Y. Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNγ/Stat1 signals. Blood 110 (2007) 2494-2500
35. Glimcher L.H. Trawling for treasure: tales of T-bet. Nat. Immunol. 8 (2007) 448-450
36. Usui T., Preiss J.C., Kanno Y., Yao Z.J., Bream J.H., and O'Shea J.J. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J. Exp. Med. 203 (2006) 755-766