FAD-mutation of APP is associated with a loss of its synaptotrophic activity

Neurobiology of Disease

Volumn 35, Issue 2, 2009, Pages 258-263

  Seeger, Gudrun ^a   Gärtner, Ulrich ^a   Ueberham, Uwe ^a   Rohn, Susanne ^a   Arendt, Thomas ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Alzheimer's disease; APP; FAD linked mutations; Mouse model; Neocortex; Quantitative ultrastructural analysis; Sub synaptic structure; Synaptic density; Synaptophysin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MEMBRANE PROTEIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ELECTRON MICROSCOPY; FAMILIAL DISEASE; GENE MUTATION; GENE OVEREXPRESSION; MOUSE; NEOCORTEX; NERVE CELL; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; STEREOLOGY; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; HUMANS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MUTATION; NEOCORTEX; NEURONS; RECEPTORS, CELL SURFACE; SYNAPSES; SYNAPTIC VESICLES;

EID: 67349127728     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.05.003     Document Type: Article

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