Nerve growth factor modulates the expression and secretion of β-amyloid precursor protein through different mechanisms in PC12 cells

Journal of Neurochemistry

Volumn 77, Issue 4, 2001, Pages 1077-1084

  Villa, Ana ^a   Latasa, Maria Jesús ^a   Pascual, Angel ^a,b  

^a CSIC   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Amyloid precursor protein; Nerve growth factor; PC12 cells; Promoter; Ras; Synthesis and secretion

Indexed keywords

AMYLOID BETA PROTEIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; TYROSINE KINASE RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; SENILE PLAQUE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; GENES, RAS; METALLOTHIONEIN; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; PC12 CELLS; PROMOTER REGIONS (GENETICS); RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 0035008390     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00315.x     Document Type: Article

References (52)

1. Barbacid M. (1994) The Trk family of neurotrophin receptors. J. Neurobiol. 25, 1386-1403.
2. Belandia B., Latasa M. J., Villa A. and Pascual A. (1998) Thyroid hormone negatively regulates the transcriptional activity of the beta-amyloid precursor protein gene. J. Biol. Chem. 273, 30366-30371.
3. Bruder J. T., Keidecker G. and Rapp U. R. (1992) Serum-, TPA-, and Ras-induced expression from AP-1/Ets driven promoters requires Raf-1 kinase. Genes Dev 6, 545-556.
4. Buxbaum J. D., Gandy S. E., Cicchetti P., Ehrlich M. E., Czernik A. J., Fracasso R. P., Ramabhadran T. V., Unterbeck A. J. and Greengard P. (1990) Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc. Natl Acad. Sci. USA 87, 6003-6006.
5. Chernak J. M. (1993) Structural features of the 5′ upstream regulatory region of the gene encoding rat amyloid precursor protein. Gene 133, 255-260.
6. Cosgaya J. M., Latasa M. J. and Pascual A. (1996) Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cells. J. Neurochem. 67, 98-104.
7. Cosgaya J. M., Recio J. A. and Aranda A. (1997) Influence of Ras and retinoic acid on nerve growth factor induction of transin gene expression in PC12 cells. Oncogene 14, 1687-1696.
8. Desdouits-Magnen J., Desdouits F., Takeda S., Syu L. J., Saltiel A. R., Buxbaum J. D., Czernik A. J., Nairn A. C. and Greengard P. (1998) Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. J. Neurochem. 70, 524-530.
9. Feig L. A. and Cooper G. M. (1988) Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins. Mol. Cell Biol. 8, 2472-2478.
10. Fukuchi K., Kamino K., Deeb S. S., Smith A. C., Dang T. and Martin G. M. (1992) Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem. Biophys. Kes. Commun. 182, 165-173.
11. Fukuyama R., Chandrasekaran K. and Rapoport S. I. (1993) Nerve growth factor-induced neuronal differentiation is accompanied by differential induction and localization of the amyloid precursor protein (APP) in PC12 cells and variant PC12S cells. Brain Res. Mol. Brain Res. 17, 17-22.
12. Games D., Adams D., Alessandrini R., Barbour R., Bertheletle P., Blackwell C., Carr T., Clemens J., Donaldson T., Gillespie F., Guido T., Hagoplan S., Johnson-Wood K., Khan K., Lee M., Leibowitz P., Lieberburg I., Little S., Masliah E., McConlogue L., Montoya-Zavala M., Mucke L., Paganini L., Penniman E., Power M., Schenk D., Seubert P., Snyder B., Soriano F., Tan H., Vitale J., Wadsworth S., Wolozin B. and Zhao J. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373, 523-527.
13. Greene L. A. and Kaplan D. R. (1995) Early events in neurotrophin signalling via Trk and p75 receptors. Curr. Opin. Neurobiol. 5, 579-587.
14. Guerrero I., Pellicer A. and Burstein D. E. (1988) Dissociation of c-fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras oncogene. Biochem. Biophys. Res. Commun, 150, 1185-1192.
15. Hadari Y. R., Kouhara H., Lax I. and Schlessinger J. (1998) Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol. Cell Biol. 18, 3966-3973.
16. Higgins G. A. and Mufson E. J. (1989) NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease. Exp. Neurol. 106, 222-236.
17. Hock C., Heese K., Muller-Spahn F., Hulette C., Rosenberg C. and Otten U. (1998) Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease. Neurosci. Lett., 241, 151-154.
18. Hunter T. and Karin M. (1992) The regulation of transcription by phosphorylation. Cell 70, 375-387.
19. Konig G., Masters C. L. and Beyreuther K. (1990) Retinoic acid induced differentiated neuroblastoma cells show increased expression of the beta A4 amyloid gene of Alzheimer's disease and an altered splicing pattern. FEBS Lett. 269, 305-310.
20. Kouhara H., Hadari Y. R., Spivak-Kroizman T., Schilling J., Bar-Sagi D., Lax I. and Schlessinger J. (1997) A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/ MAPK signaling pathway. Cell 89, 693-702.
21. La Fauci G., Lahiri D. K., Salton S. R. and Robakis N. K. (1989) Characterization of the 5′-end region and the first two exons of the beta-protein precursor gene. Biochem. Biophys. Res. Commun. 159, 297-304.
22. Lahiri D. K. and Nall C. (1995) Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1. Brain Res. Mol. Brain Res. 32, 233-240.
23. Lahiri D. K. and Robakis N. K. (1991) The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences. Brain Res. Mol. Brain Res. 9, 253-257.
24. Lahiri D. K., Nall C. and Ge Y. W. (1999) Promoter activity of the beta-amyloid precursor protein gene is negatively modulated by an upstream regulatory element. Brain Res. Mol. Brain Res. 71. 32-41.
25. Lahiri D. K., Song W. and Ge Y. W. (2000) Analysis of the 5′-flanking region of the beta-amyloid precursor protein gene that contributes to increased promoter activity in differentiated neuronal cells. Brain Res. Mol. Brain Res. 77, 185-198.
26. Latasa M. J., Belandia B. and Pascual A. (1998) Thyroid hormones regulate beta-amyloid gene splicing and protein secretion in neuroblastoma cells. Endocrinology 139, 2692-2698.
27. Meloche S., Pagès G. and Pouyssègur J. (1992) Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk. Mol. Biol. Cell 3, 63-75.
28. Milward E. A., Papadopoulos R., Fuller S. J., Moir R. D., Small D., Beyreuther K. and Masters C. L. (1992) The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neunte outgrowth. Neuron 9, 129-137.
29. Mobley W. C., Neve R. L., Prusiner S. B. and McKinley M. P. (1988) Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc. Natl Acad. Sci. USA 85, 9811-9815.
30. Muroya K., Hattori S. and Nakamura S. (1992) Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheocnromocytoma PC12 cells. Oncogene 7, 277-281.
31. Neve R. L., Finch E. A. and Dawes L. R. (1988) Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1, 669-677.
32. Ohyagi Y. and Tabira T. (1993) Effect of growth factors and cytokines on expression of amyloid beta protein precursor mRNAs in cultured neural cells. Brain Res. Mol. Brain Res. 18, 127-132.
33. Querfurth H. W., Jiang J., Xia W. and Selkoe D. J. (1999) Enhancer function and novel DNA binding protein activity in the near upstream βAPP gene promoter. Gene 232, 125-141.
34. Quon D., Wang Y., Catalano R., Scardina J. M., Murakami K. and Cordell B. (1991) Formation of beta-amyloid protein deposits in brains of transgenic mice. Nature 352, 239-241.
35. Refolo L. M., Salton S. R., Anderson J. P., Mehta P. and Robakis N. K (1989) Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures. Biochem. Biophys. Res. Commun. 164, 664-670.
36. Rossner S., Ueberham U., Schliebs R., Perez-Polo J. R. and Bigl V. (1998) The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling. Prog. Neurobiol. 56, 541-569.
37. Rossner S., Ueberham U., Schliebs R., Perez-Polo J. R. and Bigl V. (1999) Regulated secretion of amyloid precursor protein by TrkA receptor stimulation in rat pheochromocytoma-12 cells is mitogen activated protein kinase sensitive. Neurosci Lett., 271, 97-100.
38. Salbaum J. M., Weidemann A., Lemaire H. G., Masters C. L. and Beyreuther K. (1988) The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J. 7, 2807-2813.
39. Segal R. A. and Greenberg M. E. (1996) Intracellular signaling pathways activated by neurotrophic factors. Anni. Rev. Neurosci 19, 463-489.
40. Selkoe D. J. (1994) Alzheimer's disease: a central role for amyloid. J. Neuropathol. Exp. Neurol. 53, 438-447.
41. Smith C. J., Wion D. and Brachet P. (1991) Nerve growth factor-induced neuronal differentiation is accompanied by differential splicing of beta-amyloid precursor mRNAs in the PC12 cell line. Brain Res. Mol. Brain Res. 10, 351-354.
42. Sozeri O., Vollmer K., Liyanage M., Frith D., Kour G., Mark G. E. and Stabel S. (1992) Activation of the c-Raf protein kinase by protein kinase C phosphorylation. Oncogene 7, 2259-2262.
43. Szeberenyi J., Cai H. and Cooper G. M. (1990) Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell Biol. 10, 5324-5332.
44. Thomas S. M., DeMarco M., D'Arcangelo G., Halegoua S. and Brugge J. S. (1992) Ras is essential for nerve growth factor-and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68, 1031-1040.
45. Trejo J., Massamin T., Deng T., Dewji N. N., Bayney R. M. and Brown J. H. (1994) A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J. Biol. Chem. 269, 21682-21690.
46. Vostrov A. A. and Quitschke W. W. (1997) The zinc finger protein CTCF binds to the APBβ domain of the amyloid β-protein precursor promoter. Evidence for a role in transcriptional activation. J. Biol. Chem. 272, 33353-33359.
47. Weidemann A., Konig G., Bunke D., Fischer P., Salbaum J. M., Masters C. L. and Beyreuther K. (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126.
48. Wood K. W., Sarnecki C., Roberts T. M. and Blenis J. (1992) ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68, 1041-1050.
49. Wright K. L., Morgan D. G., Yu X., Goss J. R., Salbaum J. M., Duff K. and Gordon M. N. (1999) Mice transgenic for a human amyloid precursor protein promoter-lacZ reporter construct. J. Mol. Neurosci. 13, 111-120.
50. Yoshikai S., Sasaki H., Doh-ura K., Furuya H. and Sakaki Y. (1990) Genomic organization of the human amyloid beta-protein precursor gene. Gene 87, 257-263.
51. Yoshikawa K., Aizawa T. and Hayashi Y. (1992) Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359, 64-67.
52. Zhong Z., Quon D., Higgins L. S., Higaki J. and Cordell B. (1994) Increased amyloid production from aberrant beta-amyloid precursor proteins. J. Biol. Chem. 269, 12179-12184.