Transgenic activation of Ras in neurons increases synapse formation in mouse neocortex

Journal of Neural Transmission

Volumn 112, Issue 6, 2005, Pages 751-761

  Seeger, G ^a   Gartner U ^a   Arendt, Th ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Cerebral cortex; Mouse; Neuronal Ras activation; Synaptogenesis

Indexed keywords

RAS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; MALE; MOUSE; MOUSE STRAIN; NEOCORTEX; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; SOMATOSENSORY CORTEX; STATISTICAL SIGNIFICANCE; STEREOLOGY; SYNAPSE; SYNAPTOGENESIS; TRANSGENE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CELL COUNT; FEMALE; GENES, RAS; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; NEOCORTEX; NEURONS; SYNAPSES; TRANS-ACTIVATION (GENETICS);

EID: 18544389505     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-004-0226-8     Document Type: Article

References (58)

1. Alpár A, Palm A, Schierwagen T, Arendt T, Gärtner U (2003) Expression of constitutively active p21H-rasVal12 in postmitotic pyramidal neurons results in increased dendritic size and complexity. J Comp Neurol 467: 119-133
2. Alpár A, Gärtner U, Seeger G, Härtig W, Brauer K, Arendt T (2004a) Constitutive expression of p21H-rasVal12 in pyramidal neurons results in reorganisation of mouse neocortical afferents. J Neurobiol 19: 817-823
3. Alpár A, Seeger G, Härtig W, Arendt T, Gärtner U (2004b) Adaptive morphological changes of neocortical interneurons in response to enlarged and more complex pyramidal cells in p21H-RasVal12 transgenic mice. Brain Res Bull 62: 335-343
4. Alsina B, Vu T, Cohen-Cory S (2001) Visualizing synapse formation in arborizing optic axons in vivo: dynamics and modulation by BDNF. Nat Neurosci 4: 1093-1101
5. Bonhoeffer T (1996) Neurotrophins and activity-dependent development of the neocortex. Curr Opin Neurobiol 6: 119-126
6. Borasio GD, John J, Wittinghofer A, Barde YA, Sendtner M, Heumann R (1989) Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron 2: 1078-1096
7. Borasio GD, Markus A, Wittinghofer A, Barde YA, Heumann R (1993) Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons. J Cell Biol 121: 665-672
8. Borasio GD, Markus A, Heumann R, Ghezzi A, Sampietro A, Wittinghofer A, Silani V (1996) Ras p21 protein promotes survival and differentiation of human embryonic neural crest-derived cells. Neuroscience 73: 1121-1127
9. Braitenberg V, Schüz A (eds) (1998) Cortex: statistics and geometry of neuronal connectivity, 2nd rev edn. Springer, Berlin Heidelberg New York Tokyo
10. Brambilla R, Gnesutta N, Minichiello L, White G, Roylance AJ, Herron CE, Ramsey M, Wolfer DP, Cestari V, Rossi-Arnaud C, Grant SG, Chapman PF, Lipp HP, Sturani E, Klein R (1997) A role of the ras signalling pathway in synaptic transmission and long-term memory. Nature 390: 281-286
11. Causing CG, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett J, Kuchel G, Miller FD (1997) Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18: 257-267
12. Chechik G, Meilijson I, Ruppin E (1999) Neuronal regulation: a mechanism for synaptic pruning during brain maturation. Neural Comput 11: 2061-2080
13. Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H, Johnson RL, Cox AD, Philips MR (2002) Ras signalling on the endoplasmatic reticulum and the Golgi. Nat Cell Biol 4: 343-350
14. Cotman CW, Nieto-Sampedro M (1984) Cell biology of synaptic plasticity. Science 225: 1287-1294
15. De Felipe J, Marco P, Fairen A, Jones EG (1997) Inhibitory synaptogenesis in mouse somatosensory cortex. Cereb Cortex 7: 619-634
16. Feldman ML (1975a) Serial thin sections of pyramidal apical dendrites in the cerebral cortex: spine topography and related observations. Anat Rec 181: 354-355
17. Feldman ML, Dowd C (1975b) Loss of dendritic spines in aging cerebral cortex. Z Anat Entwicklungsgeschich 148: 279-301
18. Figurov A, Pozzo-Miller LD, Olafsson P, Wang Ti, Bai Lu (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381: 706-709
19. Franklin KBL, Paxinos G (eds) (1997) The mouse brain in stereotaxic coordinates. Academic Press, Sydney
20. Gärtner U, Alpár A, Seeger G, Heumann R, Arendt T (2004) Enhanced Ras activity in pyramidal neurons induces cellular hypertrophy and changes in afferent and intrinsic connectivity in synRas mice. Int J Dev Neurosci 22: 165-173
21. Guan KL, Rao Y (2003) Signalling mechanisms mediating neuronal responses to guidance cues. Nat Rev Neurosci 4: 941-956
22. Gundersen HJG (1977) Notes on the estimation of the numerical density of arbitary profiles: the edge effect. J Microsc 111: 219-223
23. Harris KM (1999) Structure, development, and plasticity of dendritic spines. Curr Opin Neurobiol 9: 343-348
24. Heumann R (1994) Neurotrophin signalling. Curr Opin Neurobiol 4: 668-679
25. Heumann R, Goemans C, Bartsch D, Lingenhöhl K, Waldmeier PC, Hengerer B, Allegrini PR, Schellander K, Wagner EF, Arendt T, Kamdem RH, Obst-Pernberg K, Narz F, Wahle P, Berns H (2000) Transgenic activation of ras in neurons promotes hypertrophy and protects from lesion-induced degeneration. J Cell Biol 151: 1537-1548
26. Holzer M, Gärtner U, Klinz F-J, Narz F, Heumann R, Arendt T (2001a) Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neuron-specific activation of p21ras. I. Mitogen-activated protein kinase cascade. Neuroscience 105: 1031-1040
27. Holzer M, Rödel L, Seeger G, Gärtner U, Narz F, Janke C, Heumann R, Arendt T (2001b) Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology. Neuroscience 105: 1041-1054
28. Huang EJ, Reichardt LF (2003) TrK receptors: roles in neuronal signal transduction. Annu Rev Biochem 72: 609-642
29. Khosravi-Far R, Der CJ (1994) The Ras signal transduction pathway. Cancer Metastasis Rev 13: 67-89
30. Lessman V, Heumann R (1998) Modulation of unitary glutamatergic synapses by neurotrophin-4/5 or brain-derived neurotrophic factor in hippocampal microcultures: presynaptic enhancement depends on pre-established paired-pulse facilitation. Neuroscience 86: 399-413
31. Lewin GR, Barde Y-A (1996) Physiology of neurotrophins. Annu Rev Neurosci 19: 289-317
32. Li AJ, Suzuki S, Suzuki M, Mizukoshi E, Imamura T (2002) Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neurons. Eur J Neurosci 16: 1313-1324
33. Lu B, Figurov A (1997) Role of neurotrophins in synapse development and plasticity. Rev Neurosci 8: 1-12
34. Manabe T, Aiba A, Yamada A, Ichise T, Sakagami H, Kondo H, Katsuki M (2000) Regulation of long-term potentiation by H-ras through NMDA receptor phosphorylation. J Neurosci 20: 2504-2525
35. Markus EJ, Petit TL, LeBoutillier JC, Brooks WJ (1994) Morphological characteristics of the synapse and their relationship to synaptic type: an electron microscopic examination of the neocortex and hippocampus of the rat. Synapse 17: 65-68
36. Marrone DF, Petit TL (2002) The role of synaptic morphology in neural plasticity: structural interactions underlying synaptic turnover. Brain Res Rev 38: 291-308
37. McAllister AK (2002) Neurotrophins and cortical development. Results Probl Cell Differ 39: 89-112
38. McAllister AK, Katz LC, Lo DC (1999) Neurotrophins and synaptic plasticity. Ann Rev Neurosci 22: 295-318
39. Micheva KD, Beaulieu C (1995) Postnatal development of GABA neurons in the rat somatosensory barrel cortex: a quantitative study. Eur J Neurosci 7: 419-430
40. Micheva KD, Beaulieu C (1996) Quantitative aspects of synaptogenesis in the rat barrel field cortex with special reference to GABA circuitry. J Comp Neurol 373: 340-354
41. Müller LJ, Verwer RW, Nunes Cardozo B, Vrensen G (1984) Synaptic characteristics of identified pyramidal and multipolar non-pyramidal neurons in the visual cortex of young and adult rabbits. A quantitative Golgi-electron microscope study. Neuroscience 12: 1071-1087
42. Pozzo-Miller LD, Gottschalk W, Zhang L, McDermott K, Du J, Gopalakrishnan R, Oho C, Sheng Z-H, Lu B (1999) Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci 19: 4972-4983
43. Reuther GW, Der CJ (2000) The ras branch of small GTPases: Ras family members don't fall far from the tree. Curr Opin Cell Biol 12: 157-165
44. Schinder AF, Berninger B, Poo M-m (2000a) Postsynaptic target specifity of neurotrophin-induced presynaptic potentiation. Neuron 25: 151-163
45. Schinder AF, Poo M-m (2000b) The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci 23: 639-645
46. Schüz A, Palm G (1989) Density of neurons and synapses in the cerebral cortex of the mouse. J Comp Neurol 286: 442-455
47. Seeger G, Gärtner U, Holzer M, Arendt T (2003) Constitutive expression of p21H-RasVal12 in neurons induces increased axonal size and dendritic microtubule density in vivo. J Neurosci Res 74: 868-874
48. Shimada A, Mason CA, Morrison ME (1998) TrkB signaling modulates spine density and morphology independent of dendrite structure in cultured neonatal Purkinje cells. J Neurosci 18: 8559-8570
49. Small JV (1968) Measurement of section thickness. In: Bocciarelli DS (ed) Proceedings, 4th European Congress on Electron Microscopy, vol 1. Tipografia Pogliglotta Vaticana, Roma, pp 609-610
50. Sterio PC (1984) The unbiased estimation of the number and sizes of arbitrary particles using the disector. J Microsc 134: 127-136
51. Sweetser DA, Kapur RP, Froelick GJ, Kafer KE, Palmiter RD (1997) Oncogenesis and altered differentiation induced by activated Ras in neuroblasts of transgenic mice. Oncogene 15: 2783-2794
52. Taschenberger H, Leao RM, Rowland KC, Spirou GA, Gersdorff H (2002) Optimizing synaptic architecture and efficiency for high-frequency transmission. Neuron 36: 1127-1143
53. Tyler WJ, Pozzo-Miller LD (2001) BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapses. J Neurosci 21: 4249-4258
54. Vicario-Abejon C, Collin C, McKay RD, Segal M (1998) Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. J Neurosci 18: 7256-7271
55. Vicario-Abejon C, Owens D, McKay R, Segal M (2002) Role of neurotrophins in central synapse formation and stabilization. Nat Rev Neurosci 3: 965-974
56. Weibel E (ed) (1979) Stereological methods, vol 1. Practical methods for biological morphometry. Academic Press, New York
57. Xue L, Murray JH, Tolkovsky AM (2000) The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons. J Biol Chem 275: 8817-8824
58. Zhang X, Poo M-m (2002) Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon. Neuron 36: 675-688