Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 2877-2887

  Bluhm, Ullvi ^a   Boucher, Jean Luc ^b   Buss, Uwe ^a   Clement, Bernd ^a   Friedrich, Friederike ^a   Girreser, Ulrich ^a   Heber, Dieter ^a   Lam, Thanh ^a   Lepoivre, Michel ^c   Rostaie Gerylow, Mojgan ^a   Wolschendorf, Ulrich ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c CNRS   (France)

Author keywords

Inhibitors; Isoform selectivity; Nitric oxide synthase; Pyrido 1,2 a pyrimidines

Indexed keywords

3 (3' FLUORO 4' METHOXYBENZOYL) 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 (3',4' DICHLOROBENZOYL) 3,4 DIHYDRO 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 (4' BROMOBENZOYL) 3,4 DIHYDRO 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 (4' CHLOROBENZOYL) 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 (4' CYANOBENZOYL) 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 (4' FLUOROBENZOYL) 3,4 DIHYDRO 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 (4' FLUOROBENZOYL) 3,4 DIHYDRO 6 METHYL 2 PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 [4' (4'' BROMOBENZYLOXY)BENZOYL] 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 [4' (4'' BROMOPHENYL)BENZOYL] 3,4 DIHYDRO 6 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 [4' (4'' BROMOPHENYL)BENZOYL] 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 [4' (4'' CHLOROBENZYLOXY)BENZOYL] 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 [4' (4'' CYANOBENZYLOXY)BENZOYL] 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 [4' (4'' CYANOPHENYL)BENZOYL] 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE; 3 [4' (4'' METHOXYPHENYL)BENZOYL] 3,4 DIHYDRO 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE; 3 BENZOYL 3,4 DIHYDRO 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 BENZOYL 3,4 DIHYDRO 6 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3 BENZOYL 3,4 DIHYDRO 9 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 3 (3',4' DIMETHOXYBENZOYL) 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 3 (3',4' DIMETHOXYBENZOYL) 6 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 3 (3',4' DIMETHOXYBENZOYL) 9 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 3 (4' FLUOROBENZOYL) 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 3 (4' HYDROXYBENZOYL) 8 METHYL 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 3 (4' METHYLBENZOYL) 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 6 METHYL 3 (4' METHYLBENZOYL) 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 6 METHYL 3 [2 (6 METHYLNAPHTHOYL)] 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 6,8 DIMETHYL 3 [2 (6 METHYLNAPHTHOYL)] 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; 3,4 DIHYDRO 8 METHYL 3 [2 (6 METHYLNAPHTHOYL)] 2H PYRIDO[1,2 A]PYRIMIDINE PERCHLORATE; NITRIC OXIDE SYNTHASE INHIBITOR; PYRIDO[1,2 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; ENZYME INHIBITION; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ETHYLENEDIAMINES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME; HUMANS; ISOENZYMES; MACROPHAGES; MICE; NADP; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PYRIMIDINES; RADIOACTIVITY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFANILAMIDES;

EID: 67349116824     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.12.007     Document Type: Article

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