N-phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: Structure-activity studies and demonstration of in vivo activity

Journal of Medicinal Chemistry

Volumn 41, Issue 15, 1998, Pages 2858-2871

  Collins, Jon L ^a,b   Shearer, Barry G ^b   Oplinger, Jeffrey A ^b   Lee, Shuliang ^b   Garvey, Edward P ^b   Salter, Mark ^c   Duffy, Claire ^c   Burnette, Thimysta C ^b   Furfine, Eric S ^b  

^a SARCO Inc   (United States)

^b GLAXOSMITHKLINE   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDINE DERIVATIVE; N [3 (AMINOMETHYL)PHENYL]ACETAMIDINE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; BRAIN ISCHEMIA; CALCIUM TRANSPORT; DRUG PENETRATION; ENZYME INDUCTION; ENZYME INHIBITION; MITOCHONDRIAL RESPIRATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

AMIDINES; ANIMALS; CEREBELLUM; CEREBRAL CORTEX; ENZYME INHIBITORS; FURANS; HUMANS; ISOENZYMES; MALE; NEURONS; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031853450     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980072p     Document Type: Article

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