Gene expression in canine atopic dermatitis and correlation with clinical severity scores

Journal of Dermatological Science

Volumn 55, Issue 1, 2009, Pages 27-33

  Wood, Shona H ^a,b   Clements, Dylan N ^c   Ollier, William E ^b   Nuttall, Tim ^a   McEwan, Neil A ^a   Carter, Stuart D ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Atopic dermatitis; Canine; qPCR; Severity scores

Indexed keywords

CADHERIN 13; CALGRANULIN A; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CHYMASE; CULLIN 4A; DIPEPTIDYL PEPTIDASE IV; ISOENZYME; MESSENGER RNA; PADGEM PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 5 PHOSPHATASE 2; PLAKOPHILIN 2; PROTEIN DERIVATIVE; SERINE PROTEASE INHIBITOR KAZAL TYPE 5; SERINE PROTEINASE INHIBITOR; SERUM AMYLOID A1; SPHINGOSINE 1 PHOSPHATE LYASE 1; STEFIN A; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGY TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DISEASE SEVERITY; EXPERIMENTAL DOG; FEMALE; GENE EXPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; SKIN BIOPSY;

ALLERGENS; ANIMALS; BASE SEQUENCE; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SKIN; SKIN TESTS;

EID: 67349091006     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2009.03.005     Document Type: Article

References (53)

1. Olivry T., and Hill P.B. The ACVD task force on canine atopic dermatitis (VIII): is the epidermal lipid barrier defective?. Vet Immunol Immunopathol 81 September (2001) 215-218
2. VickeryF B.P. Skin barrier function in atopic dermatitis. Curr Opin Pediatr 19 (2007) 89-93
3. Hiller A., and Griffin C.E. The ACVD task force on canine atopic dermatitis (I): incidence and prevalence. Vet Immunol Immunopathol 81 September (2001) 147-151
4. Williams H.C. Is the prevalence of atopic dermatitis increasing?. Clin Exp Dermatol 17 (1992) 385-391
5. Sutter N.B., Eberle M.A., Parker H.G., Puller B.J., Kirkness E.F., Kruglyak L., and Ostrander E.A. Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res 14 December (2004) 2388-2396
6. Starkey M.P., Scase T.J., Mellersh C.S., and Murphy S. Dogs really are man's best friend-canine genomics has applications in veterinary and human medicine!. Brief Funct Genomic Proteomic 4 (2005) 112-128
7. Nuttall T.J., Knight P.A., and McAleese S.M. Expression of T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis. Clin Exp Allergy 32 (2002) 789-795
8. Merryman-Simpson A.E., Wood S.H., Fretwell N., Jones P.G., McLaren W.M., McEwan N.A., et al. Gene (mRNA) expression in canine atopic dermatitis: microarray analysis. Vet Dermatol 19 April (2008) 59-66
9. Morar N., Willis-Owen S.A.G., Moffatt M.F., and Cookson W.O.C.M. The genetics of atopic dermatitis. J Allergy Clin Immunol 118 (2006) 24-34
10. Kato T., Takai T., Mitsuishi K., Okumura K., and Ogawa H. Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: Biochemical skin barrier against mite cysteine proteases. J Allergy Clin Immunol 116 (2005) 169-176
11. Vasilopoulos Y., Cork M.J., Teare D., Marinou I., Ward S.J., Duff G.W., et al. A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis. Allergy 62 (2007) 514-519
12. Weidinger S., Klopp N., Rummler L., Wagenpfeil S., Novak N., Baurecht H.J., et al. Association of NOD1 polymorphisms with atopic eczema and related phenotypes. J Allergy Clin Immunol 116 (2005) 177-184
13. de Mora F., de la Fuente C., Jasmin P., Gatto H., Marco A., Ferrer L., et al. Evaluation of the expression of P-selectin, ICAM-1, and TNF-alpha in bacteria-free lesional skin of atopic dogs with low-to-mild inflammation. Vet Immunol Immunopathol 115 February (2007) 223-229
14. Wang H.B., Wang J.T., Zhang L., Geng Z.H., Xu W.L., Xu T.H., et al. P-selectin primes leukocyte integrin activation during inflammation. Nat Immunol 8 (2007) 882-892
15. Green K.J., and Jones J.C. Desmosomes and hemidesmosomes: structure and function of molecular components. FASEB J 10 (1996) 871-881
16. Dahten A., Mergemeier S., and Worm M. PPARgamma expression profile and its cytokine driven regulation in atopic dermatitis. Allergy 62 (2007) 926-933
17. Schmuth M., Jiang Y.J., Dubrac S., Elias P.M., and Feingold K.R. Peroxisome proliferator-activated receptors (PPAR) and liver X receptors (LXR) in epidermal biology. J Lipid Res 49 3 (2008) 499-509 (Epub January)
18. Seo E.-Y., Park G.Y., Lee K.-M., Kim J.-A., Lee J.-H., and Yang J.-M. Identification of target genes of atopic dermatitis by real time PCR. J Invest Dermatol 126 (2006) 1187-1189
19. Bonness S., and Bieber T. Molecular basis of atopic dermatitis. Curr Opin Allergy Clin Immunol 7 (2007) 382-386
20. Park Y.D., Lyou Y.J., Lee K.J., Lee D.Y., and Yang J.M. Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Clin Exp Allergy 36 (2006) 649-657
21. Max X.Q., Shirakawa T., Yoshikawa T., Yoshikawa K., Kawai M., Sasaki S., et al. Association between genetic variants of mast-cell chymase and eczema. Lancet 348 August (1996) 581-583
22. Weidinger S., Rummler L., Klopp N., Wagenpfeil S., Baurecht H.J., Fischer G., et al. Association study of mast cell chymase polymorphisms with atopy. Allergy 60 (2005) 1256-1261
23. Bock O. Expression of dipeptidyl-peptidase IV (CD26) on CD8+ T cells is significantly decreased in patients with psoriasis vulgaris and atopic dermatitis. Exp Dermatol 10 (2001) 414-419
24. Nishio Y., Noguchi E., Shibasaki M., Kamioka M., Ichikawa E., Ichikawa K., et al. Association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese. Genes Immun 4 (2003) 515-517
25. Kato A., Fukai K., Oiso N., Hosomi N., Murakami T., and Ishii M. Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population. Br J Dermatol 148 (2003) 665-669
26. Thorn Z.Y.L. Regulation of the human acute phase serum amyloid A genes by tumour necrosis factor-α, interleukin-6 and glucocorticoids in hepatic and epithelial cell lines. Scand J Immunol 59 (2004) 152-158
27. DeBoer D.J., and Hillier A. The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis. Vet Immunol Immunopathol 81 September (2001) 271-276
28. Olivry T., Marsella R., Iwasaki T., and Mueller R. Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis. Vet Dermatol 18 April (2007) 78-86
29. Clements D.N., Vaughan-Thomas A., Peansukmanee S., Carter S.D., Innes J.F., Ollier W.E., et al. Assessment of the use of RNA quality metrics for the screening of articular cartilage specimens from clinically normal dogs and dogs with osteoarthritis. Am J Vet Res 67 (2006) 1438-1444
30. Wood S.H., Clements D.N., McEwan N.A., Nuttall T., and Carter S.D. Reference genes for canine skin when using quantitative real time PCR. Vet Immunol Immunopathol 126 (3-4) August (2008) 392-395
31. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3 7 (2002) research0034.1-research0034.11
32. Mohammadi M., and Day F.J.R. Oligonucleotides used as template calibrators for general application in quantitative polymerase chain reaction. Anal Biochem 335 December (2004) 299-304
33. Benoit S., Toksoy A., Ahlmann M., Schmidt M., Sunderkotter C., Foell D., et al. Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis. Br J Dermatol 155 (2006) 62-66
34. Tridandapani S., Wang Y., Yijie M., Clay B., and Anderson C.L. Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-κβ-mediated gene transcription by phagocytic FcγRs in human myeloid cells. J Immunol 169 October (2002) 4370-4378
35. Kashiwada M., Cattoretti G., McKeag L., Rouse T., Showalter B.M., Al-Alem U., et al. Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5′-phosphatase are required for regulation of CD4+CD25 + T cell development. J Immunol 176 April (2006) 3958-3965
36. Busso N., Wagtmann N., Herling C., Chobaz-Peclat V., Bischof-Delaloye A., So A., et al. Circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Am J Pathol 166 February (2005) 433-442
37. Ghersi G., Dong H., Goldstein L.A., Yeh Y., Hakkinen L., Larjava H.S., et al. Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex. J Biol Chem 277 August (2002) 29231-29241
38. Chen X., Bonne S., Hatzfeld M., van Roy F., and Green K.J. Protein Binding and Functional Characterization of Plakophilin 2. Evidence for its Diverse roles in desmosomes and beta -catenin signalling. J Biol Chem 277 March (2002) 10512-10522
39. Ding L., Shen s., Lino A.C., Curotto de Lafaille M.A., and Lafaille J.J. Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells. Nat Med 14 (2008) 162-169
40. Avgerinou G.G., Andreas V., Stavropoulos P.G., and Katsambas A.D. Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis. Br J Dermatol 47 March (2008) 219-224
41. Sertznig P., Seifert M., Tilgen W., and Reichrath J. Peroxisome Proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases. Am J Clin Dermatol 9 1 (2008) 15-31
42. Palmer C.N., Irvine A.D., Terron-Kwiatkowski A., Zhao Y., Liao H., Lee S.P., et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 38 (2006) 441-446
43. Moffatt M.F. SPINK5: A gene for atopic dermatitis and asthma. Clin Exp Allergy 34 (2004) 325-327
44. Komatsu N., Takata M., Otsuki N., Ohka R., Amano O., Takehara K., et al. Elevated stratum corneum hydrolytic Activity in Netherton Syndrome Suggests an inhibitory regulation of desquamation by SPINK5-derived peptide. J Invest Dermatol 118 (2002) 436-443
45. Tartaglia-Polcini A., Bonnart C., Micheloni A., Cianfarani F., Andre A., Zambruno G., et al. SPINK5, the defective gene in Netherton Syndrome, encodes multiple LEKTI isoforms derived from alternative pre-mRNA processing. J Invest Dermatol 126 December (2005) 315-324
46. Greenbaum D., Colangelo C., Williams K., and Gerstein M. Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol 4 (2003) 117
47. Hla T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol Res 47 (2003) 401-407
48. Reiss U., Oskouian B., Zhou J., Gupta V., Sooriyakumaran P., Kelly S., Wang E., et al. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem 279 January (2004) 1281-1290
49. Herzinger T., Kleuser B., Schafer-Korting M., and Korting H.C. Sphingosine-1-Phosphate Signaling and the Skin. Am J Clin Dermatol 8 (2007) 329-336
50. Olivry T., Dunston S.M., Pluchino K., Porter K., and Hammerberg B. Lack of detection of circulating skin-specific IgE autoantibodies in dogs with moderate or severe atopic dermatitis. Vet Immunol Immunopathol 122 March (2008) 182-187
51. Hill P.B., Hillier A., and Olivry T. The ACVD task force on canine atopic dermatitis (VI): IgE-induced immediate and late-phase reactions, two inflammatory sequences at sites of intradermal allergen injections. Vet Immunol Immunopathol 81 (2001) 199-204
52. Nodtvedt A., Bergvall K., Sallander M., Egenvall A., Emanuelson U., and Hedhammar A. A case-control study of risk factors for canine atopic dermatitis among boxer, bullterrier and West Highland white terrier dogs in Sweden. Vet Dermatol 18 (2007) 309-315
53. Bisgaard H., Simpson A., Palmer C.N., Bønnelykke K., Mclean I., Mukhopadhyay S., et al. Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLoS Med 5 (2008) e131