Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis

British Journal of Dermatology

Volumn 155, Issue 1, 2006, Pages 62-66

  Benoit, S ^a   Toksoy, A ^a   Ahlmann, M ^b   Schmidt, M ^c   Sunderkotter C ^b   Foell, D ^b   Pasparakis, M ^d   Roth, J ^b   Goebeler, M ^a,c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

Author keywords

MRP14; MRP8; Psoriasis; S100A8; S100A9

Indexed keywords

CALCIUM BINDING PROTEIN; MESSENGER RNA; S100 CALCIUM BINDING PROTEIN A8; S100 CALCIUM BINDING PROTEIN A9; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KERATINOCYTE; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; PSORIASIS; UPREGULATION;

ACUTE DISEASE; ADULT; AGED; BIOLOGICAL MARKERS; CALGRANULIN A; CALGRANULIN B; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KERATINOCYTES; MALE; MIDDLE AGED; PSORIASIS; UP-REGULATION;

EID: 33745035454     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2006.07198.x     Document Type: Article

References (23)

1. Schmidt M Goebeler M Posern G et al. Ras-independent activation of the Raf/MEK/Erk pathway upon calcium-induced differentiation of keratinocytes. J Biol Chem 2000 275: 41011 17.
2. Tu CL Oda Y Komuves L et al. The role of the calcium-sensing receptor in epidermal differentiation. Cell Calcium 2004 35: 265 73.
3. Eckert RL Broome AM Ruse M et al. S100 proteins in the epidermis. J Invest Dermatol 2004 123: 23 33.
4. Mischke D Korge BP Marenholz I et al. Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex ('epidermal differentiation complex') on human chromosome 1q21. J Invest Dermatol 1996 106: 989 92.
5. Madsen P Rasmussen HH Leffers H et al. Molecular cloning, occurrence, and expression of a novel partially secreted protein 'psoriasin' that is highly up-regulated in psoriatic skin. J Invest Dermatol 1991 97: 701 12.
6. Broome AM Ryan D Eckert RL. S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem 2003 51: 675 85.
7. Mirmohammadsadegh A Tschakarjan E Ljoljic A et al. Calgranulin C is overexpressed in lesional psoriasis. J Invest Dermatol 2000 114: 1207 8.
8. Quekenborn-Trinquet V Fogel P Aldana-Jammayrac O et al. Gene expression profiles in psoriasis: analysis of impact of body site location and clinical severity. Br J Dermatol 2005 152: 489 504.
9. Steinbakk M Naess-Andresen CF Lingaas E et al. Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin. Lancet 1990 336: 763 5.
10. Foell D Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004 50: 3762 71.
11. Frosch M Strey A Vogl T et al. Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum 2000 43: 628 37.
12. Schmidt M Gillitzer R Toksoy A et al. Selective expression of calcium-binding S100A8 and S100A9 at distinct sites of hair follicles. J Invest Dermatol 2001 117: 748 50.
13. Odink K Cerletti N Brüggen J et al. Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature 1987 330: 80 2.
14. Pasparakis M Courtois G Hafner M et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 2002 417: 861 6.
15. Thorey IS Roth J Regenbogen J et al. The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes. J Biol Chem 2001 276: 35818 25.
16. Katz AB Taichman LB. A partial catalog of proteins secreted by epidermal keratinocytes in culture. J Invest Dermatol 1999 112: 818 21.
17. Rammes A Roth J Goebeler M et al. Myeloid-related protein (MRP)8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem 1997 272: 9496 502.
18. Roth J Vogl T Sorg C et al. Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol 2003 24: 155 8.
19. Viemann D Strey A Janning A et al. Myeloid-related protein 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood 2005 105: 2955 62.
20. Clohessy PA Golden BE. Calprotectin-mediated zinc chelation as a biostatic mechanism in host defence. Scand J Immunol 1995 42: 551 6.
21. Sohnle PG Hunter MJ Hahn B et al. Zinc-reversible antimicrobial activity of recombinant calprotectin (migration inhibitory factor-related proteins 8 and 14). J Infect Dis 2000 182: 1272 5.
22. Glaser R Harder J Lange H et al. Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat Immunol 2005 6: 57 64.
23. Nomura I Goleva E Howell MD et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 2003 171: 3262 9.