PPARγ expression profile and its cytokine driven regulation in atopic dermatitis

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 62, Issue 8, 2007, Pages 926-933

  Dahten, A ^a   Mergemeier, S ^b   Worm, M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Allergy Center Charité Campus Mitte Universitätsmedizin Berlin ^*  (Germany)

Author keywords

Atopic dermatitis; Cytokines; Monocytes; PPAR ; T cells

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; INTERLEUKIN DERIVATIVE;

ADULT; ARTICLE; ATOPIC DERMATITIS; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SKIN DEFECT; UPREGULATION; BIOSYNTHESIS; BLOOD; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METHODOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; CYTOKINES; DERMATITIS, ATOPIC; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKINS; MALE; PPAR GAMMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 34447131528     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2007.01444.x     Document Type: Article

References (39)

1. Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol 2003 112 : S118 S127.
2. Leung DY, Bieber T. Atopic dermatitis. Lancet 2003 361 : 151 160.
3. Zingarelli B, Cook JA. Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation. Shock 2005 23 : 393 399.
4. Greene M, Blumberg B, McBride OW, Yi HF, Kronquist K, Kwan K. Isolation of the human PPAPgamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr 1995 4 : 281 299.
5. Chtanova T, Kemp RA, Sutherland AP, Ronchese F, Mackay CR. Gene microarrays reveal extensive differential gene expression in both CD4(+) and CD8(+) type 1 and type 2 T cells. J Immunol 2001 167 : 3057 3063.
6. Greene ME, Pitts J, McCarville MA, Wang XS, Newport JA, Edelstein C et al. PPARgamma: observations in the hematopoietic system. Prostaglandins Other Lipid Mediat 2000 62 : 45 73.
7. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998 391 : 79 82.
8. Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre AM, Saladin R et al. The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem 1997 272 : 18779 18789.
9. Fajas L, Fruchart JC, Auwerx J. PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter. FEBS Lett 1998 438 : 55 60.
10. Sundvold H, Lien S. Identification of a novel peroxisome proliferator-activated receptor (PPAR) gamma promoter in man and transactivation by the nuclear receptor RORalpha1. Biochem Biophys Res Commun 2001 287 : 383 390.
11. Huang JT, Welch MR, Ricote M, Binder CJ, Willson TM, Kelly C et al. IL-4 dependent production of PPARgamma ligands in macrophages by 12/15-lipooxygenase. Nature 1999 400 : 378 382.
12. Tanaka T, Itoh H, Doi K, Fukunaga Y, Hosoda K, Shintani M et al. Down regulation of peroxisome proliferator-activated receptorgamma expression by inflammatory cytokines and its reversal by thiazolidinediones. Diabetologia 1999 42 : 702 710.
13. Ellis CN, Varani J, Fisher GJ, Zeigler ME, Pershadsingh HA, Benson SC et al. Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol 2000 136 : 609 616.
14. Trifilieff A, Bench A, Hanley M, Bayley D, Campbell E, Whittaker P. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol 2003 139 : 163 171.
15. Mueller C, Weaver V, Vanden Heuvel JP, August A, Cantorna MT. Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. Arch Biochem Biophys 2003 418 : 186 196.
16. Ruhl R, Dahten A, Schweigert FJ, Herz U, Worm M. Inhibition of IgE-production by peroxisome proliferator-activated receptor ligands. J Invest Dermatol 2003 121 : 757 764.
17. Hanifin JM, Rajka G. Diagnostic features of atopic dermatits. Acta Dermatol Venerol 1980 Suppl. 92 44 47.
18. Kunz B, Oranje AP, Labreze L, Stalder JF, Ring J, Taieb A. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology 1997 195 : 10 19.
19. Oranje AP, Stalder JF, Taieb A, Tasset C, de Longueville M. Scoring of atopic dermatitis by SCORAD using a training atlas by investigators from different disciplines. ETAC Study Group. Early Treatment of the Atopic Child. Pediatr Allergy Immunol 1997 8 : 28 34.
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001 25 : 402 408.
21. Debril MB, Renaud JP, Fajas L, Auwerx J. The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J Mol Med 2001 79 : 30 47.
22. Lee KS, Park SJ, Hwang PH, Yi HK, Song CH, Chai OH et al. PPAR-gamma modulates allergic inflammation through up-regulation of PTEN. FASEB J 2005 19 : 1033 1035.
23. Daynes RA, Jones DC. Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2002 2 : 748 759.
24. Clark RB. The role of PPARs in inflammation and immunity. J Leukoc Biol 2002 71 : 388 400.
25. Jones DC, Ding X, Daynes RA. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem 2002 277 : 6838 6845.
26. Clark RB, Bishop-Bailey D, Estrada-Hernandez T, Hla T, Puddington L, Padula SJ. The nuclear receptor PPARg and immunregulation: PPARg mediates inhibition of helper T cell responses. American Association of Immunologists 2000 164 : 1364 1317.
27. Wang P, Anderson PO, Chen S, Paulsson KM, Sjogren HO, Li S. Inhibition of the transcription factors AP-1 and NF-kappaB in CD4 T cells by peroxisome proliferator-activated receptor gamma ligands. Int Immunopharmacol 2001 1 : 803 812.
28. Akdis CA, Blaser K, Akdis M. Apoptosis in tissue inflammation and allergic disease. Curr Opin Immunol 2004 16 : 717 723.
29. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest 2004 113 : 651 657.
30. Abramovits W. Atopic dermatitis. J Am Acad Dermatol 2005 53 : S86 S93.
31. Honda K, Marquillies P, Capron M, Dombrowicz D. Peroxisome proliferator-activated receptor gamma is expressed in airways and inhibits features of airway remodeling in a mouse asthma model. J Allergy Clin Immunol 2004 113 : 882 888.
32. Boguniewicz M, Schmid-Grendelmeier P, Leung DY. Atopic dermatitis. J Allergy Clin Immunol 2006 118 : 40 43.
33. Desvergene B, Wahli W. PPARs: nuclear control of metabolism. Endocr Rev 1999 20 : 649 688.
34. Harris SG, Phipps RP. The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. Eur J Immunol 2001 31 : 1098 1105.
35. Hornung D, Waite LL, Ricke EA, Bentzien F, Wallwiener D, Taylor RN. Nuclear peroxisome proliferator-activated receptors alpha and gamma have opposing effects on monocyte chemotaxis in endometriosis. J Clin Endocrinol Metab 2001 86 : 3108 3114.
36. Padilla J, Leung E, Phipps RP. Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. Clin Immunol 2002 103 : 22 33.
37. Floyd ZE, Stephens JM. Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes. J Biol Chem 2002 277 : 4062 4068.
38. Ricote M, Welch JS, Glass CK. Regulation of macrophage gene expression by the peroxisome proliferator-activated receptor-gamma. Horm Res 2000 54 : 275 280.
39. Hamid Q, Boguniewicz M, Leung DY. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 1994 94 : 870 876.