Principles of transcutaneous immunization using cholera toxin as an adjuvant

Vaccine

Volumn 17, Issue SUPPL. 2, 1999, Pages

  Scharton Kersten, Tanya ^a,b   M Glenn, Gregory ^a,b   Vassell, Russell ^a,b   Yu, Jian Mei ^a,b   Walwender, Deborah ^a,b   R Alving, Carl ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b IOMAI Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; DIPHTHERIA TOXOID; H2 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; LYSOZYME;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; CONFERENCE PAPER; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, CUTANEOUS; ANIMALS; CHOLERA TOXIN; DIPHTHERIA TOXOID; HUMANS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MURAMIDASE;

EID: 0033214329     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00233-9     Document Type: Conference Paper

References (17)

1. Katz S.L. Future vaccines and a global perspective. Lancet. 13:1997;1767-1770.
2. Reis E.C., Jacobson R.M., Tarbell S., Weninger B.G. Taking the sting out of shots: control of vaccination-associated pain and adverse reactions. Pediatr. Ann. 27:1998;375-386.
3. Liu M.A. Vaccine developments. Nature Med. 4:1998;515-519.
4. Glenn G.M., Rao M., Matyas G., Alving C.R. Skin immunization made possible by cholera toxin. Nature. 391:1998;851.
5. Glenn GM, Scharton-Kersten T, Vassell R, Matyas GR, Alving CR. Transcutaneous immunization using bacterial ADP-ribosylating exotoxins as antigens and adjuvants. Infection and Immunity 1999; 67:1100-1106.
6. Glenn G.M., Scharton-Kersten T., Vassell R., Mallett C.P., Hale T.L., Alving C.R. Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge. J. Immunol. 161:1998;3211-3214.
7. Lycke N. The mechanism of cholera toxin adjuvanticity. Res. Immunol. 148:1997;504-520.
8. Marchetti M., Rossi M., Giannelli V., Giuliani M.M., Pizza M., Censini S., Covacci A., Massari P., Pagliaccia C., Manetti R., Telford J.L., Douce G., Dougan G., Rappuoli R., Ghiara P. Protection against Helicobactor pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine. 16:1998;33-37.
9. Komase K., Tamura S., Matsuo K., Watanabe K., Hattori N., Odaka A., Suzuki Y., Kurata T., Aizawa C. Mutants of Escherichia coli heat-labile enterotoxin as an adjuvant for nasal influenza vaccine. Vaccine. 16:1998;248-254.
10. Rappuoli R., Pizza M. Novel molecular biology approaches to acellular vaccines. Biotech. Ann. 2:1996;391-408.
11. O' Hagan D.T. Recent advances in vaccine adjuvants for systemic and mucosal administration. J. Pharm. Pharmacol. 49:1997;1-10.
12. Elson C.O., Ealding W. Genetic control of the murine immune response to cholera toxin. J. Immunol. 135:1985;930-932.
13. Elson C.O., Ealding W. Ir gene control of the murine secretory IgA response to cholera toxin. Eur. J. Immunol. 17:1987;425-428.
14. Elson C.O. Cholera toxin as a mucosal adjuvant: effects of H-2 major histocompatibility complex and lps genes. Inf. Immun. 60:1992;2874-2879.
15. Hill S.W., Sercarz E.E. Fine specificity of the H-2 linked immune response gene for the gallinaceous lysozymes. Eur. J. Immunol. 5:1975;317-324.
16. Kameyama S., Nagaoka F., Matuhasi T. Comparison of immune responses to diphtheria and tetanus toxoids of various mouse strains. Japan J. Med. Sci. Biol. 42:1989;83-99.
17. Katoh N., Hirano S., Kishimoto S., Yasuno H. Acute cutaneous barrier perturbation induces maturation of Langerhans' cells in hairless mice. Acta. Dermato-Venereologica. 77:1997;365-369.