Modification of lipid a biosynthesis in Neisseria meningitidis lpxL mutants: Influence on lipopolysaccharide structure, toxicity, and adjuvant activity

Infection and Immunity

Volumn 69, Issue 10, 2001, Pages 5981-5990

  Van Der Ley, P ^a   Steeghs, L ^a   Hamstra, H J ^a   Ten Hove, J ^a   Zomer, B ^a   Van Alphen, L ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DISACCHARIDE; GLUCOSAMINE; LIPID A; LIPOPOLYSACCHARIDE; OLIGOSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; VACCINE;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ARTICLE; BACTERIUM MUTANT; CHEMICAL STRUCTURE; ESCHERICHIA COLI; GENE INACTIVATION; IMMUNIZATION; LIPOGENESIS; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; TOXICITY;

ACYLTRANSFERASES; ADJUVANTS, IMMUNOLOGIC; ANIMALS; BACITRACIN; BACTERIAL PROTEINS; ESCHERICHIA COLI PROTEINS; LIPID A; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; MUTAGENESIS, INSERTIONAL; NEISSERIA MENINGITIDIS; NOVOBIOCIN; RIFAMPIN; TETRACYCLINE;

EID: 0034826561     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.10.5981-5990.2001     Document Type: Article

References (39)

1. Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity
2. Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction at 12°C of an acyltransferase specific for palmitoleoyl-acyl carrier protein
3. Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A
4. Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A
5. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes
6. Electrospray mass spectrometry for characterization of lipid A from Enterobacter agglomerans
7. Lipopolysaccharide from an Escherichia coli htrB msbB mutant induces high levels of MIP-1α secretion without inducing TNF-α and IL-1β
8. Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis
9. Cloning and molecular analysis of the gaIE gene of Neisseria meningitidis and its role in lipopolysaccharide biosynthesis
10. Study of the role of the htrB gene in Salmonella typhimurium virulence
11. Isolation and characterization of the Escherichia coli htrB gene, whose product is essential for bacterial viability above 33°C in rich media
12. Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB
13. A lethal role for lipid A in Salmonella infections
14. The Toll-receptor family and control of innate immunity
15. Structural characterization of the lipid A component of pathogenic Neisseria meningitidis
16. Mutation of the htrB locus of Haemophilus influenzae non-typable strain 2019 is associated with modifications of lipid A and phosphorylation of the lipo-oligosaccharide
17. Increased resolution of lipopolysaccharides and lipooligosaccharides utilising tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis
18. htrB of Haemophilus influenzae: Determination of biochemical activity and effects on virulence and lipooligosaccharide toxicity
19. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
20. Development of a meningococcal vaccine
21. Location of fatty acids in lipid A obtained from lipopolysaccharide of Rhodopseudomonas sphaeroides ATCC 17023
22. Bacterial polysaccharide synthesis and gene nomenclature
23. The chemical structure of bacterial endotoxin in relation to bioactivity
24. A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide
25. Meningitis bacterium is viable without endotoxin
26. Immunogenicity of outer membrane proteins in an LPS-deficient mutant of Neisseria meningitidis: Influence of adjuvants on the immune response
27. Mutation of the htrB gene in a virulent Salmonella typhimurium strain by intergeneric transduction: Strain construction and phenotypic characterization
28. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
29. A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels
30. Outer membrane permeability barrier in Escherichia coli mutants that are defective in the late acyltransferases of lipid A biosynthesis
31. Use of transformation to construct antigenic hybrids of the class 1 outer membrane protein in Neisseria meningitidis
32. Construction of Neisseria meningitidis strains carrying multiple chromosomal copies of the porA gene for use in the production of a multivalent outer membrane vesicle vaccine
33. Identification of a locus involved in meningococcal lipopolysaccharide biosynthesis by deletion mutagenesis
34. Bacterial lipopolysaccharide extraction with phenol-water and further application of the procedure
35. Analytical properties of the nanoelectrospray ion source
36. Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid A and phospholipid biosynthesis
37. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes
38. New and improved vaccines against meningococcal disease