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Volumn 4, Issue 3, 2009, Pages 343-353

Omega-3 fatty acids: Their neuroprotective and regenerative potential in traumatic neurological injury

Author keywords

Long chain omega 3 fatty acid; Neuroprotection; Neuroregeneration; Spinal cord injury; Traumatic brain injury

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; INTERLEUKIN 1; INTERLEUKIN 6; LINOLEIC ACID; NITRIC OXIDE; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PIOGLITAZONE; PRESENILIN 1; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

EID: 67249145092     PISSN: 17460875     EISSN: None     Source Type: Journal    
DOI: 10.2217/CLP.09.19     Document Type: Review
Times cited : (12)

References (92)
  • 1
    • 0036517387 scopus 로고    scopus 로고
    • Efficiency of conversion of α-linolenic acid to long chain n-3 fatty acids in man
    • Brenna JT: Efficiency of conversion of α-linolenic acid to long chain n-3 fatty acids in man. Curr. Opin. Clin. Nutr. Metab. Care 5, 127-132 (2002).
    • (2002) Curr. Opin. Clin. Nutr. Metab. Care , vol.5 , pp. 127-132
    • Brenna, J.T.1
  • 3
    • 67249154549 scopus 로고    scopus 로고
    • Evolutionary aspects of diet, the omega-3:omega-6 ratio and genetic variation: Nutritional implications for genetic diseases
    • Simopoulos AP: Evolutionary aspects of diet, the omega-3:omega-6 ratio and genetic variation: nutritional implications for genetic diseases. Biomed. Pharmacother. 60, 2-7 (2006).
    • (2006) Biomed. Pharmacother , vol.60 , pp. 2-7
    • Simopoulos, A.P.1
  • 4
    • 46449123205 scopus 로고    scopus 로고
    • The importance of the omega-6:omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    • Simopoulos AP: The importance of the omega-6:omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. 233, 674-688 (2008).
    • (2008) Exp. Biol. Med , vol.233 , pp. 674-688
    • Simopoulos, A.P.1
  • 6
    • 37249002275 scopus 로고    scopus 로고
    • Whole body distribution of deuterated linoleic and α-linolenic acids and their metabolites in the rat
    • Lin YH, Salem N Jr: Whole body distribution of deuterated linoleic and α-linolenic acids and their metabolites in the rat. J. Lipid Res. 48, 2709-2724 (2007).
    • (2007) J. Lipid Res , vol.48 , pp. 2709-2724
    • Lin, Y.H.1    Salem Jr, N.2
  • 7
    • 36649024853 scopus 로고    scopus 로고
    • The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition
    • Brenna JT, Diau GY: The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. Prostaglandins Leukot. Essent. Fatty Acids 77, 247-250 (2007).
    • (2007) Prostaglandins Leukot. Essent. Fatty Acids , vol.77 , pp. 247-250
    • Brenna, J.T.1    Diau, G.Y.2
  • 8
    • 1842453667 scopus 로고    scopus 로고
    • Docosahexaenoic acid in the diet: Its importance in maintenance and restoration of neural membrane function
    • Horrocks LA, Farooqui AA: Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. Prostaglandins Leukot. Essent. Fatty Acids 70, 361-372 (2004).
    • (2004) Prostaglandins Leukot. Essent. Fatty Acids , vol.70 , pp. 361-372
    • Horrocks, L.A.1    Farooqui, A.A.2
  • 9
    • 0038734360 scopus 로고    scopus 로고
    • Long-chain n-3 fatty acids and inflammation: Potential application in surgical and trauma patients
    • Calder PC: Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients. Braz. J. Med. Biol. Res. 36, 433-446 (2003).
    • (2003) Braz. J. Med. Biol. Res , vol.36 , pp. 433-446
    • Calder, P.C.1
  • 10
    • 0037971463 scopus 로고    scopus 로고
    • n-3 polyunsaturated fatty acids and inflammation: From molecular biology to the clinic
    • Calder PC: n-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 38, 343-352 (2003).
    • (2003) Lipids , vol.38 , pp. 343-352
    • Calder, P.C.1
  • 11
    • 3843115666 scopus 로고    scopus 로고
    • Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency
    • Niu SL, Mitchell DC, Lim S-Y et al.: Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. J. Biol. Chem. 279, 31098-31104 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 31098-31104
    • Niu, S.L.1    Mitchell, D.C.2    Lim, S.-Y.3
  • 12
    • 24344438206 scopus 로고    scopus 로고
    • Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts
    • Li Q, Wang M, Tan L et al.: Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts. J. Lipid Res. 46, 1904-1913 (2005).
    • (2005) J. Lipid Res , vol.46 , pp. 1904-1913
    • Li, Q.1    Wang, M.2    Tan, L.3
  • 13
    • 0033964508 scopus 로고    scopus 로고
    • Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders
    • Martinez M, Vazquez E, Garcia-Silva MT: Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders. Am. J. Clin. Nutr. 71, 376-385 (2000).
    • (2000) Am. J. Clin. Nutr , vol.71 , pp. 376-385
    • Martinez, M.1    Vazquez, E.2    Garcia-Silva, M.T.3
  • 14
    • 36649010031 scopus 로고    scopus 로고
    • Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: Evidence from animal studies
    • Calon F, Cole G: Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostaglandins Leukot. Essent. Fatty Acids 77, 287-293 (2007).
    • (2007) Prostaglandins Leukot. Essent. Fatty Acids , vol.77 , pp. 287-293
    • Calon, F.1    Cole, G.2
  • 15
  • 16
    • 54449085055 scopus 로고    scopus 로고
    • Reduction in cerebral atrophy associated with ethyl-eicosapentanoic acid treatment in patients with Huntington's disease
    • Puri BK, Bydder GM, Manku MS et al.: Reduction in cerebral atrophy associated with ethyl-eicosapentanoic acid treatment in patients with Huntington's disease. J. Int. Med. Res. 36, 896-905 (2008).
    • (2008) J. Int. Med. Res , vol.36 , pp. 896-905
    • Puri, B.K.1    Bydder, G.M.2    Manku, M.S.3
  • 17
    • 65249117459 scopus 로고    scopus 로고
    • Neurological benefits of omega-3 fatty acids
    • Dyall SC, Michael-Titus AT: Neurological benefits of omega-3 fatty acids. Neuromolecular Med. 10(4), 219-235 (2008).
    • (2008) Neuromolecular Med , vol.10 , Issue.4 , pp. 219-235
    • Dyall, S.C.1    Michael-Titus, A.T.2
  • 18
    • 63849186608 scopus 로고    scopus 로고
    • Protection and repair of the injured spinal cord: A review of completed, ongoing and planned clinical trials for acute spinal cord injury
    • Hawryluk GWJ, Rowland J, Kwon BK, Fehlings MG: Protection and repair of the injured spinal cord: a review of completed, ongoing and planned clinical trials for acute spinal cord injury. Neurosurg. Focus 25, 1-16 (2008).
    • (2008) Neurosurg. Focus , vol.25 , pp. 1-16
    • Hawryluk, G.W.J.1    Rowland, J.2    Kwon, B.K.3    Fehlings, M.G.4
  • 19
    • 1842419475 scopus 로고    scopus 로고
    • Degenerative and regenerative mechanisms governing spinal cord injury
    • Profyris C, Cheema SS, Zang DW et al. Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol. Dis. 15, 415-436 (2004).
    • (2004) Neurobiol. Dis , vol.15 , pp. 415-436
    • Profyris, C.1    Cheema, S.S.2    Zang, D.W.3
  • 20
    • 0006713771 scopus 로고    scopus 로고
    • Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord
    • Li GL, Brodin G, Farooque M et al.: Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord. J. Neuropathol. Exp. Neurol. 55, 280-289 (1996).
    • (1996) J. Neuropathol. Exp. Neurol , vol.55 , pp. 280-289
    • Li, G.L.1    Brodin, G.2    Farooque, M.3
  • 21
    • 2342550091 scopus 로고    scopus 로고
    • Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord
    • Xu GY, Hughes MG, Ye Z, Hulsebosch CE, McAdoo DJ: Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord. Exp. Neurol. 187, 329-336 (2004).
    • (2004) Exp. Neurol , vol.187 , pp. 329-336
    • Xu, G.Y.1    Hughes, M.G.2    Ye, Z.3    Hulsebosch, C.E.4    McAdoo, D.J.5
  • 22
    • 8744287793 scopus 로고    scopus 로고
    • Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury
    • Gomes-Leal W, Corkill DJ, Freire MA, Picanco-Diniz CW, Perry VH: Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury. Exp. Neurol. 190, 456-467 (2004).
    • (2004) Exp. Neurol , vol.190 , pp. 456-467
    • Gomes-Leal, W.1    Corkill, D.J.2    Freire, M.A.3    Picanco-Diniz, C.W.4    Perry, V.H.5
  • 23
    • 0345095416 scopus 로고    scopus 로고
    • Role of inflammation in the secondary injury following experimental spinal cord trauma
    • Conti A, Cardali S, Genovese T et al.: Role of inflammation in the secondary injury following experimental spinal cord trauma. J. Neurosurg. Sci. 47, 89-94 (2003).
    • (2003) J. Neurosurg. Sci , vol.47 , pp. 89-94
    • Conti, A.1    Cardali, S.2    Genovese, T.3
  • 24
    • 33846196606 scopus 로고    scopus 로고
    • Role of peroxynutrite in secondary oxidative damage after spinal cord injury
    • Xiong Y, Rabchevsky AG, Hall ED: Role of peroxynutrite in secondary oxidative damage after spinal cord injury. J. Neurochem. 100, 639-649 (2006).
    • (2006) J. Neurochem , vol.100 , pp. 639-649
    • Xiong, Y.1    Rabchevsky, A.G.2    Hall, E.D.3
  • 25
    • 33646571167 scopus 로고    scopus 로고
    • Pharmacological approaches to repair the injured spinal Cord
    • Baptiste DC, Fehlings MG: Pharmacological approaches to repair the injured spinal Cord. J. Neurotrauma 23, 318-334 (2006).
    • (2006) J. Neurotrauma , vol.23 , pp. 318-334
    • Baptiste, D.C.1    Fehlings, M.G.2
  • 26
    • 33748804968 scopus 로고    scopus 로고
    • Inhibitors of brain phospholipase A2 activity: Their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders
    • Farooqui AA, Ong WY, Horrocks LA: Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol. Rev. 58, 591-620 (2006).
    • (2006) Pharmacol. Rev , vol.58 , pp. 591-620
    • Farooqui, A.A.1    Ong, W.Y.2    Horrocks, L.A.3
  • 27
    • 33845332735 scopus 로고    scopus 로고
    • The cellular inflammatory response in human spinal cords after injury
    • Fleming JC, Norenberg AD, Ramsay DA et al.: The cellular inflammatory response in human spinal cords after injury. Brain 129, 3249-3269 (2006).
    • (2006) Brain , vol.129 , pp. 3249-3269
    • Fleming, J.C.1    Norenberg, A.D.2    Ramsay, D.A.3
  • 28
    • 43049137966 scopus 로고    scopus 로고
    • The systemic inflammatory response after spinal cord injury damages lungs and kidneys
    • Gris D, Hamilton EF, Weaver LC: The systemic inflammatory response after spinal cord injury damages lungs and kidneys. Exp. Neurol. 211, 259-270 (2008).
    • (2008) Exp. Neurol , vol.211 , pp. 259-270
    • Gris, D.1    Hamilton, E.F.2    Weaver, L.C.3
  • 29
    • 51349087181 scopus 로고    scopus 로고
    • C-reactive protein in adults with chronic spinal cord injury; increased chronic inflammation in tetraplegia vs. paraplegia
    • Gibson AE, Bucholz AC, Martin Ginis KA et al.: C-reactive protein in adults with chronic spinal cord injury; increased chronic inflammation in tetraplegia vs. paraplegia. Spinal Cord 46, 616-621 (2008).
    • (2008) Spinal Cord , vol.46 , pp. 616-621
    • Gibson, A.E.1    Bucholz, A.C.2    Martin Ginis, K.A.3
  • 30
    • 0037385159 scopus 로고    scopus 로고
    • Macrophages and microglia in central nervous system injury: Are they helpful or harmful?
    • Schwartz M: Macrophages and microglia in central nervous system injury: are they helpful or harmful? J. Cereb. Blood Flow Metab. 23, 385-394 (2003).
    • (2003) J. Cereb. Blood Flow Metab , vol.23 , pp. 385-394
    • Schwartz, M.1
  • 31
    • 58149512333 scopus 로고    scopus 로고
    • Spinal cord injury: Plasticity, regeneration and the challenge of translational drug development
    • Blesch A, Tuszynski M: Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci. 32(1), 41-47 (2009).
    • (2009) Trends Neurosci , vol.32 , Issue.1 , pp. 41-47
    • Blesch, A.1    Tuszynski, M.2
  • 32
    • 0034803355 scopus 로고    scopus 로고
    • Current aspects of pathosphysiology and cell dysfunction after severe head injury
    • Sahuquillo J, Poca MA, Amoros S: Current aspects of pathosphysiology and cell dysfunction after severe head injury. Curr. Pharm. Design 7, 1475-1503 (2001).
    • (2001) Curr. Pharm. Design , vol.7 , pp. 1475-1503
    • Sahuquillo, J.1    Poca, M.A.2    Amoros, S.3
  • 33
    • 34447527791 scopus 로고    scopus 로고
    • Pathophysiology of traumatic brain injury
    • Werner C, Engelhard K: Pathophysiology of traumatic brain injury. Brit. J. Anaesthes. 99, 4-9 (2007).
    • (2007) Brit. J. Anaesthes , vol.99 , pp. 4-9
    • Werner, C.1    Engelhard, K.2
  • 35
    • 0035696441 scopus 로고    scopus 로고
    • The duality of the inflammatory response to traumatic brain injury
    • Lenzlinger PM, Morganti-Kossmann MC, Laurer HL et al.: The duality of the inflammatory response to traumatic brain injury. Mol. Neurobiol. 24, 169-181 (2001).
    • (2001) Mol. Neurobiol , vol.24 , pp. 169-181
    • Lenzlinger, P.M.1    Morganti-Kossmann, M.C.2    Laurer, H.L.3
  • 36
    • 0036965965 scopus 로고    scopus 로고
    • Inflammatory response in traumatic brain injury: A double-edged sword
    • Morganti-Kossmann MC, Rancan M, Stahel PF et al.: Inflammatory response in traumatic brain injury: a double-edged sword. Curr. Opin. Crit. Care 8, 101-105 (2002).
    • (2002) Curr. Opin. Crit. Care , vol.8 , pp. 101-105
    • Morganti-Kossmann, M.C.1    Rancan, M.2    Stahel, P.F.3
  • 37
    • 0142121433 scopus 로고    scopus 로고
    • Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury
    • Pilitsis JG, Coplin WM, O'Regan MH et al.: Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. Neurosci. Lett. 349, 136-138 (2003).
    • (2003) Neurosci. Lett , vol.349 , pp. 136-138
    • Pilitsis, J.G.1    Coplin, W.M.2    O'Regan, M.H.3
  • 38
    • 0038526424 scopus 로고    scopus 로고
    • Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat
    • Raghupathi R, Strauss KI, Zhang C et al.: Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat. J. Neurotrauma 20, 421-435 (2003).
    • (2003) J. Neurotrauma , vol.20 , pp. 421-435
    • Raghupathi, R.1    Strauss, K.I.2    Zhang, C.3
  • 39
    • 36049047066 scopus 로고    scopus 로고
    • Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans
    • Uryu K, Chen XH, Martinez D et al.: Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Exp. Neurol. 208, 185-192 (2007).
    • (2007) Exp. Neurol , vol.208 , pp. 185-192
    • Uryu, K.1    Chen, X.H.2    Martinez, D.3
  • 41
    • 33847323914 scopus 로고    scopus 로고
    • Neuroprotection in traumatic brain injury: A complex struggle against the biology of nature
    • Schouten JW: Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature. Curr. Opin. Crit. Care 13, 134-142 (2007).
    • (2007) Curr. Opin. Crit. Care , vol.13 , pp. 134-142
    • Schouten, J.W.1
  • 42
    • 0141835805 scopus 로고    scopus 로고
    • Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats
    • Lang-Lazdunski L, Blondeau N, Jarretou G et al.: Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. J. Vasc. Surg. 38, 564-575 (2003).
    • (2003) J. Vasc. Surg , vol.38 , pp. 564-575
    • Lang-Lazdunski, L.1    Blondeau, N.2    Jarretou, G.3
  • 43
    • 0034678889 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids are potent neuroprotectors
    • Lauritzen I, Blondeau N, Heurteaux C et al.: Polyunsaturated fatty acids are potent neuroprotectors. EMBO J. 19, 1784-1793 (2000).
    • (2000) EMBO J , vol.19 , pp. 1784-1793
    • Lauritzen, I.1    Blondeau, N.2    Heurteaux, C.3
  • 44
    • 0037185379 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids induce ischemic and epileptic tolerance
    • Blondeau N, Widmann N, Lazdunski M, Heurteaux C: Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 109, 231-241 (2002).
    • (2002) Neuroscience , vol.109 , pp. 231-241
    • Blondeau, N.1    Widmann, N.2    Lazdunski, M.3    Heurteaux, C.4
  • 45
  • 46
    • 85026146954 scopus 로고    scopus 로고
    • Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures
    • Wang X, Zhao X, Mao ZY, Wang XM, Liu ZL: Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures, Neuroreport 14, 2457-2461 (2003).
    • (2003) Neuroreport , vol.14 , pp. 2457-2461
    • Wang, X.1    Zhao, X.2    Mao, Z.Y.3    Wang, X.M.4    Liu, Z.L.5
  • 47
    • 33646844063 scopus 로고    scopus 로고
    • Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat
    • King VR, Huang WL, Dyall SC et al.: Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J. Neurosci. 26, 4672-4680 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 4672-4680
    • King, V.R.1    Huang, W.L.2    Dyall, S.C.3
  • 48
    • 35648944690 scopus 로고    scopus 로고
    • A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury
    • Huang WL, King VR, Curran OE et al.: A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain 130, 3004-3019 (2007).
    • (2007) Brain , vol.130 , pp. 3004-3019
    • Huang, W.L.1    King, V.R.2    Curran, O.E.3
  • 49
    • 67249147833 scopus 로고    scopus 로고
    • The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats
    • Presented at:, Abstract 651.11, Washington, DC, USA 15-19 November
    • Lim SN, Huang WL, Ward RE et al.: The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats. Presented at: Society of Neuroscience Meeting. (Abstract 651.11), Washington, DC, USA 15-19 November 2008.
    • (2008) Society of Neuroscience Meeting
    • Lim, S.N.1    Huang, W.L.2    Ward, R.E.3
  • 50
    • 7244240590 scopus 로고    scopus 로고
    • Omega-3 fatty acids normalize BDNF levels, reduce oxidative damage and counteract learning disability after traumatic brain injury in rats
    • Wu A, Ying Z, Gomez-Pinilla F: Omega-3 fatty acids normalize BDNF levels, reduce oxidative damage and counteract learning disability after traumatic brain injury in rats. J. Neurotrauma 21, 1457-1467 (2004).
    • (2004) J. Neurotrauma , vol.21 , pp. 1457-1467
    • Wu, A.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 51
    • 0012850301 scopus 로고    scopus 로고
    • A saturated fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor
    • Wu A, Molteni R, Ying Z, Gomez-Pinilla F: A saturated fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor. Neuroscience 119, 365-375 (2003).
    • (2003) Neuroscience , vol.119 , pp. 365-375
    • Wu, A.1    Molteni, R.2    Ying, Z.3    Gomez-Pinilla, F.4
  • 52
    • 35648952140 scopus 로고    scopus 로고
    • Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury
    • Wu A, Ying Z, Gomez-Pinilla F: Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. J. Neurotrauma 24, 1587-1595 (2007).
    • (2007) J. Neurotrauma , vol.24 , pp. 1587-1595
    • Wu, A.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 53
    • 44949168717 scopus 로고    scopus 로고
    • Does eicosapentaenoic acid (EPA) inhibit cerebral vasospasm in patients after aneurysmal subarachnoid haemorrhage?
    • Yoneda H, Shirao S, Kurokawa T et al.: Does eicosapentaenoic acid (EPA) inhibit cerebral vasospasm in patients after aneurysmal subarachnoid haemorrhage? Acta Neurol. Scand. 118, 54-59 (2008).
    • (2008) Acta Neurol. Scand , vol.118 , pp. 54-59
    • Yoneda, H.1    Shirao, S.2    Kurokawa, T.3
  • 54
    • 0029861617 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons
    • Vreugdenhil M, Bruehl C, Voskuyl RA et al.: Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc. Natl Acad. Sci. USA 93, 12559-12563 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 12559-12563
    • Vreugdenhil, M.1    Bruehl, C.2    Voskuyl, R.A.3
  • 55
    • 58149348589 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid modulation of voltage-gated ion channels
    • Boland LM, Drzewiecki MM: Polyunsaturated fatty acid modulation of voltage-gated ion channels. Cell Biochem. Biophys. 52, 59084 (2008).
    • (2008) Cell Biochem. Biophys , vol.52 , pp. 59084
    • Boland, L.M.1    Drzewiecki, M.M.2
  • 56
    • 0034672081 scopus 로고    scopus 로고
    • Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain
    • Mata de Urquiza A, Liu S, Sjoberg M et al.: Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290, 2140-2144 (2000).
    • (2000) Science , vol.290 , pp. 2140-2144
    • Mata de Urquiza, A.1    Liu, S.2    Sjoberg, M.3
  • 57
    • 33644933866 scopus 로고    scopus 로고
    • Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury
    • Schrage K, Koopmans G, Joosten EA, Mey J: Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury. Eur. J. Neurosci. 23, 285-295 (2006).
    • (2006) Eur. J. Neurosci , vol.23 , pp. 285-295
    • Schrage, K.1    Koopmans, G.2    Joosten, E.A.3    Mey, J.4
  • 58
    • 33644652740 scopus 로고    scopus 로고
    • Involvement of PPAR nuclear receptors in tissue injury and wound repair
    • Michalik L, Wahli W: Involvement of PPAR nuclear receptors in tissue injury and wound repair. J. Clin. Invest. 116, 598-606 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 598-606
    • Michalik, L.1    Wahli, W.2
  • 59
    • 34248598448 scopus 로고    scopus 로고
    • The PPAR γ agonist Pioglitazone improves anatomical and locomotor recovery after rodent spinal cord injury
    • McTigue DM, Tripathi R, Wei P, Lash AT: The PPAR γ agonist Pioglitazone improves anatomical and locomotor recovery after rodent spinal cord injury. Exp. Neurol. 205, 396-406 (2007).
    • (2007) Exp. Neurol , vol.205 , pp. 396-406
    • McTigue, D.M.1    Tripathi, R.2    Wei, P.3    Lash, A.T.4
  • 60
    • 33847093475 scopus 로고    scopus 로고
    • Thiazolidinedione class of peroxisome proliferator-activated receptor γ agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats
    • Park SW, Yi JH, Miranpuri G et al.: Thiazolidinedione class of peroxisome proliferator-activated receptor γ agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats. J. Pharmacol. Exp. Ther. 320, 1002-1012 (2007).
    • (2007) J. Pharmacol. Exp. Ther , vol.320 , pp. 1002-1012
    • Park, S.W.1    Yi, J.H.2    Miranpuri, G.3
  • 61
    • 33947204503 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and Type-2 diabetic rodents
    • Tureyen K, Kapadia R, Bowen KK et al.: Peroxisome proliferator-activated receptor-γ agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and Type-2 diabetic rodents. J. Neurochem. 101, 41-56 (2007).
    • (2007) J. Neurochem , vol.101 , pp. 41-56
    • Tureyen, K.1    Kapadia, R.2    Bowen, K.K.3
  • 62
    • 56049113451 scopus 로고    scopus 로고
    • PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms
    • Yi JH, Park SW, Brooks N, Lang BT, Vemuganti R: PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms. Brain Res. 1244, 164-172 (2008).
    • (2008) Brain Res , vol.1244 , pp. 164-172
    • Yi, J.H.1    Park, S.W.2    Brooks, N.3    Lang, B.T.4    Vemuganti, R.5
  • 63
    • 23344439553 scopus 로고    scopus 로고
    • Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival
    • Akbar M, Calderon F, Wen Z et al.: Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc. Natl Acad. Sci. USA 102, 10858-10863 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 10858-10863
    • Akbar, M.1    Calderon, F.2    Wen, Z.3
  • 64
    • 34547131318 scopus 로고    scopus 로고
    • Novel metabolism of docosahexaenoic acid in neural cells
    • Kim H-Y: Novel metabolism of docosahexaenoic acid in neural cells. J. Biol Chem. 282, 18661-18665 (2007).
    • (2007) J. Biol Chem , vol.282 , pp. 18661-18665
    • Kim, H.-Y.1
  • 65
    • 0038013967 scopus 로고    scopus 로고
    • Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation
    • Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN: Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J. Biol. Chem. 278, 14677-14687 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 14677-14687
    • Hong, S.1    Gronert, K.2    Devchand, P.R.3    Moussignac, R.L.4    Serhan, C.N.5
  • 66
    • 12344253802 scopus 로고    scopus 로고
    • Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers
    • Serhan CN, Arita M, Hong S, Gotlinger K: Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids 39, 1125-1132 (2004).
    • (2004) Lipids , vol.39 , pp. 1125-1132
    • Serhan, C.N.1    Arita, M.2    Hong, S.3    Gotlinger, K.4
  • 67
    • 0242290167 scopus 로고    scopus 로고
    • Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression
    • Marcheselli VL, Hong S, Lukiw WJ et al.: Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J. Biol. Chem. 273, 43807-43817 (2003).
    • (2003) J. Biol. Chem , vol.273 , pp. 43807-43817
    • Marcheselli, V.L.1    Hong, S.2    Lukiw, W.J.3
  • 68
    • 2942625603 scopus 로고    scopus 로고
    • Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
    • Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG: Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc. Natl Acad. Sci. USA 101, 8491-8496 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 8491-8496
    • Mukherjee, P.K.1    Marcheselli, V.L.2    Serhan, C.N.3    Bazan, N.G.4
  • 69
    • 33646128251 scopus 로고    scopus 로고
    • Cell survival matters: Docosahexaenoic acid signaling, neuroprotection and photoreceptors
    • Bazan NG: Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci. 29, 263-271 (2006).
    • (2006) Trends Neurosci , vol.29 , pp. 263-271
    • Bazan, N.G.1
  • 70
    • 4143102415 scopus 로고    scopus 로고
    • Docosahexaenoic acid promotes neurite growth in hippocampal neurons
    • Calderon F, Kim H-Y: Docosahexaenoic acid promotes neurite growth in hippocampal neurons. J. Neurochem. 90, 979-988 (2004).
    • (2004) J. Neurochem , vol.90 , pp. 979-988
    • Calderon, F.1    Kim, H.-Y.2
  • 71
    • 23944481886 scopus 로고    scopus 로고
    • Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures
    • Cao D, Xue R, Xu J, Liu Z: Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures. J. Nutr. Biochem. 16, 538-546 (2005).
    • (2005) J. Nutr. Biochem , vol.16 , pp. 538-546
    • Cao, D.1    Xue, R.2    Xu, J.3    Liu, Z.4
  • 72
    • 77049084743 scopus 로고    scopus 로고
    • Omega-3 fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals
    • DOI: 10.1016/ j.neurobiolaging.2008.05.027, Epub ahead of print
    • Robson LG, Dyall SC, Sidloff D, Michael-Titus AT: Omega-3 fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol. Aging DOI: 10.1016/ j.neurobiolaging.2008.05.027. (2008) (Epub ahead of print).
    • (2008) Neurobiol. Aging
    • Robson, L.G.1    Dyall, S.C.2    Sidloff, D.3    Michael-Titus, A.T.4
  • 74
    • 10044224770 scopus 로고    scopus 로고
    • Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils
    • Cao DH, Xu JF, Xue RH, Zheng WF, Liu ZL: Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. Pharmacol. Biochem. Behav. 79, 651-659 (2004).
    • (2004) Pharmacol. Biochem. Behav , vol.79 , pp. 651-659
    • Cao, D.H.1    Xu, J.F.2    Xue, R.H.3    Zheng, W.F.4    Liu, Z.L.5
  • 75
    • 11144224909 scopus 로고    scopus 로고
    • Docosahexaenoic acid complexed to albumin elicits high-grade ischaemic neuroprotection
    • Belayev L, Marcheselli VL, Khoutorova L et al.: Docosahexaenoic acid complexed to albumin elicits high-grade ischaemic neuroprotection. Stroke 36, 118-123 (2005).
    • (2005) Stroke , vol.36 , pp. 118-123
    • Belayev, L.1    Marcheselli, V.L.2    Khoutorova, L.3
  • 76
    • 33645812350 scopus 로고    scopus 로고
    • Omega-3 fatty acids improve the diagnosis-related clinical outcome
    • Heller AR, Rössler S, Litz RJ et al.: Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit. Care Med. 34, 972-979 (2006).
    • (2006) Crit. Care Med , vol.34 , pp. 972-979
    • Heller, A.R.1    Rössler, S.2    Litz, R.J.3
  • 77
    • 0031882046 scopus 로고    scopus 로고
    • Eicosapentaenoic and docosahexaenoic acid alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity
    • Peterson LD, Jeffery NM, Thies F et al.: Eicosapentaenoic and docosahexaenoic acid alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity. Lipids 33, 171-180 (1998).
    • (1998) Lipids , vol.33 , pp. 171-180
    • Peterson, L.D.1    Jeffery, N.M.2    Thies, F.3
  • 78
    • 38049116118 scopus 로고    scopus 로고
    • Oral administration for circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses
    • Cansev M, Wurtman RJ, Sakamoto T, Ulus IH: Oral administration for circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. Alzheimers Dement. 4(1 Suppl. 1), 153-168 (2008).
    • (2008) Alzheimers Dement , vol.4 , Issue.1 SUPPL. 1 , pp. 153-168
    • Cansev, M.1    Wurtman, R.J.2    Sakamoto, T.3    Ulus, I.H.4
  • 79
    • 55549148744 scopus 로고    scopus 로고
    • Dietary uridine enhances the improvement in learning and memory produced by administering DHA in gerbils
    • Holguin S, Martinez J, Chow C, Wurtman R: Dietary uridine enhances the improvement in learning and memory produced by administering DHA in gerbils. FASEB J. 22, 3938-3946 (2008).
    • (2008) FASEB J , vol.22 , pp. 3938-3946
    • Holguin, S.1    Martinez, J.2    Chow, C.3    Wurtman, R.4
  • 80
    • 33749633921 scopus 로고    scopus 로고
    • ε-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study
    • Freund-Levi Y, Eriksdotter-Jönhagen M, Cederholm T et al.: ε-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study. Arch. Neurol. 63, 1402-1408 (2006).
    • (2006) Arch. Neurol , vol.63 , pp. 1402-1408
    • Freund-Levi, Y.1    Eriksdotter-Jönhagen, M.2    Cederholm, T.3
  • 81
    • 49249104880 scopus 로고    scopus 로고
    • Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition
    • Wu A, Ying Z, Gomez-Pinilla F: Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience 155, 751-759 (2008).
    • (2008) Neuroscience , vol.155 , pp. 751-759
    • Wu, A.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 82
    • 33748439924 scopus 로고    scopus 로고
    • Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats
    • Browne K, Iwata A, Putt M et al.: Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats. Exp. Neurol. 201, 301-307 (2006).
    • (2006) Exp. Neurol , vol.201 , pp. 301-307
    • Browne, K.1    Iwata, A.2    Putt, M.3
  • 83
    • 27644537715 scopus 로고    scopus 로고
    • Benefits of fatty fish on dementia risk are stronger for those without APOE ε4
    • Huang PL, Zandi PP, Tucker KL et al.: Benefits of fatty fish on dementia risk are stronger for those without APOE ε4. Neurology 65, 1409-1414 (2005).
    • (2005) Neurology , vol.65 , pp. 1409-1414
    • Huang, P.L.1    Zandi, P.P.2    Tucker, K.L.3
  • 84
    • 33746813253 scopus 로고    scopus 로고
    • Healthy intakes of n-3 and n-6 fatty acids: Estimations considering worldwide diversity
    • Hibbeln JR, Nieminen LRG, Blasbalg TL et al.: Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am. J. Clin. Nutr. 83, 1483-1493 (2006).
    • (2006) Am. J. Clin. Nutr , vol.83 , pp. 1483-1493
    • Hibbeln, J.R.1    Nieminen, L.R.G.2    Blasbalg, T.L.3
  • 85
    • 33748537441 scopus 로고    scopus 로고
    • Matrix metalloproteinase-3 expression profile differentiates adaptive and maladaptive synaptic plasticity induced by traumatic brain injury
    • Falo MC, Fillmore HL, Reeves TM et al.: Matrix metalloproteinase-3 expression profile differentiates adaptive and maladaptive synaptic plasticity induced by traumatic brain injury. J. Neurosci. Res. 84, 764-781 (2006).
    • (2006) J. Neurosci. Res , vol.84 , pp. 764-781
    • Falo, M.C.1    Fillmore, H.L.2    Reeves, T.M.3
  • 86
    • 25844459665 scopus 로고    scopus 로고
    • Segmental organization of spinal reflexes mediating autonomic dysreflexia after spinal cord injury
    • Rabchevski AG: Segmental organization of spinal reflexes mediating autonomic dysreflexia after spinal cord injury. Prog. Brain Res. 152, 265-274 (2006).
    • (2006) Prog. Brain Res , vol.152 , pp. 265-274
    • Rabchevski, A.G.1
  • 87
    • 25844477606 scopus 로고    scopus 로고
    • Autonomic dysreflexia after spinal cord injury: Central mechanisms and strategies for prevention
    • Weaver LC, Marsh DR, Gris D, Brown A, Dekaban GA: Autonomic dysreflexia after spinal cord injury: central mechanisms and strategies for prevention. Prog. Brain Res. 152, 245-263 (2006)
    • (2006) Prog. Brain Res , vol.152 , pp. 245-263
    • Weaver, L.C.1    Marsh, D.R.2    Gris, D.3    Brown, A.4    Dekaban, G.A.5
  • 88
    • 48249111069 scopus 로고    scopus 로고
    • Plasticity of lumbosacral propriospinal neurons is associated with the development of autonomic dysreflexia after thoracic spinal cord transaction
    • Hou S, Duale H, Cameron AA et al.: Plasticity of lumbosacral propriospinal neurons is associated with the development of autonomic dysreflexia after thoracic spinal cord transaction. J. Comp. Neurol. 9, 382-399 (2008).
    • (2008) J. Comp. Neurol , vol.9 , pp. 382-399
    • Hou, S.1    Duale, H.2    Cameron, A.A.3
  • 89
    • 22944451144 scopus 로고    scopus 로고
    • Dietary omega-3 fatty acids may be associated with increased neuropathic pain in nerve-injured rats
    • Pérez J, Ware MA, Chevalier S et al.: Dietary omega-3 fatty acids may be associated with increased neuropathic pain in nerve-injured rats. Anesth. Analg. 101, 444-448 (2005).
    • (2005) Anesth. Analg , vol.101 , pp. 444-448
    • Pérez, J.1    Ware, M.A.2    Chevalier, S.3
  • 90
    • 45849140905 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor γ and oxidized docosahexaenoic acids as new class of ligand
    • Itoh T, Yamamoto K: Peroxisome proliferator activated receptor γ and oxidized docosahexaenoic acids as new class of ligand. Naunyn-Schmiedeberg's Arch. Pharmacol. 377, 541-547 (2008).
    • (2008) Naunyn-Schmiedeberg's Arch. Pharmacol , vol.377 , pp. 541-547
    • Itoh, T.1    Yamamoto, K.2
  • 91
    • 48249108682 scopus 로고    scopus 로고
    • Classification of traumatic brain injury for targeted therapies
    • Saatman KE, Duhaime AC, Bullock R et al.: Classification of traumatic brain injury for targeted therapies. J. Neurotrauma 25, 719-738 (2008).
    • (2008) J. Neurotrauma , vol.25 , pp. 719-738
    • Saatman, K.E.1    Duhaime, A.C.2    Bullock, R.3
  • 92
    • 10044272081 scopus 로고    scopus 로고
    • Dietary supplementation of omega-3 polyunsaturated fatty acids worsens forelimb motor function after intracerebral hemorrhage in rats
    • Clarke J, Herberg G Peeling J, Buist R, Corbett D: Dietary supplementation of omega-3 polyunsaturated fatty acids worsens forelimb motor function after intracerebral hemorrhage in rats. Exp. Neurol. 191, 119-127 (2005).
    • (2005) Exp. Neurol , vol.191 , pp. 119-127
    • Clarke, J.1    Herberg, G.2    Peeling, J.3    Buist, R.4    Corbett, D.5


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