Lack of UT-B in vasa recta and red blood cells prevents urea-induced improvement of urinary concentrating ability

American Journal of Physiology - Renal Physiology

Volumn 286, Issue 1 55-1, 2004, Pages

  Bankir, Lise ^a,b   Chen, Kai ^a   Yang, Baoxue ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUT DU FER À MOULIN   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Creatinine clearance; Protein intake; Urea clearance; Urea transport; Urinary concentrating ability

Indexed keywords

CARRIER PROTEIN; CREATININE; POTASSIUM; PROTEIN UT B; SODIUM; UNCLASSIFIED DRUG; UREA;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; ERYTHROCYTE; FEMALE; HENLE LOOP; KIDNEY BLOOD VESSEL; KIDNEY CONCENTRATING CAPACITY; KIDNEY MEDULLA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DIET; PROTEIN FUNCTION; PROTEIN INTAKE; UREA BLOOD LEVEL; UREA CYCLE;

EID: 0346099295     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00205.2003     Document Type: Article

References (39)

1. Bagnasco SM, Sands JM, Pallone TL, Turner MR, Edwards A, Jamison RL, Zhang Z, and Rhinehart K. Gene structure of urea transporters. Am J Physiol Renal Physiol 284: F3-F10, 2003.
2. Bankir L, Bouby N, and Trinh-Trang-Tan MM. The role of the kidney in the maintenance of water balance. Baillières Clin Endocrinol Metab 3: 249-311, 1989.
3. Bankir L and de Rouffignac C. Urinary concentrating ability: insights from comparative anatomy. Am J Physiol Regul Integr Comp Physiol 249: R643-R666, 1985.
4. Bankir L and Trinh-Trang-Tan MM. Urea and the kidney. In: The Kidney (6th ed.), edited by Brenner BM. Philadelphia, PA: Saunders, 2000, p. 637-679.
5. Bouby N, Ahloulay M, Nsegbe E, Dechaux M, Schmitt F, and Bankir L. Vasopressin increases glomerular filtration rate in conscious rats through its antidiuretic action. J Am Soc Nephrol 7: 842-851, 1996.
6. Bouby N, Tring-Trang-Tan MM, Laouari D, Kleinknecht C, Grünfeld JP, Kriz W, and Bankir L. Role of the urinary concentrating process in the renal effects of high protein intake. Kidney Int 43: 4-12, 1988.
7. Crawford JD, Doyle AP, and Probst JH. Service of urea in renal water conservation. Am J Physiol 196: 545-548, 1959.
8. Epstein FH, Kleeman CR, Pursel S, and Hendrikx A. The effect of feeding protein and urea on the renal concentrating process. J Clin Invest 36: 635-641, 1957.
9. Gamble JL, McKhann CF, Butler AM, and Tuthill E. An economy of water in renal function referable to urea. Am J Physiol 109: 139-154, 1934.
10. Hendrikx A and Epstein FH. Effect of feeding protein and urea on renal concentrating ability in the rat. Am J Physiol 195: 539-542, 1958.
11. Knepper MA and Roch-Ramel F. Pathways of urea transport in the mammalian kidney. Kidney Int 31: 629-633, 1987.
12. Kriz W. Structural organization of the renal medulla: comparative and functional aspects. Am J Physiol Regul Integr Comp Physiol 241: R3-R16, 1981.
13. Kriz W. Structural organization of the renal medullary counterflow system. Federation Proc 42: 2379-2385, 1983.
14. Lassiter WE, Gottschalk CW, and Mylle M. Micropuncture study of net transtubular movement of water and urea in nondiuretic mammalian kidney. Am J Physiol 200: 1139-1146, 1961.
15. Macey RI. Transport of water and urea in red blood cells. Am J Physiol Cell Physiol 246: C195-C208, 1984.
16. Marsh DJ and Knepper MA. Renal handling of urea. In: Handbook of Physiology. Renal Physiology. Bethesda, MD: Am Physiol Soc, 1992, sect, 8, vol. II, chapt. 29, p. 1317-1348.
17. Masilamani S, Knepper MA, and Burg MB. Urine concentration and dilution. In: The Kidney (6th ed.), edited by Brenner BM. Philadelphia, PA: Saunders, 2000, p. 595-635.
18. Morel F and de Rouffignac C. Micropuncture study of urea medullary recycling in desert rodents. In: Urea and the Kidney, edited by Schmidt-Nielsen B. Amsterdam: Excerpta Medica Foundation, 1970, p. 401-413.
19. Nielsen S, Terris J, Smith CP, Hediger MA, Ecelbarger CA, and Knepper MA. Cellular and subcellular localization of the vasopressin-regulated urea transporter in rat kidney. Proc Natl Acad Sci USA 93: 5495-5500, 1996.
20. Pallone TL, Turner MR, Edwards A, and Jamison RL. Countercurrent exchange in the renal medulla. Am J Physiol Regul Integr Comp Physiol 284: R1153-R1175, 2003.
21. Pallone TL, Work J, Myers RL, and Jamison RL. Transport of sodium and urea in outer medullary descending vasa recta. J Clin Invest 93: 212-222, 1994.
22. Pennel JP, Sanjana V, Frey NR, and Jamison RL. The effect of urea infusion on the urinary concentrating mechanism in protein-depleted rats. J Clin Invest 55: 399-409, 1975.
23. Rabinowitz L, Gunther RA, Shoji ES, Freedland RA, and Avery EH. Effects of high and low protein diets on sheep renal function and metabolism. Kidney Int 4: 188-207, 1973.
24. 121I-γ-M-immunoglobulin. Pflügers Arch 342: 61-72, 1973.
25. Rouffignac de C, Bankir L, and Roinel N. Renal function and concentrating ability in a desert rodent: the gundi (Ctenodactylus vali). Pflügers Arch 390: 138-144, 1981.
26. Sands JM, Bagnasco SM, Pallone TL, Turner MR, Edwards A, Jamison RL, Zhang Z, and Rhinehart K. Mammalian urea transporters. Annu Rev Physiol 65: 543-566, 2003.
27. Schmidt-Nielsen B and Robinson RR. Contribution of urea to urine concentrating ability in the dog. Am J Physiol 218: 1363-1369, 1970.
28. Schwartz MM, Karnovsky MJ, and Venkatachalam MA. Ultrastructural differences between rat inner medullary descending and ascending vasa recta. Lab Invest 35: 161-170, 1976.
29. Shayakul C, Knepper MA, Smith CP, DiGiovanni SR, and Hediger MA. Segmental localization of urea transporter mRNAs in rat kidney. Am J Physiol Renal Physiol 272: F654-F660, 1997.
30. Trimble ME. Renal anatomy and the effects of acute urea and salt loading on the concentrating mechanism of infant rats. In: Urea and the Kidney, edited by Schmidt-Nielsen B and Kerr DWS. Amsterdam: Excerpta Medica Foundation, 1970, p. 366-374.
31. Trinh-Trang-Tan MM and Bankir L. Integrated function of urea transporters in the mammalian kidney. Exp Nephrol 6: 471-479, 1998.
32. Trinh-Trang-Tan MM, Lasbennes F, Gane P, Roudier N, Ripoche P, Cartron JP, and Bailly P. UT-B1 proteins in rat: tissue distribution and regulation by antidiuretic hormone in kidney. Am J Physiol Renal Physiol 283: F912-F922, 2002.
33. Tsukaguchi H, Shayakul C, Berger UV, Tokui T, Brown D, and Hediger MA. Cloning and characterization of the urea transporter UT3: localization in rat kidney and testis. J Clin Invest 99: 1506-1515, 1997.
34. Valtin H. Structural and functional heterogeneity of mammalian nephrons. Am J Physiol Renal Fluid Electrolyte Physiol 233: F491-F501, 1977.
35. Wade JB, Lee AJ, Liu J, Ecelbarger CA, Mitchell C, Bradford AD, Terris J, Kim GH, and Knepper MA. UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin. Am J Physiol Renal Physiol 278: F52-F62, 2000.
36. Wagner L, Klein JD, Sands JM, and Baylis C. Urea transporters are distributed in endothelial cells and mediate inhibition of L-arginine transport. Am J Physiol Renal Physiol 283: F578-F582, 2002.
37. Yang B, Bankir L, Gillepsie A, Epstein CJ, and Verkman AS. Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem 277: 10633-10637, 2002.
38. Yang B and Verkman AS. Urea transporter UT3 functions as an efficient water channel. Direct evidence for a common water/urea pathway. J Biol Chem 273: 9369-9372, 1998.
39. Zerbe RL and Robertson GL. Osmoregulation of thirst and vasopressin secretion in human subjects: effect of various solutes. Am J Physiol Endocrinol Metab 244: E607-E614, 1983.