Permeability criteria for effective function of passive countercurrent multiplier

American Journal of Physiology

Volumn 270, Issue 1 PART 2, 1996, Pages

  Layton, H E ^a,b   Knepper, Mark A ^a,b   Chou, Chung Lin ^a,b  

^a DUKE UNIVERSITY   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Chinchilla; Inner medulla; Isolated perfused tubule; Kidney; Mathematical model; Thin ascending limb; Thin descending limb; Urea permeability; Urine concentrating mechanism

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE PERMEABILITY; CHINCHILLA; HENLE LOOP; KIDNEY CONCENTRATING CAPACITY; KIDNEY PROXIMAL TUBULE; NONHUMAN; OSMOLALITY; PRIORITY JOURNAL; TRANSPORT KINETICS;

ANIMALS; CALCIUM; CHINCHILLA; COMPUTER SIMULATION; LOOP OF HENLE; MODELS, BIOLOGICAL; OSMOLAR CONCENTRATION; PERFUSION; PERMEABILITY; PROTAMINES; UREA;

EID: 0030020602     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajprenal.1996.270.1.f9     Document Type: Article

References (53)

1. Chandhoke, P. S., G. M. Saidel, and M. A. Knepper. Role of inner medullary collecting duct NaCl transport in urinary concentration. Am. J. Physiol. 249 (Renal Fluid Electrolyte Physiol.18): F688-F697, 1985.
2. Chou, C.-L., and M. A. Knepper. In vitro perfusion of'chinchilla thin limb segments: segmentation and osmotic water permeability. Am. J. Phvsiol. 263 (Renal Fluid Electrolyte Physiol.32): F417-F426, 1992.
3. Chou, C.-L., and M. A. Knepper. In vitro perfusion of chinchilla thin limb segments: urea and NaCl permeabilities. Am. J. Phvsiol. 264 (Renal Fluid Electrolyte Physiol.33): F337-F343, 1993.
4. Chou, C.-L., S. Nielsen, and M. A. Knepper. Structuralfunctional correlation in chinchilla long loop of Henle thin limbs: a novel papillary subsegment. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol.34): F863-F874, 1993.
5. Chou, C.-L., J. M. Sands, H. Nonoguchi, and M. A. Knepper. Concentration dependence of urea and thiourea transport in rat inner medullary collecting duct. Am. J. PhysioJ. 258 (Renal Fluid Electrolyte Physiol.27): F486-F494, 1990.
6. Di Stefano, A., M. Wittner, and B. Gebier. Increased Ca2 or Mg2 concentration reduces relative tight-junction permeability to Na in the cortical thick ascending limb of Henle's loop of rabbit kidney. Renal Physiol. Biochem. 11: 70-79, 1988.
7. Hamada, Y., M. Imai, T. Aoki, R. Suzuki, and A. Kamiya. Simulation of the profile of water, NaCl, and urea transport in the countercurrent multiplication system between thin ascending limb and inner medullary collecting duct. Tohoku J. Exp. Med. 168: 47-62, 1992.
8. Han, J. S., K. A. Thompson, C.-L. Chou, and M. A. Knepper. Experimental tests of a three-dimensional model of urinary concentrating mechanism. J. Am. Soc. Nephrol. 2: 1677-1688, 1992.
9. Imai, M. Function of the thin ascending limb of Henle or rats and hamsters perfused in vitro. Am. J. Physiol. 232 (Renal Fluid Electrolyte Physiol.1): F201-F209, 1977.
10. Imai, M., M. Hayashi, and M. Araki. Functional heterogeneity of the descending limbs of Henle's loop. I. Internephron heterogeneity in the hamster kidney. Pflückers Arch. 402: 385-392, 1984. "
11. Imai, M., J. Taniguchi, and K. Tabei. Function of thin loops of Henle. Kidney Int. 31: 565-579, 1987.
12. Kellogg, R. B. Some singular perturbation problems in renal models. J. Math. Anal. Appl. 128: 214-240, 1987.
13. Knepper, M. A. Urea transport in isolated thick ascending limbs and collecting ducts from rats. Am. J. Physiol. 245 (Renal Fluid Electrolyte Physiol.14): F634-F639, 1983.
14. Knepper, M. A. Measurement of osmolality in kidney slices using vapor pressure osmometry. Kidney Int. 21: 653-655, 1982.
15. Knepper, M. A. Urea transport in nephron segments from medullary rays of rats. Am. J. Physiol. 244 (Renal Fluid Electrolyte Physiol.13):F622-F627, 1983.
16. Knepper, M. A., R. A. Danielson, G. M. Saidel, and R. S. Post. Quantitative analysis of renal medullary anatomy in rats and rabbits. Kidney Int. 12: 313-323, 1977.
17. Knepper, M. A., and F. C. Rector, Jr. Urinary concentration and dilution. In: The Kidney (4th ed.), edited by B. M. Brenner and F. C. Rector, Jr. Philadelphia, PA: Harcourt-Brace Jovanovich.1991, vol. 1, p. 445-482.
18. Kokko, J. P., and F. C. Rector. Countercurrent multiplication system without active transport in inner medulla. Kidney Int. 2: 214-223, 1972.
19. Koyania, S., K. Yoshitomi, and M. Imai. Effect of protamine on ion conductance of upper portion of descending limb of longlooped nephron from hamsters. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol.29): F839-F847, 199l'.
20. Koyama, S., K. Yoshitomi, and M. Imai. Effect of protamine on ion conductance of ascending thin limb of Henle's loop from hamsters. Am. J. Phvsiol. 261 (Renal Fluid Electrolyte Phvsiol.30): F593-F599, 1991.
21. Kriz, W., and L. Bankir. A standard nomenclature for structures of the kidney. Am. .J. Physiol. 254 (Renal Fluid Electrolyte Physiol.23):F1-F8, 1988.
22. Layton, H. E. Distribution of Henle's loops may enhance urine concentrating capability. Biophys. J. 49: 1033-1040. 1986.
23. Layton, H. E. Urea transport in a distributed model of the urine-concentrating mechanism. Am. J. Physiol. 258 (Renal Fluid Electrolyte PhysioJ.27): F1110-F1124, 1990.
24. Layton, H. E., and J. M. Davies. Distributed solute and water reabsorption in a central core model of the renal medulla. Math. Biosci. 116: 169-196, 1993.
25. Layton, H. E., and E. B. Pitman. A dynamic numerical method for models of renal tubules. Bull. Math. EM. 56: 547-565, 1994.
26. Layton, H. E., E. B. Pitman, and M. A. Knepper. A dynamicnumerical method for models of the urine concentrating mechanism. SfAMJ. AppL Math. 55: 1390-1418, 1995.
27. Lory, P. Effectiveness of a salt transport cascade in the renal medulla: computer simulations. Am. J. PhysioJ. 252 (Renal Fluid Electrolyte Physiol.21): F1095-F1102, 1987.
28. Moore, L. C., and D. J. Marsh. How descending limb of Henle's loop permeability affects hypertonic urine formation. Am. J. Physiol. 239 (Renal Fluid Electrolyte Physiol.8): F57-F71, 1980.
29. Morgan, T., and R. W. Berliner. Permeability of the loop of Henle, vasa recta and collecting duct to water, urea and sodium. Am. J. Physiol. 215: 108-115, 1968.
30. Nielsen, S., and M. A. Knepper. Vasopressin activates collecting duct urea transporters and water channels by distinct physical processes. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol.34): F204-F213, 1993.
31. Pallone, T. L., J. Work, and R. L. Jamison. Resistance of descending vasa recta to the transport of water. Am. J. Physiol. 259 (Renal Fluid Electrolyte Physiol.28): F688-F697, 1990.
32. Pallone, T. L. Transport of sodium chloride and water in rat ascending vasa recta. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol.30): F519-F525, 1991.
33. Pallone, T. L. Effect of sodium chloride gradients on water flux in rat descending vasa recta. J. Clin. Invest. 87: 12-19, 1991.
34. Pallone, T. L., J. Work, R. L. Myers, and R. L. Jamison. Transport of sodium and urea in outer medullary descending vasa recta. J. Clin. Invest. 93: 212-222, 1994.
35. Rocha, A. S., and J. P. Kokko. Sodium chloride and water transport in the medullary thick ascending limb of Henle. J. Clin. Invest. 52: 612-623, 1973.
36. Roy, D. R., Jr., H. E. Layton, and R. L. Jamison. Countercurrent mechanism and its regulation. In: The Kidney: Physiology and Pathophysioy (2d ed.), edited by D. W. Seldin and G. Giebisch. New York: Raven, 1992, p. 1649-1692.
37. Sands, J. M., and M. A. Knepper. Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium. J. Clin. Invest. 79: 138-147, 1987.
38. Sands, J. M., H. Nonoguchi, and M. A. Knepper. Hormone effects on NaCl permeability of rat inner medullary collecting duct. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol.24): F421-F428, 1988.
39. Sands, J. M., H. Nonoguchi, and M. A. Knepper. Vasopressin effects on urea and H^O transport in inner medullary collecting duct subsegments. Am. J. Physiol. 253 (Renal Fluid Electrolyte Physiol.22): F823-F832, 1987.
40. Sands, J. M., and D. C. Schrader. An independent effect of osmolality on urea transport in rat terminal medullary collecting ducts. J. Clin. Invest. 88: 137-142, 1991.
41. Schafer, J. A., C. S. Patlak, and T. E. Andreoli. A component of fluid absorption linked to passive ion flows in the rabbit superficial pars recta. J. Gen. Physiol. 66: 445-471, 1975.
42. Schafer, J. A., S. L. Troutman, and T. E. Andreoli. Volume reabsorption, transepithelial potential differences and ionic permeability properties in mammalian superficial proximal straight tubules. J. Gen. Physiol. 64: 582-607, 1974.
43. Stephenson, J. L. Concentration of urine in a central core model of the renal counterflow system. Kidney Int. 2: 85-94, 1972.
44. Stephenson, J. L., H. Wang, and R. P. Tewarson. Effect of vasa recta flow on concentrating ability of models of the renal inner medulla. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol.37): F698-F709, 1995.
45. Stephenson, J. L., J. F. Jen, H. Wang, and R. P. Tewarson. Convective uphill transport of NaCl from ascending thin limb of the loop of Henle. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol.37): F680-F692, 1995.
46. Valtin, H. Sequestration of urea and nonurea solutes in renal tissues of rats with hereditary hypothalamic diabetes insipidus: effect of vasopressin and dehydration on the countercurrent mechanism. J. din. Invest. 45: 337-345. 1966.
47. Wang, H., J. L. Stephenson, Y.-F. Deng, and R. P. Tewarson. An efficient parallel algorithm for solving n-nephron models of the renal inner medulla. Comput. Math. Appiic. 28: 1-12, 1994.
48. Wang, H., R. P. Tewarson, J. F. Jen, and J. L. Stephenson. A comparison of multinephron and shunt models of the renal concentrating mechanism. Appl. Math. Lett. 6: 61-65, 1993.
49. Wang, X., A. S. Wexler, and D. J. Marsh. The effect of solution non-ideality on membrane transport in three-dimensional models of the renal concentrating mechanism. Bull. Math. Biol. 56: 515-546, 1994.
50. Weisser, F., F. B. Lacy, H. Weber, and R. L. Jamison. Renal function in chinchilla. Am. J. Physiol. 219: 1706-1713, 1970.
51. Wexler, A. S., R. E. Kalaba, and D. J. Marsh. Passive, one-dimensional countercurrent models do not simulate hypertonic urine formation. Am. J. Physiol. 253 (Renal Fluid Electrolyte Physiol.22): F1020-F1030, 1987.
52. Wexler, A. S., R. E. Kalaba, and D. J. Marsh. Threedimensional anatomy and renal concentrating mechanism. I. Modeling results. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol.29): F368-F383, 1991.
53. Wexler, A. S., R. E. Kalaba, and D. J. Marsh. Threedimensional anatomy and renal concentrating mechanism. II. Sensitivity results. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol.29): F384-F394, 1991.