Urea transport in MDCK cells that are stably transfected with UT-A1

American Journal of Physiology - Cell Physiology

Volumn 286, Issue 6 55-6, 2004, Pages

  Fröhlich, Otto ^a   Klein, Janet D ^a   Smith, Pauline M ^a   Sands, Jeff M ^a   Gunn, Robert B ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arginine vasopressin; Collecting duct; Madin Darby canine kidney cells; Urea transporter A1

Indexed keywords

ARGIPRESSIN; CARBON 14; CARRIER PROTEIN; DIMETHYLUREA; FORSKOLIN; NICOTINAMIDE DERIVATIVE; PHLORETIN; RECOMBINASE; THIONICOTINAMIDE; UNCLASSIFIED DRUG; UREA; UREA TRANSPORTER PROTEIN; UT A1 PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN; DOG; GENETIC TRANSFECTION; INTRACELLULAR TRANSPORT; KIDNEY COLLECTING TUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SODIUM TRANSPORT; UREA CYCLE; WESTERN BLOTTING;

ANIMALS; ARGININE VASOPRESSIN; BIOLOGICAL TRANSPORT; CELL CULTURE TECHNIQUES; CELL LINE; CELL MEMBRANE PERMEABILITY; CLONE CELLS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; KIDNEY TUBULES, COLLECTING; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; NIACINAMIDE; PHLORETIN; TRANSFECTION; UREA; WATER-ELECTROLYTE BALANCE;

ANIMALIA; CANIS FAMILIARIS;

EID: 2442514116     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00499.2003     Document Type: Article

References (32)

1. Bardoux P, Ahloulay M, Maout SL, Bankir L, and Trinh-Trang-Tan MM. Aquaporin-2 and urea transporter-A1 are up-regulated in rats with Type I diabetes mellitus. Diabetologia 44: 637-645, 2001.
2. Barker G and Simmons NL. Identification of two strains of cultured canine renal epithelial cells (MDCK cells) which display entirely different physiological properties. Q J Exper Physiol 66: 61-72, 1981.
3. Bradford AD, Terris JM, Ecelbarger CA, Klein JD, Sands JM, Chou CL, and Knepper MA. 97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation. Am J Physiol Renal Physiol 281: F133-F143, 2001.
4. Chou CL and Knepper MA. Inhibition of urea transport in inner medullary collecting duct by phloretin and urea analogues. Am J Physiol Renal Fluid Electrolyte Physiol 257: F359-F365, 1989.
5. Crain BJ. The mechanism of conservative site-specific recombination. Ann Rev Nutr 22: 77-105, 1988.
6. Fenton RA, Howorth A, Cooper GJ, Meccariello R, Morris ID, and Smith CP. Molecular characterization of a novel UT-A urea transporter isoform (UT-A5) in testis. Am J Physiol Cell Physiol 279: C1425-421431, 2000.
7. Fenton RA, Stewart GS, Carpenter B, Howorth A, Potter EA, Cooper GJ, and Smith CP. Characterization of the mouse urea transporters UT-A1 and UT-A2. Am J Physiol Renal Physiol 283: F817-F825, 2002.
8. Fernandez-Castelo S, Bolivar JJ, Lopez-Vancell R, Beaty G, and Cereijido M. Ion transport in MDCK cells. In: Tissue Culture of Epithelial Cells, edited by Taub M. New York: Plenum Press, 1985, 37-50.
9. Gillin AG and Sands JM. Characteristics of osmolarity-stimulated urea transport in rat IMCD. Am J Physiol Renal Fluid Electrolyte Physiol 262: F1061-F1067, 1992.
10. Inoue T, Terris J, Ecelbarger CA, Chou CL, and Knepper MA. Vasopressin regulates apical targeting of aquaporin-2 but not of UT1 urea transporter in renal collecting duct. Am J Physiol Renal Physiol 276: F559-F566, 1999.
11. Kim DU, Sands JM, and Klein JD. Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats. Am J Physiol Renal Physiol 285: F303-F309, 2003.
12. Klein JD, Gunn RB, Roberts BR, and Sands JM. Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats. Kidney Int 61: 995-1002, 2002.
13. Klein JD, Lamitina T, and O'Neill WC. JNK is a volume-sensitive kinase that phosphorylates the Na-K-2Cl cotransporter in vitro. Am J Physiol Cell Physiol 277: C425-C431, 1999.
14. Klein JD and O'Neill WC. Volume-sensitive myosin phosphorylation in vascular endothelial cells: correlation with Na-K-2Cl cotransport. Am J Physiol Cell Physiol 269: C1524-C1531, 1995.
15. Klein JD, Quach DL, Cole JM, Disher K, Mongiu AK, Wang X, Bernstein KE, and Sands JM. Impaired urine concentration and the absence of tissue ACE: the involvement of medullary transport proteins. Am J Physiol Renal Physiol 283: F517-F524, 2002.
16. Klein JD, Rouillard P, Roberts BR, and Sands JM. Acidosis mediates the upregulation of UT-A protein in livers from uremic rats. J Am Soc Nephrol 13: 581-587, 2002.
17. Knauf PA, Gasbjerg PK, and Brahm J. The asymmetry of chloride transport at 30°C in human red blood cell membranes. J Gen Physiol 108: 577-589, 1996.
18. Lavelle JP, Negrete HO, Poland PA, Kinlough CL, Meyers SD, Hughey RP, and Zeidel ML. Low permeabilities of MDCK cell monolayers: a model barrier epithelium. Am J Physiol Renal Physiol 273: F67-F75, 1997.
19. + transport. J Gen Physiol 120: 71-85, 2002.
20. Naruse M, Klein JD, Ashkar ZM, Jacobs JD, and Sands JM. Glucocorticoids downregulate the vasopressin-regulated urea transporter in rat terminal inner medullary collecting ducts. J Am Soc Nephrol 8: 517-523, 1997.
21. Neuhofer W, Woo SK, Na KY, Grunbein R, Park WK, Nahm O, Beck FX, and Kwon HM. Regulation of TonEBP transcriptional activator in MDCK cells following changes in ambient tonicity. Am J Physiol Cell Physiol 283: C1604-C1611, 2002.
22. Nielsen S and Knepper MA. Vasopressin activates collecting duct urea transporters and water channels by distinct physical processes. Am J Physiol Renal Fluid Electrolyte Physiol 265: F204-F213, 1993.
23. Nielsen S, Terris J, Smith CP, Hediger MA, Ecelbarger CA, and Knepper MA. Cellular and subcellular localization of the vasopressin-regulated urea transporter in rat kidney. Proc Natl Acad Sci USA 93: 5495-5500, 1996.
24. Promeneur D, Rousselet G, Bankir L, Bailly P, Cartron JP, Ripoche P, and Trinh-Trang-Tan MM. Evidence for distinct vascular and tubular urea transporters in the rat kidney. J Am Soc Nephrol 7: 852-860, 1996.
25. Richardson JCW, Scalera V, and Simmons NL. Identification of two strains of MDCK cells which resemble separate nephron tubule segments. Biochim Biophys Acta 673: 26-36, 1981.
26. Rivers RL, McAteer JA, Clendenon JL, Connors BA, Evan AP, and Williams JC Jr. Apical membrane permeability of MDCK cells. Am J Physiol Cell Physiol 271: C226-C234, 1996.
27. Sands JM. Molecular mechanisms of urea transport. J Membrane Biol 191: 149-163, 2003.
28. 2O transport in inner medullary collecting duct subsegments. Am J Physiol Renal Fluid Electrolyte Physiol 253: F823-F832, 1987.
29. Sauer B. Site-specific recombination: developments and applications. Curr Opin Biotechnol 5: 521-527, 1994.
30. Shayakul C, Steel A, and Hediger MA. Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts. J Clin Invest 98: 2580-2587, 1996.
31. Star RA, Nonoguchi H, Balaban R, and Knepper MA. Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J Clin Invest 81: 1879-1888, 1988.
32. Zhang C, Sands JM, and Klein JD. Vasopressin rapidly increases the phosphorylation of the UT-A1 urea transporter activity in rat IMCDs through PKA. Am J Physiol Renal Physiol 282: F85-F90, 2002.